Gene AqueK526 (A.queenslandica)

AqueK526

Species: A.queenslandica
Alias: AqueK526
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-a2

Sequence

Name Sequence Type Origin Length Description Download
AqueK526.AA Protein None 222 None Fasta, JSON
AqueK526.kin_dom Protein Kinase Domain None 220 None Fasta, JSON

Protein domain

Protein domains of AqueK526.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK526.AA TKL 1-217 22 6.9e-44 152.12 In-house 79-364 (364) Show / Hide 
Range on Protein: 1-217
Range on HMM: 79-364/364
Sequence Identity: 22% (66 aa)

MSQLRHPNLLQFIGAVLDHP-----------SGNPMIITEVM-DTSLRKAYERKELTPDPGCRPVILSIMRDVAVGLNYLHC--L----PDPIIHRDVSS
||.|||||..||.|.... |           .|...|..| .   ||.  .            ........|.| |.||||        . ||||||  |
MSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKS

ANVLLESKGD----------KKWKTKISDFGSAK----------------------AANKAVTRLPGAEPYTAPEAIAQHIMSLDS--------KKLQTT
.|.|. ...           . |. ||.||| ..                        .|.  .  |   . |||.. ...   .         ..  ..
KNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSE

KMDAFSYGVLLCEIITCRFPDRDV-FRDMLCQ-------VQSINSKPRGSRK------------TQG-SLLHSLIVSCCHDDPLKRPSMSQIIERI
|.| .|.|..|.||.|.. | .|  ...|..|       .. .. . |  ..            ..    . .|.  |.. || ||||...|..|.
KCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK526.AA TK 1-217 14 2e-29 95.19 In-house 92-486 (486) Show / Hide 
Range on Protein: 1-217
Range on HMM: 92-486/486
Sequence Identity: 14% (59 aa)

MSQLR-----HPNLLQFIGAVLDHPS----------GNPMIITEVMD-TS----LRKAYERKE-------------------------------------
|....     |||.....|..... .          . .||..| |.  .    ||.   ..                                      
MKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESN

---------------LTPDPGCRPVILS-------------------IMRDVAVGLNYLHCLPD----PIIHRDVSSANVLLESKGDKKWK-------TK
               . |.| .    |.                   .....| |. ||| ..      ..|||.   |.|. ... .||.        |
SPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCK

ISDFGSAKAAN--KAVTRLPGAEPY-----------------------------------TAPEAIAQHIMSLDS-KKLQTTKMDAFSYGVLLCEIIT--
|.||| ...     |    .. . |                                   .|||... .. |    ..  ||| | .|.|||. || |  
IADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYG

-CRFPDRDVF---------RDMLCQVQSI--------------NSKPR---------GSRKTQG-----SLLHSLIVSCCHDDPLKRPSMSQIIERI
   ..              .... ....               . .|.         . .   .      ... |. .|.| || .||..||. |..
QEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK526.AA CZAK 1-165 31 1.2e-20 71.78 In-house 54-224 (279) Show / Hide 
Range on Protein: 1-165
Range on HMM: 54-224/279
Sequence Identity: 31% (58 aa)

MSQLRHPNLLQFIGA-VLDHPSGNPMIITEVMD-TSLRKAY-ERKELTPD-PGCRPVILSIMRDVAVGLNYLHC--LPDPIIHRDVSSANVLLESKGD--
|| |.||| .||.||  .| |     |..| |   |||.   ..  .    |  .   ... .|.| | ||||    | ||.||| || |.||..  .  
MSKLCHPNCVQFLGACSEDGP-NHHCIVMEWMGGGSLRRLLTDHYFYHKQNPHLQ---WNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPK

-------KKWKTKISDFGSA---KAANKAVTRLPGAEPYTAPEA-IAQHIMSLDSKKLQTTKMDAFSYGVLLCEIITCRFPDRD
       .  . ||.|||     .      |   |  .. |||  ..          . | | | .|.| .| .||||. |  .
NPVVSSRQDIICKINDFGLSREMMEQPFEMTQTMGCLCWMAPECFKGE---------NYTEKVDVYSFGMILWCIITCDQPYQN
Kinase AqueK526.AA MLK 53-162 29 2e-19 64.12 In-house 125-235 (291) Show / Hide 
Range on Protein: 53-162
Range on HMM: 125-235/291
Sequence Identity: 29% (35 aa)

VILSIMRDVAVGLNYLHC-LPDPIIHRDVSSANVLLES-----KGDKKWKTKISDFGSAKAANKA---VTRLPGAEPYTAPEAIAQHIMSLDSKKLQTTK
...... ..| |..|||. .|.||||||  | |.|.       ...   . ||.||| ..  ..     .  .|   . |||.| |           . |
HAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHG---TLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQ-----FRCEKYSEK

MDAFSYGVLLCEIITCRFP
 | .|.||.| |..|.. |
CDVWSWGVVLWEMLTREVP
Kinase AqueK526.AA Dicty4 1-103 34 9e-19 59.39 In-house 52-159 (277) Show / Hide 
Range on Protein: 1-103
Range on HMM: 52-159/277
Sequence Identity: 34% (40 aa)

MSQLRHPNLLQFIGAVL--DHPSGNPMIITEVM-DTSLRKAYER------KELTPDPGCRPVILS---IMRDVAVGLNYLHC-LPDPIIHRDVSSANVLL
|...||||...| || .     .| ..| || |  ..| .          .. ..|    | |..   ...|.| |.|.|||  |. |||||  |.| | 
MCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLD---WPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLLV

ESKGDKKWKTKISDFG
    || |. |..|||
----DKNWRVKVCDFG
Kinase AqueK526.AA Pkinase 1-217 21 8.6e-18 63.99 Pfam 54-293 (293) Show / Hide 
Range on Protein: 1-217
Range on HMM: 54-293/293
Sequence Identity: 21% (56 aa)

MSQLRHPNLLQFIGAVLDHPSGNPMIITEVMDT-----SLRKAYE---RKEL--TPDPGCRPVILSIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESK
|  |.||| ....... |  .... ...| ..      .|    .   .. .  ...     .. ..|. .. ||.|.|     |||||. ..|.|. ..
MKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEW-----ECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNN

GDKKWKTKISDFGSA----KAANKAVTRLPGAEPYTAPEAIAQHIMSLDSKKLQTTKMDAFSYGVLLCEIIT--CRFPDR---DVFRDMLCQVQSINSKP
|. . . ||.|||.|       |   | . |  .| ||| |        . .  ..| | .|.|..| | ..    ||..   |  .|..  .. | ..|
GHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-------GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPP

RGSRKTQG---------------------SLLHSLIVSCCHDDPLKRPSMSQIIER--I
  .   .                      . . ..| .|.. || |||.  || .   .
LHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK526.AA STE 1-129 23 8.2e-17 55.99 In-house 82-236 (359) Show / Hide 
Range on Protein: 1-129
Range on HMM: 82-236/359
Sequence Identity: 23% (40 aa)

MSQLR--HPNLLQFIGAVLDH---PSG--NPMIITEVMD-TSLRKAYERKELTPDPGC----------RPVILSIMRDVAVG-LNYLHCLPDPIIHRDVS
|....  |||  ...|. ..     .   .  |. | ||  ||.. ...|  ...|             ..|  | |..  | |.||| .   |||||. 
MKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIK

SANVLLESKGDKKWKTKISDFGSAKAANKAVT-------------------RLPGAEPYTAPEAIAQ
.||.||          |..||| ..  .. ..                    . |   . ||| | |
PANILL---------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQ
Kinase AqueK526.AA TKL-Unique 1-158 25 1.4e-16 55.16 In-house 49-223 (290) Show / Hide 
Range on Protein: 1-158
Range on HMM: 49-223/290
Sequence Identity: 25% (47 aa)

MSQLR-HPNLLQFIGAVLDHPSGNP--MIITEVMDT-SLRKAYE---------RKELTPDPGCRPVILSIMRDVAVGLNYLHCLPDPIIHRDVSSANVLL
|. |. |||.....|.  ||   .|   |..| ..  ||..            ........    ..... .|.| |..||| .  ||||||  | |.|.
MKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQ---QRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLV

ESK-GDKKWKTKISDFGSAKAANKA----VTRL-----PGAE---PYTAPEAIAQHIMSLDSKKLQTTKMDAFSYGVLLCEIIT
 ..    .|. ||.||| .| ..|     ....     .. .    . ||| . .        .. ..| | .|.|. | ||.|
DNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF------CQYSEKSDVYSFGIVLWEIAT
Kinase AqueK526.AA TKL-ciliate1 54-157 23 8.8e-13 40.07 In-house 105-213 (279) Show / Hide 
Range on Protein: 54-157
Range on HMM: 105-213/279
Sequence Identity: 23% (27 aa)

ILSIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGDKKWKTKISDFGSAKA---------ANKAV---TRLPGAEPYTAPEAIAQHIMSLDSKKLQT
.. . .|.| |. ||| .  |.||||  . | |.    |.    || .|.. |             ..   .   . . . ||| .  ||    . .  .
RMRWCKDIAQGMQYLHMRQNPLIHRDLKMQNILY----DEPYQYKICNFPHVKIADFHRIRNCSFQDMQNEMQRNTTFHWMAPEQMDPHIF---PNYPIN

TKMDAFSYGVLLCEII
.| | ..||... . .
EKIDIYAYGIVMYILC
Kinase AqueK526.AA S_TKc 1-221 18 1.6e-12 6.53 SMART 19-231 (231) Show / Hide 
Range on Protein: 1-221
Range on HMM: 19-231/231
Sequence Identity: 18% (47 aa)

MSQL-----------------------RHPNLLQFIGAVLDHPSGNPMIITEVMDT---SLRKAYERKEL--TPDPGCRPVILSIMRDVAVGLNYLHCLP
                           .|||. .....  |   ..  ...| .|.   .|..  ...    .. |    .. ..|. .. .|.|.| . 
RHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-

DPIIHRDVSSANVLLESKGDKKWKTKISDFGSAKAANKAVTRLPGAEPYTAPEAIAQHIMSLDSKKLQTTKMDAFSYGVLLCEIITCRFPDRDVFRDMLC
  |||||.  .|.|| .        ||.|||.|.      | . |   | ||| .          .  . | |  | |..| | .. . | .     |. 
-GIIHRDLKPENILLDE------HIKICDFGLARQL----TTFCGTPWYMAPEVL----------GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFK

QVQSINSKPRGSRKTQGSLLHSLIVSCCHDDPLKRPSMSQIIE-----RIDVIS
..               . . ..|  |.. || |||.  .. .     ...   
KIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK526.AA TyrKc 1-217 19 2.4e-12 -23.13 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-217
Range on HMM: 1-280/280
Sequence Identity: 19% (58 aa)

MS-------------------------------------------QL--RHPNLLQFIGAVLDH-----PSGNPMIITEVMDT-SLRKAYERKELTPDPG
 .                                           .|  .|||.....|.....      .. .||..| |.  .|..   ... .    
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK---L

CRPVILSIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGDKKWKTKISDFGSAKAANKA--------VTRL----PGA--EPY--TAPEAIAQHIMS
| .  ||.. ..| | .|||    ..||||    |.|. ...      |||||| ...            . |      |    |.  .|||.|      
CMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI------

LDSKKLQTTKMDAFSYGVLLCEIITC--RFPDR-----DVFRDMLCQVQSINSKPRGSR-------KTQGSLLHSLIVSCCHDDPLKRPSMSQIIERI
   ..  ||| | .|.||.. || |     .          .... .|.. .  |.               .   .. .|.| || .||..|.|.|..
--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK526.AA DRK 52-103 44 1.5e-10 32.0 In-house 98-145 (258) Show / Hide 
Range on Protein: 52-103
Range on HMM: 98-145/258
Sequence Identity: 44% (23 aa)

PVILSIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGDKKWKTKISDFG
| ....| |.| |..||||    |||||  | | |     |  |. |..|||
PLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLV----DEHWQVKVADFG
Kinase AqueK526.AA Dicty4-Unclassified 53-103 39 3.6e-09 27.5 In-house 110-154 (263) Show / Hide 
Range on Protein: 53-103
Range on HMM: 110-154/263
Sequence Identity: 39% (20 aa)

VILSIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGDKKWKTKISDFG
.|. .  |.| |. .||     .||||. |.|.|.    ||    || |||
LIIKYAFDIAQGMQHLHTR--NFIHRDIKSSNILM----DKHFNIKIADFG
Kinase AqueK526.AA Dicty4-Unclassified 194-217 54 7.7e-09 26.37 In-house 240-263 (263) Show / Hide 
Range on Protein: 194-217
Range on HMM: 240-263/263
Sequence Identity: 54% (13 aa)

SLIVSCCHDDPLKRPSMSQIIERI
.||. | |.|| |||.| |||.. 
KLIKWCWHNDPNKRPTMNQIIQYL
Kinase AqueK526.AA TKL-Unique 195-217 52 1.2e-07 23.23 In-house 268-290 (290) Show / Hide 
Range on Protein: 195-217
Range on HMM: 268-290/290
Sequence Identity: 52% (12 aa)

LIVSCCHDDPLKRPSMSQIIERI
||  |.|.|| .||| ..||.|.
LIQQCWHHDPSQRPSFDEIIHRL
Kinase AqueK526.AA Dicty4 192-219 36 1.3e-07 21.69 In-house 248-277 (277) Show / Hide 
Range on Protein: 192-219
Range on HMM: 248-277/277
Sequence Identity: 36% (11 aa)

LHSLIVSCCHDDPLKRPSMSQIIER--IDV
. .||. | . || .|||...||.|   . 
WKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase AqueK526.AA Pkinase_Tyr 1-29 31 1e-06 23.09 Pfam 57-87 (270) Show / Hide 
Range on Protein: 1-29
Range on HMM: 57-87/270
Sequence Identity: 31% (10 aa)

MSQL-RHPNLLQFIGAVL--DHPSGNPMIITE
|.|| .|||.....|...  . |. ...|..|
MKQLGHHPNIVRLYGVCTDQGEPN-QIYIVME
Kinase AqueK526.AA DRK 1-31 45 1e-06 18.85 In-house 51-79 (258) Show / Hide 
Range on Protein: 1-31
Range on HMM: 51-79/258
Sequence Identity: 45% (14 aa)

MSQLRHPNLLQFIGAVLDHPSGNPMIITEVM
|.||||||  ||.|. .  |.  . |..| |
MCQLRHPNICQFMGTCNNPPD--ICICMEYM
Kinase AqueK526.AA TKL-ciliate1 192-217 34 5e-06 16.64 In-house 254-279 (279) Show / Hide 
Range on Protein: 192-217
Range on HMM: 254-279/279
Sequence Identity: 34% (9 aa)

LHSLIVSCCHDDPLKRPSMSQIIERI
.| |.  |   .| |||. ..||...
FHNLMMRCWCQNPNKRPNFNEIIQIL
Kinase AqueK526.AA DRK 195-219 40 7e-06 15.86 In-house 234-258 (258) Show / Hide 
Range on Protein: 195-219
Range on HMM: 234-258/258
Sequence Identity: 40% (10 aa)

LIVSCCHDDPLKRPSMSQIIERIDV
|.  |   ||  |||| ...||.. 
LMNDCWNEDPQHRPSMQECLERLEA
Kinase AqueK526.AA Pkinase_Tyr 192-217 38 1e-05 20.06 Pfam 245-270 (270) Show / Hide 
Range on Protein: 192-217
Range on HMM: 245-270/270
Sequence Identity: 38% (10 aa)

LHSLIVSCCHDDPLKRPSMSQIIERI
...|. .| | || .||..|.|.|..
IYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK526.AA Pkinase_Tyr 54-103 32 1.5e-05 19.43 Pfam 113-156 (270) Show / Hide 
Range on Protein: 54-103
Range on HMM: 113-156/270
Sequence Identity: 32% (16 aa)

ILSIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGDKKWKTKISDFG
.|.. ...| |..||.  .  .||||.   |.|...   .. . ||.|||
LLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTE---NN-VVKICDFG
Kinase AqueK526.AA MLK 194-217 41 7e-05 13.01 In-house 268-291 (291) Show / Hide 
Range on Protein: 194-217
Range on HMM: 268-291/291
Sequence Identity: 41% (10 aa)

SLIVSCCHDDPLKRPSMSQIIERI
.|.  | ..|| ||||..||..  
KLMKQCWNQDPHKRPSFRQIVQHL
Kinase AqueK526.AA MLK 2-29 34 0.043955 3.18 In-house 60-90 (291) Show / Hide 
Range on Protein: 2-29
Range on HMM: 60-90/291
Sequence Identity: 34% (11 aa)

SQLRHPN----LLQFIGAVLDHPSGNPMIITE
. |.|||      || |. |..|  .  |..|
RILSHPNNHPCIIQFYGVCLQPP-CHFCIVME
Kinase AqueK526.AA Dicty4-Unclassified 4-31 28 0.145535 1.08 In-house 55-84 (263) Show / Hide 
Range on Protein: 4-31
Range on HMM: 55-84/263
Sequence Identity: 28% (10 aa)

LRHPNLLQFIGAVLDHPSGNP-------MIITEVM
. ||||..  |. .     ||       .|..| |
IQHPNLVKCYGYCI-----NPRSHKSTMCIVMEFM
Kinase AqueK526.AA CZAK 195-217 39 0.210187 1.05 In-house 257-279 (279) Show / Hide 
Range on Protein: 195-217
Range on HMM: 257-279/279
Sequence Identity: 39% (9 aa)

LIVSCCHDDPLKRPSMSQIIERI
||  |    |  ||| .||..  
LIEMCWNKNPDERPSFKQILQHL