Gene AqueK440 (A.queenslandica)

AqueK440

Species: A.queenslandica
Alias: AqueK440
External Links:
Annotation:

Classification

Group: TK
Family: Syk

Sequence

Name Sequence Type Origin Length Description Download
AqueK440.AA Protein None 767 None Fasta, JSON
AqueK440.kin_dom Protein Kinase Domain None 259 None Fasta, JSON

Protein domain

Protein domains of AqueK440.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH2 AqueK440.AA SH2 13-91 39 2.4e-29 87.96 Pfam 1-81 (81) Show / Hide 
Range on Protein: 13-91
Range on HMM: 1-81/81
Sequence Identity: 39% (32 aa)

WFHGKITRENAAHLVTSLPGKLDGYFLVRESLRIPGSFVLTMWADN---TVHHFQIIGHGDGWFSVDNGPLFQGLDELIHHY
|.||||.|. | .|  . ||. || |||||| . ||...|. . |.    |.|..|  ...| . .  .. |. | ||..||
WYHGKISRQEAERLLMN-PGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 AqueK440.AA SH2 11-97 39 2.6e-27 98.0 SMART 1-87 (87) Show / Hide 
Range on Protein: 11-97
Range on HMM: 1-87/87
Sequence Identity: 39% (35 aa)

DAWFHGKITRENAAHLVTSLPGKLDGYFLVRESLRIPGSFVLTMWADNTVHHFQIIGHGDGWFSVDN--GPLFQGLDELIHHYQVKPDG
  |.||.|.|| | .|  .  |. || ||||.| . ||..||... .. |.|..|   .||....|   .. |. | ||..|||  |.|
QPWYHGNISREEAEQLLKNP-GMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Ank AqueK440.AA Ank 189-222 35 4.8e-08 33.28 Pfam 1-33 (33) Show / Hide 
Range on Protein: 189-222
Range on HMM: 1-33/33
Sequence Identity: 35% (12 aa)

KGSTALHLAAQNGYADIIKLLVENGKADVQERNT
 | |.||||...|.....|.|..   |||  .. 
DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD
Ank AqueK440.AA Ank 156-188 36 7.2e-08 32.64 Pfam 1-33 (33) Show / Hide 
Range on Protein: 156-188
Range on HMM: 1-33/33
Sequence Identity: 36% (12 aa)

EGQTPVHEAAKRGYIEMVALLVEHKPDLSLRDS
.|.|| | |...|..|.| .|..|  |. ..| 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank AqueK440.AA Ank 224-256 36 2e-06 27.87 Pfam 1-33 (33) Show / Hide 
Range on Protein: 224-256
Range on HMM: 1-33/33
Sequence Identity: 36% (12 aa)

TGWVALHEAAFRGHVDCCKMLLTHNAPLRPRTP
 |. .|| |...||....|||| |.| .  .. 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
SH2 AqueK440.AA SH2 294-379 35 1.2e-21 79.1 SMART 1-87 (87) Show / Hide 
Range on Protein: 294-379
Range on HMM: 1-87/87
Sequence Identity: 35% (31 aa)

SEWLHKVLDRNHAVEYLRQNGQVDGSFLVRPNSRKPGYYALTLVYKQMPFHYEIICESDRWYYIDD--GPLFDSISLCVDHYMMFADG
 .| |  ..|  |.. |...|. ||.||||. ...|| |.|.. .|.   || | .. |..||||.  .. |.|.   |.||.  ..|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
SH2 AqueK440.AA SH2 296-373 33 7.5e-21 63.05 Pfam 1-81 (81) Show / Hide 
Range on Protein: 296-373
Range on HMM: 1-81/81
Sequence Identity: 33% (27 aa)

WLHKVLDRNHAVEYLRQNGQVDGSFLVRPNSRKPGYYALTLVYKQ---MPFHYEIICESDRWYYIDDGPLFDSISLCVDHY
| |. . |. | ..|.. |. ||.||||. ...|| |.|.....       || | .. .. ||| ... |.|..  |.||
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
Kinase AqueK440.AA Syk 491-743 48 1.8e-146 492.91 In-house 1-257 (257) Show / Hide 
Range on Protein: 491-743
Range on HMM: 1-257/257
Sequence Identity: 48% (127 aa)

LSLGPELGQGEFGSVLRGTYRMP----DGKSVDVAVKTLRVDAMGHG-EKEFLREAKIMMGLHHPGIVQLIGVTKNKPLMLVQELVPCGALVDYLYDGKY
| .. |.|.|.||||. |.|.|     ... ..||.|.|. |.   . ..||.|||..|..| || || .||. .  ..|.|.|... |.. .|| . . 
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGICHAEMMMMVMEMAELGPMHKYLQQHRH

PKPEIMT---LKLWAAEIASGMMYLEKKRFVHRDLAARNILVASSYVVKISDFGLSRAVGANSDYYKASQGGRWPVKWYAPESINYGTFSHASDVWSYGV
   || .   |.||.. .|.||.||| | ||||||||||.|       ||||||.|.| ||.|.||.| ..|.|||||||||.|.|..|||.|||||.||
---EITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGV

TLWEMFSYGEPPYGEMTGAEVLDFIENRNGRLDRPPTCPLPIYHLMLNCWSLETNQRPTFA
|.||||||| .|||||.|.||..||||   |. .|. ||  .| ||  ||. .   |||| 
TMWEMFSYGQKPYGEMKGQEVMKFIENGH-RMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase AqueK440.AA Pkinase_Tyr 491-749 45 4.6e-132 447.88 Pfam 1-270 (270) Show / Hide 
Range on Protein: 491-749
Range on HMM: 1-270/270
Sequence Identity: 45% (122 aa)

LSLGPELGQGEFGSVLRGTYR-MPDGKSVDVAVKTLRVDAMGHG--EKEFLREAKIMMGL-HHPGIVQLIGVTK--NKP--LMLVQELVPCGALVDYLYD
...| .||.|.||.| .||..  ||.. ..||||.|. .|| .    ..|.||||||. | ||| ||.|.||     .|  ...| |..|.| | ||| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

G--KYPKPEIMTLKLWAAEIASGMMYLEKKRFVHRDLAARNILVASSYVVKISDFGLSRAVGANSDYY-KASQGGRWPVKWYAPESINYGTFSHASDVWS
     ... . .|  ....||.|| ||| |...||||||||.||... ||||.||||.|..  | ||| ....||..|.||.|||.|||| |...|||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

YGVTLWEMFSYGEPP-YGEMTGAEVLDFIENRNGRLDRPPTCPLPIYHLMLNCWSLETNQRPTFAELYDFF
.||..||.|.||| | | .|. .||...|  ...|...|. || .||.||. ||  . ..||||.|.. ..
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK440.AA TyrKc 491-749 40 1.3e-129 437.86 SMART 1-280 (280) Show / Hide 
Range on Protein: 491-749
Range on HMM: 1-280/280
Sequence Identity: 40% (118 aa)

LSLGPELGQGEFGSVLRGTYRMPDGKSVDVAVKTLRVDAMGHGEKEFLREAKIMMGL--HHPGIVQLIGVTKN--------KPLMLVQELVPCGALVDYL
..|| .|| |.|| | .||..      ..||||.|. ||    ...|.|||.||. |  ||| ||.|.||           .|||.| |..| |.| |||
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

YDGKYPKPEIMTLKLWAAEIASGMMYLEKKRFVHRDLAARNILVASSYVVKISDFGLSRAVGAN------SDYYKASQ--GGR--WPVKWYAPESINYGT
 . .       .|  ..  ||.|| ||..|...||||||||.||.. ..||||||||||...        .|||....  ||.  .|..|.|||.||||.
RKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

FSHASDVWSYGVTLWEMFSYGEPPYGE-----MTGAEVLDFIENRNGRLDRPPT--------CPLPIYHLMLNCWSLETNQRPTFAELYDFF
|...|||||.||..||.|.||..|| .     |. .||. ...... |...||         ||  .| .|. ||  . ..||||.|....|
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGY-RMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK440.AA Ack 491-749 47 1.2e-120 407.08 In-house 1-266 (266) Show / Hide 
Range on Protein: 491-749
Range on HMM: 1-266/266
Sequence Identity: 47% (126 aa)

LSLGPELGQGEFGSVLRGTYRMPDGKSVDVAVKTLRVDAMGHG--EKEFLREAKIMMGLHHPGIVQLIGVTKNKPL-MLVQELVPCGALVDYLYDGKY-P
..|. .||.|.||.| ||.   | ||.. |||| ||.| |  .    .||||. ||. | || .| | ||    |. |.| || |||.|.| | ...  .
ITLCEKLGDGCFGVVWRGEWTNPGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRKHCRTA

KPEIMTLKLWAAEIASGMMYLEKKRFVHRDLAARNILVASS-YVVKISDFGLSRAVGANSDYYKASQGG--RWPVKWYAPESINYGTFSHASDVWSYGVT
.. | ||  ..  ||.|| ||| ||..||||||||||..|    |||.||||.|| | | |||. .       |  | |||......||||||||..|||
FFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMFGVT

LWEMFSYGEPPYGEMTGAEVLDFIENRNGRLDRPPTCPLPIYHLMLNCWSLETNQRPTFAELYDFF
||||||||| |.  ..|...|  |.    || ||. ||  || .|..||  .   ||||....|..
LWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase AqueK440.AA TK 491-749 24 1.7e-114 385.43 In-house 1-486 (486) Show / Hide 
Range on Protein: 491-749
Range on HMM: 1-486/486
Sequence Identity: 24% (118 aa)

LSLGPELGQGEFG---SVLRGTYRMPD----------------------GKSVDVAVKTLRVD-AMGHGEKE---------------FLREAKIMMG--L
. || .||.|.||    | .|..|...                      |. ..||||.|. . ||   |..               ...|.|.|.   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHPGIVQLIG-VTKN------------KPLMLVQELVPCGA----LVDYLY--DGKYPK-----------------------------------------
||| ||.|.| .|..            .|.|.| |..|.|     | |||   ..|  .                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------PEIMTLKLWAAEIASGMMYLEKK------RFVHRDLAARNILVASSYV-----------VKISDFG---
                               .   .|  ... ||.|| ||..|      .||||||||||.||....|           .||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSRAVGANSDYYKAS-----------------------QGGRWPVKWYAPESIN---------YGTFSHASDVWSYGVTLWEMFSYG-EPPYGEM
     |.|... ..|||..|                       .||..|..|.|||..|         ||.|...|||||.||..||.|.|| ||.||.|
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TG---------AEVLDFIENR-----------NGRLDRP--PTCP--------------LPIYHLMLNCWSLETNQRPTFAELYDFF
.          .||......             .|. .|  | ||                .| ||. ||... ..||||..|....
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK440.AA UTK 491-749 36 4.5e-104 352.05 In-house 1-296 (296) Show / Hide 
Range on Protein: 491-749
Range on HMM: 1-296/296
Sequence Identity: 36% (107 aa)

LSLGPELGQGEFGSVLRGTYRMPD--GKSVDVAVKTLRVDAMGHGEKE----FLREAK---IMMGLH-HPGIVQLIGV-TKNKPLMLVQELVPCGALVDY
. || .||||.|| | ..... ..  .. .|||||.....|..  |.|    |..||.   .|. .| || ...|.|| |. .|.|.| |. . | |..|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LYDGKYPKP---EIMT---LKLWAAEIASGMMYLEKKRFVHRDLAARNILVASS-------YVVKISDFG---LSRAVGA--------NSDYYKASQGGR
| . .   |   .. |   .  .|. ||.|| ||. ..||||||||||.||...       .|.||.|||   .||.|..        .|.||.|.. .|
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

WPVKWYAPESINYG-TFSHASDVWSYGVTLWEMFSYGEPPYGEMTGAEVLDFIENRN-GRLDRPPTCPLPIYHLMLNCWSLETNQRPTFAELYDFF
||..|.|||..... .|...|||||.||..||....|  ||..|. ..|. ...|..  |. .|. ||.|.| ||. ||  .   ||.| .|....
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase AqueK440.AA SFK-Src 491-749 41 2.7e-96 285.87 In-house 1-259 (259) Show / Hide 
Range on Protein: 491-749
Range on HMM: 1-259/259
Sequence Identity: 41% (111 aa)

LSLGPELGQGEFGSVLRGTYRMPDGKSVDVAVKTLRVDAMGHGEKEFLREAKIMMGLHHPGIVQLIGV-TKNKPLMLVQELVPCGALVDYLYDGKYPKPE
  |   ||.| || | .|.      .. .||||||.  ||   ..|||.|| .|  | ||  .||  | |   |.  . ||.  | | ||| . .     
IRLEKKLGSGQFGDVWKGRWN----NTTEVAVKTLKPGAM--SAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLR

IMTLKLWAAEIASGMMYLEKKRFVHRDLAARNILVASSYVVKISDFGLSRAVGANSDYYKASQGGRWPVKWYAPESINYGTFSHASDVWSYGVTLWEMFS
. .|   ||..|.|| ||| . ||||||||||.||  . |.|. |||.|| .....  | | .| . |.|| |||  |. .||  |||||.|. . |.  
MPQLVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVT

YGEPPYGEMTGAEVLDFIEN-RNGRLDRPPTCPLPIYHLMLNCWSLETNQRPTFAELY----DFF
||  ||  || .||| ...     |.. || ||   | .|..||  |   ||||  |     |||
YGRIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase AqueK440.AA Src 491-749 43 2.8e-95 322.84 In-house 1-255 (255) Show / Hide 
Range on Protein: 491-749
Range on HMM: 1-255/255
Sequence Identity: 43% (114 aa)

LSLGPELGQGEFGSVLRGTYRMPDGKSVDVAVKTLRVDAMGHGEKEFLREAKIMMGLHHPGIVQLIGVTKNK-PLMLVQELVPCGALVDYLY-DGKYPKP
. |  .|||| || |  |...    ....||||||. . |    . ||.||.||  | |. .|||  |   . |   |.|.   | | |||  ||.  . 
IKLCRKLGQGQFGEVWMGYWN----GNTKVAVKTLKPGTM--SPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHL

EIMTLKLWAAEIASGMMYLEKKRFVHRDLAARNILVASSYVVKISDFGLSRAVGANSDYYKASQGGRWPVKWYAPESINYGTFSHASDVWSYGVTLWEMF
.. .|   || .|.||.|||.....||||||||.||  . |.|. |||| | .  . | | |..| . |.|| ||| ||||.|.  |||||.|. |.|..
HLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIV

SYGEPPYGEMTGAEVLDFIENRNGRLDRPPTCPLPIYH-LMLNCWSLETNQRPTFAELYDFF
.||  ||  || .|||. .| |. |. .|..||  .|. .|| ||  .  |||||. |..|.
TYGRVPYPGMTNHEVLQQVE-RGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase AqueK440.AA EGFR 491-750 42 3.8e-88 292.75 In-house 1-258 (258) Show / Hide 
Range on Protein: 491-750
Range on HMM: 1-258/258
Sequence Identity: 42% (111 aa)

LSLGPELGQGEFGSVLRGTYRMPDGKSVD--VAVKTLRVDAMGHGEKEFLREAKIMMGLHHPGIVQLIGVTKNKPLMLVQELVPCGALVDYLYDGKYPKP
| ... || | || | .| . .|.|..|   ||.| ||     .  .|.|.||..| .. || .|.|.||   . ..||  . | |.| ||.   .  | 
LKKVKVLGSGAFGTVYKGIW-IPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQMQLVTQYMPYGCLLDYV---RQHKD

EI--MTLKLWAAEIASGMMYLEKKRFVHRDLAARNILVASSYVVKISDFGLSRAVGANSDYYKASQGGRWPVKWYAPESINYGTFSHASDVWSYGVTLWE
.|    | .|.  ||.||.|||..| |||||||||.|| |   ||| ||||..   .... |.| |||. |.|| | |.| .. . |.|||||||||.||
NIGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHA-QGGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWE

MFSYGEPPYGEMTGAEVLDFIENRNGRLDRPPTCPLPIYHLMLNCWSLETNQRPTFAELYDFFN
.  .|. ||  .  .|. |..|. . ||  || | . .| .|. || .  . |||| |||  |.
LMTFGQKPYDGIPAREIPDLLEKGE-RLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase AqueK440.AA Eph 491-749 41 1.4e-86 290.87 In-house 1-264 (264) Show / Hide 
Range on Protein: 491-749
Range on HMM: 1-264/264
Sequence Identity: 41% (113 aa)

LSLGPELGQGEFGSVLRGTYRMPDGKSVD----VAVKTLRVDAMGHGEKEFLREAKIMMGLHHPGIVQLIGV-TKNKPLMLVQELVPCGALVDYL--YDG
. .   .| |||| | .|. ..|.||       ||.|||.. ..     .||.|| ||    || |..| || || .|.| | |    |.| ..|   ||
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG

KYPKPEIMTLKLWA--AEIASGMMYLEKKRFVHRDLAARNILVASSYVVKISDFGLSRAVGANS---DYYKASQGGRWPVKWYAPESINYGTFSHASDVW
     .. ...| .    ||||| ||    .|||||||||||| |  | |.||||||| .  ..   . |  . ||. |..| ||| | |..|. |||||
-----QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTR-GGKIPIRWTAPEAIAYRKFTSASDVW

SYGVTLWEMFSYGEPPYGEMTGAEVLDFIENRNGRLDRPPTCPLPIYHLMLNCWSLETNQRPTFAELYDFF
|||. .||  |||| ||..|.. .|.  ||    ||  |. || ... |||.||  . |.||.|...  ..
SYGIVMWEVMSYGERPYWDMSNQDVIKAIEQ-GYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase AqueK440.AA TK-Unique 491-749 34 6.8e-82 278.37 In-house 1-294 (294) Show / Hide 
Range on Protein: 491-749
Range on HMM: 1-294/294
Sequence Identity: 34% (103 aa)

LSLGPELGQGEFGSVLRGTYR---MPDGKSVDVAVKTLRVDAMGHGEKEFLREAKIMMGLH-HPGIVQLIGVTK-NK-PLMLVQELVPCGALVDYLYDGK
| .| ..|.|.|| | ||...   ....| . ||||.|. .| .. ...||.|...|. |  || |||..|..  .  | |.. | .||| | .||   .
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

YP-------------------KPE---IM--TLKLWAAEIASGMMYLEK--KRFVHRDLAARNILVASSYVVKISDFGLSRAVGANSDYYKASQGGRWPV
..                   ||.   |.  .|  .| .||.||.||..  |..|||||.|||.|... .|.||.|||..| | .| .| .  . || |.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

KWYAPESIN--YGTF-SHASDVWSYGVTLWEMFSYGEPPYGEMTGAEVLDFIENRNGRLDRPPTC-PLPIYHLMLNCWSLETNQRPTFAELYDFF
.| ||||.   .|.. .  |||||.||..||.|..|..||..|  ..... |..   |...|. | .  .| || .||..|  .||.|... . .
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGY-RMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase AqueK440.AA Abl 491-749 41 6.1e-80 266.29 In-house 1-252 (252) Show / Hide 
Range on Protein: 491-749
Range on HMM: 1-252/252
Sequence Identity: 41% (108 aa)

LSLGPELGQGEFGSVLRGTYRMPDGKSVDVAVKTLRVDAMGHGEKEFLREAKIMMGLHHPGIVQLIGV-TKNKPLMLVQELVPCGALVDYLYDGKYPKPE
...   || | .| |  | ..     .  ||||||. |.|    .|||.|| ||  ..|| .|||.|| |.  |  .. | .. | |.||| . .  . .
IMMKHKLGGGQYGEVYEGVWKR---HDCTVAVKTLKEDTMEV--HEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELP

IMTLKLWAAEIASGMMYLEKKRFVHRDLAARNILVASSYVVKISDFGLSRAVGANSDYYKASQGGRWPVKWYAPESINYGTFSHASDVWSYGVTLWEMFS
 ..|   |. ||||| ||||. |.|||||||| ||.   .||. ||||.| .  . | | |  | ..|.|| ||||. | .||  |||| .|| |||.  
AVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMM--KDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIAT

YGEPPYGEMTGAEVLDFIENRNGRLDRPPTCPLPIYHLMLNCWSLETNQRPTFAELYDFF
||  ||  .   .| . .|.   |..||. ||  .|.||..||  .   ||.|.|.   .
YGMSPYPGIDLSHVYHKLEKGY-RMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase AqueK440.AA S_TKc 491-749 22 1.2e-45 158.83 SMART 1-231 (231) Show / Hide 
Range on Protein: 491-749
Range on HMM: 1-231/231
Sequence Identity: 22% (63 aa)

LSLGPELGQGEFGSVLRGTYRMPDGKSVDVAVKTLRVDAMGHGEKEFLREAKIMMGLHHPGIVQLIGVTKNKPLMLVQELVPC--GALVDYLYDGKYPKP
  .. ..|.| ||.| ... .        ||.| ..        . ..|| .|..  ||| ||.|..|  .. | .| |...   | | ||. . .....
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGL

----EIMTLKLWAAEIASGMMYLEKKRFVHRDLAARNILVASSYVVKISDFGLSRAVGANSDYYKASQGGRWPVKWYAPESINYGTFSH-ASDVWSYGVT
       . . ....|.... |. .....||||   |||. .  ..||.||||.| .       .   | .|   . ||| .    ... ..|.|| |..
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPW---YMAPEVL---GYGKCKCDWWSCGCI

LWEMFSYGEPPYGEMTGAEVLDFIENRNGRLDRPPTCPLPIYHLMLNCWSLETNQRPTFAELYD---------FF
|.||.. |.||.   . ..... |             . .  ... .|.  . ..|||  |.           .|
LYEMLC-GYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK440.AA Pkinase 491-749 23 2.5e-39 140.16 Pfam 1-293 (293) Show / Hide 
Range on Protein: 491-749
Range on HMM: 1-293/293
Sequence Identity: 23% (73 aa)

LSLGPELGQGEFGSVLRGTYRMPDGKSVD-VAVKTLRVDAMGHGE-KEFLR--EAKIMMGLHHPGIVQLIGVTKNKPLML-VQELVPCG----ALVDYLY
. .|  .|.| ||.|    |.  . .. . ||||.....   ... .. .|  |..||  |.|| ||.|...  .|. .  |.|....|     | ||. 
YHIGRKIGSGSFGCV----YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

---DGKYPKPEIMTLKLWAAEIASGMMYLEKKRFVHRDLAARNILVASSYVV----KISDFGLSRAV-GANSDYYKASQGGRWPVKWYAPESIN-YGTFS
   .|..   .  ..| .. .|..|. |. .....||||   |||. . ...    ||.||||.. .   |.  ..   | .|   . ||| |. .   .
TWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW---YMAPEVIRGGQYYG

HASDVWSYGVTLWEMFSYGEPPYGEM----TGAEVLDFIENRNG---RLDRPPTCP-------------------LPIYHLMLNCWSLETNQRPTFAELY
...|.||.|..|.||.. |.||. .     . .. .  |... |   . |.| .|.                    .  ... .|. .  ..|||.... 
PKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQIL

DF--F
    |
QHPWF