Gene AqueK538 (A.queenslandica)

AqueK538

Species: A.queenslandica
Alias: AqueK538
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-a2

Sequence

Name Sequence Type Origin Length Description Download
AqueK538.AA Protein None 281 None Fasta, JSON
AqueK538.kin_dom Protein Kinase Domain None 262 None Fasta, JSON

Protein domain

Protein domains of AqueK538.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK538.AA TKL 23-278 21 6.1e-55 188.84 In-house 1-364 (364) Show / Hide 
Range on Protein: 23-278
Range on HMM: 1-364/364
Sequence Identity: 21% (80 aa)

LGRGAWGVVLMGQLR-------------VAVKQLHQ-------------------------AIENPHYLEILYREIDIMSQLRHPNLLQFIGAVLDDP--
.|.|. |.|  |..|             ||||....                         . |. .. . . .|| .||.|||||..||.|.... |  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

---------SGYPLIITEVM-DTSLRKAYENKELTPDPGCRPVILSIMHDVAVGLNYLHC--L----PDPIIHRDVSSGNVLLQSI---------AGPNK
         .|.. |..| .   ||.  .            ........|.| |.||||        . ||||||  | |.|. .          . .. 
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

WKAKVSDFGSANLAHKS----------------------NTRAPGAAAYSAPEVLQSIKSYDSK----------KQTTKMDVFSYGVLLCEIIVCR--FP
|..|..||| .   ..|                      . .  |  .. |||||.    |..|          . ..|.||.|.|..|.||. ..  . 
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY

DMDFFQDM------LSQVKTI--GARPRCN---------RYTQGIL--LHSLIDLCMNNDPLKRPTMNQIVEKL
|..... .      . ... .  | || .               ..  . .|.  |.. || |||....|...|
DYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK538.AA TK 17-278 15 9.4e-33 106.54 In-house 1-486 (486) Show / Hide 
Range on Protein: 17-278
Range on HMM: 1-486/486
Sequence Identity: 15% (77 aa)

SSSKKALGRGA---WGVVLMGQL------------------------------RVAVKQLH---QAIENPHYLEILY---------REIDIMSQLR----
    | ||.|.   .|.| .|..                              .||||.|.    . .. . .|..          .|  .|....    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNLLQFIGAVLDDPS----------GYPLIITEVMD-TS----LRKAYENKE----------------------------------------------
 |||.....|..... .          . ..|..| |.  .    ||.   ..                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------LTPDPGCRPVILS-------------------IMHDVAVGLNYLHCLPD----PIIHRDVSSGNVLLQSIAGPNKWK-------AKVSDFGSAN
      . |.| .    |.                   .....| |. ||| ..      ..|||.   |.|. .  ...||.       .|..||| . 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGE-NNVCKWHFDGCGPVCKIADFGLSR

-----LAHKSNT--------------------------------RAPGAAAYSAPEVLQS-IKSYD--SKKQTTKMDVFSYGVLLCEIIV---CRFPD-M
     || . .                                 ..     . |||.|.. . |     .| ||| ||.|.|||. ||       ..  |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

DF--------FQDMLSQVKTI-----------GARPRCN--RYTQG-------------ILLHSLIDLCMNNDPLKRPTMNQIVEKL
.          |... ....            | | |.    .                 ... |.  | . || .|||. |..|.|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK538.AA TKL-Unique 21-218 25 2.7e-29 100.54 In-house 3-222 (290) Show / Hide 
Range on Protein: 21-218
Range on HMM: 3-222/290
Sequence Identity: 25% (59 aa)

KALGRGAWGVVLMGQL---RVAVKQLH-QAIENPHYLEILYREIDIMSQLR-HPNLLQFIGAVLD---DPSGYPLIITEVMDT-SLRKAYE---------
. .|.|. |.|  |      ||.||.| ..  ..  .. ...|. .|. |. |||.....|.  |   .|. .  |..| ..  ||..            
NKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNM-CIVMEYCPGGSLYDVLHQNNNNNNNN

NKELTPDPGCRPVILSIMHDVAVGLNYLHCLPDPIIHRDVSSGNVLLQSIAGPNKWKAKVSDFGSANLAHKS---NTRAP---------GAAAYSAPEVL
|.......    ..... .|.| |..||| .  ||||||  | |.|. .    ..|..|..||| . .. |.   ... .         | . ..|||||
NNNCKLNMQ---QRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

QSIKSYDSKKQTTKMDVFSYGVLLCEII
 .      .. ..| ||.|.|. | ||.
RMNF----CQYSEKSDVYSFGIVLWEIA
Kinase AqueK538.AA S_TKc 17-281 22 9.3e-28 99.46 SMART 1-231 (231) Show / Hide 
Range on Protein: 17-281
Range on HMM: 1-231/231
Sequence Identity: 22% (64 aa)

SSSKKALGRGAWGVVLMGQLRV-----AVKQLHQAIENPHYLEILYREIDIMSQLRHPNLLQFIGAVLDDPSGYPLIITEVMDT---SLRKAYENKEL--
    . .|.|| |.|  .. .      |.|...         | ..|||.|... .|||. .....  |   ..  ...| .|.   .|..  ...    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

TPDPGCRPVILSIMHDVAVGLNYLHCLPDPIIHRDVSSGNVLLQSIAGPNKWKAKVSDFGSANLAHKSNTRAPGAAAYSAPEVLQSIKSYDSKKQTT-KM
.. |    .. ..|. .. .|.|.| .   |||||.   |.|| .         |..|||.| .     |   |   | |||||         . .. | 
LRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE-------HIKICDFGLARQL----TTFCGTPWYMAPEVL---------GYGKCKC

DVFSYGVLLCEIIVCRFPDMDFFQDMLSQVKTIGARPRCNRYTQGILLHSLIDLCMNNDPLKRPTMNQIVE------KLDAI
|. | |..| | .. . |      .|    | ||             . ..|. |.. || ||||  .. .      .   .
DWWSCGCILYEMLCGYPPFP----QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK538.AA MLK 17-218 26 1e-27 93.27 In-house 1-230 (291) Show / Hide 
Range on Protein: 17-218
Range on HMM: 1-230/291
Sequence Identity: 26% (62 aa)

SSSKKALGRGAWGVVLMGQLR--------VAVKQLHQAIENPHYL-----EILYREIDIMSQLRHPN----LLQFIGAVLDDPSGYPLIITEVMDT-SLR
   .. .| |. |.|  |. |        ||||. .. |.          . . .|. . . |.|||      || |. |..|... .|..| ..  || 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHF-CIVMEYCEGGSLY

KAYENKELTPDPGC----------RPVILSIMHDVAVGLNYLHC-LPDPIIHRDVSSGNVLLQSIAGPN--KWKAKVSDFGSANLAHKS---NTRAPGAA
    ...  ...              .........| |..|||. .|.||||||  | |.|.  | . .  . ..|..||| .   |..    . ..| .
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICH-DMHHGTLKICDFGTSRDWHQMCTNMMSNAGTY

AYSAPEVLQSIKSYDSKKQTTKMDVFSYGVLLCEII
|. ||||.| ..   . | . | ||.|.||.| |..
AWMAPEVIQQFR---CEKYSEKCDVWSWGVVLWEML
Kinase AqueK538.AA DRK 24-218 35 2.1e-26 86.46 In-house 8-196 (258) Show / Hide 
Range on Protein: 24-218
Range on HMM: 8-196/258
Sequence Identity: 35% (73 aa)

GRGAWGVVLMGQLR---VAVKQLHQAIEN-PHYLEILYREIDIMSQLRHPNLLQFIGAVLDDPSGYPLIITEVMDT-SLRKAYENKELTPDPGCRPVILS
||| .| |  |  |   |||| |    .|    |  . |||..|.||||||  ||.|. .  |.  ..|..| |   || .   .  .  |    | ...
GRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPD--ICICMEYMPRGSLYNILHDESIEMD---WPLMKQ

IMHDVAVGLNYLHCLPDPIIHRDVSSGNVLLQSIAGPNKWKAKVSDFGSAN-----LAHKSNTRAPGAAAYSAPEVLQSIKSYDSKKQTTKMDVFSYGVL
.| |.| |..||||    |||||  | | |         |. ||.||| .      . ||    . |     ||||| .   |     | | ||.|... 
MMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVD-----EHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRN-QRY-----TEKADVYSFAIV

LCEII
| |..
LWECV
Kinase AqueK538.AA STE 18-273 20 1.7e-25 87.04 In-house 1-350 (359) Show / Hide 
Range on Protein: 18-273
Range on HMM: 1-350/359
Sequence Identity: 20% (77 aa)

SSK-KALGRGAWGVVLMGQLR--------------------VAVKQLH---------------QAIENPHYLEILYREIDIMSQLR--HPNLLQFIGAVL
  . . .|.|| |.|  .  .                    .|.||..                 . |.  .. . .||.||....  |||  ...|. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DD---PSG--YPLIITEVMD-TSLRKAYENKELTPDPGC----------RPVILSIMHDVAVG-LNYLHCLPDPIIHRDVSSGNVLLQSIAGPNKWKAKV
..    .   .  |. | ||  ||.. ...|  ...|             ..|  | ...  | |.||| .   |||||. ..|.||          .| 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL----------VKL

SDFGSAN-LAH-------------------KSNTRA--PGAAAYSAPEVLQSIKSYDS-KKQTTKMDVFSYGVLLCEIIVCRFP--DMDFFQDMLSQVKT
.||| .  |..                   |.|| .  |    . ||||.|  ..  . |. .|| |. | | ...| .  . |  ||  .. |.   . 
CDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP----WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFN

I-------------GARPR-CNRYTQG-----------------ILLHSLIDLCMNNDPLKRPTMNQ
.             |  |.  ..  |.                   ..  |..| . || |||| .|
YHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ
Kinase AqueK538.AA Dicty4 20-217 32 2.5e-24 78.21 In-house 4-210 (277) Show / Hide 
Range on Protein: 20-217
Range on HMM: 4-210/277
Sequence Identity: 32% (72 aa)

KKALGRGAWGVVLMGQLR---VAVKQL--HQAIENPHYLEILYREIDIMSQLRHPNLLQFIGAVL--DDPSGYPLIITEVM-DTSLRKAYEN------KE
 . .|.|. | |. |  |   |||| |  |.       |. . .|..||...||||...| || .     .| ..| || |  ..| .   .      ..
EQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQS

LTPDPGCRPVILS---IMHDVAVGLNYLHC-LPDPIIHRDVSSGNVLLQSIAGPNKWKAKVSDFG-SA----NLAHKSNTRAP-GAAAYSAPEVLQSIKS
 ..|    | |..   .. |.| |.|.|||  |. |||||  | | |         |..||.||| |.       || |. .. | ... ||||... ..
IKLD---WPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLLVD-----KNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMH-QP

YDSKKQTTKMDVFSYGVLLCEI
|..     | ||.|.| .| ||
YNE-----KADVYSFGIVLWEI
Kinase AqueK538.AA CZAK 53-223 31 3.5e-22 77.47 In-house 44-221 (279) Show / Hide 
Range on Protein: 53-223
Range on HMM: 44-221/279
Sequence Identity: 31% (60 aa)

LEILYREIDIMSQLRHPNLLQFIGA-VLDDPSGYPLIITEVMD-TSLRKAYENKE--LTPDPGCRPVILSIMHDVAVGLNYLHC--LPDPIIHRDVSSGN
...  .|. ||| |.||| .||.||  .| |     |..| |   |||.    .   . . |  .   ...  |.| | ||||    | ||.||| || |
ENMFQKEVSIMSKLCHPNCVQFLGACSEDGP-NHHCIVMEWMGGGSLRRLLTDHYFYHKQNPHLQ---WNMAIDIARGMNYLHDNWKPNPILHRDLSSRN

VLLQSIAG--------PNKWKAKVSDFGSANLAHKSN---TRAPGAAAYSAPEVLQSIKSYDSKKQTTKMDVFSYGVLLCEIIVCRFP
.|| .               ..|..|||   .        | . |  .. |||.     .|     | | ||.|.| .| .|| |. |
ILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEMTQTMGCLCWMAPECFKG-ENY-----TEKVDVYSFGMILWCIITCDQP
Kinase AqueK538.AA LRRK 115-280 29 5.4e-22 74.59 In-house 165-351 (351) Show / Hide 
Range on Protein: 115-280
Range on HMM: 165-351/351
Sequence Identity: 29% (56 aa)

VILSIMHDVAVGLNYLHCLPDPIIHRDVSSGNVLLQSIAGP-------NKWKAKVSDFGSAN----LAHKSNTRAPGAAAYSAPEVLQSI--KSYDSKKQ
..| |. ..| |..|||    ||||||  | |.||.|.  .       .  .||..|||       . ..   .  |   . |||...    ..|     
LKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEY-----

TTKMDVFSYGVLLCEIIVCR---FPDMDFFQDM--LSQVKT---IGARPRCN---RYT--QGILLHSLIDLCMNNDPLKRPTMNQIVEKLDA
|.| |..|.|..| |..  .   | ..|||  |   .|..     | ||  .   ..   ..  . .||..| ..||.|||...|||..|  
TEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase AqueK538.AA TK-Unique 17-217 22 5.2e-21 69.28 In-house 1-232 (294) Show / Hide 
Range on Protein: 17-217
Range on HMM: 1-232/294
Sequence Identity: 22% (55 aa)

SSSKKALGRGAWGVVLMGQLR----------VAVKQLHQAIENPHYLEILYREIDIMSQLR-HPNLLQFIGAVLDDPSGYPLIITEVMDTS-----LRKA
.  .. .|.|| | |  |...          ...  .... ....    . .|| .|..|  |||..|..|.  ..  . ..|| | .  .     ||. 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD-EPWMIIMEYCPCGNLQHYLRTC

Y-ENKEL-----------TPDPGCRPVILS------IMHDVAVGLNYLHCLPDPIIHRDVSSGNVLLQSIAGPNKWKAKVSDFGSA-----NLAHKSN-T
. . ..            .. .. |.  .|      .. ..| |..||. ... |.|||... ||||..     . ..|..||| |     | .. .. .
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE-----DKVCKICDFGMARDVYTNGVYSMMCS

RAPGAAAYSAPEVLQSIKSYDSKKQ-TTKMDVFSYGVLLCEI
. .   .. |||.|.       .   ||| || |.|||. ||
QGRIPIRWMAPESLKCY----HGMYHTTKSDVWSFGVLMWEI
Kinase AqueK538.AA Pkinase 17-214 22 6.6e-20 71.47 Pfam 1-202 (293) Show / Hide 
Range on Protein: 17-214
Range on HMM: 1-202/293
Sequence Identity: 22% (50 aa)

SSSKKALGRGAWGVVLMGQLR-----VAVKQLHQAIENPHYLEILYR--EIDIMSQLRHPNLLQFIGAVLDDPSGYPLIITEVMDT-----SLRKAYE--
   .. .|.|. |.|  .. .     ||||..    |..  .... |  || ||  |.||| ....... |  .... ...| ..      .|    .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW

-NKEL--TPDPGCRPVILSIMHDVAVGLNYLHCLPDPIIHRDVSSGNVLLQ--SIAGPNKWKAKVSDFGSA----NLAHKSNTRAPGAAAYSAPEVLQSI
 .. .  ...     .. ..|  .. ||.|.|     |||||. . |.|.      ..   . |..|||.|    .     .|   |   | ||||..  
RHGCFYFSEW-----ECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDA---CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR--

KSYDSKKQTTKMDVFSYGVLL
   .... ..| |..|.|..|
---GGQYYGPKVDMWSCGCIL
Kinase AqueK538.AA TyrKc 17-278 24 2.3e-17 57.94 SMART 1-280 (280) Show / Hide 
Range on Protein: 17-278
Range on HMM: 1-280/280
Sequence Identity: 24% (74 aa)

SSSKKALGRGAWGVVLMGQLR--VAVKQLHQAIENPHYLEILYREIDIMSQL--RHPNLLQFIGAVLDD-----PSGYPLIITEVMDT-SLRKAYENKEL
 . .| ||.|| |.|  |...  |||| |.        .| ..||. ||..|  .|||.....|.....      .. ..|..| |.  .|..   ... 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

TPDPGCRPVILSIMHDVAVGLNYLHCLPDPIIHRDVSSGNVLLQSIAGPNKWKAKVSDFGSANLAHKS----------------NTRAPGAAAYSAPEVL
.    | .  ||.....| | .|||    ..||||    |.|. .        .|.|||| .   .                  .....      |||..
K---LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

QSIKSYDSKKQTTKMDVFSYGVLLCEII---VCRFPDM----DFFQDMLSQVKTIGARPRCNRY-------TQGILLHSLIDLCMNNDPLKRPTMNQIVE
      . .| ||| ||.|.||.. ||        |.|       |... .||. . .|.   .           .   ..  | . || .|||...|.|
------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHE

KL
..
CF
Pkinase_Tyr AqueK538.AA Pkinase_Tyr 16-91 32 6.4e-16 54.55 Pfam 1-87 (270) Show / Hide 
Range on Protein: 16-91
Range on HMM: 1-87/270
Sequence Identity: 32% (29 aa)

ISSSKKALGRGAWGVVLMGQLR---------VAVKQLHQAIENPH-YLEILYREIDIMSQL-RHPNLLQFIGAVL--DDPSGYPLIITE
|.  || ||.|| |.| .| ..         |||| | .    .. ..| . ||. ||.|| .|||.....|...  ..|. ...|..|
ITFGKK-LGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVME
Kinase AqueK538.AA Dicty4 253-280 30 2.3e-09 27.54 In-house 248-277 (277) Show / Hide 
Range on Protein: 253-280
Range on HMM: 248-277/277
Sequence Identity: 30% (9 aa)

LHSLIDLCMNNDPLKRPTMNQIVEK--LDA
. .||  | ..|| .||....|...  |..
WKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase AqueK538.AA DRK 256-280 44 4.1e-08 23.63 In-house 234-258 (258) Show / Hide 
Range on Protein: 256-280
Range on HMM: 234-258/258
Sequence Identity: 44% (11 aa)

LIDLCMNNDPLKRPTMNQIVEKLDA
|.  | | ||  ||.| ...| |.|
LMNDCWNEDPQHRPSMQECLERLEA
Kinase AqueK538.AA MLK 255-278 50 1.8e-07 22.08 In-house 268-291 (291) Show / Hide 
Range on Protein: 255-278
Range on HMM: 268-291/291
Sequence Identity: 50% (12 aa)

SLIDLCMNNDPLKRPTMNQIVEKL
.|.  |.| || |||.. |||..|
KLMKQCWNQDPHKRPSFRQIVQHL
Kinase AqueK538.AA TKL-Unique 256-278 39 5.2e-07 20.96 In-house 268-290 (290) Show / Hide 
Range on Protein: 256-278
Range on HMM: 268-290/290
Sequence Identity: 39% (9 aa)

LIDLCMNNDPLKRPTMNQIVEKL
||. | . || .||. ..|...|
LIQQCWHHDPSQRPSFDEIIHRL
Kinase AqueK538.AA Pkinase_Tyr 253-278 38 7e-06 20.53 Pfam 245-270 (270) Show / Hide 
Range on Protein: 253-278
Range on HMM: 245-270/270
Sequence Identity: 38% (10 aa)

LHSLIDLCMNNDPLKRPTMNQIVEKL
...|. .|.. || .|||. .|.|.|
IYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK538.AA LRRK 16-76 14 8.2e-05 12.93 In-house 1-124 (351) Show / Hide 
Range on Protein: 16-76
Range on HMM: 1-124/351
Sequence Identity: 14% (18 aa)

ISSSKKALGRGAWG-VVLMGQLR-------------------------------VAVKQLHQ--------------------------------AIENPH
. . .. .|||. | .|  . .|                               ||.|...                                 ... ..
LKIEEQ-IGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCR

YLEILYREIDIMSQLRHPNLLQFIG
 .  . .|. ||| |.|||... .|
AFREFRHEVWIMSHLNHPNIVSLKG
Kinase AqueK538.AA Pkinase_Tyr 116-218 29 0.000193 15.66 Pfam 113-208 (270) Show / Hide 
Range on Protein: 116-218
Range on HMM: 113-208/270
Sequence Identity: 29% (32 aa)

ILSIMHDVAVGLNYLHCLPDPIIHRDVSSGNVLLQSIAGPNKWKAKVSDFGSANLA-----H-KSNTRAPGAAAYSAPEVLQSIKSYDSKKQTTKMDVFS
.|.. ...| |..||.  .  .||||.   |.|. .    |. ..|..||| | .        .. . ..      |||...  |       ||| || |
LLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTE----NN-VVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK------FTTKSDVWS

YGVLLCEII
.|||. ||.
FGVLMWEIF
Kinase AqueK538.AA TK-Unique 253-278 30 0.006928 5.93 In-house 269-294 (294) Show / Hide 
Range on Protein: 253-278
Range on HMM: 269-294/294
Sequence Identity: 30% (8 aa)

LHSLIDLCMNNDPLKRPTMNQIVEKL
...|.  | . .| .||.  ||. .|
MYNLMKSCWQWEPEERPSFRQIKHRL
Kinase AqueK538.AA CZAK 256-278 43 0.078157 2.63 In-house 257-279 (279) Show / Hide 
Range on Protein: 256-278
Range on HMM: 257-279/279
Sequence Identity: 43% (10 aa)

LIDLCMNNDPLKRPTMNQIVEKL
||  | |  |  ||.  ||.. |
LIEMCWNKNPDERPSFKQILQHL
Kinase AqueK538.AA Pkinase 255-278 38 1.868762 2.69 Pfam 268-293 (293) Show / Hide 
Range on Protein: 255-278
Range on HMM: 268-293/293
Sequence Identity: 38% (10 aa)

SLIDLCMNNDPLKRPTMNQIVEK--L
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DFIKWCLCKDPKKRPTAEQILQHPWF