Gene AqueK566 (A.queenslandica)

AqueK566

Species: A.queenslandica
Alias: AqueK566
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-B

Sequence

Name Sequence Type Origin Length Description Download
AqueK566.AA Protein None 1315 None Fasta, JSON
AqueK566.kin_dom Protein Kinase Domain None 240 None Fasta, JSON

Protein domain

Protein domains of AqueK566.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kelch_1 AqueK566.AA Kelch_1 27-74 18 3e-06 26.2 Pfam 1-45 (45) Show / Hide 
Range on Protein: 27-74
Range on HMM: 1-45/45
Sequence Identity: 18% (9 aa)

GVVYYAAAAIGREIFYFGGWCGHDTCSHNSLYSFNVDTFNWKELSPTT
  ......... .|. .||..|    . || ......|  |....| .
PRCGHGVCVHNGKIYVIGGCDG---QYLNSVECYDPETNQWTRCPPMP
Kelch_2 AqueK566.AA Kelch_2 27-74 17 0.045081 12.0 Pfam 1-51 (51) Show / Hide 
Range on Protein: 27-74
Range on HMM: 1-51/51
Sequence Identity: 17% (9 aa)

GVVYYAAAAIGREIFYFGGW---CGHDTCSHNSLYSFNVDTFNWKELSPTT
. .  |.. .|  |. |||.    ... |...... .. .|  |.....  
PRYCHASCVPGGKIYVFGGYCRHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kelch_2 AqueK566.AA Kelch_2 191-235 23 0.00414 15.94 Pfam 1-51 (51) Show / Hide 
Range on Protein: 191-235
Range on HMM: 1-51/51
Sequence Identity: 23% (13 aa)

GRNAHSSVLINTSSGPHLLVVGGT----------TGDIWIFDINNKSWKELVNLP
.|  |.|. .    |  ..|.||           . |||..| . ..|...  .|
PRYCHASCVP----GGKIYVFGGYCRHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kelch_1 AqueK566.AA Kelch_1 202-235 18 0.013811 13.04 Pfam 8-45 (45) Show / Hide 
Range on Protein: 202-235
Range on HMM: 8-45/45
Sequence Identity: 18% (7 aa)

TSSGPHLLVVGGTTG----DIWIFDINNKSWKELVNLP
.. . .. |.|| .|    .....|  ...|... ..|
CVHNGKIYVIGGCDGQYLNSVECYDPETNQWTRCPPMP
Kinase AqueK566.AA Dicty4 474-549 39 1.9e-17 54.88 In-house 3-85 (277) Show / Hide 
Range on Protein: 474-549
Range on HMM: 3-85/277
Sequence Identity: 39% (33 aa)

TERILGRGGWGEVRVARFHGLEVAAKVL--HETIISEYNVSLFSREMNIASKIRHPNLLQFIGATT-----EGNPMILTELMP
.| ..|.|. |||  ..  | ||| |.|  | .  .|.  . | .| .| .||||||...| || |      | ..| ||.||
IEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMP
Kinase AqueK566.AA TKL 478-549 19 9.8e-16 53.15 In-house 1-121 (364) Show / Hide 
Range on Protein: 478-549
Range on HMM: 1-121/364
Sequence Identity: 19% (23 aa)

LGRGGWGEVRVARFHG----------LEVAAKVLHETIISEYNV-------------------------SLFSREMNIASKIRHPNLLQFIGATTEGN--
.|.|| |||  ....|           .|| |.....  .| .                            . .|... |..||||..||.|. ....  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------PMILTELMP
            ..| .|..|
CVCMHPVGPWGQLCIVMEYCP
Kinase AqueK566.AA Shk 474-549 46 1.2e-15 52.72 In-house 3-80 (269) Show / Hide 
Range on Protein: 474-549
Range on HMM: 3-80/269
Sequence Identity: 46% (36 aa)

TERILGRGGWGEVRVARFHGLEVAAKVLHETIISEYNVSLFSREMNIASKIRHPNLLQFIGATT--EGNPMILTELMP
.| .|| |  | |  .|  | ||| ||.| .  .|.  . |  |  | |||.|||.. | || |   |  || |||||
REDFLGQGSFGKVYKGRCRGKEVAVKVMHKQNFDENTMTSFRKEVHIMSKIFHPNICLFMGACTSQPGKCMIVTELMP
Kinase AqueK566.AA LISK 477-548 26 1.4e-13 40.28 In-house 1-79 (296) Show / Hide 
Range on Protein: 477-548
Range on HMM: 1-79/296
Sequence Identity: 26% (21 aa)

ILGRGGWGEVRVARFH--GLEVAAKVLH---ETIISEYNVSLFSREMNIASKIRHPNLLQFIGATTE--GNPMILTELM
..|.|. |.|   .    | ..| | .|   .. . . .   . ||. .  ..|||| .||.|.  .  |  .|.||..
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYI
Kinase AqueK566.AA DRK 471-549 38 1.1e-12 39.39 In-house 1-80 (258) Show / Hide 
Range on Protein: 471-549
Range on HMM: 1-80/258
Sequence Identity: 38% (31 aa)

IRMTERILGRGGWGEVRVARFHGLEVAAKVLHETIIS-EYNVSLFSREMNIASKIRHPNLLQFIGATTE-GNPMILTELMP
|    || |||..|||      | .|| | |    |  |  .. | || |. .. ||||  ||.|. ..   . | .| ||
IKIGNRI-GRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMP
Kinase AqueK566.AA CZAK 475-548 33 6.1e-12 39.79 In-house 4-84 (279) Show / Hide 
Range on Protein: 475-548
Range on HMM: 4-84/279
Sequence Identity: 33% (27 aa)

ERILGRGGWGEVRVARFHGLEVAAKVLHETIISEYNV----SLFSREMNIASKIRHPNLLQFIGATTEGN---PMILTELM
..  |.|  |||. |.  |  || | .|     .         | .|  | || .||| .||.|| .|..     | .| |
GQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWM
Kinase AqueK566.AA Pkinase_Tyr 471-549 28 4.6e-10 34.7 Pfam 1-90 (270) Show / Hide 
Range on Protein: 471-549
Range on HMM: 1-90/270
Sequence Identity: 28% (26 aa)

IRMTERILGRGGWGEVRVARFH------GLEVAAKVLHETIISEY--NVSLFSREMNIASKI-RHPNLLQFIGATT-EGNP---MILTELMP
|..  . ||.|  |||. .. .      ...|| |.| |.  .|     .... |..| ... .|||.....|. | .| |   .| .|.||
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMP
Kinase AqueK566.AA TK 475-556 19 1.8e-09 27.13 In-house 4-150 (486) Show / Hide 
Range on Protein: 475-556
Range on HMM: 4-150/486
Sequence Identity: 19% (28 aa)

ERILGRGG---WGEVRVARFHGL---------------------------EVAAKVLHETIISEYN-VSL--------------FSREMNIAS--KIRHP
.. ||.|    .|||. .. .|.                           .|| |.|.|.  .. .   .              . .|| . .  . .||
GKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHP

NLLQFIGATTEGN-------------PMILTELMP-TS----LRKEL
|.....|. |.|              .||..|.||  .    ||. |
NIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYL
Kinase AqueK566.AA MLK 472-549 20 2.8e-09 28.49 In-house 1-93 (291) Show / Hide 
Range on Protein: 472-549
Range on HMM: 1-93/291
Sequence Identity: 20% (19 aa)

RMTERILGRGGWGEVRVARFHGLE-----VAAKVLHETIISEYNVS-----LFSREMNIASKIRHPN----LLQFIGATTE-GN-PMILTELMP
  .....| |. |.|  .|... .     || |  . .|. .  ..      | .| .......|||      || |. .. ..   |..| ..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCE
Kinase AqueK566.AA LISK-DD1 477-548 25 1.1e-08 27.84 In-house 1-92 (290) Show / Hide 
Range on Protein: 477-548
Range on HMM: 1-92/290
Sequence Identity: 25% (24 aa)

ILGRGGWGEVRVARFHGLEVAAKVLHE----TIISEYNVSLFSREMNIASK---IRHPNLLQFIGATTE--------------GNPMILTELM
. |.|. | |  .   | .|| |..|.     .  .| . .  ||  .      |||||. ||||.  .              .  .|.||..
EIGKGSFGKVYKGCYFGTPVAIKKIHKQPNDPNDPDYWK-FMQREIKMLKNLLNIRHPNIVQFIGICEHPLASPSLVNRLLNESSLYIVTEFI
Kinase AqueK566.AA TKL-Unique 474-546 27 2.4e-08 25.72 In-house 1-80 (290) Show / Hide 
Range on Protein: 474-546
Range on HMM: 1-80/290
Sequence Identity: 27% (22 aa)

TERILGRGGWGEVRVARFHGLEVAAKVLH-ETIISEYNVSLFSREMNIASKIR-HPNLLQFIGATT-----EGNPMILTE
    .|.|| |.|  . ..| .|| |..| .  .|   .  |..| |. .|.. |||.....|...     ..|  | .|
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVME
Kinase AqueK566.AA Pkinase 472-574 15 1.6e-05 20.64 Pfam 1-118 (293) Show / Hide 
Range on Protein: 472-574
Range on HMM: 1-118/293
Sequence Identity: 15% (18 aa)

RMTERILGRGGWGEVRVARFHGLE--VAAKVLH-ETIISEYNVSLFS-REMNIASKIRHPNLLQFIGAT-TEGNPMILTELMPT-----SLRKELE---S
  ..|..|.|. |.|. .. .| .  || |..  ... |. .....  .|  |  ...||| ......  ..... . .|...      .|   ..   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GGV--AYPAILSISLDTI
|..   .  . .. . ..
GCFYFSEWECKFYMYQIL
Kelch_1 AqueK566.AA Kelch_1 602-649 20 4.2e-05 22.07 Pfam 1-45 (45) Show / Hide 
Range on Protein: 602-649
Range on HMM: 1-45/45
Sequence Identity: 20% (10 aa)

GVNGYAASAIGREIFYFGGWCRHDDCYHNSLYSFNVDTFNWKELSPTT
   |... ... .|. .||..     | || ......|  |....| .
PRCGHGVCVHNGKIYVIGGCDG---QYLNSVECYDPETNQWTRCPPMP
Kelch_2 AqueK566.AA Kelch_2 602-649 19 0.016788 13.63 Pfam 1-51 (51) Show / Hide 
Range on Protein: 602-649
Range on HMM: 1-51/51
Sequence Identity: 19% (10 aa)

GVNGYAASAIGREIFYFGGW---CRHDDCYHNSLYSFNVDTFNWKELSPTT
.  . |.. .|  |. |||.     ..||...... .. .|  |.....  
PRYCHASCVPGGKIYVFGGYCRHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kelch_2 AqueK566.AA Kelch_2 658-719 11 0.153334 9.98 Pfam 1-51 (51) Show / Hide 
Range on Protein: 658-719
Range on HMM: 1-51/51
Sequence Identity: 11% (7 aa)

YHCDMIAIKVNGEDYLIVIGGYGPSFNNTPKQPGAQYSGSKTNEINFYKLSTGQWISPTVTG
... .... .  .. ..|.|||          ....  .. .. |... ..| .|   .. .
PRYCHASCVP--GGKIYVFGGYC---------RHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kelch_2 AqueK566.AA Kelch_2 780-825 23 0.000339 20.07 Pfam 1-51 (51) Show / Hide 
Range on Protein: 780-825
Range on HMM: 1-51/51
Sequence Identity: 23% (13 aa)

ERRGHSSVLINTSSGPHLLVVGGS---------GTYDIWIFDINKKSWKELVDLP
 | .|.|. .    |  ..|.||.          . |||..| ....|... ..|
PRYCHASCVP----GGKIYVFGGYCRHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kelch_1 AqueK566.AA Kelch_1 791-825 15 0.003034 15.4 Pfam 8-45 (45) Show / Hide 
Range on Protein: 791-825
Range on HMM: 8-45/45
Sequence Identity: 15% (6 aa)

TSSGPHLLVVGGSG---TYDIWIFDINKKSWKELVDLP
.. . .. |.||.    . .....|  ...|... ..|
CVHNGKIYVIGGCDGQYLNSVECYDPETNQWTRCPPMP
Kinase AqueK566.AA TKL 1079-1310 20 2.7e-49 170.09 In-house 1-364 (364) Show / Hide 
Range on Protein: 1079-1310
Range on HMM: 1-364/364
Sequence Identity: 20% (74 aa)

LGRGGWGEVRVAHFHG----------LEVAAKVLHETIISEYNV-------------------------SLFSREMNIASKIRHPNLLQFIGATTEGN--
.|.|| |||  ....|           .|| |.....  .| .                            . .|... |..||||..||.|. ....  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------PMILTELM-PTSLRKELESGGVAYPAILSISLDVACGLNYLHLFKP-----HPILHRDVSSANVLLQ-IMG----------GTWRAKV
            ..| .|..   ||.  |       . .....||.|.|.||||  .|      ||.|||  |.|.|.   .            .|..|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI

SDYGSANLQPLIG---------------------RTTNPGNPVYSAPEA--GNP--------------REHSPSMDVFSYGVLLLEMITRRIPLPEER--
.|.| .      |                     . |  |.| . |||.  |..              .| |...||.|.|..| |..||..|  ..   
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYM

------------VGLIDGIRR--------------------ASFRSLVKRCLIVEYRHRPTMNDIITEL
            .. .|  .|                     |...| ..|   . . ||....|. .|
PMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK566.AA Dicty4 1075-1312 28 4.4e-30 97.66 In-house 3-277 (277) Show / Hide 
Range on Protein: 1075-1312
Range on HMM: 3-277/277
Sequence Identity: 28% (79 aa)

TERILGRGGWGEVRVAHFHGLEVAAKVL--HETIISEYNVSLFSREMNIASKIRHPNLLQFIGATT-----EGNPMILTELM-PTSLRKELES------G
.| ..|.|. |||  .   | ||| |.|  | .  .|.  . | .| .| .||||||...| || |      | ..| ||.|  ..| . | .       
IEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQ

GVAYP--AILS---ISLDVACGLNYLHLFKPHPILHRDVSSANVLLQIMGGTWRAKVSDYGSAN-LQPLI----GRTTNPGNPVYSAPEAGNPREHSPSM
 .  .   |..   . .|.| |.|.||   |  |.|||  |.| |  .    ||.||.| | .   .. .    . .|  | | . |||    ..   . 
SIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLLVDK---NWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DVFSYGVLLLEMITRRIPLP---EERVGLIDGIRR------------ASFRSLVKRCLIVEYRHRPTMNDIITE--LND
||.|.| .| |. || .| .    . . ..... .            .|...|...|.  .  |||... || .  |. 
DVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase AqueK566.AA S_TKc 1073-1315 21 2e-29 104.98 SMART 1-231 (231) Show / Hide 
Range on Protein: 1073-1315
Range on HMM: 1-231/231
Sequence Identity: 21% (55 aa)

RMTERILGRGGWGEVRVAHFHG--LEVAAKVLHETIISEYNVSLFSREMNIASKIRHPNLLQFIGATTEGNPMILTELMPT---SLRKELESGG------
    |..|.|. |.|. .. ..   .|| |...           . ||..| .| .|||. .....  ...  . .|....   .|.. ... |      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-VAYPAILSISLDVACGLNYLHLFKPHPILHRDVSSANVLLQIMGGTWRAKVSDYGSANLQPLIGRTTNPGNPVYSAPEAGNPREHSP-SMDVFSYGVLL
      . ..   ..|.|.|.|  .   |.|||.  .|.||       . |..| |.| .      ||  | | | |||      ... . |. | |..|
PFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE-----HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

LEMITRRIPLPEERVGLIDGIRRASFRSLVKRCLIVEYRHRPTMNDIIT----ELNDTVY
 ||.... | | .   ... |.  ........|| .. ..|||  .. .      ..   
YEMLCGYPPFP-QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK566.AA MLK 1073-1268 24 4.1e-28 94.69 In-house 1-235 (291) Show / Hide 
Range on Protein: 1073-1268
Range on HMM: 1-235/291
Sequence Identity: 24% (58 aa)

RMTERILGRGGWGEVRVAHFHGLE-----VAAKVLHETIISEYNVS-----LFSREMNIASKIRHPN----LLQFIGATTE-GN-PMILTELMPT-SLRK
  .....| |. |.|  . ... .     || |  . .|. .  ..      | .| .......|||      || |. .. ..   |..| ..  ||  
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

ELESG---------------GVAYPAILSISLDVACGLNYLHLFKPHPILHRDVSSANVLLQI-----MGGTWRAKVSDYGSAN-LQPL-IGRTTNPGNP
 | ..                .    .....|..| |..|||  .|.|| |||  | |.|.        .||  .|..| | .  ..     .. |.|..
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGT--LKICDFGTSRDWHQMCTNMMSNAGTY

VYSAPEA---GNPREHSPSMDVFSYGVLLLEMITRRIP
 . |||.         | . ||.|.||.| ||.||..|
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase AqueK566.AA Pkinase 1073-1310 20 1.1e-24 88.39 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1073-1310
Range on HMM: 1-293/293
Sequence Identity: 20% (61 aa)

RMTERILGRGGWGEVRVAHFHGLE--VAAKVLH-ETIISEYNVSLFS-REMNIASKIRHPNLLQFIGAT-TEGNPMILTELMPT-----SLRKELE---S
  ..|..|.|. |.|. .| .| .  || |..  ... |. .....  .|  |  ...||| ......  ..... . .|...      .|   ..   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GGV--AYPAILSISLDVACGLNYLHLFKPHPILHRDVSSANVLLQIMGGTW--RAKVSDYGSAN---LQPLIGRTTNPGNPVYSAPEAGN-PREHSPSMD
|..   .  . .. . ...||.|.|      |.|||. ..|.|.    |.   . |..| |.|    . .    ||  | | | |||  .  ....|. |
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

VFSYGVLLLEMITRRIPLPEE-------RVGLIDGIRR-------------------------------ASFRSLVKRCLIVEYRHRPTMNDIITE--L
..|.|..| ||...| | |..          .|. |..                                ......|.|| .    |||  .|     .
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK566.AA TK 1076-1310 13 1.1e-23 75.56 In-house 4-486 (486) Show / Hide 
Range on Protein: 1076-1310
Range on HMM: 4-486/486
Sequence Identity: 13% (66 aa)

ERILGRGG---WGEVRVAHFHGL---------------------------EVAAKVLHETIISEYN-VSL--------------FSREMNIAS--KIRHP
.. ||.|    .|||. .  .|.                           .|| |.|.|.  .. .   .              . .|| . .  . .||
GKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHP

NLLQFIGATTEGN-------------PMILTELMP-TS----LRKELESGG-------------------------------------------------
|.....|. |.|              .||..|.||  .    ||. | .                                                   
NIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDD

----------------------------VAYPAILSISLDVACGLNYLHLFKPHPI----LHRDVSSANVLLQIMGG--------TWRAKVSDYGSAN--
                            .  .  | .....|||. |||  .         |||.   |.|.   .         .  .|..|.| .   
LIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQG

---LQPLIG------RTTNPGNPV-------------------------YSAPEAGN---------PREHSPSMDVFSYGVLLLEMIT--RRIPLP----
   |   |.      |....| ..                         . |||. |          . ...  ||.|.|||. |. |  .  . .    
SGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSN

------------------------------EERVGLI--DGIRR-------------ASFRSLVKRCLIVEYRHRPTMNDIITEL
                              ..|  .   ..                . .  | ..|   . ..|||. ..  .|
QDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK566.AA CZAK 1076-1201 37 2.5e-23 81.64 In-house 4-142 (279) Show / Hide 
Range on Protein: 1076-1201
Range on HMM: 4-142/279
Sequence Identity: 37% (52 aa)

ERILGRGGWGEVRVAHFHGLEVAAKVLHETIISEYNV----SLFSREMNIASKIRHPNLLQFIGATTEGN---PMILTELMP-TSLRKELE--SGGVAY-
..  |.|  |||. |   |  || | .|     .         | .|  | || .||| .||.|| .|..     | .| |   |||. |   .  .   
GQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYHKQN

PAI-LSISLDVACGLNYLHL-FKPHPILHRDVSSANVLL
| . ... .|.| | ||||  .|| |||||| || |.||
PHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILL
Kinase AqueK566.AA TKL-Unique 1075-1268 26 1.7e-21 72.65 In-house 1-233 (290) Show / Hide 
Range on Protein: 1075-1268
Range on HMM: 1-233/290
Sequence Identity: 26% (62 aa)

TERILGRGGWGEVRVAHFHGLEVAAKVLH-ETIISEYNVSLFSREMNIASKIR-HPNLLQFIGATT-----EGNPMILTELMPT-SLRKELE--------
    .|.|| |.|  . ..| .|| |..| .  .|   .  |..| |. .|.. |||.....|...     ..|  | .| .|  ||.. |         
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

---SGGVAYPAILSISLDVACGLNYLHLFKPHPILHRDVSSANVLLQIM--GGTWRAKVSDYGSANLQPLIGRTTNP-----------GNPVYSAPEAGN
   .    .  .... .|.| |..|||  .|  |.|||  | |.|.        |..|..| | . ..  | ..||            |.. ..|||  .
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR

P--REHSPSMDVFSYGVLLLEMITRRI------P
      | . ||.|.|. | |..|| |      |
MNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKP
Kinase AqueK566.AA LISK 1078-1216 30 1.5e-20 63.28 In-house 1-150 (296) Show / Hide 
Range on Protein: 1078-1216
Range on HMM: 1-150/296
Sequence Identity: 30% (47 aa)

ILGRGGWGEV-RVAHF-HGLEVAAKVLH---ETIISEYNVSLFSREMNIASKIRHPNLLQFIGATTE--GNPMILTELMPT-SLRKELESGGV---AYPA
..|.|. |.| .. |.  | ..| | .|   .. . . .   . ||. .  ..|||| .||.|.  .  |  .|.||..    |.  | . ..    .| 
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

IL--SISLDVACGLNYLHLFKPHPILHRDVSSANVLLQIM-GGTWRAKVSDYG
 .  .|.||.|||. |||  .   |.|||  | |.|. .   . ||.|| | |
PQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFG
Kinase AqueK566.AA DRK 1072-1216 37 1.7e-19 62.76 In-house 1-145 (258) Show / Hide 
Range on Protein: 1072-1216
Range on HMM: 1-145/258
Sequence Identity: 37% (56 aa)

IRMTERILGRGGWGEVRVAHFHGLEVAAKVLHETIIS-EYNVSLFSREMNIASKIRHPNLLQFIGATTE-GNPMILTELMPT-SLRKEL--ESGGVAYPA
|    || |||..|||      | .|| | |    |  |  .. | || |. .. ||||  ||.|. ..   . | .| ||  || . |  ||     | 
IKIGNRI-GRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPL

ILSISLDVACGLNYLHLFKPHPILHRDVSSANVLLQIMGGTWRAKVSDYG
.... .|.| |..|||   |  |.|||  | | |       |. ||.|.|
MKQMMFDCAKGMIYLHCCNPI-IIHRDLKSHNLLVD---EHWQVKVADFG
Kinase AqueK566.AA Shk 1075-1271 34 3.1e-19 65.72 In-house 3-209 (269) Show / Hide 
Range on Protein: 1075-1271
Range on HMM: 3-209/269
Sequence Identity: 34% (74 aa)

TERILGRGGWGEVRVAHFHGLEVAAKVLHETIISEYNVSLFSREMNIASKIRHPNLLQFIGATT--EGNPMILTELM-PTSLRKELESGGVAYP------
.| .|| |  | |  .   | ||| ||.| .  .|.  . |  |  | |||.|||.. | || |   |  || ||||  ..| | | .  |  |      
REDFLGQGSFGKVYKGRCRGKEVAVKVMHKQNFDENTMTSFRKEVHIMSKIFHPNICLFMGACTSQPGKCMIVTELMPKGNLEKLLHDQMVKKPFILYKR

AILSISLDVACGLNYLHLFKPHPILHRDVSSANVLLQIMGGTWRAKVSDYG-SANLQPLI----GRTTNPGNPVYSAPEAGNPREHSPSMDVFSYGVLLL
|.. . .| | | | ||   .  |.|||  .|| |  .    || || | | |.  ..      .     | | . |||    ..   . ||.| | .| 
AMR-MCRDAALGMNWLHGSNCN-IIHRDLKTANLLVDQ---NWRVKVCDFGFSQYMKKHEMLKDKQKGAKGTPLWMAPEVMMNHPYNEKADVYSFGIILW

EMITRRIPLP-E
|. |.  | | .
EILTCQEPYPKH
Kinase AqueK566.AA Pkinase_Tyr 1072-1201 25 1.9e-16 56.33 Pfam 1-144 (270) Show / Hide 
Range on Protein: 1072-1201
Range on HMM: 1-144/270
Sequence Identity: 25% (38 aa)

IRMTERILGRGGWGEVRVAHFH------GLEVAAKVLHETIISEY--NVSLFSREMNIASKI-RHPNLLQFIGATT-EGNP---MILTELMPT-SLRKEL
|..  . ||.|  |||. .. .      ...|| |.| |.  .|     .... |..| ... .|||.....|. | .| |   .| .|.||  .|.. |
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

ESG-----GVAYPAILSISLDVACGLNYLHLFKPHPILHRDVSSANVLL
 .       .  . .|......|.|..||.  .   . |||.   |.|.
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLV
Kinase AqueK566.AA TyrKc 1073-1310 22 3.6e-15 22.52 SMART 1-280 (280) Show / Hide 
Range on Protein: 1073-1310
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

RMTERILGRGGWGEVRVAHFHGLEVAAKVLHETIISEYNVSLFSREMNIASKI--RHPNLLQFIGATTE--------GNPMILTELMPT-SLRKELESGG
   ...||.|  |||. ..   ..|| |.|.|       .  | ||..| .|.  .|||.....|. |.        . .||..|.||  .|.. | . .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--VAYPAILSISLDVACGLNYLHLFKPHPILHRDVSSANVLLQIMGGTWRAKVSDYGSANLQPLI------GRTTNP-----GN---PV-YSAPEAGNPR
  .  .  ||.....||| .|||    ... |||    |.|.   .   ..|.|| | .            . .  .     |.   |.   |||. | .
PKLCMKDLLSFCWQIACGMEYLHS---KNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

EHSPSMDVFSYGVLLLEMITRRIPLPEE-----------RVGLIDGIRRASFRS---------------LVKRCLIVEYRHRPTMNDIITEL
. ..  ||.|.||.. |. |.  . ...           .  . .| |.    .               . |.|   .   |||...|. ..
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK566.AA LISK-DD1 1078-1149 25 9.4e-09 28.01 In-house 1-92 (290) Show / Hide 
Range on Protein: 1078-1149
Range on HMM: 1-92/290
Sequence Identity: 25% (24 aa)

ILGRGGWGEVRVAHFHGLEVAAKVLHE----TIISEYNVSLFSREMNIASK---IRHPNLLQFIGATTE--------------GNPMILTELM
. |.|. | |  .   | .|| |..|.     .  .| . .  ||  .      |||||. ||||.  .              .  .|.||..
EIGKGSFGKVYKGCYFGTPVAIKKIHKQPNDPNDPDYWK-FMQREIKMLKNLLNIRHPNIVQFIGICEHPLASPSLVNRLLNESSLYIVTEFI
Kinase AqueK566.AA LISK-DD1 1249-1268 65 6.9e-08 24.84 In-house 211-230 (290) Show / Hide 
Range on Protein: 1249-1268
Range on HMM: 211-230/290
Sequence Identity: 65% (13 aa)

SMDVFSYGVLLLEMITRRIP
| ||||.|..|||.|||..|
SCDVFSFGMVLLELITRKKP
Kinase AqueK566.AA LISK 1249-1270 54 2e-07 20.0 In-house 219-240 (296) Show / Hide 
Range on Protein: 1249-1270
Range on HMM: 219-240/296
Sequence Identity: 54% (12 aa)

SMDVFSYGVLLLEMITRRIPLP
| ||||.|..|.|.|||. . |
SCDVFSFGIVLCEIITRVKADP
Kinase AqueK566.AA LISK-DD1 1168-1216 42 5e-06 17.97 In-house 126-172 (290) Show / Hide 
Range on Protein: 1168-1216
Range on HMM: 126-172/290
Sequence Identity: 42% (21 aa)

LSISLDVACGLNYLHLFKPHPILHRDVSSANVLLQIM-GGTWRAKVSDYG
..|.||.||.  |||  .   |.|||  | | |. .   . ||.|| | |
VKIALDIACAMAYLHSKN---IIHRDLKSKNILVDENGDSQWRIKVCDFG
Kinase AqueK566.AA DRK 1251-1268 44 0.000501 9.57 In-house 184-201 (258) Show / Hide 
Range on Protein: 1251-1268
Range on HMM: 184-201/258
Sequence Identity: 44% (8 aa)

DVFSYGVLLLEMITRRIP
||.|... | |..|| .|
DVYSFAIVLWECVTRQDP
Kinase AqueK566.AA DRK 1283-1312 23 0.010021 5.1 In-house 229-258 (258) Show / Hide 
Range on Protein: 1283-1312
Range on HMM: 229-258/258
Sequence Identity: 23% (7 aa)

ASFRSLVKRCLIVEYRHRPTMNDIITELND
. .  | ..|.  .  |||.| ...  |  
PKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase AqueK566.AA CZAK 1235-1268 32 0.019102 4.88 In-house 188-221 (279) Show / Hide 
Range on Protein: 1235-1268
Range on HMM: 188-221/279
Sequence Identity: 32% (11 aa)

YSAPEAGNPREHSPSMDVFSYGVLLLEMITRRIP
. |||       ..  ||.|.| .| ..|| . |
WMAPECFKGENYTEKVDVYSFGMILWCIITCDQP
Kinase AqueK566.AA TKL-Unique 1284-1310 29 0.028751 4.02 In-house 264-290 (290) Show / Hide 
Range on Protein: 1284-1310
Range on HMM: 264-290/290
Sequence Identity: 29% (8 aa)

SFRSLVKRCLIVEYRHRPTMNDIITEL
..| | ..|   .   ||. ..||..|
EYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase AqueK566.AA MLK 1283-1310 25 0.095203 2.0 In-house 264-291 (291) Show / Hide 
Range on Protein: 1283-1310
Range on HMM: 264-291/291
Sequence Identity: 25% (7 aa)

ASFRSLVKRCLIVEYRHRPTMNDIITEL
... .| |.|   . . ||..  |...|
EHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase AqueK566.AA Pkinase_Tyr 1251-1265 53 0.602102 3.83 Pfam 196-210 (270) Show / Hide 
Range on Protein: 1251-1265
Range on HMM: 196-210/270
Sequence Identity: 53% (8 aa)

DVFSYGVLLLEMITR
|| |.|||. |..|.
DVWSFGVLMWEIFTY
Kinase AqueK566.AA Pkinase_Tyr 1299-1310 41 3.408398 1.28 Pfam 259-270 (270) Show / Hide 
Range on Protein: 1299-1310
Range on HMM: 259-270/270
Sequence Identity: 41% (5 aa)

HRPTMNDIITEL
.|||. .|. .|
DRPTFSEIHEQL