Gene n545 (Tetrahymena)
n545
Species: Tetrahymena
Alias: n545, 3698.m01713, 545
External Links:
Annotation:
Sequence
Protein domains of n545.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| PI3Kc | n545.AA | PI3Kc | 599-861 | 24 | 1.9e-64 | 221.37 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 599-861
Range on HMM: 1-336/336
Sequence Identity: 24% (85 aa)
HMIVKTGDNIKQEQFAVQLIYQFDQIFKME----ELDLKLTPYEIVSLGPQSGILEMVKNSITLDGLLK-------QIHSYKEIK---------------
..|.|.|| |.... |.. ... | . . .||...|| ....||..|..|.|.|. || ..| .. .|....
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM
------------------------------------DLRHFFQLYYGSQ---FKKAQYNFCSSLAAYSLVCYFLQIKDRHNGNILLH-KNGHIIHIDFGF
.|...|. .... . .|. ||..|.|.|. |.| |.|.||||.||.|. |.||..|||||.
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH
FLSNAPGKGLSI----EQNVPFKLLSDYISILG--GIESDMFQTFRRLFFQGFQAACKHQDKILILVKMLYSGHGLTL-PCFEKGEQCILDLEQRFNPPN
.....|.| . | |||.| .|.. . | |..|..|. ||.. ....|. ||...|. |. |. .. . ||. ..| | |.|||.. .
IFGHGPKKPGFKHHHRER-VPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDP---IMPCWRMMEKDIKYLRQRFRLDH
ISNDGELSMHCNM-----LINQSLDNWRARWYDKWQYFCQG
.| | . . ||. |.. | | |. .... |.
-LSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
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| PI3_PI4_kinase | n545.AA | PI3_PI4_kinase | 597-797 | 18 | 9e-43 | 153.21 | Pfam | 1-291 (300) | Show / Hide |
Range on Protein: 597-797 Range on HMM: 1-291/300 Sequence Identity: 18% (54 aa) LVHMIVKTGDNIK--QEQFAVQLI-----------------------YQFDQIFKMEELDLK----LTPYEIVSLGPQSGILEMVKNSITLDGLLKQIHS ...|.| || |.. .|.| .. . | . .|.. ..|| ....||..|..|.|.|. |...... . WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV YKEIKD--------------------------------------LRHFFQLYYGSQ---FKKAQYNFCSSLAAYSLVCYFLQIKDRHNGNILL---HKNG ...|. |...| .... . .| ||..|.| .. | | |.. ||||.||.. ...| KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG HIIHIDFGFFLSNAPGKGLSIEQNVPFKLLS------DYISILGG----IESDMFQTFRRLFFQGFQAACKHQDKILILV-------KMLY |..|||||... .. .|.. |||... .... .|| .| ....||.. .. ..| .|.. ...| ... HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMV |
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| Kinase | n545.AA | ATR | 689-796 | 26 | 2e-13 | 41.71 | In-house | 163-267 (267) | Show / Hide |
Range on Protein: 689-796 Range on HMM: 163-267/267 Sequence Identity: 26% (29 aa) AQYNFCSSLAAYSLVCYFLQIKDRHNGNILLHK-NGHIIHIDFGFFLSNAPGKGLSIEQNVPFKLLSDYISILGGIESDMFQTFRRLFFQGFQAACKHQD .. |.| | |....| | . . ||| |||. | || ..|.|. . |. . . |||.| . .| .... ||| . .|.| SRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIF--NSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGL--FRRACEVIMMCMRDHRD KILILVKML |. ... DIMSVWDCF |
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| Kinase | n545.AA | FRAP | 692-731 | 48 | 5.6e-08 | 25.55 | In-house | 139-179 (251) | Show / Hide |
Range on Protein: 692-731 Range on HMM: 139-179/251 Sequence Identity: 48% (20 aa) NFCSSLAAYSLVCYFLQIKDRHNGNILLHKN-GHIIHIDFG |. ||| |.. | | . ||| ||.| . | |.||||| NYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFG |
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| Kinase | n545.AA | PIKK | 692-732 | 42 | 2e-06 | 19.45 | In-house | 188-229 (290) | Show / Hide |
Range on Protein: 692-732 Range on HMM: 188-229/290 Sequence Identity: 42% (18 aa) NFCSSLAAYSLVCYFLQIKDRHNGNILLHK-NGHIIHIDFGF |...|.| . | | | . ||| ||.. . .| |.|||||. NYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGC |
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| Kinase | n545.AA | PIKK | 631-672 | 28 | 1.7e-05 | 16.38 | In-house | 68-109 (290) | Show / Hide |
Range on Protein: 631-672 Range on HMM: 68-109/290 Sequence Identity: 28% (12 aa) DLKLTPYEIVSLGPQSGILEMVKNSITLDGLLKQIHSYKEIK .| .. | .. .....|..| | |. || ...|| . |.|. HLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYKQWCQKKHIR |
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| Kinase | n545.AA | ATM | 696-761 | 37 | 8.3e-05 | 10.84 | In-house | 143-207 (304) | Show / Hide |
Range on Protein: 696-761 Range on HMM: 143-207/304 Sequence Identity: 37% (25 aa) SLAAYSLVCYFLQIKDRHNGNILL-HKNGHIIHIDFGFFLSNAPGKGLSIEQNVPFKLLSDYISILG | | |.| | | . ||| |||. . ..||| | || | |||.| | . .| SVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQ--GKILPTPETVPFRLTRDIVDGMG |
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| Kinase | n545.AA | ATR | 632-680 | 32 | 0.004905 | 5.7 | In-house | 70-116 (267) | Show / Hide |
Range on Protein: 632-680 Range on HMM: 70-116/267 Sequence Identity: 32% (16 aa) LKLTPYEIVSLGPQSGILEMVKNSITLDGLLKQIHSYKEIKDLRHFFQL ... | .. | |..|.| | | .|| .|... .|| | | || YHMRTYAVIPLNDQCCIIEWVNNTATLRPILDKL--WKEKKQYMQFYQL |
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