Gene MAK_d (S.moellendorffii)

MAK_d

Species: S.moellendorffii
Alias: MAK_d
External Links:
Annotation:

Classification

Group: CMGC
Family: RCK
Subfamily: MAK

Sequence

Name Sequence Type Origin Length Description Download
MAK_d.AA Protein None 337 None Fasta, JSON
MAK_d.NA RNA None 1014 None Fasta, JSON
MAK_d.kin_dom Protein Kinase Domain None 274 None Fasta, JSON

Protein domain

Protein domains of MAK_d.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MAK_d.AA MAK 120-279 54 2e-112 359.3 In-house 111-304 (352) Show / Hide 
Range on Protein: 120-279
Range on HMM: 111-304/352
Sequence Identity: 54% (107 aa)

YLQECNLYQMMKDRQK-LFPEAKIRNWCFQVLQGLAYMHREGYFHRDLKPENLLVTV------------------DVIKIADFGLAREVRSRPPYTNYVS
|..| |||||||||.. .|||  |||  .|.|||||.||. |.||||.||||....                   ..|||||||||||.||.|||| |||
YMKE-NLYQMMKDRDRRHFPEPVIRNIMYQILQGLAFMHKHGFFHRDMKPENIMCMGPTQYFEKEYMNQIGYQDNELIKIADFGLAREIRSKPPYTDYVS

TRWYRAPEVLLQSSLYNSAVDMWAMGAIMAELFNLRPIFPGASEADEIYKICSVLGNPSQAT----------------WPDGMKLAKCMNFRFPQ
||||||||||| |. |.| .||||.|.|||||. .||.|||.|| |.|.|||.||| |  ..                |||| .||  |||||||
TRWYRAPEVLLRSTYYSSPIDMWAVGCIMAELYTFRPLFPGSSEIDQIFKICQVLGTPKKDDDFVNTNHITAPPPGGFWPDGYQLAHMMNFRFPQ
Kinase MAK_d.AA RCK 125-279 60 3.9e-110 350.7 In-house 85-254 (298) Show / Hide 
Range on Protein: 125-279
Range on HMM: 85-254/298
Sequence Identity: 60% (103 aa)

NLYQMMKD---RQKLFPEAK--IRNWCFQVLQGLAYMHREGYFHRDLKPENLLVT----------VDVIKIADFGLAREVRSRPPYTNYVSTRWYRAPEV
||||||||   |.|..|| .  |.|  .|.|||||.||. |.|||||||||...|           |.||||||||.||.||.|||| |||||||||||.
NLYQMMKDFKERRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPEC

LLQSSLYNSAVDMWAMGAIMAELFNLRPIFPGASEADEIYKICSVLGNPSQATWPDGMKLAKCMNFRFPQ
|| .  ||| .|.||.|.||.||  ||| |||.|| |.|.|||.|.| |.. .|||| |||  |||.|||
LLRCTYYNSPMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQ
S_TKc MAK_d.AA S_TKc 28-301 31 1.6e-85 291.38 SMART 1-231 (231) Show / Hide 
Range on Protein: 28-301
Range on HMM: 1-231/231
Sequence Identity: 31% (91 aa)

YKVIKQLGDGTYGTVWKAVNKVTNETVAIKKMKRKYLSWDECMNLREVKSLRKLNHPNIVKLKEVIRENNELFFVFEYMVLYFCFPFSATHFYLQEC---
|......| |..|.|.|...| |.. ||||..|        .. .||.. |.| .|||||||..|... ..|..|.||.                .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYC----------------DGDLG

NLYQMMKDRQKL-----FPEAKIRNWCFQVLQGLAYMHREGYFHRDLKPENLLVTVDVIKIADFGLAREVRSRPPYTNYVSTRWYRAPEVLLQSSLYNS-
.|....|.|..      |||  .| .. |....|.|.|. |  ||||||||.|..  .|||.||||||..      | .. |.||.|||||     |.  
DLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKC

AVDMWAMGAIMAELFNLRPIFPGASEADEIYKICSVLGNPSQATWPDGMKLAKCMNFR-FPQAMFAWDPLKRPTPSQALQ-------HPFF
..|.|. | |..|..  .| ||   . ....|..                      .. | . .. .|| ||||  .|||       ||.|
KCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase MAK_d.AA Pkinase 28-301 29 2.8e-85 294.44 Pfam 1-293 (293) Show / Hide 
Range on Protein: 28-301
Range on HMM: 1-293/293
Sequence Identity: 29% (94 aa)

YKVIKQLGDGTYGTVWKAVNKVTNETVAIKKMKRKYLSWDECMNLR---EVKSLRKLNHPNIVKLKEVIRENNELFFVFEYM--VLYFCFPFS----ATH
|......| |..|.|.|...| |...||.|..|..  ........|   |.. ...|||||||.|... ...... .|.||.   || ..  .    .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYIST--

FYLQECNLYQMMKDRQKLF--PEAKIRNWCFQVLQGLAYMHREGYFHRDLKPENLLVT-VDVI----KIADFGLARE--VRSRPPYTNYVSTRWYRAPEV
             .|.. |  .|  ..... |.|.||.|.|..|  ||||||||.|.   ..|    ||.|||||.     . . .| .. |.||.||||
-------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV

LLQSSLYNSAVDMWAMGAIMAELFNLRPIFPGA----SEADEIYKICSVLGNPSQATW------------------------PDGMKLAKCMNFRFPQAM
.. .. | ..||||..| |..|... ||.|||.    . .|....|| ..| |    |                        ... .. |.        .
IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW--------C

FAWDPLKRPTPSQALQHPFF
...|| ||||. |.||||.|
LCKDPKKRPTAEQILQHPWF
Kinase MAK_d.AA CMGC 123-301 22 2.6e-78 256.75 In-house 138-513 (513) Show / Hide 
Range on Protein: 123-301
Range on HMM: 138-513/513
Sequence Identity: 22% (86 aa)

ECNLYQMMKDRQ---------------------------KLFPEAKIRNWCFQVLQGLA--YMHREG--YFHRDLKPENLLVTVD---------------
...|||..|. |                           | |.   || ...|.|.||.  |.|. .   .||||||||.|.. .               
DHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWN

------VIKIADFGLAR--EVRSRP--------------------PYTNYVSTRWYRAPEVLLQSSLYN---------SAVDMWAMGAIMAELFN-----
      ..||.||||||  ...|..                    |||.||.||||||||.|| .. |.         ...|||. | |.||...     
PCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSL

---LRPIFPGASE-----------ADEIYKICSVLGNPS---------------QATWP-------------------------------------DGMK
   ..|.||| ||            | ..||. |||.|.               . .||                                      ...
IFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWW

LAKCMN------------------------FRFP---------------------QAMFAWDPLKRPTPSQALQHPFF
  |  .                        ..|.                     . |. .|| ||.|..||||||.|
PPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase MAK_d.AA MOK 28-278 39 2.4e-72 225.91 In-house 1-238 (283) Show / Hide 
Range on Protein: 28-278
Range on HMM: 1-238/283
Sequence Identity: 39% (100 aa)

YKVIKQLGDGTYGTVWKAVNKVTNETVAIKKMKRKYLSWDECMNLREVKSLRKLN-HPNIVKLKEVI--RENNELFFVFEYMVLYFCFPFSATHFYLQEC
|| | ..|.||.  | |       .  | |.||... | ..  ||||.. .|.|| ||||..|.||.  |   .|  . | |                . 
YKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQHFESIEQVNNLREIQAMRRLNPHPNILMLHEVVFDRKTGNLALICELM----------------DM

NLYQMMKDRQKLFPEAKIRNWCFQVLQGLAYMHREGYFHRDLKPENLLVTVDVIKIADFGLAREVRSRPPYTNYVSTRWYRAPEVLLQSSLYNSAVDMWA
|.| ... |    |. ||... .|... |  ||| | |||| ||||.|.  |..|.||||  | | |. ||| |.||||||||| ||    |   .|||.
NIYELIRGRRHYLPQKKIMHYMYQLCKSLDHMHRNGIFHRDVKPENILIKQDHLKLADFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGYYTYQMDMWS

MGAIMAELFNLRPIFPGASEADEIYKICSVLGNPSQATWPDGMKLAKCMNFRFP
 | .  |.  |.|.|||. | | | ||  |.| | | .     . .. ||. ||
VGCVFYEIASLHPLFPGVNEVDQISKIHDVMGTPCQKILNKFKNQSRAMNYDFP
Kinase MAK_d.AA CDK 123-301 38 4.1e-71 226.73 In-house 101-284 (284) Show / Hide 
Range on Protein: 123-301
Range on HMM: 101-284/284
Sequence Identity: 38% (75 aa)

ECNLYQMMKDRQKLFPEAKIRNWCFQVLQGLAYMHREGYFHRDLKPENLLVTVD-V-----IKIADFGLAREVRS-------RPPYTNYVSTRWYRAPEV
.  |.. |.          |... .| |.||.|.|. .  |||||| |.|.. . .     .|||||||||.  .       . .||. | |.||||||.
DHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPEL

LLQSSLYN--SAVDMWAMGAIMAELFN---LRPIFPGASEADEIYKICSVLGNPSQATWPDGMKLAKCMNFRFPQAMFAWDPLKRPTPSQALQHPFF
|| |. |.   ..|||. | |.||.|.    .|.||| || | . ||. ..| |.  .||.  ||       . . |.. || || . .||||||.|
LLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---DLLNKMLCYDPKKRISAEQALQHPYF
Kinase MAK_d.AA RCK 28-106 74 1.5e-59 187.53 In-house 1-82 (298) Show / Hide 
Range on Protein: 28-106
Range on HMM: 1-82/298
Sequence Identity: 74% (61 aa)

YKVIKQLGDGTYGTVWKAVNKVTNETVAIKKMKRKYLSWDECMNLREVKSLRKLN-HPNIVKLKEVIRENN--ELFFVFEYM
|..||||||||||.| ||.|| |.| |||||||.|. ||.|||||||.||||||| ||||.|||||||.|.  .|.||||||
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYM
Kinase MAK_d.AA CDK7 131-276 43 7.7e-58 152.41 In-house 93-240 (288) Show / Hide 
Range on Protein: 131-276
Range on HMM: 93-240/288
Sequence Identity: 43% (64 aa)

KDRQKLFPEAKIRNWCFQVLQGLAYMHREGYFHRDLKPENLLVTVD-VIKIADFGLAREVRS-RPPYTNYVSTRWYRAPEVLLQSSLYNSAVDMWAMGAI
|| . ..  | | ..  ..|||| |.||    |||||| |||.  . ..|||||||||   |    ||  | |||||||| |     | ..||||..| |
KDKSIILTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCI

MAELFNLRPIFPGASEADEIYKICSVLGNPSQATWPDGMKLAKCMNFR
.|||    |..|| |. | . .|.. || |. ..||.  ...  . |.
FAELMLRVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFK
Kinase MAK_d.AA CDC2 122-265 40 1.8e-51 156.16 In-house 82-235 (301) Show / Hide 
Range on Protein: 122-265
Range on HMM: 82-235/301
Sequence Identity: 40% (62 aa)

QECNLYQMMK---DRQKLFPEAKIRNWCFQVLQGLAYMHREGYFHRDLKPENLLVTVD-VIKIADFGLAREVRS-RPPYT--NYVSTRWYRAPEVLLQSS
....| . |.     .| .|......  .| |||... |. . .|||||| |.|.  . .|||||||||| .     .||    | |.||||||.|| ..
LDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCK

LYNSAVDMWAMGAIMAEL---FNLRPIFPGASEADEIYKICSVLGNPSQATWPD
 |. .||||. | |.||.    . .|.|.| || |...||  .|| |.  |||.
RYSTPVDMWSIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPG
Kinase MAK_d.AA MAK 28-106 52 2.4e-51 161.45 In-house 1-112 (352) Show / Hide 
Range on Protein: 28-106
Range on HMM: 1-112/352
Sequence Identity: 52% (59 aa)

YKVIKQLGDGTYGTVWKAVN------------------------------KVTNETVAIKKMKRKYLSWDECMNLREVKSLRKLN-HPNIVKLKEVIR--
| .||||||||||.| .|                                . | | ||||.||.|. ||.|||||||||||.||| ||||||||||||  
YQMIKQLGDGTYGCVMLAKRQFPLSNILGKQHDIRGTLMDQPKNGHQNYIIDTGEKVAIKRMKKKFYSWEECMNLREVKSLKKLNAHPNIVKLKEVIRDS

ENNELFFVFEYM
||..|.||||||
ENDHLYFVFEYM
Kinase MAK_d.AA CDKL 138-257 41 9.7e-47 157.82 In-house 96-218 (286) Show / Hide 
Range on Protein: 138-257
Range on HMM: 96-218/286
Sequence Identity: 41% (52 aa)

PEAKIRNWCFQVLQGLAYMHREGYFHRDLKPENLLVT--VDVIKIADFGLAREVRSRPP--YTNYVSTRWYRAPEVLLQSSLYNSAVDMWAMGAIMAELF
.| ..|. ..|.|..... |     ||| ||||.|.|   ...|. |||.||   . |   || || |||||||| |.    | ..||.|| | .|||..
DEHVVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFAR-MLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMI

NLRPIFPGASEADEIYKICSVLGN
   |..|| |. |  |.|  .||.
DGQPLWPGQSDIDQLYHIQKCLGP
Kinase MAK_d.AA CDK5 142-264 42 7.1e-42 129.79 In-house 100-225 (287) Show / Hide 
Range on Protein: 142-264
Range on HMM: 100-225/287
Sequence Identity: 42% (55 aa)

IRNWCFQVLQGLAYMHREGYFHRDLKPENLLVTVD-VIKIADFGLARE----VRSRPPYTNYVSTRWYRAPEVLLQSSLYNSAVDMWAMGAIMAELF-NL
|.   .| |.|||. | .   |||||| |||.      | |||||||     ||    |.  | | |||.| ||. | .|.  .||| .| |.||.  ..
IKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRC---YSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAG

RPIFPGASEADEIYKICSVLGNPSQATWP
|| |||... |.  .|  ..| |.  .||
RPLFPGNDVEDQLKRIFKIMGTPCEDKWP
Kinase MAK_d.AA MAPK 121-260 39 1.1e-41 141.85 In-house 97-256 (328) Show / Hide 
Range on Protein: 121-260
Range on HMM: 97-256/328
Sequence Identity: 39% (63 aa)

LQECNLYQMMKDRQKLFPEAKIRNWCFQVLQG--LAYMHREGYFHRDLKPENLLVTVD-VIKIADFGLAREVRSRPPY---------------TNYVSTR
| |..|.| .| .|    .  |.   .|.| |  | |.|  .  ||||||.|.||. .   ||.|||||| . .   .               | ||.||
LMETDLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATR

WYRAPEVLLQ--SSLYNSAVDMWAMGAIMAELFN-LRPIFPGASEADEIYKICSVLGNPSQ
||||||..|   .  |. |||||. | |.||. .  .|.||| .  | . .| .|||.||.
WYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSE
Kinase MAK_d.AA CMGC 28-106 28 1.2e-35 113.96 In-house 1-137 (513) Show / Hide 
Range on Protein: 28-106
Range on HMM: 1-137/513
Sequence Identity: 28% (39 aa)

YKVIKQLGDGTYGTVWKAVN--------------KVTNETVAIKKMK-RKYLSWDEC----------MNLREVKSLRKLN-----------------HPN
|..||..| ||||.|.|...              . ||| |||||.| ..   ....          . |||.| |..||                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVKLKEVIRENN-----------------ELFFVFEYM
||||..... .|                 .|..|||||
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYM
Kinase MAK_d.AA CDK 28-106 34 2.4e-28 87.67 In-house 1-100 (284) Show / Hide 
Range on Protein: 28-106
Range on HMM: 1-100/284
Sequence Identity: 34% (35 aa)

YKVIKQLGDGTYGTVWKAVNKVTN-----ETVAIKKMK---RKYLSW-DECMN---LREVKSLRKLNHPNIVKLKEVIREN-----------NELFFVFE
|. ....| ||||.| || .| |.     . ||.|| .    . ..  .| ..   .||.. |..| |||||||..|.  .           | |..|||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEG-REEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE

YM
||
YM
Kinase MAK_d.AA CDC2 28-106 40 1.4e-26 78.25 In-house 1-82 (301) Show / Hide 
Range on Protein: 28-106
Range on HMM: 1-82/301
Sequence Identity: 40% (34 aa)

YKVIKQLGDGTYGTVWKAVNKVTNETVAIKKMKRKYLSWDE---CMNLREVKSLRKLN-HPNIVKLKEVIRENNELFFVFEYM
|. |. .| |||| | |. .. ||. ||.|| . .. . ..      .||   | .|. |||||||..|| . | |. ||||.
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYL
Kinase MAK_d.AA CDK7 28-106 32 3.8e-25 63.53 In-house 1-84 (288) Show / Hide 
Range on Protein: 28-106
Range on HMM: 1-84/288
Sequence Identity: 32% (28 aa)

YKVIKQLGDGTYGTVWKAVNKVTNETVAIKKMKRKYLSWDECMN------LREVKSLRKLNHPNIVKLKEVIRENNELFFVFEYM
|. ||..| |...|| ||  ..|.. ||||| | | .. .|         .||.| |. . |.|.. |  ..     .  ||..|
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIK-KLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFM
Kinase MAK_d.AA CDK5 28-106 42 5.9e-23 68.94 In-house 1-80 (287) Show / Hide 
Range on Protein: 28-106
Range on HMM: 1-80/287
Sequence Identity: 42% (35 aa)

YKVIKQLGDGTYGTVWKAVNKVTNETVAIKKMKRKYLSWDE---CMNLREVKSLRKLNHPNIVKLKEVIRENNELFFVFEYM
|. .  .|.||||||.|| || | | ||.|. .    | ||   .  .||.  |. | |.||| |  ||  .. |  |||..
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLD--SEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFC
Kinase MAK_d.AA MAPK 28-106 30 6.1e-21 68.98 In-house 1-98 (328) Show / Hide 
Range on Protein: 28-106
Range on HMM: 1-98/328
Sequence Identity: 30% (30 aa)

YKVIKQLGDGTYGTVWKAVNKV------TNETVAIKKMKRKYLSWDECMN-LREVKSLRKL-NHPNIVKLKEVIREN-----------NELFFVFEYM
|. .|..| | ||.|..|. |       ....|||||. |   .   |   .||.| || . .|.||.||.....             |.. .|.|.|
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELM
Kinase MAK_d.AA CDKL 28-106 42 7.7e-19 61.04 In-house 1-80 (286) Show / Hide 
Range on Protein: 28-106
Range on HMM: 1-80/286
Sequence Identity: 42% (34 aa)

YKVIKQLGDGTYGTVWKAVNKVTNETVAIKKMKR-KYLSWDECMNLREVKSLRKLNHPNIVKLKEVIRENNELFFVFEYM
|  .  .| | ||.| |  || |.. ||||| |  ..        .||.| |. | |.||| |.|| | ...|. ||||.
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYC
Kinase MAK_d.AA TyrKc 28-301 23 3e-16 39.91 SMART 1-280 (280) Show / Hide 
Range on Protein: 28-301
Range on HMM: 1-280/280
Sequence Identity: 23% (73 aa)

YKVIKQLGDGTYGTVWKAVNKVTNETVAIKKMKRKYLSWDECMNLREVKSLRKL--NHPNIVKLKEVIREN-------NELFFVFEYMVLYFCFPFSATH
 . .|.|| | .|.|.|.. |   ..||.|..|       . . .|| . ..||  .|||||.|  |...          |. |.|||      |  . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYM------PHGDLK

FYLQECNLYQMMKDRQKLFPEAKIRNWCFQVLQGLAYMHREGYFHRDLKPENLLVTVDV-IKIADFGLAREVRSR-------PPY-------TNY-VSTR
 ||...            .. ..  ..|.|. .| .| |. .. ||||   | ||. .  .||.||||.|.. .          |       ... .  |
DYLRKHRPK---------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR

WYRAPEVLLQSSLYNSAVDMWAMGAIMAELFNLRPIFPGASEADEI----YKICSVLGNPSQATWPDGMKL--------AKCMNFRFPQAMFAWDPLKRP
|. |||.. . . .... | |. |  | |.| .     |..   ..     .   |. .  |   .. ..         .    ..  .   . || .||
WM-APECI-NYGKFTTKSDVWSFGVCMWEIFTY-----GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP

TPSQALQHPFF
| |.   | .|
TFSEI--HECF
Kinase MAK_d.AA RCK 281-301 66 8.2e-13 36.7 In-house 278-298 (298) Show / Hide 
Range on Protein: 281-301
Range on HMM: 278-298/298
Sequence Identity: 66% (14 aa)

MFAWDPLKRPTPSQALQHPFF
| .||| ||.|..||||||.|
MLQWDPQKRITAQQALQHPYF
Kinase MAK_d.AA Pkinase_Tyr 28-106 31 2.3e-12 42.53 Pfam 1-89 (270) Show / Hide 
Range on Protein: 28-106
Range on HMM: 1-89/270
Sequence Identity: 31% (28 aa)

YKVIKQLGDGTYGTVWKAVNK----VTNETVAIKKMKRKYLSWD--ECMNLREVKSLRKL-NHPNIVKLKEVIR-ENNE--LFFVFEYM
 . .|.|| | .|.|.|.. |     |. .||.|..| .. . .    . .||.| ...| .|||||.|  |.  .     .. |.|||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYM
Kinase MAK_d.AA MAK 281-301 52 6.8e-12 33.7 In-house 332-352 (352) Show / Hide 
Range on Protein: 281-301
Range on HMM: 332-352/352
Sequence Identity: 52% (11 aa)

MFAWDPLKRPTPSQALQHPFF
| .||| ||||..|....|.|
MLQWDPNKRPTAQQCCKYPYF
Kinase MAK_d.AA CDK7 279-301 39 3.3e-08 17.51 In-house 266-288 (288) Show / Hide 
Range on Protein: 279-301
Range on HMM: 266-288/288
Sequence Identity: 39% (9 aa)

QAMFAWDPLKRPTPSQALQHPFF
. |.. .|.|| | .|.|..|.|
CGMWTMNPCKRWTCTQCLKMPYF
Kinase MAK_d.AA Pkinase_Tyr 125-235 27 1.1e-07 26.7 Pfam 93-210 (270) Show / Hide 
Range on Protein: 125-235
Range on HMM: 93-210/270
Sequence Identity: 27% (33 aa)

NLYQMMKDR---QKLFPEAKIRNWCFQVLQGLAYMHREGYFHRDLKPENLLVT-VDVIKIADFGLAREVRSRPPYTNYVST------RWYRAPEVLLQSS
.|.   ...   .. ..   . ..|.|. .|..| .. .. ||||   | |||   |.||.|||||| . .   |  ....      .|. |||..  . 
DLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWM-APECINYGK

LYNSAVDMWAMGAIMAELFNL
 .... | |. |  | |.| .
-FTTKSDVWSFGVLMWEIFTY
Kinase MAK_d.AA CDKL 279-301 34 4e-06 16.9 In-house 264-286 (286) Show / Hide 
Range on Protein: 279-301
Range on HMM: 264-286/286
Sequence Identity: 34% (8 aa)

QAMFAWDPLKRPTPSQALQHPFF
....  || .|.| .|...||.|
KKCLHMDPDERMTCEQLMHHPYF
Kinase MAK_d.AA MOK 279-301 43 6e-06 14.11 In-house 261-283 (283) Show / Hide 
Range on Protein: 279-301
Range on HMM: 261-283/283
Sequence Identity: 43% (10 aa)

QAMFAWDPLKRPTPSQALQHPFF
..| ..||  | |  |..|||.|
HKMCTYDPDERITAHQVIQHPYF
Kinase MAK_d.AA CDC2 279-301 47 8e-06 13.28 In-house 279-301 (301) Show / Hide 
Range on Protein: 279-301
Range on HMM: 279-301/301
Sequence Identity: 47% (11 aa)

QAMFAWDPLKRPTPSQALQHPFF
. | . || || .  .|||||.|
MQMLQYDPQKRISAKEALQHPYF
Kinase MAK_d.AA MAPK 279-301 52 1e-05 15.59 In-house 306-328 (328) Show / Hide 
Range on Protein: 279-301
Range on HMM: 306-328/328
Sequence Identity: 52% (12 aa)

QAMFAWDPLKRPTPSQALQHPFF
. | ..|| || |  .|||||.|
EKMLVFDPDKRITVEEALQHPYF
Kinase MAK_d.AA CDK5 279-301 39 0.000121 10.06 In-house 265-287 (287) Show / Hide 
Range on Protein: 279-301
Range on HMM: 265-287/287
Sequence Identity: 39% (9 aa)

QAMFAWDPLKRPTPSQALQHPFF
| |   .| .| .  .||.||.|
QKMLQCNPNQRISAKAALHHPYF