Gene HisK_d (S.moellendorffii)
HisK_d
Species: S.moellendorffii
Alias: HisK_d
External Links:
Annotation:
Sequence
Protein domains of HisK_d.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| GAF | HisK_d.AA | GAF | 172-318 | 19 | 2.7e-15 | 56.06 | Pfam | 1-160 (160) | Show / Hide |
Range on Protein: 172-318
Range on HMM: 1-160/160
Sequence Identity: 19% (34 aa)
DRHKILSTTMIELSHTLELESCNI--WMPRASANVL-ELAHKLGAQDTFAPPEIPLSTSLVDLVFSNNGAVV-----VPSKALGPLAGAGQT--------
|.. || |.| ||...|... | | ...... ..| . || .. .... .|. .... || . ..| | . .|... ...
DLEEILQTIMQELRQLLGCDRCMIYFFLWDEDGWELYWVAHWGWSDQPQQAR-LPM-GGIWGEVFCTCNPIVVPDVCDPRFR-WPCVDEDRPEHHHCHCH
-----SFNHGSVVAIRIPLLASS-GCVSHPDKECYALMVLSFPKNLQ-KAWGDHELE--LVEAVADQVAVAL
. |.... | . . | . ||.. . . ..| .|.|| |....|||.|.|.
YMRHMHHGIRSCLCVPIFDIIGQPGQQ--------VWGVLCCHHC-PPRHWTEHDLECFLLQMFADQIAIAI
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| GAF | HisK_d.AA | GAF | 172-328 | 14 | 1e-10 | 42.81 | SMART | 1-142 (142) | Show / Hide |
Range on Protein: 172-328 Range on HMM: 1-142/142 Sequence Identity: 14% (24 aa) DRHKILSTTMIELSHTLELESCNIWMPRA-SANVLELAHKLGAQDTFAPPEIPLSTSLVDLVFSNNGAVVVPSKALGPL---AGAGQTSFNHGSVVAIRI | . |. |.. |. ..|... | |.. . . . .|. .. ..|.. .... |. . |..| .. .... .. . .. . DLEEICQTIVEEVHQFLQMDRCMIYLFDERQNDHGQLWCHASD-------HFPPD-GICGWVWRTGRPVNIP-DVHHDPHFFCWKDWL-RYQ-IRSFLCV PLLASSGCVSHPDKECYALMVLSFPKN-LQKAWGDHELELVEAVADQVAVALSHAAVVEETL |... . . ..|| . . | ....|.....|.|||.|...|. .|. PIMND---------DGQVWGVLCAHHCHQPRHWTEEDEEFLQMIANQVAIAIQQAQLYEQLQ |
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| HisKA | HisK_d.AA | HisKA | 354-419 | 44 | 1.1e-20 | 75.11 | Pfam | 1-69 (69) | Show / Hide |
Range on Protein: 354-419 Range on HMM: 1-69/69 Sequence Identity: 44% (31 aa) ARNEFLVVMNHEMRTPMHAIIALSSLLLD-SGLTSDQ--QSMVETISKSGSLLSTLINDVLDFSRLEAG |...|| | ||.|||..||.....||.| . |...| . ..||| ... .. ||||.|||||.||| AKRQFLANMSHELRTPLTAIRGYAELLQDYTDLDPEQMRREYLETIQREAQRMQRLINDLLDFSRIEAG |
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| HisKA | HisK_d.AA | HisKA | 354-419 | 33 | 1.5e-20 | 75.51 | SMART | 1-89 (89) | Show / Hide |
Range on Protein: 354-419 Range on HMM: 1-89/89 Sequence Identity: 33% (30 aa) ARNEFLVVMNHEMRTPMHAIIALSSLLLD----------SGLTSDQ-------------QSMVETISKSGSLLSTLINDVLDFSRLEAG |...|| | ||.|||..||.....||.| . |...| . ..||| ... .. ||||.||.||.||| AKRQFLANMSHELRTPLTAIRGYAELLQDWYYKQRYHHWTDLDPEQRLPMLRREFNCEYREYLETIQREADRMQRLINDLLDLSRIEAG |
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| HATPase_c | HisK_d.AA | HATPase_c | 466-599 | 26 | 1e-38 | 135.9 | SMART | 1-130 (130) | Show / Hide |
Range on Protein: 466-599 Range on HMM: 1-130/130 Sequence Identity: 26% (44 aa) GDSTRILQVLLNVVGNAIKFTAQ--------------GHVHLTVFASKAPDAQVSHEPASPGRCMTQRYIHFEVEDTGIGIRA------TDLPRLFNKFV || .|. |||.|...||||.| . |.....| ...|||.|.|| . |.||.| .|. GDPDRLRQVLWNLLDNAIKHTPEGHADPDLHDGKPGGGRITVRVH-------------------------RITVEDNGPGIPPEMHKSIEDIPRIFEPFY QADS--------STSRKYGG--SGLGLAISKKFVELMNGSISITSEGLDKGSTCRFYVRVSVVS ..|. |.|||||| .||||.|.|..||...|.|... ..|.... . RTDDSPSRMCPDSRSRKYGGGLTGLGLSICKRIVEQHGGTIWVE---------TTFTFTLPLER |
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| HATPase_c | HisK_d.AA | HATPase_c | 466-596 | 33 | 1.3e-37 | 133.17 | Pfam | 1-120 (120) | Show / Hide |
Range on Protein: 466-596 Range on HMM: 1-120/120 Sequence Identity: 33% (47 aa) GDSTRILQVLLNVVGNAIKFTAQ-GHVHLTVFASKAPDAQVSHEPASPGRCMTQRYIHFEVEDTGIGIRA------TDLPRLFNKFVQADS-STSRKYGG || .|. ||..|.|.||||.|.. ||....| . . .....|||.|.|| . |.||.| .|...|. |. ||||| GDPDRLHQVVWNLVDNAIKHTPEGGHITVRVHRDD-------------------DHVRITVEDNGPGIPPEMHSIAEDIPRIFEPFYRTDPDSR-RKYGG --SGLGLAISKKFVELMNGSISITSEGLDKGSTCRFYVRVS .||||.|....||...|.|...|| ..|.| .|.. . GLTGLGLYICRRIVEQHGGTIWVESEP-GGGTTFTFTLPLE |
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| Kinase | HisK_d.AA | HisK | 466-596 | 21 | 1.3e-24 | 85.38 | In-house | 1-164 (164) | Show / Hide |
Range on Protein: 466-596 Range on HMM: 1-164/164 Sequence Identity: 21% (38 aa) GDSTRILQVLLNVVGNAIKFTAQG------HVHLTVF--------------ASKAPDAQVSHEPASPGRCMTQR-------YIHFEVEDTGIGIRATDLP | || |.|.| ..||.||| .| .. . | .| . | . .| . |.|||.|. .. SDPNRIKQILINLISNALKFTQKGGIPFQGYIKIKVEQINTQNNIKYNSIFIQKIQEN------------M-VQEQLQQKNLIQISVQDTGCGMPEEQQK RLFNKFVQ----------ADSSTSR--KYGGSGLGLAISKKFVELMN--------GSISITSEGLDKGSTCRFYVRVS .|..| . .. . . | ||||.|........ ..|.. || .|||| ||.. KIFKMFGNIDDQHQMIKKTFNHQNKKNNQHGCGLGLTICNNLAKGLGPEHNQNGNRGIQVQSE-VGKGSTFSFYIYNN |
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| REC | HisK_d.AA | REC | 620-736 | 23 | 3.5e-32 | 114.17 | SMART | 1-150 (150) | Show / Hide |
Range on Protein: 620-736 Range on HMM: 1-150/150 Sequence Identity: 23% (37 aa) LKILAVDDN----AVNRTVIR------RLLNNLGCK--------STVVESGE-------TCLKTLAAEGPSA----------YSIVLVDLCMP------- ..|| |||. .|.| ..| ||| .|. ... .|| |. |... ... . ....|. || MRILIVDDDPAMAPVIREMLRNYTVIQRLLEKEGYENKMWMVEVVDEA-DGETLMNEIWEALELLQEHRDKKEDATTDQSEPPDLIIMDIMMPGDPFEDG EMDGYELTAEIQKLYPREGLHIVALTANTDDSTREKCLSLGMKAVLTKPVSLKALRNEL .|||.||. .|. |..|||..|...|...| .|. . .|||.... |. . GMDGIELCRRIR--------PIIMLTAHDDEEDRVRALEAGADDYITKPFDPEELLARI |
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| Response_reg | HisK_d.AA | Response_reg | 622-737 | 25 | 2e-29 | 107.93 | Pfam | 1-115 (115) | Show / Hide |
Range on Protein: 622-737 Range on HMM: 1-115/115 Sequence Identity: 25% (30 aa) ILAVDDNAVNRTVIRRLLN-NLGC-KSTVVESGETCLKTLAAEGPSAYSIVLVDLCMPEMDGYELTAEI-QKLYPREGLHIVALTANTDDSTREKCLSLG .| |||. ..| ..|..|. |. . .....|| .|. . .. . ... |. ||.|||.||...| .... . .. |...||. |.......| .| VLIVDDHPLMREGLRQILEQKEGYEVVAEADDGEEALEWWQEHH---PDLIIMDINMPGMDGLELCRRIRRQHP-HPQTPIIMCTAHGDEDDAVEALQAG MKAVLTKPVSLKALRNELK . .|||... .|..... ANDYITKPFDPDELHAAIR |
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