Gene CDK8 (S.moellendorffii)

CDK8

Species: S.moellendorffii
Alias: CDK8
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDK8

Sequence

Name Sequence Type Origin Length Description Download
CDK8.AA Protein None 515 None Fasta, JSON
CDK8.NA RNA None 1548 None Fasta, JSON
CDK8.kin_dom Protein Kinase Domain None 314 None Fasta, JSON

Protein domain

Protein domains of CDK8.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDK8.AA CDK8 22-330 47 9.90000000001e-171 540.07 In-house 1-329 (329) Show / Hide 
Range on Protein: 22-330
Range on HMM: 1-329/329
Sequence Identity: 47% (161 aa)

K-IGEGTYGLVYLAKSKLV-SNRGVKIAIKKFKQSK------EGDGVSPTAIREIMLLRECMHENVVKLVDVHINHADMSLYLAFEYAEHDLYEIIRHHR
| || ||||.|| || |       .. |.|.|.  |      || | | .| ||| |.||  |.||..|..|  ||.|  ... |.||||||. ||..||
KYIGRGTYGHVYKAKRKKQKKKPNKEYALKQFRTEKDGVEQLEGTGISMSACREIALCRELHHPNVICLQRVFLNHKDKCVWMLFDYAEHDLWHIIKFHR

EKLLFQINPY-----TVKSLLWQILNGINYLHSNWIIHRDLKPSNILVMGVSGDGDE--QGLVKIGDFGLARIYQAPLKPLSDNG-VVVTIWYRAPELLL
.     . |       |||..||||.|| ||||||..||||||.||.||   ||| |   | |||.|.|.|||...||||| |.. ||||.|||||||||
HNKAHMKDPTMVPRNMVKSIMWQILDGIHYLHSNWVLHRDLKPANIMVM---GDGPEDMCGCVKIADMGFARIFHNPLKPLYDLDPVVVTFWYRAPELLL

GAKHYTCAVDMWAVGCIFAELLTLKPLFQGAED----KTGPNPFQLDQLDKIFKVLGHPTTERWPMLSNLPHWLANRQLIQ----SRKYDNPGLHTVVN-
||.||| |.| ||.|||||||.|..|.|.. |     || .||.. ||||.||.|.| |. . || .  .| .    .|        .| |  ||  .  
GARHYTKAIDIWAIGCIFAELITSEPIFHCKEEKLDIKT-QNPYHHDQLDRIFHVMGFPQDKMWPDIKKMPEH---QRLMKDFRRMQTYPNCSLHWYMEK

--LQPKGLAFDLLSRMLEYDPVKRITAAQALDHEYF
   ..   |..||..|| .|| ||||. ||..| ||
HKIKRDSHAYHLLYKMLTMDPTKRITCEQAMEHPYF
Kinase CDK8.AA CDK 17-330 40 4.90000000001e-146 470.33 In-house 1-284 (284) Show / Hide 
Range on Protein: 17-330
Range on HMM: 1-284/284
Sequence Identity: 40% (139 aa)

YELLGKIGEGTYGLVYLAKSKLVS--NRGVKIAIKKFK-----QSKEGDGVSPTAIREIMLLRECMHENVVKLVDVHINHADM---------SLYLAFEY
|| | |||||||| || |..|.    . |  .|.||..     ...|..|.. |||||| ||.|. |.|.||| || . ....         .||. |||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

AEHDLYEIIRHHREKLLFQINPYTVKSLLWQILNGINYLHSNWIIHRDLKPSNILVMGVSGDGDEQGL-----VKIGDFGLARIYQAPLK---PLSDNG-
..|||.....              .|...||.|.|..|.|||||.||||||.|||..       ..|      .||.||||||... |..   |.     
MDHDLKKYMD--------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILIN-------NNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTH

VVVTIWYRAPELLLGAKHYT--CAVDMWAVGCIFAELLT---LKPLFQGAEDKTGPNPFQLDQLDKIFKVLGHPTTERWPMLSNLPHWLANRQLIQSRKY
.||| ||||||||||.|||.  ...|||.|||||||..|    ||||.|  .        .|||.|||...| || . || .. ||..            
EVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSE--------IDQLFKIFRICGTPTEDNWPGVTKLPDY------------

DNPGLHTVVNLQPKGLAFDLLSRMLEYDPVKRITAAQALDHEYF
                  |||..|| ||| |||.| |||.|.||
------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase CDK8.AA CMGC 17-330 28 9.60000000001e-129 425.55 In-house 1-513 (513) Show / Hide 
Range on Protein: 17-330
Range on HMM: 1-513/513
Sequence Identity: 28% (148 aa)

YELLGKIGEGTYGLVYLAKSKL-----------VSNRGVKIAIKKFK------QSK---EGDGVSPTAIREIMLLREC----------------MHEN-V
|| ..|||||||| || .. |.             . . ..||||.|      | |   |.||.. .|.|||..|..                  |.| .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VKLVDVHINHADM---------------SLYLAFEYAEHDLYEIIRHHR------EKLLFQINP----------YTVKSLL------WQILNGIN--YLH
||| |.   . .                .||| ||| .||||..|....       .. .              ...|...      .|||.|..  |.|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

SNW--IIHRDLKPSNILVM----------------GVSGDGDEQGLVKIGDFGLARIYQAPLKPLS-------------------DNGVVVTIWYRAPEL
|.|  ||||||||.|||.                  .    ...| .||.||||||.|  . ..                         ||| ||||||.
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPC---QKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

LLGAKHYT---------CAVDMWAVGCIFAELLT--------LKPLFQGAED----KTGPNPFQLDQLDKIFKVLGHPT---------------TERWPM
|||.||||         ...|||.|||||||..|        .||||.|  .    . .     .|||.||||||| ||               .| || 
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDD-KNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPN

LSNLPHW------------------LANRQLIQSRKYDNPGLHTVVNLQPK-------------------------------------GLAFDLLSRMLE
 ..||..                   | ... . ... ..  ..  || |.                                      .|.|||..||.
MIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQ

YDPVKRITAAQALDHEYF
||| |||||.|||.|.||
YDPDKRITAEQALQHPYF
Kinase CDK8.AA CDC2 17-330 40 5.3e-116 358.13 In-house 1-301 (301) Show / Hide 
Range on Protein: 17-330
Range on HMM: 1-301/301
Sequence Identity: 40% (134 aa)

YELLGKIGEGTYGLVYLAKSKLVSNRGVKIAIKKFKQSKEGDG--VSPTAIREIMLLRECM-HENVVKLVDVHINHADMSLYLAFEYAEHDLYEIIR-HH
|. . |||||||| || .| .        .|.||..   | .|  |  |||||| .| |   |.|.||| || ..    .||. ||| ..|| .  .   
YQKIEKIGEGTYGVVYKCKDMQTNQ---IVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSI

REKLLFQINPYTVKSLLWQILNGINYLHSNWIIHRDLKPSNILVMGVSGDGDEQGLVKIGDFGLARIYQAPLKPLSDNGVVVTIWYRAPELLLGAKHYTC
  .   .. | .|||...|||.|....|.. |.||||||.|||.       |..| .||.||||||  . |....  .  ||| ||||||.|||.|.|..
PKN--KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILI-------DKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYST

AVDMWAVGCIFAEL---LTLKPLFQGAEDKTGPNPFQLDQLDKIFKVLGHPTTERWPMLSNLPHWLA-----NRQLIQSRKYD-NPGLHTVVNLQPKGLA
.||||..||||||.    | ||||.|          . ||| |||..|| |. . || ...||.. .     ..| ...  ..   ...    | |.|. 
PVDMWSIGCIFAEMFMDVTKKPLFHGD--------SEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQ-SCLDPEGI-

FDLLSRMLEYDPVKRITAAQALDHEYF
 |||..|| ||| |||.| .||.| ||
-DLLMQMLQYDPQKRISAKEALQHPYF
Kinase CDK8.AA CDK7 17-272 41 1e-107 287.95 In-house 1-234 (288) Show / Hide 
Range on Protein: 17-272
Range on HMM: 1-234/288
Sequence Identity: 41% (108 aa)

YELLGKIGEGTYGLVYLAKSKLVSNRGVKIAIKKFK----QSKEGDGVSPTAIREIMLLRECMHENVVKLVDVHINHADMSLYLAFEYAEHDLYEIIRHH
|| . .||||... ||.|   .. . | ..|||| |    .|   ||.  |||||| .|.|  |.||. |.|. . | . ...| |.. . || ..|.  
YEKIKHIGEGQFATVYKA---CDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDI-FMHKS-NIQLVFDFMDWDLEVVIKD-

REKLLFQINPYTVKSLLWQILNGINYLHSNWIIHRDLKPSNILVMGVSGDGDEQGLVKIGDFGLARIYQAPLKPLSDNGVVVTIWYRAPELLLGAKHYTC
  ....   |  .|.   ..| |. |.| ||| |||||| | |.       .| | .||.|||||| | .| . .. .  |||.|||||||| ||.||. 
-KSIILT--PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLM-------NENGQLKIADFGLARFYGSPNRIYTHQ--VVTRWYRAPELLFGARHYGT

AVDMWAVGCIFAELLTLKPLFQGAEDKTGPNPFQLDQLDKIFKVLGHPTTERWPMLSNLP
.||||.||||||||.   | . |  |        .||| .||. || || | || .. ..
GVDMWSVGCIFAELMLRVPYLPGDSD--------IDQLTRIFQTLGTPTEEEWPNMCCMM
Kinase CDK8.AA PITSLRE 17-330 40 1.1e-105 357.38 In-house 1-295 (295) Show / Hide 
Range on Protein: 17-330
Range on HMM: 1-295/295
Sequence Identity: 40% (130 aa)

YELLGKIGEGTYGLVYLAKSKLVSNRGVKIAIKKFKQS--KEGDGVSPTAIREIM-LLRECMHENVVKLVDVHINHADMSLYLAFEYAEHDLYEIIRHHR
.. | .|.||||| || || |.    .  .|.|..|    || .|   |..|||  .|..  |.|.|..  . .     . |...|| ||||  ..  ..
FQCLNRIHEGTYGVVYRAKDKR---TDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMK

-EKLLFQINPYTVKSLLWQILNGINYLHSNWIIHRDLKPSNILVMGVSGDGDEQGLVKIGDFGLARIYQAPLKPLSDNGVVVTIWYRAPELLLGAKHYTC
  .  |..    .|.|. | |.|. ..|.|||.||||| ||.|          .|  ||.|||||| |. |.||..   .||| ||||||||||.| |. 
RRNQPFKPG--EIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYS-------HKGILKICDFGLAREYGSPIKPYTP--CVVTLWYRAPELLLGCKKYST

AVDMWAVGCIFAELLTLKPLFQGAEDKTGPNPFQLDQLDKIFKVLGHPTTERWPMLSNLPHWLANRQLIQSRKYDNPGLHTVVN--LQPKGLAFDLLSRM
.|||| |||||||..|.||||||  .        .||...||| .| ||   ||  . |||| .  . ..  .| |  |   .         .|||| .|
PVDMWSVGCIFAEFITMKPLFQGKSE--------IDQINCIFKEMGTPTEKIWPGWTELPHWKMMNN-FPHYPYNN--LRKRFPAENHISDTGFDLLNQM

LEYDPVKRITAAQALDHEYF
|.|.| .|||| .||.|..|
LTYNPKNRITASDALKHPWF
Kinase CDK8.AA CDK5 17-330 38 1.4e-103 328.24 In-house 1-287 (287) Show / Hide 
Range on Protein: 17-330
Range on HMM: 1-287/287
Sequence Identity: 38% (122 aa)

YELLGKIGEGTYGLVYLAKSKLVSNRGVKIAIKKFKQSKEGDGVSPTAIREIMLLRECMHENVVKLVDVHINHADMSLYLAFEYAEHDLYEIIRHHREKL
|| . |||||||| || |. |   . .. .|.|. .   |  ||  |||||| ||.|  |.|.| | ||   |..  | | ||.   ||   .    .  
YEKMEKIGEGTYGTVYKARNK---ETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVI--HSEKKLTLVFEFCDQDLKKYMDSCNG--

LFQINPYTVKSLLWQILNGINYLHSNWIIHRDLKPSNILVMGVSGDGDEQGLVKIGDFGLARIYQAPLKPLSDNGVVVTIWYRAPELLLGAKHYTCAVDM
  .... ..||...| | |. . |.. . |||||| | |.         .|  | .|||||| .  | .  |    ||| |||.|  |.|.|||.  .||
--EMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLI-------NKNGELKLADFGLARAFGIPVRCYSHE--VVTLWYRPPDVLMGSKHYSTSIDM

WAVGCIFAELL-TLKPLFQGAEDKTGPNPFQLDQLDKIFKVLGHPTTERWPMLSNLPHWLANRQLIQSRKYDNPGLHTVVNLQPKGLAFDLLSRMLEYDP
| .||||||.  ...||| |....        ||| .|||..| |. ..|| ...|| . .| |   ..    .    | .|  ||.  |||..||...|
WSCGCIFAEMANAGRPLFPGNDVE--------DQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGM--DLLQKMLQCNP

VKRITAAQALDHEYF
 .||.|..|| | ||
NQRISAKAALHHPYF
Kinase CDK8.AA S_TKc 17-330 28 1.1e-97 331.71 SMART 1-231 (231) Show / Hide 
Range on Protein: 17-330
Range on HMM: 1-231/231
Sequence Identity: 28% (94 aa)

YELLGKIGEGTYGLVYLAKSKLVSNRGVKIAIKKFKQSKEGDGVSPTAIREIMLLRECMHENVVKLVDVHINHADMSLYLAFEYAEH---DLYEIIRHHR
||.| |||.|..| ||... |     | . |||. |          ...||| .|..  |.|.||| ||  .    .||. .||...   ||...|....
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRG

EKLL-FQINPYTVKSLLWQILNGINYLHSNWIIHRDLKPSNILVMGVSGDGDEQGLVKIGDFGLARIYQAPLKPLSDNGVVVTIWYRAPELLLGAKHYTC
 . | |.... .......||.....|.||..||||||||.|||.            .||.||||||..         . ...| ||.|||.|    .|..
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---------HIKICDFGLARQL---------TTFCGTPWYMAPEVL----GYGK

-AVDMWAVGCIFAELLTLKPLFQGAEDKTGPNPFQLDQLDKIFKVLGHPTTERWPMLSNLPHWLANRQLIQSRKYDNPGLHTVVNLQPKGLAFDLLSRML
 ..|.|..|||..|.|. .|.|.              |....||..|                                            | |.....|
CKCDWWSCGCILYEMLCGYPPFP--------------QMQMMFKKIG-----------------------------------------SPEAKDFIRKCL

EYDPVKRITAAQALD-------HEYF
..|| ||.|| .||        |..|
QKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CDK8.AA CRK7 17-330 32 1.3e-90 307.29 In-house 1-343 (343) Show / Hide 
Range on Protein: 17-330
Range on HMM: 1-343/343
Sequence Identity: 32% (122 aa)

YELLGKIGEGTYGLVYLAKSKLVSNRGVKIAIKKFKQSKE---GDGVSPTAIREIMLLRECMHENVVKLVDVHINH-------ADM-SLYLAFEYAEHDL
||... ||||||| || || |   . |  .| ||..   |    .|   |||||| .||.  |.|.|.| .. .          .  | |. |||. |||
YEMIMQIGEGTYGQVYKAKNK---HTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDL

YEIIRHHREKLLFQINPYTVKSLLWQILNGINYLHSNWIIHRDLKPSNILVMGVSGDGDEQGLVKIGDFGLARIYQAPL-KPLSDNGVVVTIWYRAPELL
      .. | . ....  .|... |.| |..|.| . ..|||.| ||||.       . || ||| |||||| | .   ..   |  |.| |||.||||
MGL---LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILM-------NNQGEVKIADFGLARLYNSEEKRRPYTN-RVITLWYRPPELL

LGAKHY--------------------------------------TCAVDMWAVGCIFAELLTLKPLFQGAEDKTGPNPFQLDQLDKIFKVLGHPTTERWP
||...|                                      . ..||| .|||..||.| ||.|||           ..||.||.|. | |... ||
LGEERYTEQHILKELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNE--------MAQLEKIYKICGSPNPNNWP

MLSNLPHWLANRQLIQSRKYDNPGLHTVV------NLQPKGLAFDLLSRMLEYDPVKRITAAQALDHEYF
 .  || | .   . . |.|    .  ..      .. ..  ..|||  || .|| ||.|| ..|.|..|
EVMKLPWWNT---MKPKRQYNRRLREEFYHHKKPVFMPKE--CLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase CDK8.AA MAPK 17-330 35 9.5e-90 304.47 In-house 1-328 (328) Show / Hide 
Range on Protein: 17-330
Range on HMM: 1-328/328
Sequence Identity: 35% (125 aa)

YELLGKIGEGTYGLVYLAKSKLVSNR---GVKIAIKKFKQSKEGDGVSPTAIREIMLLREC-MHENVVKLVDVHINH-----AD----MSLYLAFEYAEH
|..| .||.| ||.|  |. |. . .   | |.||||. .  .       ..|||.|||..  |||..|| |.   .      .      .|. .|. |.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLYEIIRHHREKLLFQINPYTVKSLLWQILNG--INYLHSNWIIHRDLKPSNILVMGVSGDGDEQGLVKIGDFGLARIYQAP-------LKP-------L
||. ||.  .     . .   ......|||.|  . |.||  .||||||||||||       .| ...||.||||||.            .|       .
DLHQIIKSQQ-----PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILV-------NENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHM

SDNGVVVTIWYRAPELLLG--AKHYTCAVDMWAVGCIFAELLT-LKPLFQGAEDKTGPNPFQLDQLDKIFKVLGHPTTERWPMLSNLPHWLAN---RQLI
...  |.| ||||||..|.  ..||| |||||.|||||||.||  ||||.|           .||. .|..||| |. | .  ...      .   |..|
TEY--VATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKD--------YIDQWNLIMEVLGTPSEEFIQCICM------SEHARNYI

QSRK-YDNPGLHTVVNLQPK------GLAFDLLSRMLEYDPVKRITAAQALDHEYF
||.. . ..  ..  .. |.       .| |||..||. || ||||...|| |.||
QSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase CDK8.AA Pkinase 17-330 28 5.9e-83 286.69 Pfam 1-293 (293) Show / Hide 
Range on Protein: 17-330
Range on HMM: 1-293/293
Sequence Identity: 28% (93 aa)

YELLGKIGEGTYGLVYLAKSKLVSNRGVKIAIKKFKQSKEGDGVSPTAIR--EIMLLRECMHENVVKLVDVHINHADMSLYLAFEYAEH-----DLYEII
|....|||.|..| ||... |  .    . |.|..| ..| ...  |..|  || ..... |.|.|.| |.  .  . ..|. .||.|.     ||...|
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYI

RHHREKLLFQINPYTVKSLLWQILNGINYLHSNWIIHRDLKPSNILVMGVSGDGDEQGLVKIGDFGLARIYQAPLKPLSDNGVVVTIWYRAPELLLGAKH
. .|.. .    . ..|. ..||| |..|.||..||||||||.|||.      ..    |||.|||||. ..   .    .....|.||.|||...|...
STWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA---CVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQY

YTCAVDMWAVGCIFAELLTLKPLFQGA-EDKTGPNPFQLDQLDKIFKVLGHPTTERWPMLSNLPHWLANRQLIQSRKYDNPGLHTVVNLQPKGLAFDLLS
|. .||||..|||..|.|. .|.|.|.  ...  .. |. ....  ..  .  ... .......|| .               |...       . |...
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHW-H-------------F-HWTF-HNWSEECKDFIK

RMLEYDPVKRITAAQALDHEYF
..|..|| ||.||.|.| |..|
WCLCKDPKKRPTAEQILQHPWF
Kinase CDK8.AA CDK10 17-330 39 4e-75 255.89 In-house 1-285 (285) Show / Hide 
Range on Protein: 17-330
Range on HMM: 1-285/285
Sequence Identity: 39% (125 aa)

YELLGKIGEGTYGLVYLAKSKLVSNRGVKIAIKKFKQSKEGDGVSPTAIREIMLLRECMHENVVKLVDVHINHADMSLYLAFEYAEHDLYEIIRHHREKL
.| | ..||||||.|| |.    |.  |  |.|| .  || ||.   ..|||||| .| |||.|.| .| . .   |..|  .| | ||  ..    . .
FEKLNRVGEGTYGIVYRAR-DMRSDEIV--ALKKVRMDKEKDGLPISGLREIMLLIQCRHENIVELHEVVVGQHLDSIFLVMQYCEQDLASLL----DNM

LFQINPYTVKSLLWQILNGINYLHSNWIIHRDLKPSNILVMGVSGDGDEQGLVKIGDFGLARIYQAPLKPLSDNGVVVTIWYRAPELLLGAKHYTCAVDM
        || .  |.| |. |||.|..|||||| ||.|.        ..| .|. |||||| |  | ||.     .||.||||||||||..  | |.||
PQPFTETQVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMT-------DKGCIKVADFGLARMYGVPVKPMTPK--MVTLWYRAPELLLGCRTQTTAIDM

WAVGCIFAELLTLKPLFQGAEDKTGPNPFQLDQLDKIFKVLGHPTTERWPMLSNLPHWLANRQLIQSRKYDNPGLHTVVNLQPKGLAFDLLSRMLEYDPV
|||||| .|||  |||. |. .        . |.| | ..|| |  . ||  |.||  ....  ..   | |   |    |   |.   ||  .. |.| 
WAVGCILGELLVHKPLMPGNSE--------IHQIDMIIDLLGTPSENIWPGFSDLP--MVQNFTLKKQPYNN-LKHKFHWLSQSGRR--LLNFLFMYNPK

KRITAAQALDHEYF
|| || ..|. .||
KRATAEECLESSYF
Kinase CDK8.AA Pkinase_Tyr 17-178 31 6.7e-17 57.86 Pfam 1-159 (270) Show / Hide 
Range on Protein: 17-178
Range on HMM: 1-159/270
Sequence Identity: 31% (54 aa)

YELLGKIGEGTYGLVYLAKSK-LVSNRGVKIAIKKFKQSKEGDGVSPTA------IREIMLLREC-MHENVVKLVDVHINHADM-SLYLAFEYAEH-DLY
 ... |.||| .| ||... | . .| ... |.|. |.     | .. .      .||. ....   |.|.|.|. | . . .  ..|. .||..| ||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-----GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

EIIRHHREKLLFQINPYTVKSLLWQILNGINYLHSNWIIHRDLKPSNILVMGVSGDGDEQGLVKIGDFGLAR
.  | ||     .... .  .  ||| .| .||.|. .|||||   |.||        |.. |||.||||||
DYLRKHR-EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVT-------ENNVVKICDFGLAR
Kinase CDK8.AA CDK7 303-330 39 4.3e-15 36.22 In-house 261-288 (288) Show / Hide 
Range on Protein: 303-330
Range on HMM: 261-288/288
Sequence Identity: 39% (11 aa)

AFDLLSRMLEYDPVKRITAAQALDHEYF
. ||...|.  .|.||.|..|.| ..||
LLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CDK8.AA TyrKc 17-330 24 2.3e-14 9.56 SMART 1-280 (280) Show / Hide 
Range on Protein: 17-330
Range on HMM: 1-280/280
Sequence Identity: 24% (82 aa)

YELLGKIGEGTYGLVYLAKSKLVSNRGVKIAIKKFKQSKEGDGVSPTA--IREIMLLREC--MHENVVKLVDVHINH-----ADMSLYLAFEYAEH-DLY
 .|. |.||| .| ||... |      .. |.|. | ..        .  .||. ....    |.|.|.|. | . .      .  |.. .||..| || 
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

EIIRHHREKLLFQINPYTVKSLLWQILNGINYLHSNWIIHRDLKPSNILVMGVSGDGDEQGLVKIGDFGLAR-IYQA-------PLKPLSD--NGV-VVT
. .| ||.|    ... .  |  ||| .| .||||. .|||||   |.||       .|.. |||.||||.| ||           .  .   .|  .. 
DYLRKHRPK----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLV-------GENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP

IWYRAPELLLGAKHYTCAVDMWAVGCIFAELLTLKPLFQGAEDKTG-----PNPFQLDQLDKIFKVLGHPTT-ERWPMLSNLPHWLANRQLIQSRKYDNP
|   ||| .   . .| . | |. |    |..|.     |..   |      ..... .. |  . .  |   .  | .|                    
IRWMAPECI-NYGKFTTKSDVWSFGVCMWEIFTY-----GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MS--------------------

GLHTVVNLQPKGLAFDLLSRMLEYDPVKRITAAQALDHEYF
         |. .   . ..  ..|| .| | ..   ||.|
----F-VCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF