AqueK510

Species: A.queenslandica
Alias: AqueK510
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-a1

Sequence

Name Sequence Type Origin Length Description Download
AqueK510.AA Protein None 401 None Fasta, JSON
AqueK510.kin_dom Protein Kinase Domain None 210 None Fasta, JSON

Protein domain

Protein domains of AqueK510.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK510.AA TKL 28-299 18 7.4e-34 118.8 In-house 1-364 (364) Show / Hide
Range on Protein: 28-299
Range on HMM: 1-364/364
Sequence Identity: 18% (70 aa)

ISDGAYGVVNEVKIDD---------GTLCAGKTPHEYL-----------------------VREDKTFLKKFCDEVLLHVKQHHPNIVQVIG-LHYPPS-
|  |..|.|   |            |.  | |. ..                          .| . | ...  |.... . .|||||| .|   .||. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

--------SRFIPMLIMEYLPM-T-LGNCLDKKQPMLEPEELKRPQTQYSILLGVANGLIYLHQKE------PPVYHRDLTAYNVLLTANFT--------
        .   ....||| |  . | . .              ..   .. |..| |. |||...      ||. ||||.  |.|.  |.|        
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYN

------AKISDLGMSRIVAVSGE-------------------KLTAAPGNVNVMPPEAKKDNP---------------IYNHKIDVFAFGCLILHIASGQ
      .||.|.| || .  ||.                   ..    |. . |.||. ....                |. |.||..|| ..  |....
PNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRC

FPVPKRDSFQENPNDDTCTSYIKI-----------TEWS-RRYKYVKAILDEDDHELLPLAQQCLEDNPRDRPEMIDLVHFI
 |  . ..... ..|.    ....           ..|. .. | .    .  ....  |.|.| . .|..|| . .... .
RPYYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHH-K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase AqueK510.AA TK 22-299 15 6.4e-27 86.65 In-house 1-486 (486) Show / Hide
Range on Protein: 22-299
Range on HMM: 1-486/486
Sequence Identity: 15% (76 aa)

VEIGLKISDGAYG---VVNEVKIDDG--------------------------TLCAGKTPHEYLVREDKTFLK-------------KFCDEVLLHV--KQ
...| |.  |..|   .| . .  ..                          | .| |. .|    ... |.              ... |  .    . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHPNIVQVIG--LHYPPSSRFI-------PMLIMEYLPMT-----LGNCLDKKQPM--------------------------------------------
||||||. .|  ..  |...|        .|..||| |       | . | |. |                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----------LEPEELKR--------------PQTQYSILLGVANGLIYLHQKEP----PVYHRDLTAYNVLLTANFT-----------AKISDLGMS-
           |   .| .              ....  . . .|.|. |||.|       . |||| | |.|.. | .           .||.| |.| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-------RIVAVSGEKLTAAPGNVNV--------------------------MPPEAKKDNP--------IYNHKIDVFAFGCLILHIAS-G-QFPVPKR
       | .  ...  .. .. ...                          |.||. .|.         .. .| ||..||.|.  | . | . . .  
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

DS--------------------------------FQENPNDDTCTSYIKITEWSRRYKYVKAILDEDDHELLPLAQQCLEDNPRDRPEMIDLVHFI
..                                  . |  . |...         |.. . .  ... |.  | ||| . .|.||| . .|....
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWM-R------YRM-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase AqueK510.AA HH498 128-231 33 2.7e-22 67.14 In-house 120-225 (284) Show / Hide
Range on Protein: 128-231
Range on HMM: 120-225/284
Sequence Identity: 33% (35 aa)

PQTQYSILLGVANGLIYLHQ-KEPPVYHRDLTAYNVLLTANFTAKISDLGMSRIVAVSGEK-LTAAPGNVNVMPPEAKKDNPIYNHKIDVFAFGCLILHI
.|    | . ||.|  |||    .|. ||||.  |.|. ..  |.. | | || |   ... .|  |||   | ||  . .  |  |.||| ..  |  .
LQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIWEM

ASGQFP
 ..  |
HTREVP

Kinase AqueK510.AA TKL-Unique 61-219 27 5.1e-22 74.55 In-house 36-215 (290) Show / Hide
Range on Protein: 61-219
Range on HMM: 36-215/290
Sequence Identity: 27% (51 aa)

KTFLKKFCDEVLLHVKQH-HPNIVQVIGLHY----PPSSRFIPMLIMEYLPM-TLGNCLDKKQPML---EPEELKRPQTQYSILLGVANGLIYLHQKEPP
......| .|| .  | | |||||. .|       .|. ..|   .|||.|. .| . |.   .     ...    .| .... . .| |..||| .|||
NEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCI---VMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP

VYHRDLTAYNVLLTAN-----FTAKISDLGMSRIVAVSGEKLTAAP---------GNVNVMPPEAKKDN-PIYNHKIDVFAFG
..||||.  |.|.. |     . .||.| | |.. . . .. .  .         |. . |.||  ..|   |. |.||..||
IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFG

Kinase AqueK510.AA TK-Unique 79-222 28 1.8e-18 60.4 In-house 63-229 (294) Show / Hide
Range on Protein: 79-222
Range on HMM: 63-229/294
Sequence Identity: 28% (51 aa)

HPNIVQVIGLHYPPSSRFIPMLIMEYLPMT-LGNCLDKKQPM-------------------------LEPEELKRPQTQYSILLGVANGLIYLHQ--KEP
|||||| .|    ..  . .|.||||.|.  | ..| ...|                          . |. | .      .. ..|.|. ||..  |. 
HPNIVQCLGCCTKSD--EPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYH------FAWQIACGMEYLASQRKK-

PVYHRDLTAYNVLLTANFTAKISDLGMSRIVA---VSGEKLTAAPGNVNVMPPEAKK--DNPIYNHKIDVFAFGCLI
 . |||| | ||||| ....||.|.||.| |    |   . .  .  .  |.||. |  ...... | || .||.|.
-IVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLM

Kinase AqueK510.AA S_TKc 22-299 19 6.6e-17 63.42 SMART 1-231 (231) Show / Hide
Range on Protein: 22-299
Range on HMM: 1-231/231
Sequence Identity: 19% (59 aa)

VEIGLKISDGAYGVVNEVK-IDDGTLCAGKTPHEYLVREDKTFLKKFCDEVLLHVKQHHPNIVQVIGLHYPPSSRFIPMLIMEYLPM---TLGNCLDKKQ
 ||. ||  ||.|.|  .. ...| ..| |  .           .... |. .. | ||||||. ..  .         ..|||..    .|   ..|..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLFDYIKKRG

PM-----LEPEELKRPQTQYSILLGVANGLIYLHQKEPPVYHRDLTAYNVLLTANFTAKISDLGMSRIVAVSGEKLTAAPGNVNVMPPEAKKDNPIYNH-
.      . . . ..      ..  ....| |.|..   . ||||   |.||.   . ||.| |..|..       |   |  . |.||       |.. 
RHGLRFPFPE-HARF------YMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKC

KIDVFAFGCLILHIASGQFPVPKRDSFQENPNDDTCTSYIKITEWSRRYKYVKAILDEDDHELLPLAQQCLEDNPRDRPEMIDLVH---------FI
|.|. ..||..   ..|. | |            .    .|.                 ..|.. . ..||. .|..||   .. .         ..
KCDWWSCGCILYEMLCGYPPFP------------QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase AqueK510.AA UTK 22-219 21 9.7e-16 50.32 In-house 1-227 (296) Show / Hide
Range on Protein: 22-219
Range on HMM: 1-227/296
Sequence Identity: 21% (51 aa)

VEIGLKISDGAYGVVNEVKIDDGT---LCAGKTPHEYLVREDKTFLK----KFCDEVL---LHVKQH-HPNIVQVIGLHYPPSSRFIPMLIMEYLP-MTL
|..| ..  ||.|.|.. . .. .   . ...  ..  ...|... .    .|  |     .  . | |||.....|..   .    .|...|| .   |
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP---WMIVTEYMENGDL

GNCLDKKQPMLEPEELKRPQTQ-YSILLGVANGLIYLHQKEPPVYHRDLTAYNVLLTAN-------FTAKISDLG---MSRIVA---------VSGEKLT
 ..| .  | ......    .|  .  . .|.|. |||..   . |||| | |.|....        ..||.|.|   ||| |.          | .   
RSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCG--FVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMA

AAPGNVNV--MPPEAKKDNPIYNHKIDVFAFG
.  . . .  | |||  ..  . .| ||..||
QHQDRWPIRWMAPEALTHHTRFTTKSDVWSFG

Kinase AqueK510.AA TyrKc 22-299 23 1.4e-15 29.37 SMART 1-280 (280) Show / Hide
Range on Protein: 22-299
Range on HMM: 1-280/280
Sequence Identity: 23% (72 aa)

VEIGLKISDGAYGVVNEVKIDDGTLCAGKTPHEYLVREDKTFLKKFCDEVLLHVKQ--HHPNIVQVIGLHYPPSSRF----IPMLIMEYLPM-TLGNCLD
.. | |.  ||.|.| . . .  . .| |. .|.        .. |..|  .  |   ||||||. .|    .. .|     .|..||| |   | . | 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KKQPMLEPEELKRPQTQYSILLGVANGLIYLHQKEPPVYHRDLTAYNVLLTANFTAKISDLGMSRIVAVS------GEKLTAA---PGN--VNV--MPPE
|..|         ...  |. . .|.|  |||.|  .. |||| | |.|...|.|.|||| |.|| .         ..  ...    |.  . .  |.||
KHRPK------LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

AKKDNPIYNHKIDVFAFGCLILHIASGQFPVPKRDSFQENPNDDTCTSYIKITEWSRRYKYVKAILD-------EDDHELLPLAQQCLEDNPRDRPEMID
. ... ....| ||..|| ..  | .   . .  . .|         | . . |. .. .. .   .       .   |.  . .|| . .| ||| . .
CINYG-KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-------MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSE

LVHFI
.....
IHECF

Kinase AqueK510.AA Pkinase 22-290 20 3.7e-15 54.66 Pfam 1-282 (293) Show / Hide
Range on Protein: 22-290
Range on HMM: 1-282/293
Sequence Identity: 20% (61 aa)

VEIGLKISDGAYGVVNE-VKIDDGTLCAGKTPHEYLVREDKTFLKKFCD--EVLLHVKQHHPNIVQVIGLHYPPSSRFIPMLIMEYLPMTLGNCLDKK--
 .|| ||  |..|.| . .....| . | |.    ...|.. ...      |. .. . .|||||. ..  . ...     ..|||....|  ..| .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKI--IKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIY---MVMEYCEGGLY-VMDLFDY

-----QPML--EPEELKRPQTQYSILLGVANGLIYLHQKEPPVYHRDLTAYNVLLTANFTA----KISDLGMSRIV-AVSGEKLTAAPGNVNVMPPEAKK
     .  .  ...|.|.      ... .. || |.|..   . ||||   |.|.  | .     ||.| | .. .   ... .|   |  . |.||  .
ISTWRHGCFYFSEWECKF------YMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR

DNPIYNHKIDVFAFGCLILHIASGQFPVPKR------DSFQENPNDDTCTSYIKITEWSRRY--------KYVKAILDEDDHELLPLAQQCLEDNPRDRP
... | .|.|....||..   ..|..| | .      |  |   ..  .     . .|....        .  .   .. . |.. .   ||. .| .||
GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHF-HWTF-HNWSEECKDFIKWCLCKDPKKRP





Kinase AqueK510.AA Fer 134-300 25 5.3e-15 47.63 In-house 116-283 (283) Show / Hide
Range on Protein: 134-300
Range on HMM: 116-283/283
Sequence Identity: 25% (47 aa)

ILLGVANGLIYLHQKEPPVYHRDLTAYNVLLTA-NFTAK--ISDLGMSRIVAVSGEKLTAAP--GNVNV--MPPEAKKDNPIYNHKIDVFAFGCLILHIA
.....|.|. |||.|   . |||. | |.|... ..  |  ||| ||||  .. |.. . ..    |..  ..||. . . ||..| ||..||...  | 
MCYQAACGMEYLHSKN--CIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQ-TGIYSPKTDVWSFGVMCWEIF

S-GQ--FPV-PKRDSFQENPNDDTCTSYIKITEW--SRRYKYVK-----AILDEDDHELLPLAQ-QCLEDNPRDRPEMIDLVHFIE
. |.  .|  |  .              .| |..  ..| ...|      . ...  |.  .   || . .| ||| | .... ..
TNGAEPYPGQPH-G--------------MKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK

Kinase AqueK510.AA Dicty5 130-219 33 8.4e-15 47.38 In-house 105-190 (260) Show / Hide
Range on Protein: 130-219
Range on HMM: 105-190/260
Sequence Identity: 33% (30 aa)

TQYSILLGVANGLIYLHQKEPPVYHRDLTAYNVLLTANFTAKISDLGMSRIVAVSGEKLTAAPGNVNVMPPEAKKDNPIYNHKIDVFAFG
.| .. ...|... .|| .   . ||||   |.|.| |...|| | | || |.    . |   |  . | .|  . .| |  | ||..||
QQLHMAIDIAQSMRHLHSMN--IIHRDLKSMNFLITENWKIKIIDFGTSRFVDNR-YHMTMHVGTQCWMACELFNGQP-YHQKCDVYSFG

Kinase AqueK510.AA Pkinase_Tyr 78-222 29 1.1e-14 50.36 Pfam 62-204 (270) Show / Hide
Range on Protein: 78-222
Range on HMM: 62-204/270
Sequence Identity: 29% (45 aa)

HHPNIVQVIGLHY---PPSSRFIPMLIMEYLPM-TLGNCLDKKQPMLEPEELKRPQTQYSILLGVANGLIYLHQKEPPVYHRDLTAYNVLLTANFTAKIS
||||||. .|  .    |.    ....||| |   | . | |.    ... |. ..   .. . .|.|. ||..|     |||| | |.|.| |...||.
HHPNIVRLYGVCTDQGEPN---QIYIVMEYMPHGDLLDYLRKHR--EDKQPLTMKD-LLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKIC

DLGMSRIVAVSG---EKLTAAPGNVNVMPPEAKKDNPIYNHKIDVFAFGCLI
| |..| .   .    | . ..  .  |.||. ...  ...| || .|| |.
DFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK-FTTKSDVWSFGVLM

Kinase AqueK510.AA MLK 136-219 31 2.1e-13 43.0 In-house 131-223 (291) Show / Hide
Range on Protein: 136-219
Range on HMM: 131-223/291
Sequence Identity: 31% (30 aa)

LGVANGLIYLHQKEP-PVYHRDLTAYNVLLTA------NFTAKISDLGMSRIVAVSGEK-LTAAPGNVNVMPPEA--KKDNPIYNHKIDVFAFG
| .|.|. |||...| |. ||||   |.|...      . |.||.| | || .  .. .  . ..|..  | ||.  .. .  |. | ||. .|
LQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWG

Kinase AqueK510.AA LRRK 128-231 30 3.2e-12 39.51 In-house 163-282 (351) Show / Hide
Range on Protein: 128-231
Range on HMM: 163-282/351
Sequence Identity: 30% (37 aa)

PQTQYSILLGVANGLIYLHQKEPPVYHRDLTAYNVLL---T---------ANFTAKISDLGMSRIVAVSGEK-LTAAPGNVNVMPPEAKKDN--PIYNHK
..... | | .| |. ||| . ||. ||||.  |.||   .         |. .|||.| | ||. .. ... .    ||   | ||  ..|    |. |
WMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEK

IDVFAFGCLILHIASGQ-FP
.|...|| .. .. ..| .|
VDCYSFGMILWELLTRQHHP

Kinase AqueK510.AA UTK 272-299 32 0.001518 8.0 In-house 269-296 (296) Show / Hide
Range on Protein: 272-299
Range on HMM: 269-296/296
Sequence Identity: 32% (9 aa)

HELLPLAQQCLEDNPRDRPEMIDLVHFI
|..  | ..| . .|..|| . ||| ..
HPVYRLMHRCWHYDPQERPDFEDLVQQM

Kinase AqueK510.AA MLK 279-299 28 0.002882 7.34 In-house 271-291 (291) Show / Hide
Range on Protein: 279-299
Range on HMM: 271-291/291
Sequence Identity: 28% (6 aa)

QQCLEDNPRDRPEMIDLVHFI
.|| ...|..|| .   | . 
KQCWNQDPHKRPSFRQIVQHL

Kinase AqueK510.AA LRRK 272-301 26 0.005592 6.36 In-house 322-351 (351) Show / Hide
Range on Protein: 272-301
Range on HMM: 322-351/351
Sequence Identity: 26% (8 aa)

HELLPLAQQCLEDNPRDRPEMIDLVHFIEN
|... | |.| . .|..|| ... | ... 
HMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ

Kinase AqueK510.AA HH498 271-299 27 0.054394 1.65 In-house 256-284 (284) Show / Hide
Range on Protein: 271-299
Range on HMM: 256-284/284
Sequence Identity: 27% (8 aa)

DHELLPLAQQCLEDNPRDRPEMIDLVHFI
.|  . | |.| . .| .||.  . |  .
PHHWSNLIQMCWHPCPENRPDFDQIVTIL

Kinase AqueK510.AA TKL-Unique 279-299 33 0.073696 2.56 In-house 270-290 (290) Show / Hide
Range on Protein: 279-299
Range on HMM: 270-290/290
Sequence Identity: 33% (7 aa)

QQCLEDNPRDRPEMIDLVHFI
|||  ..| .||  .. .| .
QQCWHHDPSQRPSFDEIIHRL

Kinase AqueK510.AA Pkinase_Tyr 279-299 28 0.675871 3.66 Pfam 250-270 (270) Show / Hide
Range on Protein: 279-299
Range on HMM: 250-270/270
Sequence Identity: 28% (6 aa)

QQCLEDNPRDRPEMIDLVHFI
.|| . .| ||| . ......
KQCWHYDPEDRPTFSEIHEQL

IBR AqueK510.AA IBR 334-371 32 3.5e-10 32.99 Pfam 1-35 (44) Show / Hide
Range on Protein: 334-371
Range on HMM: 1-35/44
Sequence Identity: 32% (13 aa)

SCPT--CNYIIEHAPDGSNRSSKFVVCPRCKKEYCFLCLQ
 ||.  |.|.||| .....     . ||.|..|.|..|..
WCPNPDCQYWIEHEDGCNH-----MTCPKCGHEFCWNCKE