Gene AqueK047 (A.queenslandica)

AqueK047

Species: A.queenslandica
Alias: AqueK047
External Links:
Annotation:

Classification

Group: Atypical
Family: PIKK
Subfamily: SMG1

Sequence

Name Sequence Type Origin Length Description Download
AqueK047.AA Protein None 1828 None Fasta, JSON

Protein domain

Protein domains of AqueK047.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK047.AA SMG1 231-472 59 3.1e-125 416.97 In-house 1-242 (242) Show / Hide 
Range on Protein: 231-472
Range on HMM: 1-242/242
Sequence Identity: 59% (145 aa)

VSVLPTKTKPKKISMIGSDGRRHTYLFKGLEDLHLDERIMQFMAIVNNMFAKAHKHQTQLYLARDYAVIPLGARSGLIQWVDNVTPLFGIYKRWQQREAL
. .|||||||||.  .||||.   ||||||||||||||||||..||| |||   .  |  . || |.| ||| |||||||||  |||||.||||||||| 
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQREAA

AKAMQQAGSQPTAPLQVQVRKPNELFYAKIIPLLNEKGLNEHTPRKEWPLGIQMRVLKELMNETPRDLLTKELWCASSCASEWWAVTQTYCRSTAVMCMI
 .| .   |  |      | .| ||.|.|| | |   ||     |..||| .   || |||  || .|| |||| .     ||| ||| | |||||| |.
LQAQKAQDSYQTPQNPGIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMV

GYIIGLGDRHLDNLLVEFTTGQVVHVDYNVCFEKGKSLRVPE
||||||||||||| |.. ||| |||.||..||||||.|.|||
GYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE
Kinase AqueK047.AA PIKK 223-520 37 6.5e-119 401.35 In-house 1-290 (290) Show / Hide 
Range on Protein: 223-520
Range on HMM: 1-290/290
Sequence Identity: 37% (113 aa)

LLESFCLDVSVLPTKTKPKKISMIGSDGRRHTYLFKGLEDLHLDERIMQFMAIVNNMFAKAHKHQTQLYLARDYAVIPLGARSGLIQWVDNVTPLFGIYK
   ..   | |...|.|||||.. |.||. . ||.||.|||..|.|.||.  ..|....|    |.  . .| |.|||.. |.|||.|||| ..|..|||
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

RWQQREALAKAMQQAGSQPTAPLQVQVRKPNELFYAKIIPLLNEKGLNEHTPRKEWPLGIQMRVLKELMNETPRDLLTKELWCASSCASEWWAVTQTYCR
.|.|...  ..     ...|   .  . ..           .  ...  .  .. |||     |. |.|. ||.|.. |..|  .. . .||.... |.|
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMS---------YYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTR

STAVMCMIGYIIGLGDRHLDNLLVEFTTGQVVHVDYNVCFE-KGKSLRVPERVPFRMTQNIENALGFTGVEGLFRISCEDILRILRRGRETLLTLLEAF
|.||||| |||.||||||..|...  .|| .||.|...||| ... |.||| ||||.|.|..||.| .||||.|| .||......|..||||.|..|.|
SYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase AqueK047.AA PI3_PI4_kinase 254-530 24 3.6e-64 224.28 Pfam 1-300 (300) Show / Hide 
Range on Protein: 254-530
Range on HMM: 1-300/300
Sequence Identity: 24% (82 aa)

TY--LFKGLEDLH--LDERIMQFM-----------------------AIVNNMFAKAHKHQTQLYLARDYAVIPLGARSGLIQWVDNVTPLFGIYKRWQQ
.|  .||| .||.   |.|.||.                         ..|..  |      . . .. | .||.| ..|.|.||.|.|.. .| . .  
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

REALAK-------AMQQAGSQPTAPLQVQVRKPNELFYAKIIPLLNEKGLNEHTPRKEWPLGIQMRVLKELMNETPRDLLTKELWCASSCA-SEWWAVTQ
... .         |..... ...                                    . .   |  . .. ||.. | ...|  .  |  |||.. .
KCKHKHFNKEHKMWMKMWPDWWHLM-----------------------------------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARD

TYCRSTAVMCMIGYIIGLGDRHLDNLLV--EFTTGQVVHVDYNVCFE--KGKSLRVPERVPFRMTQ------NIENAL------GFTGVEGLFRISCEDI
...|| |.||...||.|.||||.||..|  . |||...|.|.. ||.  |.| . .||||||| |.      .. .|.      . .| .|.|| .|...
NFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHA

LRILRRGRETLLTLL-------EAFVYDPLIDWTQ
.|.|||  . ...||       |..|.|.|..|. 
YRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS
Kinase AqueK047.AA PI3Kc 254-578 18 2.4e-54 187.78 SMART 1-336 (336) Show / Hide 
Range on Protein: 254-578
Range on HMM: 1-336/336
Sequence Identity: 18% (75 aa)

TYLFKGLEDLHLDERIMQFMAIVNNMFAKA-HKHQTQLYLARDYAVIPLGARSGLIQWVDNVTPLFGIYK------------------------------
  .||. .||. |.|.||.  ..|.. .|   ...  |.. . |..||.| ..|.|.|| |...|  | |                              
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRP-YKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMY

-------------------------------RWQQREALAKAMQQAGSQPTAPLQVQVRKPNELFYAKIIPLLNEKGLNEHTPRKEWPLGIQMRVLKELM
                                 .. . |.. ...   .|                                                  
MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPN-------------------------------------------------

NETPRDLLTKELWCASSCASEWWAVTQTYCRSTAVMCMIGYIIGLGDRHLDNLLVEFTTGQVVHVDYNVCFEKGKSLRVP-----ERVPFRMTQNIENAL
                    .||..  ...||.|..||..|| |.||||.||...  .||...|.|.. .|..|... ..     |||||| |... .. 
-------------------EDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVM

G----FTGVEGLFRISCEDILRILRRGRETLLTLLEAFVYDPL-IDWTQSEEAAFPLAMRTTTE-LGVRQTRKEM------EWEVAE-GMLITKLAESEP
|     .|..|.||  |. ..|..|. ......|.|..||||. ..|. .|..  .| .|   . | ... .. .      .  ... . ..|.. ..  
GGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFH

HWQKN
.|...
NWAQY
Kinase AqueK047.AA ATR 412-520 46 2.4e-48 162.64 In-house 159-267 (267) Show / Hide 
Range on Protein: 412-520
Range on HMM: 159-267/267
Sequence Identity: 46% (51 aa)

EWWAVTQTYCRSTAVMCMIGYIIGLGDRHLDNLLVEFTTGQVVHVDYNVCFEKGKSLRVPERVPFRMTQNIENALGFTGVEGLFRISCEDILRILRRGRE
.|..  . ||||.||.||.|||||||||| ||.|..  .| .||||||. | .|. . ||| ||||.|.|.....|  . .||||  ||.|....|  |.
QWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRD

TLLTLLEAF
 .. ....|
DIMSVWDCF
Kinase AqueK047.AA ATM 420-529 50 3e-43 135.81 In-house 140-249 (304) Show / Hide 
Range on Protein: 420-529
Range on HMM: 140-249/304
Sequence Identity: 50% (56 aa)

YCRSTAVMCMIGYIIGLGDRHLDNLLVEFTTGQVVHVDYNVCFEKGKSLRVPERVPFRMTQNIENALGFTGVEGLFRISCEDILRILRRGRETLLTLLEA
| || |   ..|||.||||||  |.|.      .||.|  | ||.|| |  || ||||.|  |   .| ||||| ||  ||  . ..|   |||||. | 
YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEV

FVYDPLIDWT
 .|||| |||
LLYDPLFDWT
Kinase AqueK047.AA FRAP 386-530 40 2.6e-40 140.26 In-house 106-251 (251) Show / Hide 
Range on Protein: 386-530
Range on HMM: 106-251/251
Sequence Identity: 40% (59 aa)

VLKELMNETPRDLLTKELWCASSCASEWWAVTQTYCRSTAVMCMIGYIIGLGDRHLDNLLVEFTTGQVVHVDYNVCFEKG-KSLRVPERVPFRMTQNIEN
. .  || |  . | | ||  |     |      | || |.| |.|||.||||||. |.. .  || .||.|.  |||   .  . ||..|||.|  . |
IFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVN

ALGFTGVEGLFRISCEDILRILRRGRETLLTLLEAFVYDPLIDWTQ
|.  .|.|| .|. || .....|  .| ..  |||||||||. |  
AMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL
Kinase AqueK047.AA DNAPK 395-530 27 5e-26 91.61 In-house 165-301 (301) Show / Hide 
Range on Protein: 395-530
Range on HMM: 165-301/301
Sequence Identity: 27% (38 aa)

PRDLLTKELWCASSCASEWWAVTQTYCRSTAVMCMIGYIIGLGDRHLDNLLVEFTTGQVVHVDYNVCFE-KGKSLRVPERVPFRMTQNIENALGFTGVEG
|||.. . .   |.    . .    . |. || |  ..| | |||||.| .| . .| .. .|.   |   .  | |||  |||.|    | .   .. |
PRDVFRRAFVRMSTTCETYLYLREHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKING

LFRISCEDILRILRRGRETLLTLLEAFVYDPLIDWTQ
... .    .. .|. |  |.   . |. ||..|| .
IMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFDWKN
Kinase AqueK047.AA ATR 222-317 36 2.1e-17 55.49 In-house 1-96 (267) Show / Hide 
Range on Protein: 222-317
Range on HMM: 1-96/267
Sequence Identity: 36% (35 aa)

VLLESFCLDVSVLPTKTKPKKISMIGSDGRRHTYLFKGLEDLHLDERIMQFMAIVNNMFAKAHKHQTQLYLARDYAVIPLGARSGLIQWVDNVTPL
  .  |   | .| .  ||||||. ||||. .  . |  .||  | | |.|  ..| .  |  . . . |  | ||||||  ....| ||.|   |
AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATL
Kinase AqueK047.AA DNAPK 222-313 39 1.9e-15 52.56 In-house 2-93 (301) Show / Hide 
Range on Protein: 222-313
Range on HMM: 2-93/301
Sequence Identity: 39% (36 aa)

VLLESFCLDVSVLPTKTKPKKISMIGSDGRRHTYLFKGLEDLHLDERIMQFMAIVNNMFAKAHKHQTQLYLARDYAVIPLGARSGLIQWVDN
| .  |   | |.    .||.| . | | | | ...|| ||| .| || |   . || |.     | .    | | .||.  | ||| ||||
VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDN
Kinase AqueK047.AA FRAP 253-313 34 2.5e-13 45.43 In-house 2-62 (251) Show / Hide 
Range on Protein: 253-313
Range on HMM: 2-62/251
Sequence Identity: 34% (21 aa)

HTYLFKGLEDLHLDERIMQFMAIVNNMFAKAHKHQTQLYLARDYAVIPLGARSGLIQWVDN
. .| || ||.  |||.||  ...| . .   . |      . |..|||  ..||| || .
YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHH
Kinase AqueK047.AA ATM 255-310 28 0.004691 5.15 In-house 2-57 (304) Show / Hide 
Range on Protein: 255-310
Range on HMM: 2-57/304
Sequence Identity: 28% (16 aa)

YLFKGLEDLHLDERIMQFMAIVNNMFAKAHKHQTQLYLARDYAVIPLGARSGLIQW
 | || .||  |  . |   . | .  .             | |.||  ||| . |
QLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW
FATC AqueK047.AA FATC 1798-1828 58 7.6e-15 50.59 Pfam 3-33 (33) Show / Hide 
Range on Protein: 1798-1828
Range on HMM: 3-33/33
Sequence Identity: 58% (18 aa)

MTVAEQVKFVIDEATSPENLCQLYEGWTPWV
..| .||   |.|||.||||||.| || ||.
LSVEQQVDRLIQEATDPENLCQMYIGWCPWW