Gene AqueK019 (A.queenslandica)
AqueK019
Species: A.queenslandica
Alias: AqueK019
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
---|---|---|---|---|---|
AqueK019.AA | Protein | None | 161 | None | Fasta, JSON |
AqueK019.kin_dom | Protein Kinase Domain | None | 157 | None | Fasta, JSON |
Protein domains of AqueK019.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
---|---|---|---|---|---|---|---|---|---|
Kinase | AqueK019.AA | Iota | 1-161 | 90 | 1.2e-128 | 430.88 | In-house | 17-177 (271) | Show / Hide |
Range on Protein: 1-161 Range on HMM: 17-177/271 Sequence Identity: 90% (145 aa) MVELKQTKRIYAMKVIKKELVMDEEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIECVNGGDLMFHMQRHRRLPEEHARFYSAEIALALNFL |||.|.|.|||||||||||.| |.|||||||||||||||||||||||||||||||||||||||| |||||||||||| |.|||||||||||||.|||||| MVEHKKTRRIYAMKVIKKEMVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEFVNGGDLMFHMQRQRKLPEEHARFYSAEICLALNFL HEKGIIYRDLKLDNVLLDQDGHIKLTDYGMCKEGLRAGDTTSTFCGTPNYIAPEILRGQDY ||.|||||||||||||||..||||||||||||||.| |||||||||||||||||||||.|| HERGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDY |
|||||||||
Kinase | AqueK019.AA | PKC | 1-161 | 65 | 1.7e-125 | 408.78 | In-house | 17-177 (262) | Show / Hide |
Range on Protein: 1-161 Range on HMM: 17-177/262 Sequence Identity: 65% (105 aa) MVELKQTKRIYAMKVIKKELVMDEEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIECVNGGDLMFHMQRHRRLPEEHARFYSAEIALALNFL ..|.|.|...||.||.||..... .|.....|||.|...|..||||..||.||||..|||||.| |||||||||.|. ||..|||||||.|||..||.|| LAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEEHARFYAAEIICALQFL HEKGIIYRDLKLDNVLLDQDGHIKLTDYGMCKEGLRAGDTTSTFCGTPNYIAPEILRGQDY ||||||||||||||||||..||||..|.|||||... |||||||||||.|||||||..|.| HEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEY |
|||||||||
Kinase | AqueK019.AA | AGC | 2-161 | 32 | 1.3e-110 | 286.67 | In-house | 18-280 (395) | Show / Hide |
Range on Protein: 2-161 Range on HMM: 18-280/395 Sequence Identity: 32% (87 aa) VELK------QTKRIYAMKVIKKEL---VMDEEDIDWVQTE------------KHVFEQASN---------HPFLVG-LHSCFQTESR--LFFVIE---- |. | .|...|||||.||. ... ... ..|| ....|.... |||.| ||..||.... |.|| | VRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHTYLYFVMEYMPR CVN-----GG-DLMFHMQ---RHRRLPEEHARFYSAE-------IALALNFLHE-KGIIYRD-LKLDNVLLDQDGHIKLTDYGMCKEGLRAG-------- || || .|..|.| . .|..||.|||| || |.||| .||. .|||.|| ||..|.|||.|||||||| |.|||| . | YVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQS ------------------------------------------DTTSTFCG--TPNYIAPEILRGQDY |.|.|||| ||.|.||||| | NMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----Y |
|||||||||
Kinase | AqueK019.AA | Eta | 1-161 | 58 | 2.7e-84 | 286.35 | In-house | 17-177 (261) | Show / Hide |
Range on Protein: 1-161 Range on HMM: 17-177/261 Sequence Identity: 58% (94 aa) MVELKQTKRIYAMKVIKKELVMDEEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIECVNGGDLMFHMQRHRRLPEEHARFYSAEIALALNFL . |.|.| .||.||.||. .. ..|.. ||| . | .|||| ||.||||. |||||.| ||||||||..|| |. | |||| ||. .|| || LAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLARKHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFDEPRARFYAAEVTCALMFL HEKGIIYRDLKLDNVLLDQDGHIKLTDYGMCKEGLRAGDTTSTFCGTPNYIAPEILRGQDY |..|.|||||||||.|||..|| || |.||||||. | ||.|||||| |||||||. ..| HQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEY |
|||||||||
Kinase | AqueK019.AA | Akt | 5-161 | 50 | 9.8e-84 | 267.53 | In-house | 21-179 (264) | Show / Hide |
Range on Protein: 5-161 Range on HMM: 21-179/264 Sequence Identity: 50% (81 aa) KQTKRIY-AMKVIKKELVMDEEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIECVNGGDLMFHMQRHRRLPEEHARFYSAEIALALNFLHEK |.|...| ||||.||. . . ..||. . . |||.|.|| |||. .|.|| . .|||.| .|.|| || .|. |||| ||| ||. .||.| KDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN-HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSEDRARFYCAEIILAIEHLHSK GIIYRD-LKLDNVLLDQDGHIKLTDYGMCKEG-LRAGDTTSTFCGTPNYIAPEILRGQDY .||||| ||. |.|.|.||||.||| |.|||. . .|.| |||||| |.||||| |... NIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGH |
|||||||||
Kinase | AqueK019.AA | SGK | 1-161 | 42 | 1.4e-83 | 257.9 | In-house | 17-202 (283) | Show / Hide |
Range on Protein: 1-161 Range on HMM: 17-202/283 Sequence Identity: 42% (79 aa) MVELKQT------------------KRIYAMKVIKKELVM-------DEEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIECVNGGDLMFHM .|. |.. . .|||||..|. . . ...|. | . .|||.|.|| |||. |.|| . ||||.. .|. QVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKLYFVMDYVNGGEMFYHL QRHRRLPEEHARFYSAEIALALNFLHEKGIIYRDLKLDNVLLDQDGHIKLTDYGMCKEGLRAGDTTSTFCGTPNYIAPEILRGQDY || ...|| |||| |||..|| ||.. ||||||| .|.||| .||..||| | |||| . |||.|||||| | |||.||.| . QREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQPH |
|||||||||
Kinase | AqueK019.AA | Alpha | 3-161 | 57 | 7.7e-81 | 274.88 | In-house | 19-177 (259) | Show / Hide |
Range on Protein: 3-161 Range on HMM: 19-177/259 Sequence Identity: 57% (91 aa) ELKQTKRIYAMKVIKKELVMDEEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIECVNGGDLMFHMQRHRRLPEEHARFYSAEIALALNFLHE | | |. || |. || . . |.. .|| | . |||| .|||||| ||.|| | |||||||.|.|. . | || || |||| .| |||| ERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGKPPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFKEPHAVFYAAEIAIGLFFLHE KGIIYRDLKLDNVLLDQDGHIKLTDYGMCKEGLRAGDTTSTFCGTPNYIAPEILRGQDY |||||||||||||.|| .||||..|.|||||.. ..|| ||||||.|||||| | | KGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPY |
|||||||||
Kinase | AqueK019.AA | Delta | 1-161 | 55 | 1.7e-76 | 260.43 | In-house | 17-177 (259) | Show / Hide |
Range on Protein: 1-161 Range on HMM: 17-177/259 Sequence Identity: 55% (89 aa) MVELKQTKRIYAMKVIKKELVMDEEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIECVNGGDLMFHMQRHRRLPEEHARFYSAEIALALNFL ..|||.... ||.| .||. |. ..|.. |..| |..|||| | |||.. ||||.| .||||||.|.| .| |. ||||..|| ..| || LAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEKRARFYACEIICGLQFL HEKGIIYRDLKLDNVLLDQDGHIKLTDYGMCKEGLRAGDTTSTFCGTPNYIAPEILRGQDY |.||||||||||||||||.|||||. |.||||| . ..||||||| ||||||..|| | HKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKY |
|||||||||
Kinase | AqueK019.AA | AktR | 1-159 | 43 | 2.1e-64 | 220.25 | In-house | 17-180 (268) | Show / Hide |
Range on Protein: 1-159 Range on HMM: 17-180/268 Sequence Identity: 43% (72 aa) MVELK-QTKRIYAMKVIKKELVMDEEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIECVNGGDLMFHMQRHRRLPEEHARFYSAEIALALNF .|. | .....||||.|||. ... .. ..||. . | .||||.| || ||||.. |||..| . ||.| .| .. ... || ||||.|.| ||| . LVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSEEQARFYFAQILLALEY LHEK-GIIYRDLKLDNVLLDQDGHIKLTDYGMCK-EGLRAG-DTTSTFCGTPNYIAPEILRG-Q ||.. ||||||| .| |||.|||.|.||.|. | .. .. ... .||||| |.|||... . LHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKK |
|||||||||
Kinase | AqueK019.AA | RSK | 5-161 | 42 | 4.8e-61 | 209.11 | In-house | 21-189 (278) | Show / Hide |
Range on Protein: 5-161 Range on HMM: 21-189/278 Sequence Identity: 42% (72 aa) KQTKRIYAMKVIKKELVMDEE-DIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIECVNGGDLMFHMQRHRR---LPEEHARFYSAEIALALNFL ..|..||||||.|| .. . |. . || . | .|||.| || ||||. |. . |...||.| | |.... . |. |.|| |||.||. .| HDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHL HEKGIIYRDLKLDNVLLDQ---DGHIKLTDYGMCKEG-LRAGDTTSTFCGTPNYIAPEILR---GQD-Y |..|||.||||..|.|.|. .||||||| | ||.. .. . | |||.| .|.|||.|. .| . HQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGH |
|||||||||
Kinase | AqueK019.AA | Pkinase | 7-161 | 35 | 1.7e-48 | 172.26 | Pfam | 23-189 (293) | Show / Hide |
Range on Protein: 7-161 Range on HMM: 23-189/293 Sequence Identity: 35% (60 aa) TKRIYAMKVIKKELVMDEEDIDWVQ-TEKHVFEQASNHPFLVGLHSCFQTESRLFFVIECVNGG----DLMFHMQ--RHRRL--PEEHARFYSAEIALAL | .|.|.|.|||. ...|. . .| .. |||. | |. .|...... .| |...|| ||. ... ||... .|....|| .|. .| TGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGL NFLHEKGIIYRDLKLDNVLLDQDGHI----KLTDYGMCKEG-LRAGDTTSTFCGTPNYIAPEILR-GQDY ...|..|||.||||..|.|.|..||| |..| | .| . . ..||||||.|.|||..| ||.| EYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYY |
|||||||||
Kinase | AqueK019.AA | S_TKc | 1-161 | 25 | 5e-16 | 58.13 | SMART | 17-231 (231) | Show / Hide |
Range on Protein: 1-161 Range on HMM: 17-231/231 Sequence Identity: 25% (62 aa) MVELKQTKRIYAMKVIKKELVMDEEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIECVNG--GDLMFHMQRHRR------LPEEHARFYSAE . | |.||.|.|.|| . .. | . .. .||..| |. .||. ..|..| |...| |||. ......| .|| ||||| .. KCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQ IALALNFLHEKGIIYRDLKLDNVLLDQDGHIKLTDYGMCKEGLRAGDTTSTFCGTPNYIAPEILRGQD-------------------------------- |..||...|..|||.|||| .|.|||. |||..| |.... .||||||.|.|||.| | . ICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKK --------------------------------------Y IGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF |
|||||||||
Kinase | AqueK019.AA | TyrKc | 2-156 | 12 | 2e-06 | -120.1 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 2-156 Range on HMM: 1-280/280 Sequence Identity: 12% (37 aa) VELKQT------KRIY--------AMKVIKKELVMDEEDIDWVQTEKHVFEQA-SNHPFLVGLHSCFQTE-------SRLFFVIECVNGGDLMFHMQRHR ..|... ..| | |..|.. . | . . .|| .| |. . .. |. | | . .||| . ..|| ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR R-LPEEHARFYSAEIALALNFLHEKGIIYRDLKLDNVLLDQDGHIKLTDYGMCKEGLRA-----------------GD-------------TTS------ . |. .. .. || ..||.|..| ||| |.|.. ....| .| |..... |. .. PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS -------------TFCGTPNYI----------------------APEI-------------------------------------L |....| . |. . DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
|||||||||
Kinase | AqueK019.AA | Pkinase_Tyr | 89-132 | 29 | 6e-06 | 20.75 | Pfam | 116-159 (270) | Show / Hide |
Range on Protein: 89-132 Range on HMM: 116-159/270 Sequence Identity: 29% (13 aa) YSAEIALALNFLHEKGIIYRDLKLDNVLLDQDGHIKLTDYGMCK ....|| ....|..|..| ||| |.|.. ....| .| |... MCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR |