Gene AqueK549 (A.queenslandica)

AqueK549

Species: A.queenslandica
Alias: AqueK549
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-B

Sequence

Name Sequence Type Origin Length Description Download
AqueK549.AA Protein None 1300 None Fasta, JSON
AqueK549.kin_dom Protein Kinase Domain None 165 None Fasta, JSON

Protein domain

Protein domains of AqueK549.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK549.AA TKL 118-248 22 2.7e-24 84.41 In-house 109-288 (364) Show / Hide 
Range on Protein: 118-248
Range on HMM: 109-288/364
Sequence Identity: 22% (42 aa)

TEGNPMILTELM-PTSLRKELEIGGVAYPAILSISLDVACALNYLHLFKP-----HPILHRDVSSANVLLQ-----------PMIGVWRAKVSDYGSANL
..|...| .|..   ||.  |       . .....||.|...||||  .|      ||.|||  |.|.|.            . .  |..|..|.| .  
PWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRF

QHSI---------------------IRSVNPGGPLYAAPEAANPK----------------EHSPSMDVFSYGVLLLEMITRRIP
 .                        ..   | | . |||. . .                | |...||.|.|..| |..||..|
MSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRP
Kinase AqueK549.AA MLK 147-248 31 3.6e-17 56.21 In-house 126-235 (291) Show / Hide 
Range on Protein: 147-248
Range on HMM: 126-235/291
Sequence Identity: 31% (35 aa)

ILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQP---MIGVWRAKVSDYGSANLQHSI-I-RSVNPGGPLYAAPEA---ANPKEHSPSMDVFSYGVL
.....|..| ...|||  .|.|| |||  | |.|.      ..   .|..| | .   |..   .  |.| . . |||.   .     | . ||.|.||.
AMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVV

LLEMITRRIP
| ||.||..|
LWEMLTREVP
Kinase AqueK549.AA LRRK 150-248 29 4.4e-16 53.37 In-house 169-282 (351) Show / Hide 
Range on Protein: 150-248
Range on HMM: 169-282/351
Sequence Identity: 29% (34 aa)

ISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMI---------GVWRAKVSDYGSAN----LQHS-IIRSVNPGGPLYAAPEAAN---PKEHSPSMDV
|.|..| ...||| ..| ||.|||  | |.||. .              ||..|.|       .... . ..| .  |.. |||  .    .| .   |.
IALQIAKGMEYLHSHNP-PIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGN--PGWMAPEIMRYNGEEEYTEKVDC

FSYGVLLLEMITRR-IP
.|.|..| | .||. .|
YSFGMILWELLTRQHHP
Kinase AqueK549.AA TKL-Unique 147-248 28 2.1e-14 47.37 In-house 112-233 (290) Show / Hide 
Range on Protein: 147-248
Range on HMM: 112-233/290
Sequence Identity: 28% (35 aa)

ILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPM--IGVWRAKVSDYGSANLQHSIIRSVNP-----------GGPLYAAPEAANP--KEHSPSMD
.... .|.| ...|||  .|  |.|||  | |.|.     |  |..|..| | . .. .|... |            | ....|||  .   .  | . |
RVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSD

VFSYGVLLLEMITRRI------P
|.|.|. | |..|| |      |
VYSFGIVLWEIATRKITKTYKKP
Kinase AqueK549.AA TK 117-245 14 1.2e-12 37.92 In-house 125-390 (486) Show / Hide 
Range on Protein: 117-245
Range on HMM: 125-390/486
Sequence Identity: 14% (39 aa)

TTEGNPMILTELMP-TS----LRKELEIGG----------------------------------------------------------------------
. .. .||..|.||  .    ||. |                                                                          
VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQW

-------VAYPAILSISLDVACALNYLHLFKPHPI----LHRDVSSANVLLQ-PMIGVWR-------AKVSDYGSAN-----LQHSI------IRSVNPG
       .  .  | .....||.. |||  .         |||.   |.|.   ..  |        .|..|.| .      |   |       |. ..|
CLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYG

GPL-------------------------YAAPEAAN---------PKEHSPSMDVFSYGVLLLEMITR
...                         . |||. |          . ...  ||.|.|||. |. |.
TGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTY
Pkinase AqueK549.AA Pkinase 117-252 21 1.4e-12 45.52 Pfam 70-215 (293) Show / Hide 
Range on Protein: 117-252
Range on HMM: 70-215/293
Sequence Identity: 21% (33 aa)

TTEGNPMILTELMPT-----SLRKELE---IGGV--AYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQ--PMIGVWRAKVSDYGSAN---LQ
...... . .|...      .|   ..    |..   .  . .. . ....|.|.|      |.|||. ..|.|.   . |.  . |..| |.|    . 
EDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDA-CVKICDFGLAKQFDY-

HSIIRSVNPGGPLYAAPEAAN-PKEHSPSMDVFSYGVLLLEMITRRIPLPEE
..   ..  | | |.|||  .  ....|. |..|.|..| ||...| | |..
NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGH
Kinase AqueK549.AA CZAK 148-196 36 6.4e-12 39.72 In-house 108-167 (279) Show / Hide 
Range on Protein: 148-196
Range on HMM: 108-167/279
Sequence Identity: 36% (22 aa)

LSISLDVACALNYLHL-FKPHPILHRDVSSANVLLQPMIG----------VWRAKVSDYG
... .|.|   ||||  .|| |||||| || |.||   .              .|..|.|
WNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFG
Kinase AqueK549.AA STE 157-252 25 4.1e-11 35.61 In-house 163-271 (359) Show / Hide 
Range on Protein: 157-252
Range on HMM: 163-271/359
Sequence Identity: 25% (31 aa)

A-LNYLHLFKPHPILHRDVSSANVLLQPMIGVWRAKVSDYGSAN-LQHSII-----------------RSVNPGGPLYAAPEAANP------KEHSPSMD
. |.|||  .   | |||. .||.||        .| .| | .  |..|.                  |    | | . |||  ..      |... . |
GLLYYLHSHH---IIHRDIKPANILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCD

VFSYGVLLLEMITRRIPLPEE
. | | ...||.| . |. ..
IWSLGCTIIEMATGKPPWHDM
S_TKc AqueK549.AA S_TKc 33-296 16 3.1e-10 -26.78 SMART 1-231 (231) Show / Hide 
Range on Protein: 33-296
Range on HMM: 1-231/231
Sequence Identity: 16% (46 aa)

SSVLINTGSGPHLLVVGGYNRTSDIW----IFDINNKSWEKLFNLSDIVIERYSHSLSVWSVTPTTNWIIVFGGSTSYTDPAVIELRATTEGNPMILTEL
  .|   |.|    |  .... ..      | .             .|  |.  ..           .|. . ..                ..  . .|.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK-------HHPNIVKLYDVFQD-------------DHLYMVMEY

MPT---SLRKELEIGG-------VAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMIGVWRAKVSDYGSANLQHSIIRSVNPGGPLYAAP
...   .|.. ..  |            . ..   ..|||.|.|  .   |.|||.  .|.||       . |..| |.| .      .   | | | ||
CDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE-----HIKICDFGLARQL-----TTFCGTPWYMAP

EAANPKEHSP-SMDVFSYGVLLLEMITRRIPLPEERVGLIDDYQPVERSGHSTVRYVGSENVNRRRGDAEAARYC-----LPTL
|      ... . |. | |..| ||.... | | .   ...      ... . .|     . ..| .  || ...      | .
EVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK549.AA IRAK 148-181 45 1.7e-08 26.37 In-house 112-146 (317) Show / Hide 
Range on Protein: 148-181
Range on HMM: 112-146/317
Sequence Identity: 45% (16 aa)

LSISLDVACALNYLHLFKPH-PILHRDVSSANVLL
.||..  ||....|| . |  || |.|..|||.||
CSICWGTACGIQFLHQNHPCTPIIHGDIKSANILL
Kinase AqueK549.AA LISK-DD1 229-248 65 6.9e-08 24.84 In-house 211-230 (290) Show / Hide 
Range on Protein: 229-248
Range on HMM: 211-230/290
Sequence Identity: 65% (13 aa)

SMDVFSYGVLLLEMITRRIP
| ||||.|..|||.|||..|
SCDVFSFGMVLLELITRKKP
Kinase AqueK549.AA PTB 264-399 19 1.7e-07 32.18 SMART 1-156 (156) Show / Hide 
Range on Protein: 264-399
Range on HMM: 1-156/156
Sequence Identity: 19% (32 aa)

ERSGHSTVRYVGSENVNRRR-------GDAEAARYCLPTLRTASKNMRAHKPKAVLGLNLKGVSLYDERSK-SITRVPVDKVTYVTLDP-----------
.   .  |.|.|.  | . |       |.. ... |. ..|     .. |. | .| .  .||.| |. .|  | . |. .....  ||           
PWGCCFNVWYLGCVEVPHHRNSMAPGKGMQVCQE-CMRKIR----QHWKHWQKMHLHISVDGVKLIDPQTKQVIHHHPIHRISFCAHDPYRWNTGGHHCC

EDQCYFGVIIQTKESH------TGFRLYCFKAERPIAVTFVNSSRELFDLIMKLRQAKKKM
.| ..||.|.  . ..      . ||...|. | | |   . . ...|.......|.... 
DDDRCFGYICRHPNDRGSHRMTYWFRCHVFWCEDPHAEDIAQTIGQAFQVCYQQCQKQRCQ
Kinase AqueK549.AA LISK 229-250 54 2e-07 20.0 In-house 219-240 (296) Show / Hide 
Range on Protein: 229-250
Range on HMM: 219-240/296
Sequence Identity: 54% (12 aa)

SMDVFSYGVLLLEMITRRIPLP
| ||||.|..|.|.|||. . |
SCDVFSFGIVLCEIITRVKADP
Kinase AqueK549.AA LISK 148-196 42 3e-06 15.97 In-house 104-150 (296) Show / Hide 
Range on Protein: 148-196
Range on HMM: 104-150/296
Sequence Identity: 42% (21 aa)

LSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPM-IGVWRAKVSDYG
..|.||.||.. |||  .   |.|||  | |.|.     ..||.|| | |
VKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFG
Kinase AqueK549.AA LISK-DD1 148-196 44 2.5e-05 15.46 In-house 126-172 (290) Show / Hide 
Range on Protein: 148-196
Range on HMM: 126-172/290
Sequence Identity: 44% (22 aa)

LSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPM-IGVWRAKVSDYG
..|.||.|||  |||  .   |.|||  | | |.     . ||.|| | |
VKIALDIACAMAYLHSKN---IIHRDLKSKNILVDENGDSQWRIKVCDFG
Kinase AqueK549.AA OmpH 393-1030 3 0.000102 18.42 Pfam 36-116 (165) Show / Hide 
Range on Protein: 393-1030
Range on HMM: 36-116/165
Sequence Identity: 3% (24 aa)

RQAKKKMKEEREEADKAPQDPDTSNLPAENAPPPSYTSVSKAPDRPPPPMPKQAPAMPPRPQEADIFSFGNEPPPPTFDDVYDVSSGALTSLYGNQPQAP
..|.|....| .. ..                                                                                    
KDAQKQLEKEFKQWQAE-----------------------------------------------------------------------------------

PTFAPPPQPNPFGMAGQPPPPNYPPPPVQEPSITMDLMDAIRNPQQSTTTAYLIGMGMRMPGLGMGPPAGLPADLLLDSNFSQPLLPTNTGGAGPPGGGQ
                                                                                                    
----------------------------------------------------------------------------------------------------

PPQGAGGKIDAFSDLVSIARDKTTSKPEPAPPTIFQSPPTNTETSPPLPYRPPDLDFTDAPPTTSGPAPSGFDNTFGALPPAPGTGGWFWRXKASPPNKM
                                                                                                    
----------------------------------------------------------------------------------------------------

AAKAPDYQPGKRREHSTVRVGDYLYMWGGGQPDLPAVHNNEKKKSMCSVMEVCHLRTGRWEQKPTTGNPPLGVNGYAAAAIGREIFYFGGYCNHGDCYHN
                                                                                                    
----------------------------------------------------------------------------------------------------

SLYSAILFGGYTDNGASNNVYILNFTDTSVNCSKLSNPGGSVQWPKGRRGHSSVLINTSSGPHLLVVGGTGGAYDIWIFDINNKSWKELVNLPVNVTNRC
                                                                                                    
----------------------------------------------------------------------------------------------------

WHSLSVWSVTPTTNWIIVFGGSSSYTDTAVVELRYTSNNDWSTSIIPLDQYQEKLQERRREWEASQPVQPEDRREIDRLTRVLQERERELEEEKR-----
                                                                                  ||... ||..|.      
----------------------------------------------------------------------------------LQKMQKELQKEQQKYQKQ

-EK----EQVRNRLQQQLQGREQQLQQAQQQGQEREREIQQARERERQ
 ..    |. |  .||..| ..|..||.||| |   .|.||... ..|
IRAGTMSEEQRQKKQQEFQQKQQEFQQYQQQYQ-P-QEMQQKQQELMQ
Kinase AqueK549.AA IRAK 197-244 26 0.000369 10.83 In-house 167-219 (317) Show / Hide 
Range on Protein: 197-244
Range on HMM: 167-219/317
Sequence Identity: 26% (14 aa)

SANLQHSI---IRSVNPGGPLYAAPEAAN--PKEHSPSMDVFSYGVLLLEMIT
|.......   . |.  |   | .||. .   .. ..  ||.| |. ||| .|
SHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDVYSFGIVLLEVLT
Kelch_1 AqueK549.AA Kelch_1 28-74 16 0.000506 18.19 Pfam 1-45 (45) Show / Hide 
Range on Protein: 28-74
Range on HMM: 1-45/45
Sequence Identity: 16% (8 aa)

KRRSHSSVLINTGSGPHLLVVGGYN--RTSDIWIFDINNKSWEKLFNLS
.|..|... .|     .. |.||..  ........|  ...|... ...
PRCGHGVCVHNG----KIYVIGGCDGQYLNSVECYDPETNQWTRCPPMP
Kelch_2 AqueK549.AA Kelch_2 28-74 23 0.000894 18.47 Pfam 1-51 (51) Show / Hide 
Range on Protein: 28-74
Range on HMM: 1-51/51
Sequence Identity: 23% (13 aa)

KRRSHSSVLINTGSGPHLLVVGGY--------NRTSDIWIFDINNKSWEKLFNLS
 | .|.|. .    |  ..|.|||         ...|||..| . ..|...  . 
PRYCHASCVP----GGKIYVFGGYCRHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kinase AqueK549.AA Pkinase_Tyr 117-181 21 0.002298 12.02 Pfam 74-144 (270) Show / Hide 
Range on Protein: 117-181
Range on HMM: 74-144/270
Sequence Identity: 21% (16 aa)

T-TEGN--PMILTELMPT-SLRKELEIG-----GVAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLL
|  ..   ..| .|.||  .|.. |         .  . .|......|....||.  .   . |||.   |.|.
TDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLV
Kinase AqueK549.AA Kelch_2 703-759 17 0.00369 16.13 Pfam 1-51 (51) Show / Hide 
Range on Protein: 703-759
Range on HMM: 1-51/51
Sequence Identity: 17% (10 aa)

KRREHSTVRVGDYLYMWGGGQPDLPAVHNNEKKKSMCSVMEVCHLRTGRWEQKPTTG
 |  |... .|. .|..||         ..  . . .... .....| ||.  |  .
PRYCHASCVPGGKIYVFGGYC------RHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kinase AqueK549.AA Kelch_1 839-885 22 0.008157 13.86 Pfam 1-45 (45) Show / Hide 
Range on Protein: 839-885
Range on HMM: 1-45/45
Sequence Identity: 22% (11 aa)

GRRGHSSVLINTSSGPHLLVVGGTGG--AYDIWIFDINNKSWKELVNLP
 |.||... .|     .. |.||  |    .....|  ...|... ..|
PRCGHGVCVHNG----KIYVIGGCDGQYLNSVECYDPETNQWTRCPPMP
Kinase AqueK549.AA CZAK 215-248 32 0.008787 6.12 In-house 188-221 (279) Show / Hide 
Range on Protein: 215-248
Range on HMM: 188-221/279
Sequence Identity: 32% (11 aa)

YAAPEAANPKEHSPSMDVFSYGVLLLEMITRRIP
. |||       ..  ||.|.| .| ..|| . |
WMAPECFKGENYTEKVDVYSFGMILWCIITCDQP
Kinase AqueK549.AA Kelch_2 839-885 23 0.128622 10.27 Pfam 1-51 (51) Show / Hide 
Range on Protein: 839-885
Range on HMM: 1-51/51
Sequence Identity: 23% (13 aa)

GRRGHSSVLINTSSGPHLLVVGGT--------GGAYDIWIFDINNKSWKELVNLP
.| .|.|. .    |  ..|.||             |||..| . ..|...  .|
PRYCHASCVP----GGKIYVFGGYCRHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kinase AqueK549.AA Pkinase_Tyr 231-245 53 0.602102 3.83 Pfam 196-210 (270) Show / Hide 
Range on Protein: 231-245
Range on HMM: 196-210/270
Sequence Identity: 53% (8 aa)

DVFSYGVLLLEMITR
|| |.|||. |..|.
DVWSFGVLMWEIFTY
Kinase AqueK549.AA Kelch_1 764-796 21 3.458157 4.44 Pfam 1-30 (45) Show / Hide 
Range on Protein: 764-796
Range on HMM: 1-30/45
Sequence Identity: 21% (7 aa)

GVNGYAAAAIGREIFYFGGYCNHGDCYHNSLYS
   |....... .|. .||...    | || ..
PRCGHGVCVHNGKIYVIGGCDG---QYLNSVEC
Kinase AqueK549.AA Kelch_1 703-759 15 3.593993 4.38 Pfam 1-45 (45) Show / Hide 
Range on Protein: 703-759
Range on HMM: 1-45/45
Sequence Identity: 15% (9 aa)

KRREHSTVRVGDYLYMWGGGQPDLPAVHNNEKKKSMCSVMEVCHLRTGRWEQKPTTG
.|. |. . .....|  ||  .            .  .  |. ...|..|.. |. .
PRCGHGVCVHNGKIYVIGGCDG------------QYLNSVECYDPETNQWTRCPPMP
Kinase AqueK549.AA Kelch_2 764-795 25 5.781577 3.99 Pfam 1-35 (51) Show / Hide 
Range on Protein: 764-795
Range on HMM: 1-35/51
Sequence Identity: 25% (9 aa)

GVNGYAAAAIGREIFYFGGY---CNHGDCYHNSLY
.  . |.. .|  |. ||||     ..||......
PRYCHASCVPGGKIYVFGGYCRHTHNNDCWSMDIW
Kinase AqueK549.AA Kelch_2 890-936 27 9.387128 3.19 Pfam 1-32 (51) Show / Hide 
Range on Protein: 890-936
Range on HMM: 1-32/51
Sequence Identity: 27% (13 aa)

NRCWHSLSVWSVTPTTNWIIVFGGSSSYTDTAVVELRYTSNNDWSTS
.|. |. .|.      ..|.||||..          |.| |||....
PRYCHASCVP-----GGKIYVFGGYC----------RHTHNNDCWSM
Kelch_2 AqueK549.AA Kelch_2 79-103 36 14.875008 2.43 Pfam 1-20 (51) Show / Hide 
Range on Protein: 79-103
Range on HMM: 1-20/51
Sequence Identity: 36% (9 aa)

ERYSHSLSVWSVTPTTNWIIVFGGS
 ||.|. .|.      ..|.||||.
PRYCHASCVP-----GGKIYVFGGY
Kinase AqueK549.AA Kelch_1 800-828 16 56.747322 0.08 Pfam 17-45 (45) Show / Hide 
Range on Protein: 800-828
Range on HMM: 17-45/45
Sequence Identity: 16% (5 aa)

FGGYTDNGASNNVYILNFT-DTSVNCSKLS
.||...  ..|.|.... . ..   |. ..
IGGCDG-QYLNSVECYDPETNQWTRCPPMP
Kinase AqueK549.AA TKL 1121-1282 20 2.2e-31 110.25 In-house 1-244 (364) Show / Hide 
Range on Protein: 1121-1282
Range on HMM: 1-244/364
Sequence Identity: 20% (52 aa)

LGRGGWGEVRVARFHG----------LEVAAKVLHETIISEYNV-------------------------SLFSREMNIASKIRHPNLLQFIGATTEGN--
.|.|| |||  ....|           .|| |.....  .| .                            . .|... |..||||..||.|. ....  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------PIILTELM-PTSLRKELEIGGVTYPAILSISLDVACALNYLHLFKP-----HPILHRDVSSANVLLQ-----------PMLGVWRAKV
            . | .|..   ||.  |       . .....||.|...||||  .|      ||.|||  |.|.|.            .    |..|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI

SDYGSANLQPLIG---------------------RTTNPGNPVYSAPEA
.|.| .      |                     . |  |.| . |||.
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEV
Kinase AqueK549.AA MLK 1115-1282 21 4e-21 70.1 In-house 1-204 (291) Show / Hide 
Range on Protein: 1115-1282
Range on HMM: 1-204/291
Sequence Identity: 21% (44 aa)

RMTERILGRGGWGEVRVARFHGLE-----VAAKVLHETIISEYNVS-----LFSREMNIASKIRHPN----LLQFIGATTE-GN-PIILTELMPT-SLRK
  .....| |. |.|  .|... .     || |  . .|. .  ..      | .| .......|||      || |. .. ..   |..| ..  ||  
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

EL---EI------------GGVTYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQP---MLGVWRAKVSDYGSAN-LQPL-IGRTTNPGNPVY
 |   ..            . ..   .....|..| ...|||  .|.|| |||  | |.|.      ..   .|..| | .  ..     .. |.|.. .
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAW

SAPEA
 |||.
MAPEV
Kinase AqueK549.AA TKL-Unique 1117-1281 25 9e-17 55.82 In-house 1-196 (290) Show / Hide 
Range on Protein: 1117-1281
Range on HMM: 1-196/290
Sequence Identity: 25% (50 aa)

TERILGRGGWGEVRVARFHGLEVAAKVLH-ETIISEYNVSLFSREMNIASKIR-HPNLLQFIGATT-----EGNPIILTELMPT-SLRKELE--------
    .|.|| |.|  . ..| .|| |..| .  .|   .  |..| |. .|.. |||.....|...     ..| .| .| .|  ||.. |         
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

---IGGVTYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPM--LGVWRAKVSDYGSANLQPLIGRTTNP-----------GNPVYSAPE
       ..  .... .|.| ...|||  .|  |.|||  | |.|.        |..|..| | . ..  | ..||            |.. ..|||
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE
Kinase AqueK549.AA TK 1118-1258 14 3.2e-16 50.14 In-house 4-296 (486) Show / Hide 
Range on Protein: 1118-1258
Range on HMM: 4-296/486
Sequence Identity: 14% (43 aa)

ERILGRGG---WGEVRVARFHGL---------------------------EVAAKVLHETIISEYN-VSL--------------FSREMNIAS--KIRHP
.. ||.|    .|||. .. .|.                           .|| |.|.|.  .. .   .              . .|| . .  . .||
GKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHP

NLLQFIGATTEGN-------------PIILTELMP-TS----LRKELEIGG-------------------------------------------------
|.....|. |.|              ..|..|.||  .    ||. |                                                     
NIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDD

----------------------------VTYPAILSISLDVACALNYLHLFKPHPI----LHRDVSSANVLLQ-PMLGVWR-------AKVSDYG
                            .| .  | .....||.. |||  .         |||.   |.|.   .   |        .|..|.|
LIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFG
Pkinase_Tyr AqueK549.AA Pkinase_Tyr 1114-1243 25 3e-15 52.29 Pfam 1-144 (270) Show / Hide 
Range on Protein: 1114-1243
Range on HMM: 1-144/270
Sequence Identity: 25% (38 aa)

IRMTERILGRGGWGEVRVARFH------GLEVAAKVLHETIISEY--NVSLFSREMNIASKI-RHPNLLQFIGATT-EGNP---IILTELMPT-SLRKEL
|..  . ||.|  |||. .. .      ...|| |.| |.  .|     .... |..| ... .|||.....|. | .| |   .| .|.||  .|.. |
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

EIG-----GVTYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLL
         .| . .|......|....||.  .   . |||.   |.|.
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLV
Kinase AqueK549.AA Pkinase 1115-1243 18 2.9e-13 47.96 Pfam 1-141 (293) Show / Hide 
Range on Protein: 1115-1243
Range on HMM: 1-141/293
Sequence Identity: 18% (27 aa)

RMTERILGRGGWGEVRVARFHGLE--VAAKVLH-ETIISEYNVSLFS-REMNIASKIRHPNLLQFIGAT-TEGNPIILTELMPT-----SLRKELE---I
  ..|..|.|. |.|. .. .| .  || |..  ... |. .....  .|  |  ...||| ......  ..... . .|...      .|   ..    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GGV--TYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLL
|..  ..  . .. . ....|.|.|      |.|||. ..|.|.
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILI
Kinase AqueK549.AA STE 1116-1281 19 3.6e-13 42.95 In-house 1-232 (359) Show / Hide 
Range on Protein: 1116-1281
Range on HMM: 1-232/359
Sequence Identity: 19% (47 aa)

MTE-RILGRGGWGEVRVARFH-----------------GLEVAAKVLH----ETIISE------------YNVSLFSREMNIASKIR--HPNLLQFIGAT
 .  ...|.|. |.|  |. |                 |  .| |...    .. . |             ..  . .|..| .| .  |||  ...|. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

T--------EGNPIILTELMP-TSLRKELEIGGVTY---------------PAILSISLDVACA-LNYLHLFKPHPILHRDVSSANVLLQPMLGVWRAKV
         ...  |  |.|.  ||.. ..  . .                . |  |  ..  . |.|||  .   | |||. .||.||        .| 
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL--------VKL

SDYGSAN-LQPLIG-----------------RTTNPGNPVYSAPE
.| | .  |.. .                  |.|  | | . |||
CDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE
Kinase AqueK549.AA LISK 1120-1178 26 2.1e-12 36.41 In-house 1-64 (296) Show / Hide 
Range on Protein: 1120-1178
Range on HMM: 1-64/296
Sequence Identity: 26% (17 aa)

ILGRGGWGEVRVARFH--GLEVAAKVLH---ETIISEYNVSLFSREMNIASKIRHPNLLQFIGA
..|.|. |.|   .    | ..| | .|   .. . . .   . ||. .  ..|||| .||.|.
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGV
Kinase AqueK549.AA CZAK 1210-1258 36 8.3e-12 39.3 In-house 108-167 (279) Show / Hide 
Range on Protein: 1210-1258
Range on HMM: 108-167/279
Sequence Identity: 36% (22 aa)

LSISLDVACALNYLHL-FKPHPILHRDVSSANVLLQPMLG----------VWRAKVSDYG
... .|.|   ||||  .|| |||||| || |.||   .              .|..|.|
WNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFG
Kinase AqueK549.AA LRRK 1115-1281 20 8.5e-12 38.0 In-house 1-249 (351) Show / Hide 
Range on Protein: 1115-1281
Range on HMM: 1-249/351
Sequence Identity: 20% (53 aa)

RMTERILGRGGWG-EVRVARFHG----------------------------LEVAAKVLHET-------------------------------IISEYNV
 . |. .|||| | .|  |.. |                             .||.|... .                               ...  ..
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

-SLFSREMNIASKIRHPNLLQFIGATTEGNPIIL-TELMPT-SLRKELE---IGG------V-TYPAILSISLDVACALNYLHLFKPHPILHRDVSSANV
 ..| .|. | |. .|||... .| .   .|... .|..|  .| . |.     |      . .   .| |.|..| ...||| ..| ||.|||  | |.
FREFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP-PIIHRDLKSPNI

LLQPML---------GVWRAKVSDYGSAN----LQP-LIGRTTNPGNPVYSAPE
||. .              ||..|.|       ... .. . .  |||.. |||
LLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCV--GNPGWMAPE
Kinase AqueK549.AA CZAK 1118-1191 33 8.7e-12 39.22 In-house 4-84 (279) Show / Hide 
Range on Protein: 1118-1191
Range on HMM: 4-84/279
Sequence Identity: 33% (27 aa)

ERILGRGGWGEVRVARFHGLEVAAKVLHETIISEYNV----SLFSREMNIASKIRHPNLLQFIGATTEGN---PIILTELM
..  |.|  |||. |.  |  || | .|     .         | .|  | || .||| .||.|| .|..     | .| |
GQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWM
Kinase AqueK549.AA IRAK 1210-1243 45 1.7e-08 26.37 In-house 112-146 (317) Show / Hide 
Range on Protein: 1210-1243
Range on HMM: 112-146/317
Sequence Identity: 45% (16 aa)

LSISLDVACALNYLHLFKPH-PILHRDVSSANVLL
.||..  ||....|| . |  || |.|..|||.||
CSICWGTACGIQFLHQNHPCTPIIHGDIKSANILL
Kinase AqueK549.AA TyrKc 1115-1290 17 4.1e-08 -91.48 SMART 1-280 (280) Show / Hide 
Range on Protein: 1115-1290
Range on HMM: 1-280/280
Sequence Identity: 17% (50 aa)

RMTERILGRGGWGEVRVARFHGLEVAAKVLHETIISEYNVSLFSREMNIASKI--RHPNLLQFIGATTE--------GNPIILTELMPT-SLRKELEIGG
   ...||.|  |||. ..   ..|| |.|.|       .  | ||..| .|.  .|||.....|. |.        . . |..|.||  .|.. |   .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--VTYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMLGVWRAKVSDYG-SANLQPL--------IGRT-----TN----------------
  .. .  ||.....||  .|||    ... |||    |.|.   .   ..|.|| | | ..             |.     ..                
PKLCMKDLLSFCWQIACGMEYLHS---KNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

--------------------------PG-----NPVYSAPEAGIQG------ST------------------------------------LL
                          ||      . . . |   ||                                            ..
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK549.AA LISK-DD1 1120-1178 31 3.6e-07 22.23 In-house 1-65 (290) Show / Hide 
Range on Protein: 1120-1178
Range on HMM: 1-65/290
Sequence Identity: 31% (21 aa)

ILGRGGWGEVRVARFHGLEVAAKVLHE----TIISEYNVSLFSREMNIASK---IRHPNLLQFIGA
. |.|. | |  .   | .|| |..|.     .  .| . .  ||  .      |||||. ||||.
EIGKGSFGKVYKGCYFGTPVAIKKIHKQPNDPNDPDYWK-FMQREIKMLKNLLNIRHPNIVQFIGI
Kinase AqueK549.AA LISK 1210-1258 42 3e-06 16.08 In-house 104-150 (296) Show / Hide 
Range on Protein: 1210-1258
Range on HMM: 104-150/296
Sequence Identity: 42% (21 aa)

LSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPM-LGVWRAKVSDYG
..|.||.||.. |||  .   |.|||  | |.|.     ..||.|| | |
VKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFG
Kinase AqueK549.AA LISK-DD1 1210-1258 44 2.6e-05 15.44 In-house 126-172 (290) Show / Hide 
Range on Protein: 1210-1258
Range on HMM: 126-172/290
Sequence Identity: 44% (22 aa)

LSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPM-LGVWRAKVSDYG
..|.||.|||  |||  .   |.|||  | | |.     . ||.|| | |
VKIALDIACAMAYLHSKN---IIHRDLKSKNILVDENGDSQWRIKVCDFG
Kinase AqueK549.AA IRAK 1117-1177 23 0.000123 12.54 In-house 3-70 (317) Show / Hide 
Range on Protein: 1117-1177
Range on HMM: 3-70/317
Sequence Identity: 23% (16 aa)

TERILGRGGWGEVRVARFHGLE--VAAKVLHETIISEYN---VSLFS--REMNIASKIRHPNLLQFIG
 .. .| || |.|  .......  .| | |.|.  .. |   ... .   |. . ...||||.. . |
KDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYG