Gene AqueK130 (A.queenslandica)

AqueK130

Species: A.queenslandica
Alias: AqueK130
External Links:
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: p38

Sequence

Name Sequence Type Origin Length Description Download
AqueK130.AA Protein None 1609 None Fasta, JSON
AqueK130.kin_dom Protein Kinase Domain None 287 None Fasta, JSON

Protein domain

Protein domains of AqueK130.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK130.AA p38 39-325 59 4.2e-178 597.97 In-house 1-289 (289) Show / Hide 
Range on Protein: 39-325
Range on HMM: 1-289/289
Sequence Identity: 59% (172 aa)

YQDMSPIGIGGFSTVCCAVDSETGEK---VALKKLARPFQSPVHAKRAYREIKLLKMLTRSNANVVELLDVFTP-NDSLDSFNDIYLVTCFMQSDLDNAI
||...|.| | . .|| |.|..||.|   || |||.|||||..||||.|||..|||..     ||..||||||| ..|...|.|.|.|| ||..|| | .
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRH--ENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIM

KIQPITDDQVQLLVYQILRGLKYIHSAGVIHRDIKPSNIGVSSDLEIKILDFGLGRKKKGEMTGYVTTRFWRAPEVLLQWMHYDQKVDIWSVGCILAELL
|.| ..||..|.||||||||||||||||.|||| ||||| |  | |..|||||| |..  |||||| ||  ||||..| ||||.|.|||||||||.|||.
KCQRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAELI

TGRVLFFGKNYRDHLNTILQICGTPDEEMMSKIDSDDARTYIRSLPTFAKKNFKEYFTGANPLAVDLLEKLLHLDPDRRPSAAEALEHPYF
|||.|| |... | |. |...|||||||...|| |. ||.||.|.|.  ...|.. |.||||.|.|||||.|.||||.| .|.||..||||
TGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase AqueK130.AA MAPK 39-325 48 7.70000000001e-160 537.31 In-house 1-328 (328) Show / Hide 
Range on Protein: 39-325
Range on HMM: 1-328/328
Sequence Identity: 48% (160 aa)

YQDMSPIGIGGFSTVCCAVDSE------TGEKVALKKLARPFQSPVHAKRAYREIKLLKMLTRSNANVVELLDVFTPN-----DSLDSFNDIYLVTCFMQ
||. .||| | . .|| |.| .      .|.|||.||. ||||.|.|.||.|||||||... .   |.. |||.|||      .||..|||||.|. .|.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHF-HHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELME

SDLDNAIKIQP-ITDDQVQLLVYQILRG--LKYIHSAGVIHRDIKPSNIGVSSDLEIKILDFGLGRKKKGE-----------------MTGYVTTRFWRA
.|| . || |.  .|| .| ..||||||  |||||||.|||||.||||| | .. . ||.|||| |.   |                 ||.||.||. ||
TDLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRA

PEVLLQ--WMHYDQKVDIWSVGCILAELLT-GRVLFFGKNYRDHLNTILQICGTPDEEMMSKID-SDDARTYIRSL---PTFAKKNFKEYFTG----ANP
||..|   ||||...||.||||||.||.|| ...|| ||.| | .| |....|||.||....|  |. ||.||.||   |   ||.... | .    |||
PEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANP

LAVDLLEKLLHLDPDRRPSAAEALEHPYF
.|.|||||.|..|||.| ...|||.||||
QAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase AqueK130.AA ERK 39-325 46 6.1e-129 434.66 In-house 1-307 (307) Show / Hide 
Range on Protein: 39-325
Range on HMM: 1-307/307
Sequence Identity: 46% (143 aa)

YQDMSPIGIGGFSTVCCAVDSE-----TGEKVALKKLARPFQSPVHAKRAYREIKLLKMLTRSNANVVELLDVFTPNDSLDSFNDIYLVTCFMQSDLDNA
||. ..|| |.. .|| |.| |     ||.||| ||  ..|  |. .||..||||||.....   |.. |.|.. || .  ..||||.|. .|..||.  
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKG-HENIICLFDIMMPNSPE-QYNDIYCVEELMETDLHQI

IKIQ-PITDDQVQLLVYQILRGLKYIHSAGVIHRDIKPSNIGVSSDLEIKILDFGLGR----KKKGE-------MTGYVTTRFWRAPEVLLQWMHYDQKV
|. | ...|| .| ..||||.||||||||.|||||.||||| | |.   || |||| |    .           ||.||.||  ||||..| |  |....
INSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAM

DIWSVGCILAELLTGRVLFFGKNYRDHLNTILQICGTP-DEEMMSKIDSDDARTYIRSLPT--FAKKNFKEYFTGAN--PLAVDLLEKLLHLDPDRRPSA
||||.|||.||.| .. || ||.|....| |.|| ||| .|| ...|.|..|. ||..||    ..|.... |  ||  |.|.|||||.|. ||| | ..
DIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITV

AEALEHPYF
.|.||||||
EECLEHPYF
Kinase AqueK130.AA CMGC 39-325 26 8.60000000001e-127 419.01 In-house 1-513 (513) Show / Hide 
Range on Protein: 39-325
Range on HMM: 1-513/513
Sequence Identity: 26% (135 aa)

YQDMSPIGIGGFSTVCCAVD--------------SETGEKVALKKLARPFQSPVHAK----------RAYREIKLLKMLT---------------RSNAN
|. ...|| | ...|. ..|               ||.|.||.||. .||  . .||          ||.||||.||.|                .   |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVELLDVFTPNDS------------LDSFNDIYLVTCFMQSDLDNAIKIQP----------ITDDQ------------VQLLV------YQILRGLK--Y
.| |.|.|....|            . .||..|||. .|. || . || ..           .. .            .. ..      ||||||||  |
IVKLYDIFYHKNSDGNEYEDKHIISQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

IHSAG--VIHRDIKPSNIGVSSD--------------------LEIKILDFGLGRKKKGE------------------------MTGYVTTRFWRAPEVL
.||..  .||||.||.|| ....                     ..|| |||| |.   .                        .| || ||. ||||.|
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LQW---------MHYDQKVDIWSVGCILAELLTG--------RVLFF-----------GKNYRDHLNTILQICGTP----------------DEEMMSKI
| |         |||....|.||||||.||..||        . ||            ||.. |.|. | ...|||                .||....|
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

D--------------------SDDARTYIRS---LPTFAKKNFKEYFTG-----------------------------------ANPLAVDLLEKLLHLD
.                    |..||.||.|   .|.. .|..|. | .                                   ..|.|.|||.|.|..|
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PDRRPSAAEALEHPYF
||.|..|..||.||||
PDKRITAEQALQHPYF
Kinase AqueK130.AA JNK 39-291 40 3.5e-94 319.19 In-house 1-260 (309) Show / Hide 
Range on Protein: 39-291
Range on HMM: 1-260/309
Sequence Identity: 40% (107 aa)

YQDMSPIGIGGFSTVCCAVDSETGEKVALKKLARP--FQSPVHAKRAYREIKLLKMLTRSNANVVELLDVFTPNDSLDSFNDIYLVTCFMQSDLDNAIK-
||  ..|| |.  .|| | |  |...|| ||. ||  ||   |.|||||| ...| .     |.. .. .|||  .|..|.|.|.|  .|   | . |  
YQNLKFIGQGAQGIVCMAFDQVTNQRVAIKKMMRPDNFQNWMHWKRAYREFICMKCIN--HKNIIKMYNCFTPQETLEEFQDVYIVMEYMDWNLCQVIHS

-IQPITDDQVQLLVYQILRGLKYIHSAGVIHRDIKPSNIGVSSDLEIKILDFGLGRKKKGE--MTGYVTTRFWRAPEVLLQWM-HYDQKVDIWSVGCILA
       . .  |.||...| |. ||.|.|||| ||||| | .|  .||.|||. |...    || || ||. |||||..  |  |  .|||||||||.|
TFMELDHERMSYLFYQMCCGIKHLHSMGIIHRDLKPSNIVVNQDCTLKICDFGHARTEDPTFMMTPYVVTRYYRAPEVICGMMDNYKENVDIWSVGCIMA

ELLTGRVLFFGKNYRDHLNTILQICGTPDEEMMSKIDSDDARTYIRSL---PTFAKKNFKEYF
|.....||| || ..|  | | .  |||| . |..   . .|.|....   |  .  ||.| |
EMIRHHVLFPGKDHIDQWNKIIEFLGTPDPHFMMQMQ-PHVRNYVENRNMDPYYQPYNFHEHF
Kinase AqueK130.AA nmo 40-325 42 1.7e-89 275.33 In-house 2-292 (292) Show / Hide 
Range on Protein: 40-325
Range on HMM: 2-292/292
Sequence Identity: 42% (125 aa)

QDMSPIGIGGFSTVCCAVDSETGEKVALKKLARPFQSPVHAKRAYREIKLLKMLTRSNANVVELLDVFTPNDSLDSFNDIYLVTCFMQSDLDNAI-KIQP
|   ||| | |  |    |   | .|||||.   ||. | .|| .||.|.| .    |  |. .||.  | . .| |..|| ||  |||||   |   |.
QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDN--VLSALDILQPPH-KDFFQEIYVVTELMQSDLHKIIVSPQH

ITDDQVQLLVYQILRGLKYIHSAGVIHRDIKPSNIGVSSDLEIKILDFGLGR----KKKGEMTGYVTTRFWRAPEVLLQWMHYDQKVDIWSVGCILAELL
.. | |.  .|||||||||.|||...|||||| |. | |.  .|| |||| |    ... .||  | | ..||||.|.   || . ||||||||| ||||
LSSDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELL

TGRVLFFGKNYRDHLNTILQICGTPDEEMMSKIDSDDARTYIRSLPTFAKKNFKEYFTGA----NPLAVDLLEKLLHLDPDRRPSAAEALEHPYF
  |.||  ..  . |. | .. |||  | | |   . |.. .   |  . .  . |   .    .  ||.|| ..|| |||.| |. .||.||| 
GRRILFQAQSPIQQLQMITDLLGTPSMEDM-KYACEGAKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase AqueK130.AA S_TKc 39-325 29 8.3e-88 298.94 SMART 1-231 (231) Show / Hide 
Range on Protein: 39-325
Range on HMM: 1-231/231
Sequence Identity: 29% (89 aa)

YQDMSPIGIGGFSTVCCAVDSETGEKVALKKLARPFQSPVHAKRAYREIKLLKMLTRSNANVVELLDVFTPNDSLDSFNDIYLVTCFMQS---DLDNAIK
|. . .|| |.|..|..... .||..||.|..          ....|||..||.      |.| |.|||         ...|.|. ..     ||   ||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK---HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIK

IQP-------ITDDQVQLLVYQILRGLKYIHSAGVIHRDIKPSNIGVSSDLEIKILDFGLGRKKKGEMTGYVTTRFWRAPEVLLQWMHYDQ-KVDIWSVG
 ..       ..  ... ..|||...|.|.|| |.||||.||.|| ...  .||| |||| |.     | .. |....|||||    .|.  |.|.||.|
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL----GYGKCKCDWWSCG

CILAELLTGRVLFFGKNYRDHLNTILQICGTPDEEMMSKIDSDDARTYIRSLPTFAKKNFKEYFTGANPLAVDLLEKLLHLDPDRRPSAAEALE------
|||.|.|.|. .|       .........|                                      | | |...|.|. ||..||.| |||.      
CILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK

-HPYF
 ||.|
CHPWF
Kinase AqueK130.AA ERK1 39-325 41 8.4e-87 294.68 In-house 1-289 (289) Show / Hide 
Range on Protein: 39-325
Range on HMM: 1-289/289
Sequence Identity: 41% (121 aa)

YQDMSPIGIGGFSTVCCAVDSETGEKVALKKLARPFQSPVHAKRAYREIKLLKMLTRSNANVVELLDVFTPNDSLDSFNDIYLVTCFMQSDLDNAIKIQP
| ... || | .. || |.|  ....||.||.. ||    . .|  ||||.|.       |.... |.    |..... |.|.| | |  ||   .| |.
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKIS-PFEHQTYCQRTLREIKILTRFKH--ENIINIQDIIR-ADTIEQMRDVYIVQCLMETDLYKLLKTQH

ITDDQVQLLVYQILRGLKYIHSAGVIHRDIKPSNIGVSSDLEIKILDFGLGR------KKKGEMTGYVTTRFWRAPEVLLQWMHYDQKVDIWSVGCILAE
.  | .   .||||||||||||| |.|||.||||. .    ..|| |||| |         | .| || ||..||||..|    | . .|||||||||||
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAE

LLTGRVLFFGKNYRDHLNTILQICGTPDEEMMSKIDSDDARTYIRSLPTFAKKNFKEYFTGANPLAVDLLEKLLHLDPDRRPSAAEALEHPYF
.|  | .| || | | || || . | | .. .  |  . || |..|||  .|  ... | .| . |.|||.|.|   |..|    ||| ||| 
MLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase AqueK130.AA ERK5 39-325 37 5.9e-85 288.54 In-house 1-295 (295) Show / Hide 
Range on Protein: 39-325
Range on HMM: 1-295/295
Sequence Identity: 37% (111 aa)

YQDMSPIGIGGFSTVCCAVDSETGEKVALKKLARPFQSPVHAKRAYREIKLLKMLTRSNANVVELLDVFTPNDSLDSFNDIYLVTCFMQSDLDNAIK-IQ
|. .  || | .  || |.   .|..||.||.   |     ||| .||.|.|.       |.. . |.  |   .  . |.| |   | |||   |   |
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRH--DNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQ

PITDDQVQLLVYQILRGLKYIHSAGVIHRDIKPSNIGVSSDLEIKILDFGLGR--------KKKGEMTGYVTTRFWRAPEVLLQWMHYDQKVDIWSVGCI
|.| . .   .|||||||||.||| |||||.||||. |    |.|| |||. |        |..  || || ||..||||...    | | .|.||||||
PFTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCI

LAELLTGRVLFFGKNYRDHLNTILQICGTPDEEMMSKIDSDDARTYIRS-LPTFAKKNFKEYFTGANPLAVDLLEKLLHLDPDRRPSAAEALEHPYF
. |... | .| |||| . |. |... |.|   |.  . .|  . |. . .|    |.... . .| . |.||| ..|  .|  | ....|| ||. 
FGEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase AqueK130.AA Pkinase 39-325 30 5.1e-83 286.9 Pfam 1-293 (293) Show / Hide 
Range on Protein: 39-325
Range on HMM: 1-293/293
Sequence Identity: 30% (95 aa)

YQDMSPIGIGGFSTVCCAVDSETGEKVALKKLARPFQSPVHAKRAYR--EIKLLKMLTRSNANVVELLDVFTPNDSLDSFNDIYLVTCFMQS-----DLD
|.  ..|| |.|..|. ...  ||..||.|.. .. ...   ... |  ||...|.| .   |.|.|.|.|.        ..||.|. ...      || 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-N-HPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLF

NAIK---IQPI--TDDQVQLLVYQILRGLKYIHSAGVIHRDIKPSNIGVSSDLEI----KILDFGLGRK---KKGEMTGYVTTRFWRAPEVLLQWMHYDQ
  |.     ..  ......  .|||||||.|.|| |.||||.||.|| .... .|    || |||| ..   ... ||... |....||||..   .|..
DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQYYGP

KVDIWSVGCILAELLTGRVLFFGK----NYRDHLNTILQICGTPDEEMMSKIDSDDARTYIRSLPTFAKKNFKEYFTGANPLAVDLLEKLLHLDPDRRPS
|||.||.||||.|.|.|| .| |.    | .|..  | .| |.| ..  .. .|   .. .|  .    . ...  . ... . |.....|..|| .||.
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPT

AAEALEHPYF
|...|.||.|
AEQILQHPWF
Kinase AqueK130.AA ERK7 39-325 35 4.4e-80 272.37 In-house 1-292 (292) Show / Hide 
Range on Protein: 39-325
Range on HMM: 1-292/292
Sequence Identity: 35% (106 aa)

YQDMSPIGIGGFSTVCCAVDSETGEKVALKKLARPFQSPVHAKRAYREIKLLKMLTRSNANVVELLDVFTPNDSLDSFNDIYLVTCFMQSDLDNAIK-IQ
|.  . .| | .  |  |.|  |.. |||||    |. .. | | .||| .|. . .   |.. |..|.  .  .    |||||  || .|| . |.  .
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEF-HCHPNIIRLINVIRADNDR----DIYLVFEFMETDLHAVIRKGN

PITDDQVQLLVYQILRGLKYIHSAGVIHRDIKPSNIGVSSDLEIKILDFGLGR---------KKKGEMTGYVTTRFWRAPEVLLQWMHYDQKVDIWSVGC
 . |  .|  .||.|| .||.||. |||||.||||| . |.  .|. |||| |         .... .| || || .||||.||   .| . || ||.||
ILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGC

ILAELLTGRVLFFGKNYRDHLNTILQICGTPDEEMMSKIDSDDARTYIRSLPTFAKKNFKEYFTGANPLAVDLLEKLLHLDPDRRPSAAEALEHPYF
||.|.|.|. .| |    . .. ||.. . | .| .  |.|. | . . ....  .| ... .... . |.||| .|| . |..| .| .||.||| 
ILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase AqueK130.AA MAPK-Unclassified 39-190 38 4.6e-49 169.32 In-house 1-157 (575) Show / Hide 
Range on Protein: 39-190
Range on HMM: 1-157/575
Sequence Identity: 38% (62 aa)

YQDMSPIGIGGFSTVCCAVDSET-GEKVALKKLARPFQSPVHAKRAYREIKLLKMLTRSNANVVELLDVFTPNDSLD-SFNDIYLVTCFMQS---DLDNA
|     || |... || |.|. . . .|| ||... |. .. .||. ||| .|  |  .  |.. . |.|.. . .   | |||.|. .||.   ||   
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYL--NHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQI

IK-IQ-PITDDQVQLLVYQILRGLKYIHSAGVIHRDIKPSNIGVSSDLEIKILDFGLGR
||  | .  . ..| . |||||||||.|||..|||| ||||. .  |. ..| |||. |
IKSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase AqueK130.AA MAPK-Unclassified 193-325 31 6.4e-41 142.27 In-house 402-575 (575) Show / Hide 
Range on Protein: 193-325
Range on HMM: 402-575/575
Sequence Identity: 31% (55 aa)

KGEMTGYVTTRFWRAPEVLLQWMHYDQKVDIWSVGCILAELLTG-----------RVLFFGKN--------------------YRDHLNTILQICGTPDE
...||.|| ||. |||| .|    || .|||||.|||.||..             | || |..                    . | .. |.   |.|.|
CYHMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPE

EMMSKIDSDDARTYIRSLPTFAKKNFKEYFTGANP----------LAVDLLEKLLHLDPDRRPSAAEALEHPYF
| .. | .| || ||.|.   .   |.. .  ..|          .. |.. |.|  .| .| .| .|||||||
EDCNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase AqueK130.AA TyrKc 39-325 21 3.2e-13 -9.02 SMART 1-280 (280) Show / Hide 
Range on Protein: 39-325
Range on HMM: 1-280/280
Sequence Identity: 21% (68 aa)

YQDMSPIGIGGFSTVCCAVDSETGEKVALKKLARPFQSPVHAKRAYREIKLLKMLTRSNANVVELLDVFTP---NDSLDSF---NDIYLVTCFMQS-DLD
 .    .| | | .|. .. .   ..|| |.|          .  .||......|  .. |.| |. | |    |     |     ...|. .|   ||.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-----FMYIEPLMIVMEYMPHGDLK

NAIKIQP--ITDDQVQLLVYQILRGLKYIHSAGVIHRDIKPSNIGVSSDLEIKILDFGLGRKKKGE-----MTGYVT------TR-----FWRAPEVLLQ
. ..     .. ..     .|| .|  |.|| ..||||.   |. |.... .|| |||| |. . .      . | .      ..      | |||.. .
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-N

WMHYDQKVDIWSVGCILAELLT-GRVLFFG-----KNYRDHLNTILQI--CGTPDE--EMMSKIDSDDARTYIRSLPTFAKKNFKEYFTGANPLAVDLLE
   .  | |.|| |  . |..| |     |     .. .. .. . |      |..  . ||                         | .. .   .. .
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MS-------------------------FVCCPDEMYQIMK

KLLHLDPDRRPSAAEALEHPYF
.  | ||. ||. .|   | .|
QCWHEDPEDRPTFSEI--HECF
Kinase AqueK130.AA JNK 300-325 50 5e-06 18.66 In-house 284-309 (309) Show / Hide 
Range on Protein: 300-325
Range on HMM: 284-309/309
Sequence Identity: 50% (13 aa)

DLLEKLLHLDPDRRPSAAEALEHPYF
||| . |  .||.| |  .||.||| 
DLLFRMLVINPDDRISVDDALQHPYI
Kinase AqueK130.AA Pkinase_Tyr 149-235 31 0.000164 15.9 Pfam 118-209 (270) Show / Hide 
Range on Protein: 149-235
Range on HMM: 118-209/270
Sequence Identity: 31% (30 aa)

YQILRGLKYIHSAGVIHRDIKPSNIGVSSDLEIKILDFGLGRKK-KGEMTGYVTTR------FWRAPEVLLQWMHYDQKVDIWSVGCILAELLT
.|| .|. | .| . ||||.   |. |.... .|| |||| |   . .   |...       .| |||..     .  | |.|| |  . |..|
WQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGK-FTTKSDVWSFGVLMWEIFT
PI3K_rbd AqueK130.AA PI3K_rbd 884-981 26 4e-11 43.48 Pfam 14-115 (115) Show / Hide 
Range on Protein: 884-981
Range on HMM: 14-115/115
Sequence Identity: 26% (27 aa)

EENKLLVKVYYE----SGASQTFQVDVNTVADDFLPTVFPTEPHKRKRLGLPEHCNISDYVLKVAGRSSFIHGNFELIDFSPIVKALSKRRDIVLALVRR
..||... |  |    .. ..|||...| ...... . |     |.. .  ..  |  ||||||.||. ..||. .|. |  |.  .. .|.. | |...
DNNKIIIMVHWEQVCNCQMTFTFQCNPNDTPFQVMHQAFCKMAMKHSVHDQNDVQNPGDYVLKVCGRDEYLHGDHPLCQFEYIRNCIMWGRCPHLTLMEC

SD
..
CS
PI3K_rbd AqueK130.AA PI3K_rbd 870-981 20 1e-08 36.23 SMART 1-116 (116) Show / Hide 
Range on Protein: 870-981
Range on HMM: 1-116/116
Sequence Identity: 20% (24 aa)

QFTPLPPHVKAMIGEENKLLVKVYYE-----SGASQTFQVDVNTVADDFLPTVFPTE-PHKRKRLGLPEHCNISDYVLKVAGRSSFIHGNFELIDFSPIV
 ....| |  .| .. ||... |. |       ...|.....| ..|... ..| ..   ... .. ..  .  ||.|||.||. ..|.. .|. |  |.
MSRKCPEHI-WMKTINNKIIIVVHWEKRVCNWQQTKTMDCNPNCTPDSVMHQFF-CKMMMNHSMHDQNDPTDECDYILKVCGRDEYLHPDHPLGQFEYIR

KALSKRRDIVLALVRRSD
  .. .|.. . |.....
NCIMWGRCPHFVLMECCK
PI3K_C2 AqueK130.AA PI3K_C2 1047-1170 25 3.6e-22 82.1 Pfam 1-118 (168) Show / Hide 
Range on Protein: 1047-1170
Range on HMM: 1-118/168
Sequence Identity: 25% (34 aa)

DFDVIYVDVAVF--HGGEELCRTL-STHEITAC----KYPRWNQWLVFN-IAVKNLPKAARLCFAVSGGVRRNDSRKRSSTWSKKDFVKQNTLRGDNIQA
. . .|| ..|.  |||. ||  . ||   . .    . ..||.|. |. | ...|| .||||. .             .. .|| . ..    ..  ..
PYMDFYVECQVYDGHGGKPLCKPVQSTSYKPFNNHFFPRWNWNEWITFPQIQYCDLPRDARLCITIW------------EIYCKKKSESNM---NEQNKK

DRPLHWVNMQILDH-RALLRQGVLRLNL-WPYST
 .|. |.|... || . .||.|  .|.. ||...
-CPIGWCNLPLFDHEKCMLRCGMHKLHMTWPSKP
PI3K_C2 AqueK130.AA PI3K_C2 1019-1126 22 2.9e-17 64.62 SMART 1-133 (133) Show / Hide 
Range on Protein: 1019-1126
Range on HMM: 1-133/133
Sequence Identity: 22% (30 aa)

VFTMSMWDLQHKFR-----VRILGL-DNLRDCSPDFD----VIYVDVAVFHG-GEELCRTLSTHE---ITACKYP------RWNQWLVF-NIAVKNLPKA
|.. | |..  .|.     ..| .. | .  .|.|..     .|| ....|| |. .| . .| .   . .. ..      .||.|| | .| ...||..
VKICSLWCCNRPFVFLPHEITIYCIHDIMLNWSQDYESSCVDLYVECQLYHGMGKQFCCPVRTSYHQYVKHFFNRTFHLFWKWNEWLTFFPIQYCDLPRM

ARLCFAVSGGVRRNDSRKRSS----TWSKKDFV
||||...... .  .. . .     .||..|. 
ARLCITIWDVYDDSKKSEPFFSRCVGWSNFDWF
PI3Ka AqueK130.AA PI3Ka 1223-1258 34 6.3e-08 28.81 Pfam 170-211 (211) Show / Hide 
Range on Protein: 1223-1258
Range on HMM: 170-211/211
Sequence Identity: 34% (15 aa)

YLRSEM------DSPQF-SQRFGILLEAFLKGCGKNIFIELQK
|..|||      ... . .||||.|||.....||... ..|.|
YMKSEMYKDDEGHDKDYICQRFGVLLESYCRECGTHM-QHLNK
PI3Kc AqueK130.AA PI3Kc 1347-1609 34 3.6e-118 399.79 SMART 1-336 (336) Show / Hide 
Range on Protein: 1347-1609
Range on HMM: 1-336/336
Sequence Identity: 34% (115 aa)

KVIAKHGDDLRQDMLTLQMLTIMDSLWQSE----GLDLYIIPYGCVATGNEMGMIEVVQDAETVAKIQ--LHHGGSF-----------------------
 || |.||||||||...||. .|. .||..    ..||.. ||.|..|| ..||||.| ..||...||  .|   ..                       
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

------------------------------STLKDEPLYEWLKKKNPNP-KHFEQAIERFVYSCAGYCVATYVLGIGDRHNDNIMLT-VSGNLFHIDFGH
                              .  |...||.|.....|.|   . .|...|..||||||..||.|||||||||||||.  .|..|||||||
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH

FLGNTKAFLGVN---RDRAPFVLTPDFEYVLG--KRTSENFKKFEEIAVRAYLIIRKNANLFINLFSMMKCTGI-PELRSV-EDLDYLKSVLVLG-KNEE
..|. . ..| .   |.|.||.||.|. || |  .  |..|..| ....|||...||..||..|||.|| ...| |..|.  .|..||.. . |  ...|
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDE

QAADHFRQ----QIQKCLRLQWSTQLSWLAHNWVHR
.|| .| |    .. ....  | |.. |..||| . 
EAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
PI3_PI4_kinase AqueK130.AA PI3_PI4_kinase 1345-1559 28 4.8e-86 296.96 Pfam 1-300 (300) Show / Hide 
Range on Protein: 1345-1559
Range on HMM: 1-300/300
Sequence Identity: 28% (84 aa)

PIKVIAKHGDDLR--QDMLTLQML-----------------------TIMDSLWQSEGLDLY----IIPYGCVATGNEMGMIEVVQDAETVAKIQLHHG-
 ...| |.|||||  |||...||.                       ..|. .|...|.|.     . || |..|| ..||||.| ...| ..|.  .. 
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

-GSFSTLKD---------------------------------EPLYEWLKKKNPNP-KHFEQAIERFVYSCAGYCVATYVLGIGDRHNDNIML---TVSG
 ...  . .                                 . ||.|..|.||..   . .|...||.||||.||..|.||.|||||||||.   . .|
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG

NLFHIDFGHFLGNTKAFLGVNRDRAPFVLTP------DFEYVLGK----RTSENFKKFEEIAVRAYLIIRKNANLFINLF-------SMMKCTGIPELRS
.||||||||.....| . . ...| ||..|.      .. ...|.      |. . .|... ..||...|...||..||.       ..| ..|.|..||
HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS