Gene AqueK634 (A.queenslandica)

AqueK634

Species: A.queenslandica
Alias: AqueK634
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH498

Sequence

Name Sequence Type Origin Length Description Download
AqueK634.AA Protein None 617 None Fasta, JSON
AqueK634.kin_dom Protein Kinase Domain None 179 None Fasta, JSON

Protein domain

Protein domains of AqueK634.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kelch_2 AqueK634.AA Kelch_2 188-244 19 1.6e-05 25.07 Pfam 1-51 (51) Show / Hide 
Range on Protein: 188-244
Range on HMM: 1-51/51
Sequence Identity: 19% (11 aa)

KRREHSTVRVGDYLYMWGGSQPDLPKVHNNEKKKSMCSVMEVCDLRTGRWEQKPTTG
 |  |... .|. .|..||.        ..  . . .... ..|..| ||.  |  .
PRYCHASCVPGGKIYVFGGYC------RHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kelch_1 AqueK634.AA Kelch_1 188-244 17 0.112793 9.77 Pfam 1-45 (45) Show / Hide 
Range on Protein: 188-244
Range on HMM: 1-45/45
Sequence Identity: 17% (10 aa)

KRREHSTVRVGDYLYMWGGSQPDLPKVHNNEKKKSMCSVMEVCDLRTGRWEQKPTTG
.|. |. . .....|  ||. .            .  .  |. |..|..|.. |. .
PRCGHGVCVHNGKIYVIGGCDG------------QYLNSVECYDPETNQWTRCPPMP
Kelch_1 AqueK634.AA Kelch_1 249-296 18 2.6e-05 22.84 Pfam 1-45 (45) Show / Hide 
Range on Protein: 249-296
Range on HMM: 1-45/45
Sequence Identity: 18% (9 aa)

GVRNYVAAAIGREIFYFGGWCNHVSCYHNSLYSFNVDTFNWKELSPTT
  ... ..... .|. .||...    | || ......|  |....| .
PRCGHGVCVHNGKIYVIGGCDG---QYLNSVECYDPETNQWTRCPPMP
Kelch_2 AqueK634.AA Kelch_2 249-296 15 0.567705 7.82 Pfam 1-51 (51) Show / Hide 
Range on Protein: 249-296
Range on HMM: 1-51/51
Sequence Identity: 15% (8 aa)

GVRNYVAAAIGREIFYFGGW---CNHVSCYHNSLYSFNVDTFNWKELSPTT
.  . ... .|  |. |||.     . .|...... .. .|  |.....  
PRYCHASCVPGGKIYVFGGYCRHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kinase AqueK634.AA TKL 440-612 20 1.4e-29 103.72 In-house 109-364 (364) Show / Hide 
Range on Protein: 440-612
Range on HMM: 109-364/364
Sequence Identity: 20% (54 aa)

TEGNPIILTELM-PTSLRKELESGGVAYPAILSISLDVACALNYLHLFKP-----HPILHRDVSSANVLLQ-PMG----------GVWRAKVSDYGSANL
..|.. | .|..   ||.  |       . .....||.|...||||  .|      ||.|||  |.|.|.   .             |..|..|.| .  
PWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRF

QPLIG---------------------RTTNPGNPVYSAPEA--GNP--------------REHSPSMDVFSYGVLLLEMITRRIPLPEER----------
    |                     . |  |.| . |||.  |..              .| |...||.|.|..| |..||..|  ..           
MSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPF

----VGLIDGIRR--------------------ASFRSLVERCLIVEYRHRPTMNDIKTEL
    .. .|  .|                     |...| ..|   . . ||....|. .|
EEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK634.AA HH498 467-570 38 2.1e-18 54.58 In-house 121-225 (284) Show / Hide 
Range on Protein: 467-570
Range on HMM: 121-225/284
Sequence Identity: 38% (42 aa)

PAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGVWRAKVSDYG-SANLQPLIGRT-TN-PGNPVYSAPEAGN-PREHSPSMDVFSYGVLLL
. .. ||.|||   ||||   .||| |||  | |.|.   |   .|.| |.| |  .. .   . |  |||. . |||        |   |||||.  . 
QSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDG---HAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIW

EMITRRIP
|| ||..|
EMHTREVP
Kinase AqueK634.AA MLK 469-570 31 1.9e-17 57.16 In-house 126-235 (291) Show / Hide 
Range on Protein: 469-570
Range on HMM: 126-235/291
Sequence Identity: 31% (35 aa)

ILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQP-----MGGVWRAKVSDYGSAN-LQPL-IGRTTNPGNPVYSAPEA---GNPREHSPSMDVFSYG
.....|..| ...|||  .|.|| |||  | |.|.        .|.  .|..| | .  ..     .. |.|.. . |||.         | . ||.|.|
AMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGT--LKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWG

VLLLEMITRRIP
|.| ||.||..|
VVLWEMLTREVP
Kinase AqueK634.AA Pkinase 439-612 18 1.8e-16 59.35 Pfam 70-293 (293) Show / Hide 
Range on Protein: 439-612
Range on HMM: 70-293/293
Sequence Identity: 18% (43 aa)

TTEGNPIILTELMPT-----SLRKELE---SGGV--AYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGV-WRAKVSDYGSAN---LQP
...... . .|...      .|   ..   .|..   .  . .. . ....|.|.|      |.|||. ..|.|.   | .  . |..| |.|    . .
EDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-N

LIGRTTNPGNPVYSAPEAGN-PREHSPSMDVFSYGVLLLEMITRRIPLPEE-------RVGLIDGIRR-------------------------------A
    ||  | | | |||  .  ....|. |..|.|..| ||...| | |..          .|. |..                                
NS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSE

SFRSLVERCLIVEYRHRPTMNDIKTE--L
........|| .    |||  .|.    .
ECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK634.AA Dicty5 464-570 31 3.6e-16 52.13 In-house 101-202 (260) Show / Hide 
Range on Protein: 464-570
Range on HMM: 101-202/260
Sequence Identity: 31% (34 aa)

VAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGVWRAKVSDYG-SANLQPLIGRTTNPGNPVYSAPEAGNPREHSPSMDVFSYGVLLL
.||. .|.. .|.| .. .||      | |||. | |.|.      | .|. |.| | .     . |.. | . . |.|  | .      ||.|.|. | 
IAYFQQLHMAIDIAQSMRHLHSMN---IIHRDLKSMNFLITEN---WKIKIIDFGTSRFVDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLW

EMITRRIP
||.||  |
EMFTRKEP
Kinase AqueK634.AA STE 479-607 18 1.6e-13 44.26 In-house 163-350 (359) Show / Hide 
Range on Protein: 479-607
Range on HMM: 163-350/359
Sequence Identity: 18% (37 aa)

A-LNYLHLFKPHPILHRDVSSANVLLQPMGGVWRAKVSDYGSAN-LQPLIG-----------------RTTNPGNPVYSAPEAGNP------REHSPSMD
. |.|||  .   | |||. .||.||        .| .| | .  |.. .                  |.|  | | . |||  ..       ... . |
GLLYYLHSHH---IIHRDIKPANILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCD

VFSYGVLLLEMITRRIPL---PEERVGLIDGIRR-------------------------------------------ASFRSLVERCLIVEYRHRPTMND
. | | ...||.| . |.   .  |. .   .                                              .|.  ...||. ....||| ..
IWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ
Kinase AqueK634.AA LRRK 472-570 29 2.8e-13 43.31 In-house 169-282 (351) Show / Hide 
Range on Protein: 472-570
Range on HMM: 169-282/351
Sequence Identity: 29% (35 aa)

ISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMG---------GVWRAKVSDYGSAN----LQP-LIGRTTNPGNPVYSAPEAGNPR---EHSPSMDV
|.|..| ...||| ..| ||.|||  | |.||. .              ||..|.|       ... .. . .  |||.. |||  .     | .   |.
IALQIAKGMEYLHSHNP-PIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCV--GNPGWMAPEIMRYNGEEEYTEKVDC

FSYGVLLLEMITRR-IP
.|.|..| | .||. .|
YSFGMILWELLTRQHHP
S_TKc AqueK634.AA S_TKc 393-617 18 5.9e-13 13.12 SMART 1-231 (231) Show / Hide 
Range on Protein: 393-617
Range on HMM: 1-231/231
Sequence Identity: 18% (46 aa)

ILFGGDTANGESNNVYILNFTD-TSVNCSKLSNPGGSVQWPKERRGAT--------------TEGNPIILTELMPT---SLRKELESGG-------VAYP
  ..     |    ||    ..   .   |  .     .  .|..                 . ..  . .|....   .|.. ... |           
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-

AILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGVWRAKVSDYGSANLQPLIGRTTNPGNPVYSAPEAGNPREHSP-SMDVFSYGVLLLEMIT
 . ..   ..|||.|.|  .   |.|||.  .|.||       . |..| |.| .      ||  | | | |||      ... . |. | |..| ||..
HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE-----HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

RRIPLPEERVGLIDGIRRASFRSLVERCLIVEYRHRPTMNDIKT----ELNDTVY
.. | | .   ... |.  ........|| .. ..|||  .. .      ..   
GYPPFP-QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK634.AA TK 437-612 12 1.6e-12 37.54 In-house 110-486 (486) Show / Hide 
Range on Protein: 437-612
Range on HMM: 110-486/486
Sequence Identity: 12% (48 aa)

GATTEGN-------------PIILTELMP-TS----LRKELESGG-------------------------------------------------------
|. |.|              ..|..|.||  .    ||. | .                                                         
GVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHP

----------------------VAYPAILSISLDVACALNYLHLFKPHPI----LHRDVSSANVLLQ-PMGGVWR-------AKVSDYGSAN-----LQP
                      .  .  | .....||.. |||  .         |||.   |.|.   .   |        .|..|.| .      |  
PPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLAR

LIG------RTTNPGNPV-------------------------YSAPEAGN---------PREHSPSMDVFSYGVLLLEMIT--RRIPLP----------
 |.      |....| ..                         . |||. |          . ...  ||.|.|||. |. |  .  . .          
DIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKD

------------------------EERVGLI--DGIRR-------------ASFRSLVERCLIVEYRHRPTMNDIKTEL
                        ..|  .   ..                . .  |  .|   . ..|||. ... .|
GDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK634.AA CZAK 470-503 54 2.8e-11 37.38 In-house 108-142 (279) Show / Hide 
Range on Protein: 470-503
Range on HMM: 108-142/279
Sequence Identity: 54% (19 aa)

LSISLDVACALNYLHL-FKPHPILHRDVSSANVLL
... .|.|   ||||  .|| |||||| || |.||
WNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILL
Kinase AqueK634.AA LISK-DD1 551-570 65 6.9e-08 24.84 In-house 211-230 (290) Show / Hide 
Range on Protein: 551-570
Range on HMM: 211-230/290
Sequence Identity: 65% (13 aa)

SMDVFSYGVLLLEMITRRIP
| ||||.|..|||.|||..|
SCDVFSFGMVLLELITRKKP
Kinase AqueK634.AA LISK 551-572 54 2e-07 20.0 In-house 219-240 (296) Show / Hide 
Range on Protein: 551-572
Range on HMM: 219-240/296
Sequence Identity: 54% (12 aa)

SMDVFSYGVLLLEMITRRIPLP
| ||||.|..|.|.|||. . |
SCDVFSFGIVLCEIITRVKADP
TyrKc AqueK634.AA TyrKc 410-612 15 3.4e-07 -106.37 SMART 1-280 (280) Show / Hide 
Range on Protein: 410-612
Range on HMM: 1-280/280
Sequence Identity: 15% (46 aa)

LNFTDT---------------------SVNCSKLSNPGGSVQWPKERR-----G------------ATTE-------GNPIILTELMPT-SLRKELESGG
. . ..                     ... ..           .| |     |            .|..       . . |..|.||  .|.. | . .
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--VAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGVWRAKVSDYGSANLQPLI------GRTTNP-----GN---PV-YSAPEAGNPR
  .  .  ||.....||  .|||    ... |||    |.|.   .   ..|.|| | .            . .  .     |.   |.   |||. | .
PKLCMKDLLSFCWQIACGMEYLHS---KNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

EHSPSMDVFSYGVLLLEMITRRIPLPEE-----------RVGLIDGIRRASFRS---------------LVERCLIVEYRHRPTMNDIKTEL
. ..  ||.|.||.. |. |.  . ...           .  . .| |.    .               . ..|   .   |||...|. ..
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK634.AA LISK 470-518 42 1e-06 17.66 In-house 104-150 (296) Show / Hide 
Range on Protein: 470-518
Range on HMM: 104-150/296
Sequence Identity: 42% (21 aa)

LSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPM-GGVWRAKVSDYG
..|.||.||.. |||  .   |.|||  | |.|.     ..||.|| | |
VKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFG
Kinase AqueK634.AA LISK-DD1 470-518 44 1e-05 16.89 In-house 126-172 (290) Show / Hide 
Range on Protein: 470-518
Range on HMM: 126-172/290
Sequence Identity: 44% (22 aa)

LSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPM-GGVWRAKVSDYG
..|.||.|||  |||  .   |.|||  | | |.     . ||.|| | |
VKIALDIACAMAYLHSKN---IIHRDLKSKNILVDENGDSQWRIKVCDFG
Kinase AqueK634.AA Pkinase_Tyr 437-503 24 0.001409 12.74 Pfam 71-144 (270) Show / Hide 
Range on Protein: 437-503
Range on HMM: 71-144/270
Sequence Identity: 24% (19 aa)

GATT-EGNP---IILTELMPT-SLRKELESG-----GVAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLL
|. | .| |   .| .|.||  .|.. | .       .  . .|......|....||.  .   . |||.   |.|.
GVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLV
Kinase AqueK634.AA CZAK 537-570 32 0.019102 4.88 In-house 188-221 (279) Show / Hide 
Range on Protein: 537-570
Range on HMM: 188-221/279
Sequence Identity: 32% (11 aa)

YSAPEAGNPREHSPSMDVFSYGVLLLEMITRRIP
. |||       ..  ||.|.| .| ..|| . |
WMAPECFKGENYTEKVDVYSFGMILWCIITCDQP
Kinase AqueK634.AA Pkinase_Tyr 553-567 53 0.602102 3.83 Pfam 196-210 (270) Show / Hide 
Range on Protein: 553-567
Range on HMM: 196-210/270
Sequence Identity: 53% (8 aa)

DVFSYGVLLLEMITR
|| |.|||. |..|.
DVWSFGVLMWEIFTY