Gene AqueK517 (A.queenslandica)

AqueK517

Species: A.queenslandica
Alias: AqueK517
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-a2

Sequence

Name Sequence Type Origin Length Description Download
AqueK517.AA Protein None 154 None Fasta, JSON
AqueK517.kin_dom Protein Kinase Domain None 111 None Fasta, JSON

Protein domain

Protein domains of AqueK517.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK517.AA TKL 1-154 20 6.6e-23 79.33 In-house 138-362 (364) Show / Hide 
Range on Protein: 1-154
Range on HMM: 138-362/364
Sequence Identity: 20% (45 aa)

MHDVAVGLNYLHTLPI-----DNIVHHDVSSANVLLESKGP----------EKWKTKISDFGSANIVRR----------------------AVSRAPGAE
..|.| |.||||.         .|.| |  |.|.|. ...           . |. ||.||| .  . .                      . ..  |  
ALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTP

VYSAPECFQGVSNQYSAV----------QTPKMDVYSYGILFCEALTCKFPDR-SSFQDML------QQVWSSTKSVGLITRS------------LHH--
 . |||...|  |  ..|           ..|.||||.||...| ||.. | .   . .|.      .  .   .     ..              .   
RWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPP

---ELIKSCTKDNPYKRPTMNEVIS
   .|.. | . .| |||...|...
SMKKLMQDCWDHDPEKRPSFQEILK
Kinase AqueK517.AA CZAK 3-104 32 1.7e-13 45.5 In-house 113-221 (279) Show / Hide 
Range on Protein: 3-104
Range on HMM: 113-221/279
Sequence Identity: 32% (37 aa)

DVAVGLNYLHT-LPIDNIVHHDVSSANVLLESKGP---------EKWKTKISDFGSANIVRRAVS---RAPGAEVYSAPECFQGVSNQYSAVQTPKMDVY
|.| | ||||.      |.| | || |.||..               . ||.|||     .   .    . |   . ||||| | ..      |.| |||
DIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEMTQTMGCLCWMAPECFKGENY------TEKVDVY

SYGILFCEALTCKFP
|.|..  . .||  |
SFGMILWCIITCDQP
Kinase AqueK517.AA TK 1-154 17 6e-11 32.15 In-house 240-484 (486) Show / Hide 
Range on Protein: 1-154
Range on HMM: 240-484/486
Sequence Identity: 17% (44 aa)

MHDVAVGLNYLHTLPI---DNIVHHDVSSANVLLESKGPEKWK-------TKISDFGSA---------------NIVRRA-VSRAPGAEV----------
....| |. ||| ...    |.|| |.   |.|. .... ||.        ||.||| .               . .|.   ... ..            
CWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDY

------------YSAPECFQ-GVSNQY--SAVQTPKMDVYSYGILFCEALT---CKFPDRSSFQD-----MLQQVWSSTKSV-------------GLITR
            . ||||.. .|  .     . |.| ||.|.|.|  | .|     ..   | ||      .|.|    ..              ..   
YRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMP

--------------------SLHHELIKSCTKDNPYKRPTMNEVIS
                     ....|...| . .| .|||. .. .
QPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHE
Kinase AqueK517.AA TKL-Unique 2-104 29 2.4e-10 32.87 In-house 117-233 (290) Show / Hide 
Range on Protein: 2-104
Range on HMM: 117-233/290
Sequence Identity: 29% (36 aa)

HDVAVGLNYLHTLPIDNIVHHDVSSANVLLESK-GPEKWKTKISDFG----SANIVRRAVSRA-----PGAE---VYSAPECFQGVSNQYSAVQTPKMDV
.|.| |..|||..    | | |  | |.|. ..    .|. ||.|||    ...| .  ...      .. .    ..||| . .. .|||     | ||
IDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSE----KSDV

YSYGILFCEALTCKF------P
||.||   | .| |       |
YSFGIVLWEIATRKITKTYKKP
Kinase AqueK517.AA MLK 1-104 29 9.9e-10 30.06 In-house 130-235 (291) Show / Hide 
Range on Protein: 1-104
Range on HMM: 130-235/291
Sequence Identity: 29% (32 aa)

MHDVAVGLNYLHTLPIDNIVHHDVSSANVLLES--KGPEKWKTKISDFGSANIVRRA---VSRAPGAEVYSAPECFQG-VSNQYSAVQTPKMDVYSYGIL
....| |..||| .  . |.|.|  | |.|.    .  .. . ||.||| .  . .       ..|   . ||| .|   ...||     | ||.|.|..
ALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSE----KCDVWSWGVV

FCEALTCKFP
. | ||.. |
LWEMLTREVP
Kinase AqueK517.AA TK-Unique 3-94 29 1.6e-09 29.14 In-house 139-228 (294) Show / Hide 
Range on Protein: 3-94
Range on HMM: 139-228/294
Sequence Identity: 29% (29 aa)

DVAVGLNYLHTLPIDNIVHHDVSSANVLLESKGPEKWKTKISDFGSA------NIVRRAVSRAPGAEVYSAPECFQGVSNQYSAVQ-TPKMDVYSYGIL
..| |..||. .. ..|||.|... |||| .    . . ||.||| |      . . .  |. .    . ||| ..        .  |.| ||.|.|.|
QIACGMEYLASQR-KKIVHRDLCARNVLLTE----DKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCY----HGMYHTTKSDVWSFGVL
Kinase AqueK517.AA Dicty5 3-104 35 1.8e-09 28.79 In-house 112-202 (260) Show / Hide 
Range on Protein: 3-104
Range on HMM: 112-202/260
Sequence Identity: 35% (37 aa)

DVAVGLNYLHTLPIDNIVHHDVSSANVLLESKGPEKWKTKISDFGSANIVRRAVSRAP--GAEVYSAPECFQGVSNQYSAVQTPKMDVYSYGILFCEALT
|.| .. .||     ||.| |. | |.|.     | || || |||    |  .       |   . |.| |.|  . |    . | ||||.||   | .|
DIAQSMRHLHSM---NIIHRDLKSMNFLIT----ENWKIKIIDFGTSRFVDNRYHMTMHVGTQCWMACELFNG--QPY----HQKCDVYSFGIVLWEMFT

CKFP
 | |
RKEP
Kinase AqueK517.AA C8 7-95 29 2.4e-09 28.69 In-house 135-226 (226) Show / Hide 
Range on Protein: 7-95
Range on HMM: 135-226/226
Sequence Identity: 29% (28 aa)

GLNYLHTLPIDNIVHHDVSSANVLLESKGPEKWKTKISDFGSANIVRRAVS----RAP---GAEVYSAPECFQGVSNQYSAVQTPKMDVYSYGILF
|.||.|   . ||.| |.   | |.  .. .  . |..||| |  |.   |    .     |   |.|||  ..  |||   .  . |..| |.. 
GVNYIH---CKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRI-QSDLFSVGLVL
Kinase AqueK517.AA Dicty4-Unclassified 3-100 31 1.3e-07 22.11 In-house 117-203 (263) Show / Hide 
Range on Protein: 3-100
Range on HMM: 117-203/263
Sequence Identity: 31% (31 aa)

DVAVGLNYLHTLPIDNIVHHDVSSANVLLESKGPEKWKTKISDFGSANIVRRAVSRAPGA--EVYSAPECFQGVSNQYSAVQTPKMDVYSYGILFCEALT
|.| |. .|||    |..| |. |.|.|.          || ||| .  .         |      .|||  . |  |    . | |||||...  | .|
DIAQGMQHLHTR---NFIHRDIKSSNILMD----KHFNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLMHES--Y----NQKSDVYSYAMMLYELAT
Kinase AqueK517.AA LRRK 3-94 28 5e-07 20.89 In-house 172-271 (351) Show / Hide 
Range on Protein: 3-94
Range on HMM: 172-271/351
Sequence Identity: 28% (30 aa)

DVAVGLNYLHTLPIDN--IVHHDVSSANVLL-ESKGP-------EKWKTKISDFGSAN---IVRRA-VSRAPGAEVYSAPECFQGV-SNQYSAVQTPKMD
..| |..|||     |  |.| |  | |.|| .|. .       .  . ||.|||      ... . ...  | ... |||. ..    .|    | | |
QIAKGMEYLHS---HNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEY----TEKVD

VYSYGIL
.||.|..
CYSFGMI
Kinase AqueK517.AA S_TKc 1-154 15 6.8e-05 -105.12 SMART 18-220 (231) Show / Hide 
Range on Protein: 1-154
Range on HMM: 18-220/231
Sequence Identity: 15% (36 aa)

MHDVA-----------------------------------------------VG-----LNYLHTLPI---------------------------DNIVH
 ...                                                 |     . |..  .                             .|.|
CRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPEHARFYMYQICCALEYCHSHGIIH

HDVSSANVLLESKGPEKWKTKISDFGSANIVRRAVSRAPGAEVYSAPECFQGVSNQYSAVQTPKMDVYSYGILFCEALTCKFPDRSSFQDMLQQVWSSTK
 |.  .|.|| .        ||.|||.| ..    .   |   | ||| .           ..| |..| |... | |. . | .   | |....     
RDLKPENILLDE------HIKICDFGLARQL----TTFCGTPWYMAPEVL--------GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG----

SVGLITRSLHHELIKSCTKDNPYKRPTMNEVIS
     .... . .|. | . .| ||||  |.  
-----SPEAKD-FIRKCLQKDPEKRPTA-EALQ
Kinase AqueK517.AA Dicty4-Unclassified 134-153 60 0.000183 11.16 In-house 241-260 (263) Show / Hide 
Range on Protein: 134-153
Range on HMM: 241-260/263
Sequence Identity: 60% (12 aa)

LIKSCTKDNPYKRPTMNEVI
||| |  . | ||||||..|
LIKWCWHNDPNKRPTMNQII
Kinase AqueK517.AA Pkinase 7-104 28 0.000211 16.65 Pfam 120-211 (293) Show / Hide 
Range on Protein: 7-104
Range on HMM: 120-211/293
Sequence Identity: 28% (29 aa)

GLNYLHTLPIDNIVHHDVSSANVLLESKGPEKWKTKISDFGSA----NIVRRAVSRAPGAEVYSAPECFQGVSNQYSAVQTPKMDVYSYGILFCEALTCK
||.|.|     .|.| |. ..|.|. ..|  . . ||.|||.|    .   .  .   |   | |||  .      .   .|| |..|.|... | |. .
GLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-----GGQYYGPKVDMWSCGCILYEMLCGR

FP
.|
PP
Kinase AqueK517.AA LRRK 133-154 31 0.000373 10.58 In-house 326-347 (351) Show / Hide 
Range on Protein: 133-154
Range on HMM: 326-347/351
Sequence Identity: 31% (7 aa)

ELIKSCTKDNPYKRPTMNEVIS
.||..| . .| |||.......
DLIQHCWQHDPKKRPHFSQIVK
Kinase AqueK517.AA TKL-Unique 133-154 36 0.014704 5.06 In-house 267-288 (290) Show / Hide 
Range on Protein: 133-154
Range on HMM: 267-288/290
Sequence Identity: 36% (8 aa)

ELIKSCTKDNPYKRPTMNEVIS
.||. | ...| .||. .|.|.
DLIQQCWHHDPSQRPSFDEIIH
Kinase AqueK517.AA TK-Unique 132-154 30 0.033016 3.56 In-house 270-292 (294) Show / Hide 
Range on Protein: 132-154
Range on HMM: 270-292/294
Sequence Identity: 30% (7 aa)

HELIKSCTKDNPYKRPTMNEVIS
..|.|||....| .||.  ....
YNLMKSCWQWEPEERPSFRQIKH
Kinase AqueK517.AA MLK 133-154 31 0.073261 2.4 In-house 268-289 (291) Show / Hide 
Range on Protein: 133-154
Range on HMM: 268-289/291
Sequence Identity: 31% (7 aa)

ELIKSCTKDNPYKRPTMNEVIS
.|.| | ...| |||.. ....
KLMKQCWNQDPHKRPSFRQIVQ
Kinase AqueK517.AA Dicty5 134-153 40 0.082795 2.0 In-house 234-253 (260) Show / Hide 
Range on Protein: 134-153
Range on HMM: 234-253/260
Sequence Identity: 40% (8 aa)

LIKSCTKDNPYKRPTMNEVI
|||.|  . | .||.  |..
LIKKCWQQKPHNRPSFKEIC