Gene AqueK439 (A.queenslandica)

AqueK439

Species: A.queenslandica
Alias: AqueK439
External Links:
Annotation:

Classification

Group: TK
Family: Syk

Sequence

Name Sequence Type Origin Length Description Download
AqueK439.AA Protein None 577 None Fasta, JSON
AqueK439.kin_dom Protein Kinase Domain None 258 None Fasta, JSON

Protein domain

Protein domains of AqueK439.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH2 AqueK439.AA SH2 9-86 41 8.6e-37 109.85 Pfam 1-81 (81) Show / Hide 
Range on Protein: 9-86
Range on HMM: 1-81/81
Sequence Identity: 41% (34 aa)

WYHGRISRSDAEQILTQCGGVDGSFLVRDSLTTSGEYVLSLCHQT---KRYHYLISRKPDGTLAIQDGTKFDSPVDLVRYH
|||| |||..||..| . |. ||.||||.| .| |.|.||....    . .|| | | ..|.. | ...||.|  .|| ..
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 AqueK439.AA SH2 7-92 45 1.5e-34 122.06 SMART 1-87 (87) Show / Hide 
Range on Protein: 7-92
Range on HMM: 1-87/87
Sequence Identity: 45% (40 aa)

EPWYHGRISRSDAEQILTQCGGVDGSFLVRDSLTTSGEYVLSLCHQTKRYHYLISRKPDGTLAIQD--GTKFDSPVDLVRYHGQKIDG
.|||||.|||..|||.| . |. ||.|||||| .. |.||||.... | .||.| |..||   |..  ..||.|  .||... .  .|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
SH2 AqueK439.AA SH2 161-245 38 2.2e-26 94.88 SMART 1-87 (87) Show / Hide 
Range on Protein: 161-245
Range on HMM: 1-87/87
Sequence Identity: 38% (34 aa)

QQWFHGPISRDESELRLRQFGLKDGLFLVRERTQ-VNSFALCISFKMKIYHYLLDMNTLGQLSIEN--GRKFENLLQVVDHYSRTPDG
|.|.||.|||.| |  |.. | .|| ||||.. .  ....|.. .| |..||..  |  |. .|.   .|||..| . |.||...|.|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
SH2 AqueK439.AA SH2 163-239 34 1.2e-23 71.21 Pfam 1-81 (81) Show / Hide 
Range on Protein: 163-239
Range on HMM: 1-81/81
Sequence Identity: 34% (28 aa)

WFHGPISRDESELRLRQFGLKDGLFLVRERT-QVNSFALCISFKM---KIYHYLLDMNTLGQLSIENGRKFENLLQVVDHY
|.||.||| | | .|.. | .|| |||||.  . ....|.  ..    ...||    .  |.. |  ..||..| . |.||
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
Kinase AqueK439.AA Syk 282-533 49 2.3e-137 462.64 In-house 1-257 (257) Show / Hide 
Range on Protein: 282-533
Range on HMM: 1-257/257
Sequence Identity: 49% (128 aa)

LETQGELGAGTFGTVRQGVYRPLSG---EPPVKCALKFLKPTEELPNQKAEILREADAMAMLDHPNIVRLYGICVGDPIRLVMELAACGPLNKFLRKHV-
|.   |.| | ||.|..|.|.  ||   .  .| |.| ||     |..| |..|||  |. |||| |||. ||| . .  .|||.|  ||..|.| .|  
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGICHAEMMMMVMEMAELGPMHKYLQQHRH

GFPVLKIVNMII-QVAKGMEYLEKTRFVHRDLAARNVLVVDDDNVKISDFGMSRAIGGGSEYYRAETAGRWPLKWYAPECIYYAKFDSKSDVWSYGVTAW
  ..  .. ..  ||| || |||   |||||||||||| |.    ||||||||.| | .|.||.|.|.|.||.|||||||||| || .||||||.||| |
EITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTMW

EAFSYGAKPYQGMRGTDIMQMLEGNERLDRPDKCPQAIYEIMLRCWSWRPEDRPSFG
|.||||.||| .|.| ..|...|  .|. .|..||| .|..| .||. ...||| |.
EMFSYGQKPYGEMKGQEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase AqueK439.AA Pkinase_Tyr 282-539 42 3.1e-125 424.75 Pfam 1-270 (270) Show / Hide 
Range on Protein: 282-539
Range on HMM: 1-270/270
Sequence Identity: 42% (115 aa)

LETQGELGAGTFGTVRQGVYRPLSGEPPVKCALKFLKPTEELPNQ---KAEILREADAMAML-DHPNIVRLYGICV--GDP--IRLVMELAACGPLNKFL
..   .||.| ||.|..|..... ... ...| | ||.      .   ... .|||  |  | .|||||||||.|.  |.|  | .|||....| | ..|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

RKH----VGFPVLKIVNMIIQVAKGMEYLEKTRFVHRDLAARNVLVVDDDNVKISDFGMSRAIGGGSEYY-RAETAGRWPLKWYAPECIYYAKFDSKSDV
|||      ...  ...| .|.||||||||  ...||||||||.|| ..  |||.|||..|.|    .|| |. . |..| ||.||||| | || .||||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

WSYGVTAWEAFSYGAKP-YQGMRGTDIMQML-EGNERLDRPDKCPQAIYEIMLRCWSWRPEDRPSFGELVSTI
||.||. || |.||..| |.||  ....... | ..|...|..||. ||..|..|| . |||||.| |... .
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK439.AA TyrKc 282-539 37 6.1e-122 412.32 SMART 1-280 (280) Show / Hide 
Range on Protein: 282-539
Range on HMM: 1-280/280
Sequence Identity: 37% (110 aa)

LETQGELGAGTFGTVRQGVYRPLSGEPPVKCALKFLKPTEELPNQKAEILREADAMAML--DHPNIVRLYGICVG--------DPIRLVMELAACGPLNK
..   .|| | ||.|..|...       ...| | ||.       .....|||  | .|  .|||||||||.|.         .|. .|||... | |..
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FLRKHVG-FPVLKIVNMIIQVAKGMEYLEKTRFVHRDLAARNVLVVDDDNVKISDFGMSRAIGGG------SEYYRAET--AGR--WPLKWYAPECIYYA
.|||| . ... . ... .|.|.|||||.. ...||||||||.|| ..  |||||||.||.|. .      ..|||. .   |.  .|..|.||||| | 
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

KFDSKSDVWSYGVTAWEAFSYGAKPYQG-----MRGTDIMQMLEGNERLDRPDK--------CPQAIYEIMLRCWSWRPEDRPSFGELVSTI
|| .||||||.||. || |.||..|| |     |  ..... ..  .|...|.         ||...|.||..||   |||||.| |... .
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK439.AA TK 282-539 22 6.30000000001e-109 366.43 In-house 1-486 (486) Show / Hide 
Range on Protein: 282-539
Range on HMM: 1-486/486
Sequence Identity: 22% (110 aa)

LETQGELGAGTFG---TVRQGVYRPLS---------------------GEPPVKCALKFLKP--TEELPNQKAEILR----------EADAMAMLD----
..   .||.| ||   .|..| .|...                     .. ....| | ||.  ...   ...|...          || .|.|..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNIVRLYGICVGD-------------PIRLVMELAACGP----LNKFLRKHVG---------------------------------------------
 |||||||||.|. .             |. .|||....|     | ..|||. .                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FPVLKIVNMIIQVAKGMEYLEKT------RFVHRDLAARNVLVVDDDN-----------VKISDFGMS-
                               ...   . |  |.|.|||||..       .||||||||||.|| ....           .||.|||.| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-------RAIGGGSEYYRAE-----------------------TAGRWPLKWYAPECIY---------YAKFDSKSDVWSYGVTAWEAFSYGAKPYQGMR
       |.|. ...|||..                       . |..|..|.||||.          | || .||||||.||. || |.||..|| |. 
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

G----------TDIMQMLEGN--------------ERLDRPDKCP--------------QAIYEIMLRCWSWRPEDRPSFGELVSTI
           ...|..|.                 |. .|. ||              ...|..|..||.. |||||.| .|.. .
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK439.AA Ack 282-539 41 2e-102 346.31 In-house 1-266 (266) Show / Hide 
Range on Protein: 282-539
Range on HMM: 1-266/266
Sequence Identity: 41% (112 aa)

LETQGELGAGTFGTVRQGVYRPLSGEPPVKCALKFLKPTEELPNQ--KAEILREADAMAMLDHPNIVRLYGICVGDPI-RLVMELAACGPLNKFLRKHVG
.    .|| | || |..|.    .|   .  | | |..  ...      . |||. .|  ||||..|||||.  . |  ..|.||| || |   |||| .
ITLCEKLGDGCFGVVWRGEWTN-PGGKHIQVAVKCLRSD-KMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRKHCR

--FP-VLKIVNMIIQVAKGMEYLEKTRFVHRDLAARNVLVVDDD-NVKISDFGMSRAIGGGSEYYRAETAG--RWPLKWYAPECIYYAKFDSKSDVWSYG
  |. .  . .   |.|.|| |||  |..||||||||.|.  ||  |||.||| .|| |..  ||| |       |. | ||||. . .| ..||||..|
TAFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMFG

VTAWEAFSYGAKPYQGMRGTDIMQMLE-GNERLDRPDKCPQAIYEIMLRCWSWRPEDRPSFGELVSTI
|| || |||| .|. |..| .|.| ..   ||| ||| ||..||..|..||   |.|||.|....   
VTLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase AqueK439.AA UTK 282-539 32 1.1e-88 300.96 In-house 1-296 (296) Show / Hide 
Range on Protein: 282-539
Range on HMM: 1-296/296
Sequence Identity: 32% (97 aa)

LETQGELGAGTFGTVRQGVYRPLSGEPPV-KCALKFLKPTEELPNQKA---EILREAD---AMAMLD-HPNIVRLYGICV-GDPIRLVMELAACGPLNKF
..   .||.| ||.|. . ... |.  .. ..|.| .....  . ...   ....||     |.... |||..||.|.|. . |. .|.|... | | ..
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRKHVG--------FPVLKIVNMIIQVAKGMEYLEKTRFVHRDLAARNVLVVDD-------DNVKISDFG---MSRAIGG--------GSEYYRAETAGR
||.|          .   . . |  ..| ||.||.  .||||||||||.|| ..         .||.|||   |||....        .|.||.|  ..|
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

WPLKWYAPECIYYA-KFDSKSDVWSYGVTAWEAFSYGAKPYQGM-RGTDIMQMLEGN-ERLDRPDKCPQAIYEIMLRCWSWRPEDRPSFGELVSTI
||..|.|||..... .| .||||||.||. || ...|..|| ||     . | ..|.  |. .|. || ..|..|.|||   |..||.| .||...
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase AqueK439.AA EGFR 282-540 41 4.1e-85 282.54 In-house 1-258 (258) Show / Hide 
Range on Protein: 282-540
Range on HMM: 1-258/258
Sequence Identity: 41% (109 aa)

LETQGELGAGTFGTVRQGVYRPLSGEPPVK--CALKFLKPTEELPNQKAEILREADAMAMLDHPNIVRLYGICVGDPIRLVMELAACGPLNKFLRKHVG-
|   . ||.| ||||  |.. |  ||  ||   | | |. . . |... |.|.|| .|| .|||..||| |.|... ..||  .   | |  ..|.| . 
LKKVKVLGSGAFGTVYKGIWIPE-GE-NVKIPVAIKVLREQTG-PKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQMQLVTQYMPYGCLLDYVRQHKDN

FPVLKIVNMIIQVAKGMEYLEKTRFVHRDLAARNVLVVDDDNVKISDFGMSRAIGGGSEYYRAETAGRWPLKWYAPECIYYAKFDSKSDVWSYGVTAWEA
    . .|  .|.||||.|||. | ||||||||||||     ||| |||...     .. |.|.  |. | || | ||| . .. ..||||||||| || 
IGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQ-GGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWEL

FSYGAKPYQGMRGTDIMQMLEGNERLDRPDKCPQAIYEIMLRCWSWRPEDRPSFGELVSTIS
  .|.|||.|..  .| ..||  |||  |. | . .| .|..||   .. || | ||..  .
MTFGQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase AqueK439.AA Fer 282-540 33 4.5e-83 282.31 In-house 1-283 (283) Show / Hide 
Range on Protein: 282-540
Range on HMM: 1-283/283
Sequence Identity: 33% (96 aa)

LETQGELGAGTFGTVRQGV-----YRPLSGE-PPVKCALKFLKPTEELPNQKAEILREADAMAM-LDHPNIVRLYGICVGD-PIRLVMELAACGPLNKFL
 . .  || | ||.|..|      ... . . ..|... | .| .     |..|...||  | . .||||.|..||.|| . || .|||.. .| | ..|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

RKHVG--FPVLKIVNMIIQVAKGMEYLEKTRFVHRDLAARNVLVVDDDNVK---ISDFGMSRA-IGGGSEYYRAETAGRWPLKWYAPECIYYAKFDSKSD
.|  .   .. ....|..|.|.|||||..   .|||.||||.|. .|...|   ||||||||.  ..|. |. .|.| . | .| |||.. .  . .|.|
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTD

VWSYGVTAWEAFSYGAKPYQG---------MRGTDIMQMLEGNERLDRPDKCPQAIYEIML-RCWSWRPEDRPSFGELVSTIS
|||.||..|| |. ||.|| |         ........  ... ..  |. .| .|..||. .||   |||||.. |.. .. 
VWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase AqueK439.AA Src 282-539 38 5.1e-82 278.45 In-house 1-255 (255) Show / Hide 
Range on Protein: 282-539
Range on HMM: 1-255/255
Sequence Identity: 38% (101 aa)

LETQGELGAGTFGTVRQGVYRPLSGEPPVKCALKFLKPTEELPNQKAEILREADAMAMLDHPNIVRLYGICVGD-PIRLVMELAACGPLNKFLR-KHVGF
.    .||.| || | .|...       .| | | |||      . .  |.|| .|  |.|...|.|| .|  . ||  | |. . | | ..|. .  | 
IKLCRKLGQGQFGEVWMGYWNGN-----TKVAVKTLKPGT---MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGR

--PVLKIVNMIIQVAKGMEYLEKTRFVHRDLAARNVLVVDDDNVKISDFGMSRAIGGGSEYYRAETAGRWPLKWYAPECIYYAKFDSKSDVWSYGVTAWE
  .. . . |  |||.||.|||. ...||||||||||| ..  .|. |||  | |  . . | |..  . | || |||.| | .|  ||||||.|.  .|
HLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTE

AFSYGAKPYQGMRGTDIMQMLEGNERLDRPDKCPQAIYE-IMLRCWSWRPEDRPSFGELVSTI
 ..||  || ||.  . .|..| . |. .|..||. .|| |||.||  .||.|| |  | .  
IVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase AqueK439.AA TK-Unique 282-539 32 8.9e-81 274.66 In-house 1-294 (294) Show / Hide 
Range on Protein: 282-539
Range on HMM: 1-294/294
Sequence Identity: 32% (97 aa)

LETQGELGAGTFGTVRQGVYRPLSGEPPVK-CALKFLKPTEELPNQKAEILREADAMAMLD-HPNIVRLYGICV-GD-PIRLVMELAACGPLNKFLR---
|| . ..| | ||.|  | .......   . |..  .   .. . .|.. |.|.  |  |. |||||...|.|.  | |  ..|| ..|| | ..||   
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

-------------------KHVGFPV-LK---IVNMIIQVAKGMEYLEK--TRFVHRDLAARNVLVVDDDNVKISDFGMSRAIGGGSEYYRAETAGRWPL
                   ..  ..  ..    .. ..|.|.|||||..   ..|||||.|||||. .| ..||.||||.| .  . .| . .. || |.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

KWYAPECIY--YAKF-DSKSDVWSYGVTAWEAFSYGAKPYQGMRGTDIMQMLEGNERLDRPDKC-PQAIYEIMLRCWSWRPEDRPSFGELVSTI
.| ||| ..  .  .  .||||||.||. || |..|| || ||. .|||....   |...|..| ....|..| .||.| ||.|||| .... .
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase AqueK439.AA FAK 282-544 35 5.2e-77 257.55 In-house 1-285 (285) Show / Hide 
Range on Protein: 282-544
Range on HMM: 1-285/285
Sequence Identity: 35% (103 aa)

LETQGELGAGTFGTVRQGVYRPLSG-----------------------EPPVKCALKFLKPTEELPNQKAEILREADAMAMLDHPNIVRLYGICVGDPIR
 .    .| | || | ||||    .                        . .. | |  |  .  ...| . . ||  |  .||| ||.| |||  .|| 
ITLNRCIGEGQFGDVYQGVYTNHKNGKGKNLAGNGKNSNSDQRNADSRPDKIQVAIKTCK-KCCDDDNKEKFMQEAYIMKQFDHPHIVKLIGICEEMPIW

LVMELAACGPLNKFLRKHVG-FPVLKIVNMIIQVAKGMEYLEKTRFVHRDLAARNVLVVDDDNVKISDFGMSRAIGGGSEYYRAETAGRWPLKWYAPECI
..|||.  | | ..|. .     .   .    |... | |||  .||||| |||||||.  |.||  |||.|| .   ..||.|   |. | || .|| |
IIMELCKYGELRHYLQRNKNSLKHATLILYCYQLCMAMAYLESKKFVHRDIAARNVLVSSPDCVKLGDFGLSRWM-HDHSYYKASPKGKLPIKWMSPESI

YYAKFDSKSDVWSYGVTAWEAFSYGAKPYQGMRGTDIMQMLEGNERLDRPDKCPQAIYEIMLRCWSWRPEDRPSFGELVSTISEIAQ
 .  | . |||| .||  ||  .|| ||.|...  |.   .|  |||  |. ||   | .| |||.. | .|| | ||. . ..| |
NFRRFTTASDVWMFGVCMWEILMYGVKPFQWVKNNDVIGRIENGERLPMPPNCPPTLYSLMTRCWAYDPSKRPRFKELKCQLKDIYQ
Kinase AqueK439.AA Eph 282-539 40 7.6e-74 247.41 In-house 1-264 (264) Show / Hide 
Range on Protein: 282-539
Range on HMM: 1-264/264
Sequence Identity: 40% (108 aa)

LETQGELGAGTFGTVRQGVYRPLSGEPPV---KCALKFLKPTEELPNQKAEILREADAMAMLDHPNIVRLYG-ICVGDPIRLVMELAACGPLNKFLRKHV
.  .  .||| || |..|  .. ||.  |     | | || .     |... |.||  |   |||||.|| | .  . |.  | |  . |.| .|||.| 
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYT-EKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHD

G-FPVLKIVNMIIQVAKGMEYLEKTRFVHRDLAARNVLVVDDDNVKISDFGMSRAIGGGS---EYYRAETAGRWPLKWYAPECIYYAKFDSKSDVWSYGV
| | |...| |.  .| || ||    .|||||||||.||  .   |.||||.|| .   .     |  .  |. |..| ||| | | || | |||||||.
GQFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTR-GGKIPIRWTAPEAIAYRKFTSASDVWSYGI

TAWEAFSYGAKPYQGMRGTDIMQMLEGNERLDRPDKCPQAIYEIMLRCWSWRPEDRPSFGELVSTI
  ||  ||| .||  | . |...  |   ||  |  ||.|....|| ||   ...|| | ..||..
VMWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase AqueK439.AA S_TKc 282-548 22 6.3e-48 166.46 SMART 1-231 (231) Show / Hide 
Range on Protein: 282-548
Range on HMM: 1-231/231
Sequence Identity: 22% (62 aa)

LETQGELGAGTFGTVRQGVYRPLSGEPPVKCALKFLKPTEELPNQKAEILREADAMAMLDHPNIVRLYGICVGDPIRLVMELAAC--GPLNKFLRKHVG-
 |   ..| |.||.|.... .        ..|.| .|           |.|| . . . .|||||.||.... | . .|||..    | | ....|. . 
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRH

-----FPVLKIVNMIIQVAKGMEYLEKTRFVHRDLAARNVLVVDDDNVKISDFGMSRAIGGGSEYYRAETAGRWPLKWYAPECIYYAKFDS-KSDVWSYG
     ||   .  .. |.....||. . ...||||   |.|. .  ..||.|||..| .          |     . . ||| .   ...  |.|.|| |
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

VTAWEAFSYGAKPYQGMRGTDIMQMLEGNERLDRPDKCPQAIYEIMLRCWSWRPEDRPSFGELVSTISEIAQFHMT
.. .| .. |  |..      .....            ..   ... .|. . ||.||.  |.    ..|..    
CILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK439.AA Pkinase 282-539 23 4.7e-45 160.39 Pfam 1-293 (293) Show / Hide 
Range on Protein: 282-539
Range on HMM: 1-293/293
Sequence Identity: 23% (70 aa)

LETQGELGAGTFGTVRQGVYRPLSGEPPVKCALKFLKPTEELPNQKAEILR--EADAMAMLDHPNIVRLYGICV-GDPIRLVMELAACG----PLNKFLR
... . .|.|.||.|.... .  .     . |.| .|  .| .... . .|  |.  |..|.||||||||...  .| | .|||.. .|     |  ...
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

--KHVGF--PVLKIVNMIIQVAKGMEYLEKTRFVHRDLAARNVLVVDDDNV----KISDFGMSRAI-GGGSEYYRAETAGRWPLKWYAPECIY-YAKFDS
  .| .|  .   . ... |...|.||. . ...||||   |.|.......    ||.||| .. .    .. .   .  .|   . ||| |  . . ..
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW---YMAPEVIRGGQYYGP

KSDVWSYGVTAWEAFSYGAKPYQGM----RGTDIMQMLEGNER----LDRPDKCP-------------------QAIYEIMLRCWSWRPEDRPSFGELVS
|.|.||.|.. .| .. |  |..|     .  | |||.. . .     |.| .|.                   ..  ... .|. . |..||.. ... 
KVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ

T--I
   .
HPWF