Gene AqueK553 (A.queenslandica)
AqueK553
Species: A.queenslandica
Alias: AqueK553
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| AqueK553.AA | Protein | None | 354 | None | Fasta, JSON |
| AqueK553.kin_dom | Protein Kinase Domain | None | 189 | None | Fasta, JSON |
Protein domains of AqueK553.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | AqueK553.AA | TKL | 169-354 | 20 | 1.7e-36 | 127.55 | In-house | 1-282 (364) | Show / Hide |
Range on Protein: 169-354
Range on HMM: 1-282/364
Sequence Identity: 20% (60 aa)
LGRGGWGEVRVARFHG----------LEVAVKVLHETIISEYNV-------------------------SLFSREMNIASKIRHPNLLQFIGATTEGN--
.|.|| ||| ....| .||||..... .| . . .|... |..||||..||.|. ....
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
------------PIILTELM-PTSLRKELETGGLAYPAILSISLDVACALNYLHLFKP-----HPILHRDVSSANVLLQPMGGGH---------GWRAKV
. | .|.. ||. | . .....||.|...|||| .| ||.||| |.|.|. . . |..|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI
SDYGSANLQHLI---------------------IRSVNPGGPLYAAPEA--GNP--------------REHSPSMDVFSYGVLLLEM
.|.| . . .. | | . |||. |.. .| |...||.|.|..| |.
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
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| Kinase | AqueK553.AA | MLK | 163-354 | 24 | 1.6e-23 | 78.51 | In-house | 1-229 (291) | Show / Hide |
Range on Protein: 163-354 Range on HMM: 1-229/291 Sequence Identity: 24% (57 aa) RMTERILGRGGWGEVRVARFHGLE-----VAVKVLHETIISEYNVS-----LFSREMNIASKIRHPN----LLQFIGATTE-GN-PIILTELMPT-SLRK .....| |. |.| .|... . |||| . .|. . .. | .| .......||| || |. .. .. |..| .. || IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN ELETG---------------GLAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQ----PMGGGHGWRAKVSDYGSANLQHLI-I-RSVNPGG | .. .....|..| ...||| .|.|| ||| | |.|. .|..|. .|..| | . | . . |.| VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGT---LKICDFGTSRDWHQMCTNMMSNAGT PLYAAPEA---GNPREHSPSMDVFSYGVLLLEM . . |||. | . ||.|.||.| || YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEM |
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| Kinase | AqueK553.AA | CZAK | 166-291 | 35 | 2e-23 | 82.06 | In-house | 4-142 (279) | Show / Hide |
Range on Protein: 166-291
Range on HMM: 4-142/279
Sequence Identity: 35% (50 aa)
ERILGRGGWGEVRVARFHGLEVAVKVLHETIISEYNV----SLFSREMNIASKIRHPNLLQFIGATTEGN---PIILTELMP-TSLRKEL-ETGGLAYP-
.. |.| |||. |. | ||.| .| . | .| | || .||| .||.|| .|.. | .| | |||. | . . .
GQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYHKQN
--AILSISLDVACALNYLHL-FKPHPILHRDVSSANVLL
... .|.| |||| .|| |||||| || |.||
PHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILL
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| Kinase | AqueK553.AA | TK | 166-354 | 15 | 5e-22 | 69.95 | In-house | 4-387 (486) | Show / Hide |
Range on Protein: 166-354
Range on HMM: 4-387/486
Sequence Identity: 15% (60 aa)
ERILGRGG---WGEVRVARFHGL---------------------------EVAVKVLHETIISEYN-VSL--------------FSREMNIAS--KIRHP
.. ||.| .|||. .. .|. .||||.|.|. .. . . . .|| . . . .||
GKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHP
NLLQFIGATTEGN-------------PIILTELMP-TS----LRKELETGG-------------------------------------------------
|.....|. |.| ..|..|.|| . ||. | .
NIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDD
----------------------------LAYPAILSISLDVACALNYLHLFKPHPI----LHRDVSSANVLLQPMGG------GHGWRAKVSDYGSAN--
| . | .....||.. ||| . |||. |.|. . | | .|..|.| .
LIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQG
---LQHLI------IRSVNPGGPL-------------------------YAAPEAGN---------PREHSPSMDVFSYGVLLLEM
| | |. ..|... . |||. | . ... ||.|.|||. |.
SGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEI
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| Kinase | AqueK553.AA | Pkinase | 163-354 | 21 | 2.6e-20 | 72.9 | Pfam | 1-205 (293) | Show / Hide |
Range on Protein: 163-354 Range on HMM: 1-205/293 Sequence Identity: 21% (46 aa) RMTERILGRGGWGEVRVARFHGLE--VAVKVLH-ETIISEYNVSLFS-REMNIASKIRHPNLLQFIGAT-TEGNPIILTELMPT-----SLRKELE---T ..|..|.|. |.|. .. .| . ||||.. ... |. ..... .| | ...||| ...... ..... . .|... .| .. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH GGL--AYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGHGWRAKVSDYGSAN---LQHLIIRSVNPGGPLYAAPEAGN-PREHSPSMD |.. . . .. . ....|.|.| |.|||. ..|.|. | . . |..| |.| . . .. | | |.||| . ....|. | GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD VFSYGVLLLEM ..|.|..| || MWSCGCILYEM |
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| Kinase | AqueK553.AA | Dicty4 | 165-308 | 33 | 1.2e-19 | 62.36 | In-house | 3-159 (277) | Show / Hide |
Range on Protein: 165-308
Range on HMM: 3-159/277
Sequence Identity: 33% (55 aa)
TERILGRGGWGEVRVARFHGLEVAVKVL--HETIISEYNVSLFSREMNIASKIRHPNLLQFIGATT-----EGNPIILTELM-PTSLRKELET------G
.| ..|.|. ||| .. | |||||.| | . .|. . | .| .| .||||||...| || | | . | ||.| ..| . |
IEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQ
GLAYP--AILS---ISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGHGWRAKVSDYG
. |.. . .|.| .|.|| | |.||| |.| | ||.||.| |
SIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLLVD-----KNWRVKVCDFG
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| Kinase | AqueK553.AA | TKL-Unique | 165-354 | 25 | 3.3e-19 | 64.53 | In-house | 1-221 (290) | Show / Hide |
Range on Protein: 165-354
Range on HMM: 1-221/290
Sequence Identity: 25% (57 aa)
TERILGRGGWGEVRVARFHGLEVAVKVLH-ETIISEYNVSLFSREMNIASKIR-HPNLLQFIGATT-----EGNPIILTELMPT-SLRKELE--------
.|.|| |.| . ..| .||.|..| . .| . |..| |. .|.. |||.....|... ..| .| .| .| ||.. |
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN
---TGGLAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGHGWRAKVSDYGSANLQHLIIRSVNP-----------GGPLYAAPEAGN
| . .... .|.| ...||| .| |.||| | |.|. |..|..| | . .. |... | | ....||| .
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR
P--REHSPSMDVFSYGVLLLEM
| . ||.|.|. | |.
MNFCQYSEKSDVYSFGIVLWEI
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| Kinase | AqueK553.AA | DRK | 162-308 | 36 | 9.5e-19 | 60.15 | In-house | 1-145 (258) | Show / Hide |
Range on Protein: 162-308 Range on HMM: 1-145/258 Sequence Identity: 36% (55 aa) IRMTERILGRGGWGEVRVARFHGLEVAVKVLHETIIS-EYNVSLFSREMNIASKIRHPNLLQFIGATTE-GNPIILTELMPT-SLRKEL--ETGGLAYPA | || |||..||| | .|||| | | | .. | || |. .. |||| ||.|. .. . | .| || || . | | . | IKIGNRI-GRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPL ILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGHGWRAKVSDYG .... .|.| ..||| | |.||| | | | |. ||.|.| MKQMMFDCAKGMIYLHCCNPI-IIHRDLKSHNLLVD-----EHWQVKVADFG |
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| Kinase | AqueK553.AA | Pkinase_Tyr | 162-291 | 26 | 1.4e-17 | 60.14 | Pfam | 1-144 (270) | Show / Hide |
Range on Protein: 162-291 Range on HMM: 1-144/270 Sequence Identity: 26% (39 aa) IRMTERILGRGGWGEVRVARFH------GLEVAVKVLHETIISEY--NVSLFSREMNIASKI-RHPNLLQFIGATT-EGNP---IILTELMPT-SLRKEL |.. . ||.| |||. .. . ...||||.| |. .| .... |..| ... .|||.....|. | .| | .| .|.|| .|.. | ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL ETG-----GLAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLL . | . .|......|....||. . . |||. |.|. RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLV |
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| Kinase | AqueK553.AA | STE | 164-354 | 18 | 4.1e-16 | 53.49 | In-house | 1-261 (359) | Show / Hide |
Range on Protein: 164-354
Range on HMM: 1-261/359
Sequence Identity: 18% (52 aa)
MTE-RILGRGGWGEVRVARFH-----------------GLEVAVKVLH----ETIISE------------YNVSLFSREMNIASKIR--HPNLLQFIGAT
. ...|.|. |.| |. | | .|.|... .. . | .. . .|..| .| . ||| ...|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY
T--------EGNPIILTELMP-TSLRKELE-TGGLA--------------YPAILSISLDVACA-LNYLHLFKPHPILHRDVSSANVLLQPMGGGHGWRA
... | |.|. ||.. .. ..| . | | .. . |.||| . | |||. .||.|| .
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL----------V
KVSDYGSAN-LQHLII-----------------RSVNPGGPLYAAPEAGNP------REHSPSMDVFSYGVLLLEM
| .| | . |.. . | | | . ||| .. ... . |. | | ...||
KLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
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| Kinase | AqueK553.AA | Shk | 165-240 | 46 | 4.1e-16 | 54.42 | In-house | 3-80 (269) | Show / Hide |
Range on Protein: 165-240 Range on HMM: 3-80/269 Sequence Identity: 46% (36 aa) TERILGRGGWGEVRVARFHGLEVAVKVLHETIISEYNVSLFSREMNIASKIRHPNLLQFIGATT--EGNPIILTELMP .| .|| | | | .| | ||||||.| . .|. . | | | |||.|||.. | || | | | ||||| REDFLGQGSFGKVYKGRCRGKEVAVKVMHKQNFDENTMTSFRKEVHIMSKIFHPNICLFMGACTSQPGKCMIVTELMP |
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| Kinase | AqueK553.AA | LISK | 168-226 | 26 | 8e-13 | 37.8 | In-house | 1-64 (296) | Show / Hide |
Range on Protein: 168-226 Range on HMM: 1-64/296 Sequence Identity: 26% (17 aa) ILGRGGWGEVRVARFH--GLEVAVKVLH---ETIISEYNVSLFSREMNIASKIRHPNLLQFIGA ..|.|. |.| . | ..|.| .| .. . . . . ||. . ..|||| .||.|. EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGV |
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| Kinase | AqueK553.AA | S_TKc | 163-354 | 17 | 1e-11 | -5.2 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 163-354
Range on HMM: 1-231/231
Sequence Identity: 17% (46 aa)
RMTERILGRGGWGEVRVARFHG--LEVAVKVLHETIISEYNVSLFSREMNIASKIRHPNLLQFIGATTEGNPIILTELMPT---SLRKELETGG------
|..|.|. |.|. .| .. .||.|... . ||..| .| .|||. ..... ... . .|.... .|.. .. |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF
-LAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGHGWRAKVSDYGSANLQHLIIRSVNPGGPLYAAPEAGNPREHSP-SMDVFSYGV
. . .. ..|||.|.| . |.|||. .|.|| . |..| |.| . . | | | ||| ... . |. | |.
PFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE-------HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC
LL---------------------------------------------LE----------M
.| |. .
ILYEMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
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| Kinase | AqueK553.AA | TyrKc | 163-354 | 19 | 1.1e-09 | -66.22 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 163-354 Range on HMM: 1-280/280 Sequence Identity: 19% (57 aa) RMTERILGRGGWGEVRVARFHGLEVAVKVLHETIISEYNVSLFSREMNIASKI--RHPNLLQFIGATTE--------GNPIILTELMPT-SLRKELETGG ...||.| |||. .. ..||||.|.| . | ||..| .|. .|||.....|. |. . . |..|.|| .|.. | . ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR --LAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGHGWRAKVSDYG-SANLQHL--------IIRS----VNPG-GPL-YAAPEAGN | . ||.....|| .||| ... ||| |.|. . ..|.|| | | .. . .|. . |. |||. | PKLCMKDLLSFCWQIACGMEYLHS---KNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN PREHSPSMDVFSYGVLL--------------------------------------L------------------------------------EM .. .. ||.|.||.. .. YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | AqueK553.AA | LISK | 258-308 | 41 | 4.2e-05 | 12.32 | In-house | 104-150 (296) | Show / Hide |
Range on Protein: 258-308 Range on HMM: 104-150/296 Sequence Identity: 41% (21 aa) LSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGHGWRAKVSDYG ..|.||.||.. ||| . |.||| | |.|. . .||.|| | | VKIALDIACGMSYLHSMN---IIHRDLKSKNCLVREN-DNNQWRIKVCDFG |
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| Kinase | AqueK553.AA | LISK | 341-354 | 57 | 0.001507 | 7.17 | In-house | 219-232 (296) | Show / Hide |
Range on Protein: 341-354 Range on HMM: 219-232/296 Sequence Identity: 57% (8 aa) SMDVFSYGVLLLEM | ||||.|..|.|. SCDVFSFGIVLCEI |
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| Kinase | AqueK553.AA | Shk | 323-354 | 37 | 0.046556 | 3.62 | In-house | 168-199 (269) | Show / Hide |
Range on Protein: 323-354 Range on HMM: 168-199/269 Sequence Identity: 37% (12 aa) GGPLYAAPEAGNPREHSPSMDVFSYGVLLLEM | ||. ||| .. . ||.| | .| |. GTPLWMAPEVMMNHPYNEKADVYSFGIILWEI |
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