Gene CDK7-1 (S.moellendorffii)

CDK7-1

Species: S.moellendorffii
Alias: CDK7-1
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDK7

Sequence

Name Sequence Type Origin Length Description Download
CDK7-1.AA Protein None 400 None Fasta, JSON
CDK7-1.NA RNA None 1203 None Fasta, JSON
CDK7-1.kin_dom Protein Kinase Domain None 281 None Fasta, JSON

Protein domain

Protein domains of CDK7-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDK7-1.AA CDK7 13-293 53 1.3e-215 581.28 In-house 1-288 (288) Show / Hide 
Range on Protein: 13-293
Range on HMM: 1-288/288
Sequence Identity: 53% (154 aa)

YVKGISLGEGTYGVVFKALDTQTNRTVAVKKIR-LGKYKE---GVHVTALREIKLLKELRDPNIIELIDVYPHKRNLHLVFEFMESDLEAVIRDRNILLS
| |   .|||....|.||.|.||.. ||.|||. ||   |   |.  ||.||||.|.|.. .|.|.|||.. || |. |||.||. ||| ||.|  |.| 
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

PADVKSYMQMCLRGLAHCHKKWVLHRDLKPNNLLISSDGQLKLGDFGLARIFGSPDRKFTHQVFARWYRSPELLFGSKQYGSGVDIWAAGCIFAELLLRR
||..|.|| | |.|| .||. |.|||||||||||....||||..|||||| .||| | .||||  ||||.|||||| ..||.|||.|. |||||||.|| 
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

PFLQGSSDIDQLGKIFQAFGTPRETQWPDMTSLPDYVEFQFTPA---PALRSLFPMATEDALDLLSKMFAFDPKARITAQQALEHRYF
|.| | |||||| .|||. ||| | .||.|....||..|.  |.    .|| .|  |..|.|||...|....| .|.|. |.|.. ||
PYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CDK7-1.AA CDK 13-293 44 9.5e-159 511.66 In-house 1-284 (284) Show / Hide 
Range on Protein: 13-293
Range on HMM: 1-284/284
Sequence Identity: 44% (141 aa)

YVKGISLGEGTYGVVFKALDTQTN-----RTVAVKKIRLGK-----YKEGVHVTALREIKLLKELRDPNIIELIDVYPHK-----------RNLHLVFEF
| |   .||||||||.|| |.||.     . || ||||. .      |||.  ||.|||.|||||  |||. |.||...|           ..| .|||.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

MESDLEAVIRDRNILLSPADVKSYMQMCLRGLAHCHKKWVLHRDLKPNNLLISSDGQ-----LKLGDFGLARIFGS------PDRKFTHQVFARWYRSPE
|. ||  ...          .|.||.. ||||..||..|..||||||.|.||...|.     ||..||||||.||.      | |..||.|  .|||.||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

LLFGSKQYG--SGVDIWAAGCIFAELLL---RRPFLQGSSDIDQLGKIFQAFGTPRETQWPDMTSLPDYVEFQFTPAPALRSLFPMATEDALDLLSKMFA
||.|||.|.   ..|.|..||||||...   |.|...|.|.|||| |||. .||| | .||..|.||||                       |||.||..
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-----------------------DLLNKMLC

FDPKARITAQQALEHRYF
.||| ||.|.|||.| ||
YDPKKRISAEQALQHPYF
Kinase CDK7-1.AA CDC2 13-293 45 5.6e-138 426.9 In-house 1-301 (301) Show / Hide 
Range on Protein: 13-293
Range on HMM: 1-301/301
Sequence Identity: 45% (137 aa)

YVKGISLGEGTYGVVFKALDTQTNRTVAVKKIRLGKYKEG--VHVTALREIKLLKELR-DPNIIELIDVYPHKRNLHLVFEFMESDLEAVIR---DRNIL
| |   .||||||||.|. |.|||. ||.|||||    ||  |  ||.||| .||||. .|||. | ||.   ..| .|||... ||    .     |  
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

LSPADVKSYMQMCLRGLAHCHKKWVLHRDLKPNNLLISSDGQLKLGDFGLARIFGSPDRKFT--HQVFARWYRSPELLFGSKQYGSGVDIWAAGCIFAEL
..|. |||||   |.|...|| . ..|||||| |.||...|..|..|||||| || | |. |  | |  .|||.||.|.|.|.|  .||.|. ||||||.
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---LLRRPFLQGSSDIDQLGKIFQAFGTPRETQWPDMTSLPDYVEF--QFTPAPALRSLFPM---------ATEDALDLLSKMFAFDPKARITAQQALEH
     ..|. .| | |||| |||. .||| |  ||..|.|||| .   ...|   |....|.         ......|||..| . ||  ||.|..||.|
FMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQ-DLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQH

RYF
.||
PYF
Kinase CDK7-1.AA CMGC 13-293 27 1.3e-135 448.53 In-house 1-513 (513) Show / Hide 
Range on Protein: 13-293
Range on HMM: 1-513/513
Sequence Identity: 27% (140 aa)

YVKGISLGEGTYGVVFKALDTQTN--------------RTVAVKKIRLGKY---------KEGVHVTALREIKLLKELR-----------------DPNI
| .   .||||||||.|. |..||              . ||.|||.. .|         |.|.  .||||||.||.|.                 ..||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

IELIDVYPHKR-----------------NLHLVFEFMESDLEAVIRD--------RNILLSPAD------------VKSYM------QMCLRGLA--HCH
. |.|.. ||                  .|.||||.|. ||  .|..        |.. ||.              .|..|      .. ||||.  .||
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

KKW--VLHRDLKPNNLLISSD--------------------GQLKLGDFGLARIFGSP---------------------DRKFTHQVFARWYRSPELLFG
..|  ..|||||| |.||...                    |.||..||||||.....                      | .||.|  ||||.||.|.|
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

SKQY---------GSGVDIWAAGCIFAELLLR--------RPFLQGSSD-----------IDQLGKIFQAFGTPR---------------ETQWPDMTSL
.|.|         ....|.|..||||||....        .|. .|.|.           |||| |||. .|||                | .||.|..|
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

PDYVE---------------------------FQFTPAPALRSLFPM-----------------------------------ATEDALDLLSKMFAFDPK
|.|                             |.  | . ...|||                                    ....|.|||.||. .||.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

ARITAQQALEHRYF
 ||||.|||.| ||
KRITAEQALQHPYF
Kinase CDK7-1.AA CDK5 13-293 47 7.69999999999e-125 396.57 In-house 1-287 (287) Show / Hide 
Range on Protein: 13-293
Range on HMM: 1-287/287
Sequence Identity: 47% (135 aa)

YVKGISLGEGTYGVVFKALDTQTNRTVAVKKIRLGKYKEGVHVTALREIKLLKELRDPNIIELIDVYPHKRNLHLVFEFMESDLEAVIRDRNILLSPADV
| |   .||||||.|.||.. .|   || |..||    |||  ||.||| |||||. .||. |.||    . | |||||.  ||   . ..|  .... .
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

KSYMQMCLRGLAHCHKKWVLHRDLKPNNLLISSDGQLKLGDFGLARIFGSPDRKFTHQVFARWYRSPELLFGSKQYGSGVDIWAAGCIFAELL-LRRPFL
||.|   |.||| ||.. |||||||| ||||.  |.|||.|||||| || | | ..| |   ||| |  |.|||.|   .|.| .||||||.    ||  
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

QGSSDIDQLGKIFQAFGTPRETQWPDMTSLPDY----VEFQFTPAPA-LRSLFPMATEDALDLLSKMFAFDPKARITAQQALEHRYF
 |... ||| .||.  ||| | .|| .| ||||    ...   ||   . .. |   |  .|||.||  ..|. ||.|..||.| ||
PGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDK7-1.AA PITSLRE 13-293 41 1.3e-108 367.14 In-house 1-295 (295) Show / Hide 
Range on Protein: 13-293
Range on HMM: 1-295/295
Sequence Identity: 41% (123 aa)

YVKGISLGEGTYGVVFKALDTQTNRTVAVKKIRLG--KYKEGVHVTALREIK-LLKELRDPNIIEL--IDVYPHKRNLHLVFEFMESDLEAVIRDRN---
...  . .|||||||..| |..|.. || |.. ..  | |||  .|.||||. .|..|. |||. .  | .   .    .|.|..| ||  ..   .   
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

ILLSPADVKSYMQMCLRGLAHCHKKWVLHRDLKPNNLLISSDGQLKLGDFGLARIFGSPDRKFTHQVFARWYRSPELLFGSKQYGSGVDIWAAGCIFAEL
   .|  .|. ||  ||| .| |..|..|||||  |||.|  |.||..|||||| .||| ...|  |   |||.|||| |.| |   ||.|  ||||||.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

LLRRPFLQGSSDIDQLGKIFQAFGTPRETQWPDMTSLPDYVEFQ-FTPAPA--LRSLFP---MATEDALDLLSKMFAFDPKARITAQQALEHRYF
.. .| .||.|.|||. .||...||| |  ||. |.||    .. |.. |   ||..||     .. ..||| .|  ..||.|||| .|| | .|
ITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase CDK7-1.AA CCRK 13-293 49 1.1e-105 357.47 In-house 1-285 (285) Show / Hide 
Range on Protein: 13-293
Range on HMM: 1-285/285
Sequence Identity: 49% (142 aa)

YVKGISLGEGTYGVVFKALDTQTNRTVAVKKIRLGKYKEGVHVTALREIKLLKELRDPN-IIELIDVYPHKRNLHLVFEFMESDLEAVIRDRNILLSPAD
|     .|||  |.||||    |   ||.||. | .  .|.  .|||||| |.|. |   ...| ||.||     |||||| |||  |.|. .  |..| 
YCILDRIGEGAHGIVFKAKHVETGEIVALKKVALRRLDDGIPNQALREIKALQEIEDNQYVVQLKDVFPHGTGFVLVFEFMLSDLAEVVRHAQRPLAEAQ

VKSYMQMCLRGLAHCHKKWVLHRDLKPNNLLISSDGQLKLGDFGLARIFGSPD--RKFTHQVFARWYRSPELLFGSKQYGSGVDIWAAGCIFAELLLRRP
||||||| |.|.||||.  ..|||||| |||||  |.||. ||||||.| |.|  |..||||  |||| ||||.| .||  |||.|| |||. |||   |
VKSYMQMLLKGVAHCHENNIMHRDLKPANLLISESGHLKIADFGLARVF-SNDEGRQYTHQVATRWYRAPELLYGARQYDQGVDLWAVGCIMGELLNNSP

FLQGSSDIDQLGKIFQAFGTPRETQWPDMTSLPDY--VEFQFTPAPALRSLFPMATEDALDLLSKMFAFDPKARITAQQALEHRYF
   |  ||.||  .    ||| .  ||.|. ||||  . |.  |   |  . | |  .||||| .   . |. ||.| ||| |.||
IFPGENDIEQLCCVLRILGTPTPKVWPEMKDLPDYNKISFKEQPPMPLEQVVPDASPQALDLLKQFLVYPPRQRIAASQALLHQYF
Kinase CDK7-1.AA CDK-Unclassified 13-293 31 8.5e-99 325.66 In-house 1-324 (324) Show / Hide 
Range on Protein: 13-293
Range on HMM: 1-324/324
Sequence Identity: 31% (102 aa)

YVKGISLGEGTYGVVFKALDTQTNRTVAVKKIRLGKYKE----------GVHVTALREIKLLKELRDPNIIELIDVYPHKRNLH-------------LVF
|     .||||.| |.||.|.||.. || ||| .   |              .|..|||..|. . . |||...|...    .              .| 
YRMQCKYGEGTFGCVCKAIDFQTQKHVAIKKIMVNNKKGNKCKHILPLLNSKITDQREISCLQNCNHMNIIKFMDMHYDHDRCSKNPYYDNLHPSFYMVM

EFMESDLEAVIRDRNILLSPADVKSYMQMCLRGLAHCHKKWVLHRDLKPNNLLISSDG-----QLKLGDFGLARIFG------------SPDRKFTHQVF
| |  ..  .     . ||  ... .|   | |.|  | .   |||.|| |..|.. .      ||..|||.|.                |..... ||.
EYMPYTWYNQLHNNRYNLSMCQIRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPMLKIADFGQACFYMNCPPNLNYQTPADPMQQYSTQVS

ARWYRSPELLFGSKQYGSGVDIWAAGCIFAELLLRRPFLQGSSDIDQLGKIFQAFGTPRETQWPDMTSLPDYVEFQFTPAPALR-----SLFPMATEDAL
 ||||.||||||||.|. |||||..|||.||.. . | .|| ..|.|...||.  |||.| .|||....|||    | . . ..      ..  |.|  .
TRWYRAPELLFGSKCYDTGVDIWSFGCIYAEWFQGKPIFQGRTEIEQMHHIFKMLGTPCEDMWPDWRYMPDYCKIFFKYKQKFHWWNRFPKCKHASE--N

DLLSKMFAFDPKARITAQQALEHRYF
.... | ...|. | .....| | .|
NCEFQMVMYQPYNRWKCMEILQHPWF
Kinase CDK7-1.AA Pkinase 13-293 33 3e-96 330.85 Pfam 1-293 (293) Show / Hide 
Range on Protein: 13-293
Range on HMM: 1-293/293
Sequence Identity: 33% (100 aa)

YVKGISLGEGTYGVVFKALDTQTNRTVAVKKIRLGKYKEGVHVTALR--EIKLLKELRDPNIIELIDVYPHKRNLHLVFEFMES-----DLEAVIR-DRN
|..|  .|.|..|.|.|. .  |...||||.|.. . |.....|..|  ||...|.|. |||..|.|..  |.....|.|..|      || ..|. .|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

ILL--SPADVKSYMQMCLRGLAHCHKKWVLHRDLKPNNLLISSDGQL----KLGDFGLARIF-GSPDRKFTHQVFARWYRSPELLFGSKQYGSGVDIWAA
  .  |. ..|.||   ||||..||.....|||||| |.||...|..    |..|||||. |   ... .|. .  .||..||.. |.. ||. ||.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCIFAELLLRRPFLQGS----SDIDQLGKIFQAFGTPRETQWPDMTSLPDYVEFQFTPAPALRSLFPMATEDALDLLSKMFAFDPKARITAQQALEHRYF
|||..|.|..||  .|.    . .||. .|..  |.| . .||   | ...  |.. ... .. . . ..|...|........||| |.||.|.|.| .|
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-WHF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CDK7-1.AA S_TKc 13-293 27 8e-96 325.56 SMART 1-231 (231) Show / Hide 
Range on Protein: 13-293
Range on HMM: 1-231/231
Sequence Identity: 27% (81 aa)

YVKGISLGEGTYGVVFKALDTQTNRTVAVKKIRLGKYKEGVHVTALREIKLLKELRDPNIIELIDVYPHKRNLHLVFEFMES---DLEAVIRDRNIL---
| ..  .|.|..|.|.|. .. |.| ||.|.|.          ...|||..||. . |||. |.||. .  .|..|.|...    ||  .|..|.     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LSPADVKSYMQMCLRGLAHCHKKWVLHRDLKPNNLLISSDGQLKLGDFGLARIFGSPDRKFTHQVFARWYRSPELLFGSKQYGS-GVDIWAAGCIFAE
  ... ....||.  ...|..||.....|||||| |.|...  ..|..||||||..       |...  .||..||.|    .||   .|.|. |||..|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

LLLRRPFLQGSSDIDQLGKIFQAFGTPRETQWPDMTSLPDYVEFQFTPAPALRSLFPMATEDALDLLSKMFAFDPKARITAQQALE-------HRYF
.| ..|  .      |. ..|.  |                                  ...|.|...|.. .||. |.|| .||.       | .|
MLCGYPPFP------QMQMMFKKIG----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CDK7-1.AA MAPK 13-293 33 7.4e-93 314.79 In-house 1-328 (328) Show / Hide 
Range on Protein: 13-293
Range on HMM: 1-328/328
Sequence Identity: 33% (111 aa)

YVKGISLGEGTYGVVFKALDTQ------TNRTVAVKKIR-----LGKYKEGVHVTALREIKLLKEL-RDPNIIELIDVYPHK-----------RNLHLVF
|.    .|.| ||||..| |.       ....||.|||      .   |      ..||||||... ...||| |.|..  .           . . .|.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCK-----RTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVM

EFMESDLEAVIRDRNILLSPADVKSYMQMCLRG--LAHCHKKWVLHRDLKPNNLLISSDGQLKLGDFGLARIFGS-PDRKF-------------THQVFA
|.||.|| ..|. ..  ||   ... |   |||  | . |   |.|||||| |.|. ....||..||||||.. .    .              |  |  
ELMETDLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVAT

RWYRSPELLFG--SKQYGSGVDIWAAGCIFAELLL-RRPFLQGSSDIDQLGKIFQAFGTPRETQWPDMT-S-LP-DYVE----FQFTPAPALRSLFPM--
||||.||....  .. |  .||.|..||||||.|  |.|...|.. |||. .|..  ||| |  .  .. |  . .|..    .. .|.  ....||   
RWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNAN

--ATEDALDLLSKMFAFDPKARITAQQALEHRYF
  |. .|.|||.|| .|||. |||...||.| ||
FNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase CDK7-1.AA PFTAIRE 13-293 42 2.9e-89 302.85 In-house 1-287 (287) Show / Hide 
Range on Protein: 13-293
Range on HMM: 1-287/287
Sequence Identity: 42% (121 aa)

YVKGISLGEGTYGVVFKALDTQTNRTVAVKKIRLGKYKEGVHVTALREIKLLKELRDPNIIELIDVYPHKRNLHLVFEFMESDLEAVIRDRNILLSPADV
|.|   ||||.|  |.|.    ... || | ||| .  ||.  || ||  |||.|.  ||. | |.   |. | .|||... ||   .   .  . |  |
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRL-QQEEGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLTFVFEYVHTDLCQYMDKHPGGMHPNNV

KSYMQMCLRGLAHCHKKWVLHRDLKPNNLLISSDGQLKLGDFGLARIFGSPDRKFTHQVFARWYRSPELLFGSKQYGSGVDIWAAGCIFAELLLRRPFLQ
. ..   ||||. ||.. |||||||| |||||  | ||| ||||||    | . . | |   ||| |  | ||  | . .|.| .|||| |..  .|   
RLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWGQPAFP

GSSDI-DQLGKIFQAFGTPRETQWPDMTSLPDYVEFQFT---PAP-ALRSLFPMAT--EDALDLLSKMFAFDPKARITAQQALEHRYF
| .|| |||.|||.  |||.|  ||  ..|| |   .|.   . |  |.  .|      .| ||..||    |. |. ||.|..| ||
GMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase CDK7-1.AA Pkinase_Tyr 13-158 29 5.3e-14 48.04 Pfam 1-159 (270) Show / Hide 
Range on Protein: 13-158
Range on HMM: 1-159/270
Sequence Identity: 29% (48 aa)

YVKGISLGEGTYGVVFKALDT----QTNRTVAVKKIRLGKYKEGVHVTA------LREIKLLKEL-RDPNIIELIDVYP-HKRN--LHLVFEFMES-DLE
 ..|  |||| .|.|.|.  .    .|. .||||...     || .  .      .||.|..|.| . |||. |. |   ...   . .|.|.|.  || 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

AVIRDR---NILLSPADVKSYMQMCLRGLAHCHKKWVLHRDLKPNNLLISSDGQLKLGDFGLAR
   |..   .  |.. |  .. .   .|... . |   ||||   | |...... | .||||||
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase CDK7-1.AA TyrKc 13-293 17 9.1e-14 -0.11 SMART 1-280 (280) Show / Hide 
Range on Protein: 13-293
Range on HMM: 1-280/280
Sequence Identity: 17% (60 aa)

YVKGISLGEGTYGVVFKALDTQTNRTVAVKKIRLGKYKEGVHVTALREIKLLKEL--RDPNIIELIDVYPHK-------RNLHLVFEFMES-DLEAVIRD
 ..|  |||| .|.|.|.  .   ..||||... ..     .   .||......|  . |||. |. |  ..         | .|.|.|.  ||   .|.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

RNILLSPADVKSYMQMCLRGLAHCHKKWVLHRDLKPNNLLISSDGQLKLGDFGLARIFGSP-------DRKFT-----HQ--VFARWYRSPELL------
.   |...|  |..    .| .. |.| . ||||   | |...... | .||||.|  ..        | . .         .  ||. .|| .      
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECINYGKFT

-----------------FGSKQYGS-----GVDIWAAGCIFAELLLRRPFL----QGSSDIDQLGKIFQAFGTPRETQWPDMTSLPDYVEFQFTPAPALR
                 .| . |         .. .  .. .   ...|                                                   
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------------------------

SLFPMATEDALDLLSKMFAFDPKARITAQQALEHRYF
  |. ....  .. ..  ..||. | | ..   |..|
--FVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF