Gene CRK7_b (S.moellendorffii)
CRK7_b
Species: S.moellendorffii
Alias: CRK7_b
External Links:
Annotation:
Sequence
Protein domains of CRK7_b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | CRK7_b.AA | CDK | 3-241 | 37 | 1.6e-106 | 341.87 | In-house | 57-284 (284) | Show / Hide |
Range on Protein: 3-241 Range on HMM: 57-284/284 Sequence Identity: 37% (99 aa) REIQVLRRLNHPNVIKLEGLVTSRMSF---------SLYLVFEYMEHDLAGLAACPGITFTEPQVKCYMQQLIRGLDHCHTRGVLHRDIKGSNLLLDNSG ||| |. | |||..|| ... . .||.|||||.|||... .||||.||.|||..|| ....|||.| .|.|..| | REISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNG I-----LKIADFGLATFFHP--D---QRQALTSRVVTLWYRPPELLLGATEYG--AAVDLWSTGCILAELLA---GKPIMPGRTEVEQLHKIFKLCGSPA . ||||||||| |. . ....|..|||||||.||||||...|. ..|.|| |||.||.. .||..||..| .||.|||..||.| EVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPT EEYWKKW-KLPHAIIFKPQQPYKRCIAETFKDFPASALALLDTLLAIEPADRQTAAAALESDFF |. | . |||. ||. .|. .|. | .| .||....| EDNWPGVTKLPDY-------------------------DLLNKMLCYDPKKRISAEQALQHPYF |
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Kinase | CRK7_b.AA | CRK7 | 3-241 | 40 | 5.4e-106 | 358.43 | In-house | 50-343 (343) | Show / Hide |
Range on Protein: 3-241 Range on HMM: 50-343/343 Sequence Identity: 40% (118 aa) REIQVLRRLNHPNVIKLEGLVTS--------RMSFSLYLVFEYMEHDLAGLAACPGIT-FTEPQVKCYMQQLIRGLDHCHTRGVLHRDIKGSNLLLDNSG ||| .|| |||.|...| ||. . | |.||||| |||.|| . . | . |.||.| || |.| || ...||||||.||.|..|.| REIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGLLESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQG ILKIADFGLATFFHPDQ-RQALTSRVVTLWYRPPELLLGATEY--------------------------------------GAAVDLWSTGCILAELLAG ..|||||||| .... |. .| ||.||||||||||||...| | ..| ||.||||.||. . EVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTK KPIMPGRTEVEQLHKIFKLCGSPAEEYW-KKWKLPHAIIFKPQQPYKRCIAETFK------DFPASALALLDTLLAIEPADRQTAAAALESDFF ||| .|. | .|| ||.|.|||| . | ||| .||.. |.| . | | .|. .| ||| .|. | | || .|..|.| KPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRRLREEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF |
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Kinase | CRK7_b.AA | CMGC | 3-241 | 22 | 1.3e-95 | 314.66 | In-house | 70-513 (513) | Show / Hide |
Range on Protein: 3-241 Range on HMM: 70-513/513 Sequence Identity: 22% (99 aa) REIQVLRRLN-----------------HPNVIKLEGLVTSRMSF---------------SLYLVFEYMEHDLAGLAACPG--------ITFTEPQ----- |||. |..|| |.|..|| .... | .||||||||.|||... . ..| . REIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHP -------VKCYM------QQLIRGLD--HCHTRG--VLHRDIKGSNLLLDNS--------------------GILKIADFGLATFFHPDQRQ-------- .|..| .|..|||. .|| .. ..|||.| .|.|... |.|||.|||||...|| ... HRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQS ------------ALTSRVVTLWYRPPELLLGA---------TEYGAAVDLWSTGCILAELLAG--------KPIMPGRTE-----------VEQLHKIFK ..|..|||.|||.||.|||. ..|. ..| || |||.||.. | ||. ||..| ..||.|||| FKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFK LCGSPA---------------EEYWKKW--------------------------KLPHAIIFKPQQPYKRCIAETFKDFP-------------------- ..|.| || | .. ... . .. ...... . . |...| VLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKF ---------------ASALALLDTLLAIEPADRQTAAAALESDFF |. ||. .| ..|..| ||. ||. ..| KSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF |
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Kinase | CRK7_b.AA | CDK7 | 3-241 | 38 | 3.6e-92 | 245.7 | In-house | 51-288 (288) | Show / Hide |
Range on Protein: 3-241 Range on HMM: 51-288/288 Sequence Identity: 38% (92 aa) REIQVLRRLNHPNVIKLEGLVTSRMSFSLYLVFEYMEHDLAGLAACPGITFTEPQVKCYMQQLIRGLDHCHTRGVLHRDIKGSNLLLDNSGILKIADFGL ||| .|. . |.||| | . ...|||..|. || | .| .| || .. .|| .|| .||||.| |||.. |.|||||||| REIKILQEMQHDNVIGLIDIFMHKS--NIQLVFDFMDWDLEVVIKDKSIILTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGL ATFFHPDQRQALTSRVVTLWYRPPELLLGATEYGAAVDLWSTGCILAELLAGKPIMPGRTEVEQLHKIFKLCGSPAEEYWKKW-KLPHAIIFKPQQPY-K | |. . ...|. ||| ||| |||| || || .||.|| |||.|||. |..|| .. || .||. | | || | ... |.||.. .| . ARFY-GSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSR RCIAETFKDFPASALALLDTLLAIEPADRQTAAAALESDFF . | . .| |. ... .| | |.. .|....| TPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF |
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Kinase | CRK7_b.AA | PITSLRE | 3-241 | 40 | 1.1e-80 | 274.3 | In-house | 49-295 (295) | Show / Hide |
Range on Protein: 3-241 Range on HMM: 49-295/295 Sequence Identity: 40% (101 aa) REIQ-VLRRLNHPNVIKLEGLVTSRMSFSLYLVFEYMEHDLAGLAACPG---ITFTEPQVKCYMQQLIRGLDHCHTRGVLHRDIKGSNLLLDNSGILKIA |||. .|. |.|||.... | . |.|.||.||||..| |.....|| |||| || .| | ..||| | ||||. ..|||||. REINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRNQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKIC DFGLA-TFFHPDQRQALTSRVVTLWYRPPELLLGATEYGAAVDLWSTGCILAELLAGKPIMPGRTEVEQLHKIFKLCGSPAEEYWKKW-KLPHAIIFK-- ||||| . | . ..|. ||||||| ||||||. .| .||.|| |||.||.. .||...|. |..|...|||. | | | | | .|||. .. DFGLAREYGSP--IKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEFITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNF PQQPYKRCIAETFK---DFPASALALLDTLLAIEPADRQTAAAALESDFF |..| . |. .. || .| |. | || .|| ..| PHYP-YNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF |
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Kinase | CRK7_b.AA | CDC2 | 3-182 | 43 | 2.6e-76 | 233.9 | In-house | 49-233 (301) | Show / Hide |
Range on Protein: 3-182 Range on HMM: 49-233/301 Sequence Identity: 43% (81 aa) REIQVLRRLN-HPNVIKLEGLVTSRMSFSLYLVFEYMEHDLAGLAA---CPGITFTEPQVKCYMQQLIRGLDHCHTRGVLHRDIKGSNLLLDNSGILKIA ||| | |. |||..||. . . .||.||||...|| . .. ... || || |...|...||.|...|||.| .|.|.|..| .||| REISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIA DFGLATFFHPDQRQALTS-RVVTLWYRPPELLLGATEYGAAVDLWSTGCILAEL---LAGKPIMPGRTEVEQLHKIFKLCGSPAEEYW ||||| | |. .| |||||||.||.|||. | .||.|| |||.||. ||. .| | .|| |||. |.| |. | DFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTW |
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Kinase | CRK7_b.AA | CDK10 | 3-241 | 41 | 5.2e-72 | 245.54 | In-house | 47-285 (285) | Show / Hide |
Range on Protein: 3-241 Range on HMM: 47-285/285 Sequence Identity: 41% (101 aa) REIQVLRRLNHPNVIKLEGLVTSRMSFSLYLVFEYMEHDLAGLAACPGITFTEPQVKCYMQQLIRGLDHCHTRGVLHRDIKGSNLLLDNSGILKIADFGL |||..| .. |.|...| | . |..|| .| | ||| | ||| |||| | |..||| | . ..|||.| ||||. | .|.||||| REIMLLIQCRHENIVELHEVVVGQHLDSIFLVMQYCEQDLASLLDNMPQPFTETQVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGL ATFFHPDQRQALTSRVVTLWYRPPELLLGATEYGAAVDLWSTGCILAELLAGKPIMPGRTEVEQLHKIFKLCGSPAEEYWKKW-KLPHAIIFK-PQQPYK | . . .| ..|||||| ||||||... |.|.| ||||.|||..||.||| |. |. | .| |.|.|. | . .|| . | .||| ARMYGVPVK-PMTPKMVTLWYRAPELLLGCRTQTTAIDMWAVGCILGELLVHKPLMPGNSEIHQIDMIIDLLGTPSENIWPGFSDLPMVQNFTLKKQPYN RCIAETFKDFPASALALLDTLLAIEPADRQTAAAALESDFF . . |. | . ||. |. .| | || .||| .| -NLKHKFHWLSQSGRRLLNFLFMYNPKKRATAEECLESSYF |
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Kinase | CRK7_b.AA | CDK-DD1 | 33-182 | 45 | 7.5e-71 | 217.83 | In-house | 75-224 (379) | Show / Hide |
Range on Protein: 33-182 Range on HMM: 75-224/379 Sequence Identity: 45% (69 aa) LVFEYMEHDLAGLAACPGITFTEPQVKCYMQQLIRGLDHCHTRGVLHRDIKGSNLLLDNSGILKIADFGLATFFHPDQR--QALTSRVVTLWYRPPELLL .||||.|||| .. . . . |..||.. || |.. || |. ||||| .||| | | |||.|||..| . | . ..||.|||||||||. MVFEYFEHDLWKFMSNHQCYMSLPCIKCFFHQLLEGINECHNQGIMHRDIKPANLLINNRGDLKITDFGFTTYYT--KRSEKHFSHQVVSLWYRPPELLM GATEYGAAVDLWSTGCILAELLAGKPIMPGRTEVEQLHKIFKLCGSPAEEYW | . || .|.|| |||| |.. . ...| | || |.|||| | |. | GSCQYGPEIDMWSVGCILMEMITNFYMFAGSNEQQQLELICKLCGCPTEKNW |
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Kinase | CRK7_b.AA | CDK5 | 3-241 | 38 | 8e-70 | 219.65 | In-house | 47-287 (287) | Show / Hide |
Range on Protein: 3-241 Range on HMM: 47-287/287 Sequence Identity: 38% (95 aa) REIQVLRRLNHPNVIKLEGLVTSRMSFSLYLVFEYMEHDLAG-LAACPGITFTEPQVKCYMQQLIRGLDHCHTRGVLHRDIKGSNLLLDNSGILKIADFG ||| .|. | |.|.. | . | | ||||.. || . | | . .| .| || .|| || . ||||| | ||| |.|| |||| REICLLKELKHKNIVRLHDVIHSEK--KLTLVFEFCDQDLKKYMDSCNG-EMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFG LATFFHPDQRQALTSRVVTLWYRPPELLLGATEYGAAVDLWSTGCILAELL-AGKPIMPGRTEVEQLHKIFKLCGSPAEEYWKKW-KLPHA---IIFKPQ || | | .. ||||||||| |.|. | .|.|| |||.||. ||.| || . .|| .|||. |.| |. | ||| . | LARAFGIPVR-CYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPM QPYKRCIAETFKDFPASALALLDTLLAIEPADRQTAAAALESDFF | . .. . . . || .| ..|. | .|.|||. .| YPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF |
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Pkinase | CRK7_b.AA | Pkinase | 2-241 | 31 | 4.3e-68 | 237.32 | Pfam | 46-293 (293) | Show / Hide |
Range on Protein: 2-241 Range on HMM: 46-293/293 Sequence Identity: 31% (82 aa) AR--EIQVLRRLNHPNVIKLEGLVTSRMSFSLYLVFEYMEHD--LAGLA----ACPGITF--TEPQVKCYMQQLIRGLDHCHTRGVLHRDIKGSNLLLDN .| |||...||||||...| . ... . ..|.|.||.|.. .. |. . . .| .| ..|.|| |..|||..|| .|..|||.| .|.|.|| RRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDN SGIL----KIADFGLATFF-HPDQRQALTSRVVTLWYRPPELLLGATEYGAAVDLWSTGCILAELLAGKPIMPGR----TEVEQLHKIFKLCGSPAEEYW | . ||.||||| .| . .. .|....|.||..||...|...|| .|| || ||||.|.| |.|. ||. . ..|...|.. | | .. | NGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDW KKWKLPHAIIFKPQQPYKRCIAETFKDFPASALALLDTLLAIEPADRQTAAAALESDFF .| . .. . .. . . . ... ... .|. |..| ||. .|....| PWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | CRK7_b.AA | CDK9 | 3-182 | 45 | 2.9e-58 | 199.6 | In-house | 58-250 (340) | Show / Hide |
Range on Protein: 3-182 Range on HMM: 58-250/340 Sequence Identity: 45% (87 aa) REIQVLRRLNHPNVIKL------EGLVTSRMSF--SLYLVFEYMEHDLAGLAACPGITFTEPQVKCYMQQLIRGLDHCHTRGVLHRDIKGSNLLLDNSGI |||..| | |.||. | . | ..||||.. ||||||| . . |. .| ||.|. || | .|||| | | | || REIKMLQLLKHENVVNLIEICRTKATAYNRYKDRATFYLVFDFCEHDLAGLLSNMNVKFSLGHIKKMMQHLMNGLYYIHRNKILHRDMKAANVLITKDGI LKIADFGLATFF---HPDQRQA--LTSRVVTLWYRPPELLLGATEYGAAVDLWSTGCILAELLAGKPIMPGRTEVEQLHKIFKLCGSPAEEYW || |||||| | |. | ||||||||||||||| .|| ..|.| |||.||. ||| | || || | .|||| .. | LKLADFGLARAFSQPKNDAPNRPLYTNRVVTLWYRPPELLLGDRNYGPPIDMWGAGCIMAEMWTRSPIMQGNTEQHQLQLISQLCGSITPDVW |
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S_TKc | CRK7_b.AA | S_TKc | 1-241 | 26 | 3.9e-55 | 190.41 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1-241 Range on HMM: 1-231/231 Sequence Identity: 26% (76 aa) M-----------------------------------AREIQVLRRLNHPNVIKLEGLVTSRMSFSLYLVFEYMEH---DLAGLAACPGI-----TFTEPQ ||||.|.. .|||..|| . . .||.|.||... || . | |.| . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H VKCYMQQLIRGLDHCHTRGVLHRDIKGSNLLLDNSGILKIADFGLATFFHPDQRQALTSRVVTLWYRPPELLLGATEYGA-AVDLWSTGCILAELLAGKP ...||.|....|..|| .|..|||.| .|.|||. .||.|||||... |. ..|.||..||.| || ..| || ||||.|.|.|.| ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYP IMPGRTEVEQLHKIFKLCGSPAEEYWKKWKLPHAIIFKPQQPYKRCIAETFKDFPASALALLDTLLAIEPADRQTAAAALE-------SDFF | |....||..| . .|. ... .| .|..| || ||. .| PFP------QMQMMFKKIG-----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | CRK7_b.AA | Pkinase_Tyr | 3-103 | 30 | 3.8e-13 | 45.13 | Pfam | 52-158 (270) | Show / Hide |
Range on Protein: 3-103 Range on HMM: 52-158/270 Sequence Identity: 30% (33 aa) REIQVLRRL-NHPNVIKLEGLVT-SRM-SFSLYLVFEYMEH-DL-AGLAAC--PGITFTEPQVKCYMQQLIRGLDHCHTRGVLHRDIKGSNLLLDNSGIL ||..... | .|||...| | .| . . ..|.|.|||.| || | . .. .| .. .. .| .|... . .. |||. | |...... REAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVV KIADFGLA ||.||||| KICDFGLA |
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Kinase | CRK7_b.AA | CDK9 | 214-241 | 42 | 2e-08 | 24.9 | In-house | 313-340 (340) | Show / Hide |
Range on Protein: 214-241 Range on HMM: 313-340/340 Sequence Identity: 42% (12 aa) ALALLDTLLAIEPADRQTAAAALESDFF |. |.| ||.| |. | ... ||. |.| ACHLIDKLLNIDPKKRMDSDEALDHDWF |
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TyrKc | CRK7_b.AA | TyrKc | 1-241 | 15 | 2.6e-08 | -88.38 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1-241 Range on HMM: 1-280/280 Sequence Identity: 15% (49 aa) M------------------------------------AREIQVLRRL--NHPNVIKLEGLVTSR----MSF-SLYLVFEYMEH--------DLAGLAACP ||......| .|||...| | .|. |. |..|.|||.| . . ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK---- GITFTEPQVKCYMQQLIRGLDHCHTRGVLHRDIKGSNLLLDNSGILKIADFGLATFFHPD-------QRQAL----TSR-VVTLWYRPPELLLGATEYGA .. .. .. | .| .. | ... |||. | |... .. ||.||||. . . | . .. .. . .|| . .. ---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTT AVDLWSTGCILAELLAG----KPI-----MPGRTEVEQLHKIFKLCGSPA----EEYWKKWKLPHAIIFKPQQPYKRCIAETFKDFPASALALLDTLLAI . | || | . |.. | |. . .|.. . . . | | |. . . . KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------------------------FVCCPDEMYQIMKQCWHE EPADRQTAAAALESDFF .|.|| | .. ..| DPEDRPTFSEI--HECF |
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Kinase | CRK7_b.AA | CDC2 | 214-241 | 32 | 1.1e-05 | 12.9 | In-house | 274-301 (301) | Show / Hide |
Range on Protein: 214-241 Range on HMM: 274-301/301 Sequence Identity: 32% (9 aa) ALALLDTLLAIEPADRQTAAAALESDFF .. ||. .|...|..| .| .||. .| GIDLLMQMLQYDPQKRISAKEALQHPYF |
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Kinase | CRK7_b.AA | CDK-DD1 | 213-241 | 31 | 0.002102 | 5.69 | In-house | 351-379 (379) | Show / Hide |
Range on Protein: 213-241 Range on HMM: 351-379/379 Sequence Identity: 31% (9 aa) SALALLDTLLAIEPADRQTAAAALESDFF | | |. .| | | .. ||.. .| SFLDLIERMLTLCPKKRINTKEALQHPWF |