Gene n810 (Tetrahymena)
n810
Species: Tetrahymena
Alias: 810, n810, 22.m00330
External Links:
Annotation:
Sequence
Protein domains of n810.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | n810.AA | Ciliate-C8 | 49-244 | 20 | 2.7e-25 | 87.75 | In-house | 1-238 (238) | Show / Hide |
Range on Protein: 49-244
Range on HMM: 1-238/238
Sequence Identity: 20% (50 aa)
GLNSLVLK-----VNDDTALKIMKVTNQN-LELLKELDQRVSNLRTAGKNNYVQQVDSSYFLSENISNTS---------------TPVFYVQEMDLCT--
| ..||| | |||. ...|.. ... .. .. . .| || ...|.| .. .|.| || .|
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKK-SFFVMEMEKCQQN
GNLDSYLSGLNQKEQSLNDTQNERIAIQLLDALMIIHAFGFIHNNIKLTNILYKEQSNGQIVFKIAD------LGLYRLEDFSKWNIQGRLNRNAQKTID
.||..|. . .|.. ... . | |||| .| . .| | ..| ||. |.|. .. ..| |..| .|. . .| . . . . .|.
CNLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIE
I-------YQPQEAYYNQYSSKSDLFC-------LGLIF
| . | ...|. .||.|. .||..
MYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
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| Kinase | n810.AA | C2 | 49-256 | 22 | 7.1e-25 | 81.99 | In-house | 1-245 (245) | Show / Hide |
Range on Protein: 49-256 Range on HMM: 1-245/245 Sequence Identity: 22% (54 aa) GLNSLVLKV-----NDDTALKIMKVTNQNLELLKELDQRVSNLRTAGKNNYVQQVDSSYFLSENISNT--------------------STPVFYVQEMDL | .||||. | ..|||| .. .... .|. . .. .| |. .| ...|..| . .|.| |. GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF CTGNLDSYLSGLNQKEQSLNDTQNERIAIQLLDALMIIHAFGFIHNNIKLTNILYKEQSNGQIVFKIAD----------LGLYRLEDFSKWNIQGRLNRN |.||| .|.. . .... ... . . .||| .|. .| |...| ||. |.|| .. .| . |..| . . .| .| . CQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKW AQKTIDIYQPQEAYYNQYSSKSDLFC-LGLIFLQLENTN-FDFQN | .. | | | | .||||. .|...| | |.. .... TQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC |
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| Kinase | n810.AA | C8 | 40-244 | 24 | 1.6e-21 | 71.57 | In-house | 1-226 (226) | Show / Hide |
Range on Protein: 40-244 Range on HMM: 1-226/226 Sequence Identity: 24% (57 aa) YSSYEFVGAGLNSLVLKV-----NDDTALKIMKVTNQ----NLELLK---ELDQRVSNLRTAGKNNYVQQVDSSYFLSENIS-----NTSTPVFYVQEMD ..... | ..||| | . .||..|..|. |.| .. |..| .. .. ... . . | |. | | . |.||. FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME LCTGNLDSYLSGLNQKEQSLNDTQNERIAIQLLDALMIIHAFGFIHNNIKLTNILYKEQSNGQIVFKIADLGLYRLEDFSKWNIQGRL-NRNAQKTIDIY || || . . .|.| ... . | ||||..| . || . ..| ||. |.| ... | |..|.|. .| || . | . | LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNT---CGTWAY QPQEAYYN------QYSSKSDLFCLGLIF | . ||. .|||| .||. FAPEIEKKQDNQYKQYRIQSDLFSVGLVL |
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| Kinase | n810.AA | Ciliate-E1 | 116-238 | 20 | 6.2e-17 | 51.99 | In-house | 71-202 (202) | Show / Hide |
Range on Protein: 116-238 Range on HMM: 71-202/202 Sequence Identity: 20% (27 aa) FYVQEMDLCTGNLDSYLS---------GLNQKEQSLNDTQNERIAIQLLDALMIIHAFGFIHNNIKLTNILYKEQSNGQIV-FKIADLGLYRLEDFSKWN .... ...| .| ||. ..|........| ..|..||.|.| ..|....|| .|| .|||.. |.|... | |.... . .. .. . ICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYK IQGRLNRNAQKTIDIYQPQEAYYNQYSSKSDLF . . .. ...| .. . .... |||.. GYTHYYYPPEQYNCPEQ-EHNKNQKINYKSDIY |
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| Kinase | n810.AA | S_TKc | 40-313 | 17 | 1e-09 | -34.4 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 40-313 Range on HMM: 1-231/231 Sequence Identity: 17% (52 aa) YSSYEFVGAGLNSLVLKVNDDT-----ALKIMKVTNQNLELLKELDQRVSNLRTAGKNNYVQQVDSSYFLSENISNTSTPVFYVQEMDLCTG---NLDSY | . .| | . | |. . |.||.| . . . .. |. . | |. |. . . .. | |..| | .| .| YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---------DHLYMV--MEYCDGDLGDLFDY LSGLNQ--KEQSLNDTQNERIAIQLLDALMIIHAFGFIHNNIKLTNILYKEQSNGQIVFKIADLGLYRLEDFSKWNIQGRLNRNAQKTIDIYQPQEAYYN . . . . .. . ... |...|| .| |.|| .| ||| | . ||.| || |. . | . | IKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------------TTFCGTPWYMAPEVL--- QYSS-KSDLFCLGLIFLQLENTNFDFQNMQISEFVAFQNKLDKNEFPFEESLLKDSLLSQIIQEWLKDIPSERKDEKAVLA-------HLLL .|. |.| .| |. . |. ... |.. . .. . ..|. |. |..| .|. | . GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | n810.AA | Ciliate-E2 | 121-313 | 17 | 4.7e-09 | 27.22 | In-house | 113-365 (365) | Show / Hide |
Range on Protein: 121-313
Range on HMM: 113-365/365
Sequence Identity: 17% (49 aa)
MDLCTG-NLDSYLS--GLNQKEQ-----SLNDTQNERIAIQLLD---------------ALMIIHAFG-FIHNNIKLTNILYKEQSNGQIVFKIADLGLY
|..| | .| .|. ...... .... . .| |.|. || .| . || .||. |||. ||.|.||
MEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLS
RLEDFS----------KWNIQGRLNRNAQKT----------------IDIYQPQEAYYNQ----------YSSKSDLFCLGLIFLQLENTNFDFQNMQIS
. | . || .. . ... . . |.. | . .. |. |.|...|| |. .. .. |
KKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF------
EFVAFQNKLD-KNEFPFEE-------------SLLKDSLL-SQIIQE----WLKDIPSERKD-EKAVLAHLLL
.|.... | .||..| | .| |. ..|. |. |..| . . .| | .
----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
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| Kinase | n810.AA | ULK | 121-195 | 24 | 9.5e-07 | 19.68 | In-house | 99-188 (329) | Show / Hide |
Range on Protein: 121-195 Range on HMM: 99-188/329 Sequence Identity: 24% (22 aa) MDLCTG-NLDSYLS-----GLNQ-KEQSLNDTQNERIAIQLLDALMIIHAFGFIHNNIKLTNILYKEQSNG--------QIVFKIADLGL |..| | .|..|.. .... ... |. . . .|.| ... .| . || ||. ||| .. . ..|.|||| |. MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGF |
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| Kinase | n810.AA | Ciliate-E3 | 121-195 | 30 | 1e-06 | 17.15 | In-house | 83-152 (202) | Show / Hide |
Range on Protein: 121-195 Range on HMM: 83-152/202 Sequence Identity: 30% (23 aa) MDLCTG-NLDSYLSGLNQKEQSLNDTQNERIAIQLLDALMIIHAFGFIHNNIKLTNILYKEQSNGQIVFKIADLGL ...|. .| |. .|. .. . | |.||.. ...||. || || ||| ..|.|.. ||.|.|. QEYCSNGDLYHYIKQQNKTQNIIYD-----ICIQIIQGMIAIHEKNIIHSDIKPDNILV-DKNNNQLIIKICDFGE |
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| Kinase | n810.AA | Ciliate-E2-Unclassified | 121-313 | 15 | 2e-06 | 18.29 | In-house | 100-352 (352) | Show / Hide |
Range on Protein: 121-313 Range on HMM: 100-352/352 Sequence Identity: 15% (39 aa) MDLCTG-NLDSYLSGLNQ---------------KEQSLNDTQ---NERIAIQLLDALMIIHAFG-FIHNNIKLTNILYKEQSNGQIVFKIADLGLYRLED |..| | .| |.. .. |. . . .. .... |.|..| .| . .|| .||. |||.... . ||.|.|. . . MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-NYYIKIIDFGISKKYQ FSKWNIQGRL--------NRNAQKTI--DIYQ----PQEAYYN-QYS----SKSDLFCLGLIFLQLENTNFDFQNMQISE----------------FVAF . . .. . ... .. .|. . | . . .|. |.| ..|| |. .. .. |. . . . QNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQN QNKLDKNEFPFEE-------SLLKDSLLSQIIQEWLKDIPSERKDEKAVLAHLLL ... . . ..|.. | ......| || |..| . . .| | .. IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | n810.AA | CK1 | 149-177 | 51 | 5e-06 | 17.01 | In-house | 136-164 (339) | Show / Hide |
Range on Protein: 149-177 Range on HMM: 136-164/339 Sequence Identity: 51% (15 aa) RIAIQLLDALMIIHAFGFIHNNIKLTNIL .||||.|.|| .| |||| .|| .|.. MIAIQMLEALEYMHDCGFIHRDIKPDNFC |
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| Kinase | n810.AA | NKF4 | 121-195 | 35 | 6e-06 | 14.61 | In-house | 114-190 (336) | Show / Hide |
Range on Protein: 121-195 Range on HMM: 114-190/336 Sequence Identity: 35% (28 aa) MDLCT-GNLDSYLSGLNQKEQSLNDTQNERIAIQLLDALMIIHAFGFIHNNIKLTNILYKEQSNGQ----IVFKIADLGL || | | . || | ... ||| . . .|| |. | . ||. | ||. | || | |.|| || MDFCDGGDMNQYL--LSRHPR-LNDDTYKSFMMQLAQAMAHLHKNHIIHRDLKPYNIIIVEGRKGQSDLEPVVKVADFGL |
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| Kinase | n810.AA | Ciliate-E3 | 228-248 | 38 | 0.035565 | 2.93 | In-house | 182-202 (202) | Show / Hide |
Range on Protein: 228-248 Range on HMM: 182-202/202 Sequence Identity: 38% (8 aa) YNQYSSKSDLFCLGLIFLQLE ..| | ||. .| .|.|| QQQISKESDYYSVGAVFCQLC |
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