Gene SRPK_a (S.moellendorffii)

SRPK_a

Species: S.moellendorffii
Alias: SRPK_a
External Links:
Annotation:

Classification

Group: CMGC
Family: SRPK

Sequence

Name Sequence Type Origin Length Description Download
SRPK_a.AA Protein None 513 None Fasta, JSON
SRPK_a.NA RNA None 1542 None Fasta, JSON
SRPK_a.kin_dom Protein Kinase Domain None 363 None Fasta, JSON

Protein domain

Protein domains of SRPK_a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SRPK_a.AA SRPK 280-443 55 7.1e-134 347.03 In-house 391-554 (554) Show / Hide 
Range on Protein: 280-443
Range on HMM: 391-554/554
Sequence Identity: 55% (91 aa)

DLRCKIVDLGNACWTYKQFTNDIQTRQYRSPEVLLGCKYSTPVDIWSFACLVFELATGDVLFDPHSGDQFDKDEDHLALMIELLGRMPRKVSLGGRFSRE
... ||.|||||||... ||.||||||||||||..| .|.||.||||.||..||||||| ||.||||. . .|.||.|..|||.|. |... | |. |||
KIKIKIADLGNACWVHHHFTEDIQTRQYRSPEVIIGAGYNTPADIWSTACMAFELATGDYLFEPHSGEDYSRDDDHIAHIIELCGKIPWHFALSGKYSRE

FFNRQGDLRHIKKLRYWPLDKVLHDKYSFPAQDAQELAEFLCPLLDFVADKRPTAGQCLLHPWV
|||..|.||||.|| .|||  ||  || .. ..|.. ..|| | |...  || ||..|| ||| 
FFNKKGELRHIPKLKPWPLMNVLIEKYEWSHEEAKQFEDFLMPMLHYNPEKRATAKECLQHPWL
Kinase SRPK_a.AA SRPK 81-222 56 1.1e-125 325.4 In-house 1-165 (554) Show / Hide 
Range on Protein: 81-222
Range on HMM: 1-165/554
Sequence Identity: 56% (93 aa)

YVVQRKVGWGHFSTVWLAWDTQQKRYVALKVQKSAKHYTEAAFDEISILKQIADGDPS-----------------------NSKCVVKLLDHFKHSGPNG
|.| || ||||||||||.||.| .||||.|..|||.||||.|.||| .|..... ||.                       | ..||.|||||||.||||
YHVIRKLGWGHFSTVWLCWDMQYDRYVAMKIVKSAPHYTETAVDEIKLLQCVRKHDPNPQWMHFLKEYYEDYKRDCKEFDPNRCHVVQLLDHFKHRGPNG

QHVCMVFEFLGDNLLTIIKLYNYRGLPLPMVKQLSMQILIGLDYLHRQLSIIHTDLKPENVLLTL
.|.||||| ||.||| .|| |||.|.|.. |||.. |.|||||||||  .|||||.|||||||..
NHYCMVFEVLGHNLLKWIKHYNYQGMPMHCVKQIARQVLIGLDYLHRKCGIIHTDIKPENVLLCV
Kinase SRPK_a.AA CMGC 81-443 19 6.1e-102 335.82 In-house 1-513 (513) Show / Hide 
Range on Protein: 81-443
Range on HMM: 1-513/513
Sequence Identity: 19% (110 aa)

YVVQRKVGWGHFSTVWLAWD--------------TQQKRYVALKVQKSAKHYTEAAF-------------DEISILKQIA----------DGDPSNSKC-
| . .|.|.|....|. ..|              .. ...||.|  |... |.| |              .||.|||..           | ||.| .  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRD-DPDNKHHN

-VVKLLDHFKHSGPNGQ-------------HVCMVFEFLGDNLLTIIKLYN--YRG-----LPLPM------------VKQLS------MQILIGLD--Y
 .|||.|.|.|....|.             |...|||... .|. .|| ..  |.|     |.               .| ..       ||| ||.  |
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

LHRQ-LSIIHTDLKPENVLLTLPLDP-------SKDPLNDGAPRHENHKIHADEATGAADAQAPGEAPRLANKHEKRLKVTDLGELDLRC----------
.|.. ..|||.||||||.|..   .        |                                                                  
CHSHWGNIIHRDLKPENILINHNCELITRMMWKS-------------------------------------------------------EDWNPCQKNGR

-KIVDLGNACWTYKQ------------------------FTNDIQTRQYRSPEVLLGCK----------YSTPVDIWSFACLVFELATG--------DVL
 || | |.|.|. .                         .|....|| ||.||.|||.|          |.||.|.||..|  .|. ||        . |
LKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPL

FDPHSGD-----QFDKDEDHLALMIELLGRMPRKVSLGGR-------FSREFFNRQGDLRHIKKL-------------------------RYWPLDKVLH
| .||..     . ... |.|......||  . ..   |.        ..|..|. . ....|..                           |.  | ..
FPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWK

DKYSFPAQ--------------------------------DAQELAEFLCPLLDFVADKRPTAGQCLLHPWV
... .                                   . ... ..|. .| .  |||.|| |.| ||. 
NLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase SRPK_a.AA S_TKc 81-443 21 2.1e-65 224.5 SMART 1-231 (231) Show / Hide 
Range on Protein: 81-443
Range on HMM: 1-231/231
Sequence Identity: 21% (82 aa)

YVVQRKVGWGHFSTVWLAWDTQQKRYVALKVQKSAKHYTEAAFDEISILKQIADGDPSNSKCVVKLLDHFKHSGPNGQHVCMVFEFLGD---NLLTIIKL
| . ||.| | |..|......  .|.||.|. |      | .  ||.|||.       . . .|||.|.| .     .|..||.|...    .|...|| 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKK

YNYRG----LPLPMVKQLSMQILIGLDYLHRQLSIIHTDLKPENVLLTLPLDPSKDPLNDGAPRHENHKIHADEATGAADAQAPGEAPRLANKHEKRLKV
....|    .|  ... .  ||. .|.|.|..  ||| ||||||.||.                                                    
RGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE---------------------------------------------------

TDLGELDLRCKIVDLGNACWTYKQFTNDIQTRQYRSPEVLLGCKYST-PVDIWSFACLVFELATGDVLFDPHSGDQFDKDEDHLALMIELLGRMPRKVSL
        . || | | |.      |  . |. |..||||   .|.. ..|.||. |...|...|  .|.            ....|....|        
--------HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP------------QMQMMFKKIG--------

GGRFSREFFNRQGDLRHIKKLRYWPLDKVLHDKYSFPAQDAQELAEFLCPLLDFVADKRPTAGQCLL-------HPWV
                                         .|. .|.. .|..  .||||| ..|        |||.
----------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase SRPK_a.AA CLK 81-385 26 2.6e-65 194.51 In-house 1-289 (350) Show / Hide 
Range on Protein: 81-385
Range on HMM: 1-289/350
Sequence Identity: 26% (87 aa)

YVVQRKVGWGHFSTVWLAWDTQQ-KRYVALKVQKSAKHYTEAAFDEIS-ILKQIADG-DPSNSKC--VVKLLDHFKH-SGPNGQHVCMVFEFLGDNLLTI
|..  ..| | |..|   ||..  |.|||||. .... |.|||  ||. |.|.|.   || | .   ..|..| |..  |    |.|.||| .| ..   
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHG----HICIVFELYGLSIYDF

IKLYN------YRGLPLPMVKQLSMQILIGLDYLHRQLSIIHTDLKPENVLLTLP-LDPSKDPLNDGAPRHENHKIHADEATGAADAQAPGEAPRLANKH
.|  |      |...|.  ..... |..  .  ||  ....|||||||| ... . .                                     .   | 
MKSNNSKMPNKYIPYPIDHIRHMAYQLCEAVKFLH-DMKLTHTDLKPENICFVDSRF----------------------------------THFDCTFKY

EKRLK--------VTDLGEL-DLRCKIVDLGNAC---WTYKQFTNDIQTRQYRSPEVLLGCKYSTPVDIWSFACLVFELATGDVLFDPHSGDQFDKDEDH
. . |        | ..  . ..  ...| |.|      .   .  ..||.|| ||| ||. .|.| |.||..|  ||| ||. ||. |.        .|
NHKKKINKKSNNCVCHYWHVKNTHICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHD------NREH

LALMIELLG-RMPRKVSLGGR---FSREFFNRQG
||.| ...|   |   .   |    ....|....
LAMMERIMGMPIPQWMIQRTRRFKVKQKYFYHNR
Kinase SRPK_a.AA Pkinase 81-365 21 9.5e-37 131.02 Pfam 1-233 (293) Show / Hide 
Range on Protein: 81-365
Range on HMM: 1-233/293
Sequence Identity: 21% (66 aa)

YVVQRKVGWGHFSTVWLAWDTQQKRYVALKVQKSAKHYTEA---AFD--EISILKQIADGDPSNSKCVVKLLDHFKHSGPNGQHVCMVFEFLGDNLLTII
|.. ||.| | |..|... .    . ||.|. |  .   .    ..   ||.|.| . .     ....|.|.| |      ..|..||.|...  |   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-N-----HPNIVRLYDWFED----KDHIYMVMEYCEGGLY-VM

KLY------NYRGL--PLPMVKQLSMQILIGLDYLHRQLSIIHTDLKPENVLLTLPLDPSKDPLNDGAPRHENHKIHADEATGAADAQAPGEAPRLANKH
 |.      .....  .   .|    ||| ||.|.|.. .||| ||||||.|.    ...                                        
DLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM-GIIHRDLKPENILIDNNGHIDA---------------------------------------

EKRLKVTDLGELDLRCKIVDLGNAC---WTYKQFTNDIQ-TRQYRSPEVLL-GCKYSTPVDIWSFACLVFELATGDVLFDPHSGDQFDKDEDHLALMIEL
              . || | | |.   .  .. ....  |. |..|||.. | .|...||.||. |...|...|  .|. ... . |.  |..... . 
--------------CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHC-WHDN-HDQMQMICRI

LGR
.|.
MGP
Kinase SRPK_a.AA DYRK 81-220 35 4.5e-35 122.83 In-house 1-137 (320) Show / Hide 
Range on Protein: 81-220
Range on HMM: 1-137/320
Sequence Identity: 35% (50 aa)

YVVQRKVGWGHFSTVWLAWDTQQKRYVALKVQKSAKHYTEAAFDEISILKQIADGDPSNSKCVVKLLDHFKHSGPNGQHVCMVFEFLGDNLLTIIKLYNY
| .    | | |. |  .||.. . .||.|. .. | .   | .||.||. . . || ... .|...|.|.|     .|.|.||| |  ||   .| .. 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHR----NHLCIVFELLSMNLYEFLKNNHF

RGL-PLPMVKQLSMQILIGLDYLHRQLSIIHTDLKPENVLL
.|. .|  |..   ||| .|..||.  .||| ||||||..|
QGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIML
Kinase SRPK_a.AA Ciliate-E2 81-443 15 6.5e-31 103.34 In-house 1-365 (365) Show / Hide 
Range on Protein: 81-443
Range on HMM: 1-365/365
Sequence Identity: 15% (76 aa)

YVVQRKVGWGHFSTVWLAWDTQQKRYVA--------------------LKVQKSAKHY-TEAAFDEISILKQIADGD-----------PSNSKCVVKLLD
| ...| | | |..|... . .... .|                    ..  |. |..  |. . ||.|...| . .             |.. ..|. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYE

HFK--HSGPNGQHVCMVFEFLGDNLLT--IIKLYNYR--------GLPLPMVKQLSMQIL---------------IGLDYLHRQLSIIHTDLKPENVLLT
.|.        ... .|.|..  . |   |.. .  |         . .  .|... |||                .| ||| . .||| |.||||.|. 
CFQEKDD----NNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-

LPLDPSKDPLNDGAPRHENHKIHADEATGAADAQAPGEAPRLANKHEKRLKVTDLGELDLRCKIVDLGNA---------------CWTYKQFTND-----
                                                             .||.|.|..               |  |..  ||     
-------------------------------------------------------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTP

---------------IQTRQYRSPEVLLGCK---------YSTPVDIWSFACLVFELATGDVLFDPHSGDQFDKDEDHLALMIELLGRMPRKVSLGGRFS
               . |  | .||.| | |         |.. .||||. .. .|. .|   |                                    
GYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF------------------------------------

REFFNRQGDLRHIKKLRYWPLDKVLHDKYSFP------------------AQDAQELAEFLCP----LLDFVADKRPT-AGQCLLHPWV
                    ... .  |..||                   .  ||   ..      .|.   .||.| . |.| ||| 
--------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase SRPK_a.AA Ciliate-E2-Unclassified 81-443 16 3.1e-30 102.08 In-house 1-352 (352) Show / Hide 
Range on Protein: 81-443
Range on HMM: 1-352/352
Sequence Identity: 16% (73 aa)

YVVQRKVGWGHFSTVWLAWDTQQKRYV-----ALKVQKSAKHYTEAAFDEISILKQIADGD----------------PSNSKCVVKLLDHFKHSGPNGQH
| .... | | |..|... . .|| ..     . |.|. .... .   ... ..|..                     ... ..||....|.      |.
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDK----QN

VCMVFEFL-GDNLLTIIKLYNY---------------RGLPLPMVK-----QLSMQILIGLDYLHRQLSIIHTDLKPENVLLTLPLDPSKDPLNDGAPRH
...| |.. | .|. .|| ..                . ..   .|     ..  ||| ||.|||... ||| |.||||.|..                 
IYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-------------

ENHKIHADEATGAADAQAPGEAPRLANKHEKRLKVTDLGELDLRCKIVDLGNA------------------CWTYKQFTNDIQTRQYR----SPEVLLGC
                                          ...|| |.|..                   | .. ..  ..| .|     .|||| |.
-----------------------------------------NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQ

KYSTP----VDIWSFACLVFELATGDVLFDPHSGDQ--------------FDKDEDHLALMIELLGRMPRKVSLGGRFSREFFNRQGDLRHIKKLRYWPL
.|...    .||||. .. .|. .|   |.  . .|              .   .. ..  |.     ...                             
NYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQ-----------------------------

DKVLHDKYSFPAQDAQELAEFLCPLLDFVADKRPTAGQCLLHPWV
    ... |. |.|  .  ..|. .|.   .||.|. | | ||| 
---IPKHWSPEAKDFIN--DLLQKMLKKNPNKRITFEQILNHPWF
Kinase SRPK_a.AA DYRK2 81-220 36 4e-29 91.59 In-house 1-135 (318) Show / Hide 
Range on Protein: 81-220
Range on HMM: 1-135/318
Sequence Identity: 36% (51 aa)

YVVQRKVGWGHFSTVWLAWDTQQKRYVALKVQKSAKHYTEAAFDEISILKQIADGDPSNSKCVVKLLDHFKHSGPNGQHVCMVFEFLGDNLLTIIKLYNY
| .    | | |  |  . |   | .||.|.    | . . |  || ||. |   |. |.  .|..|| |   .    |.|..|| |. ||   ||  ..
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRN----HHCITFELLSMNLYEYIKKNHF

RGLPLPMVKQLSMQILIGLDYLHRQLSIIHTDLKPENVLL
 |. |  |     .|| .|. ||.   ||| ||||||.||
QGFSLQLVRRFAHSILQCLRFLHKN-NIIHCDLKPENILL
Kinase SRPK_a.AA DYRK1 81-223 34 9.3e-28 94.22 In-house 1-140 (321) Show / Hide 
Range on Protein: 81-223
Range on HMM: 1-140/321
Sequence Identity: 34% (49 aa)

YVVQRKVGWGHFSTVWLAWDTQQKRYVALKVQKSAKHYTEAAFDEISILKQIADGDPSNSKCVVKLLDHFKHSGPNGQHVCMVFEFLGDNLLTIIKLYNY
| ..  .| | |  |  |.|.|.. |||.|. |  | . . |  || .|  .   |. .   .|.|  ||..      |.|.|||.|  ||  ...  ..
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFR----NHLCLVFELLSYNLYDLLRNTHF

RGLPLPMVKQLSMQILIGLDYLHR-QLSIIHTDLKPENVLLTLP
||  | .....  |..  | ..    |.||| ||||||.||  |
RGVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNP
Kinase SRPK_a.AA DYRK 284-443 26 2.8e-26 93.65 In-house 147-320 (320) Show / Hide 
Range on Protein: 284-443
Range on HMM: 147-320/320
Sequence Identity: 26% (51 aa)

KIVDLGNACWTYKQFTNDIQTRQYRSPEVLLGCKYSTPVDIWSFACLVFELATGDVLFDPHSGDQFDKDEDHLALMIELLGRMPRKVSLGG--RFSREFF
|..| | .|   ....  || | ||.|||.|||.|....|.||. | . || || .||   .|.      | ||...|.|| .|...   |  |. ..||
KVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLF---PGENEY---DQLACIMEVLGMPPKWMIDKGRCRRKHKFF

NRQGDLRHIKKLRYWPLDKVLHDKY----------------------------SFPAQDAQELAEFLCPLLDFVADKRPTAGQCLLHPWV
..         ..|  .|..   ..                             .  .| ...  |.  .|..  .||.|. | | |||.
DC---------FMYCECDEWTKQNKITDHYMTPKCHPTKRGQRRPPGRRNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase SRPK_a.AA DYRK2 284-443 28 1.8e-24 76.19 In-house 144-318 (318) Show / Hide 
Range on Protein: 284-443
Range on HMM: 144-318/318
Sequence Identity: 28% (53 aa)

KIVDLGNACWTYK-QFTNDIQTRQYRSPEVLLGCKYSTPVDIWSFACLVFELATGDVLFDPHSGDQFDKDEDHLALMIELLGRMPRKVSLGG------RF
|..| |  |  .  ..  .||.| ||.||| ||.||....|.||| | . || ||  ||    |.  .   | .|.|.|.|| || |. .        . 
KVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLF---PGENEN---DQFACMMEVLG-MPPKKFFDTWFYIHCFR

SREFFNR-------------QGDLRHIKKL----RYWPLDKVLHDKYSFPAQDAQELAEFLCPLLDFVADKRPTAGQCLLHPWV
 . |||.             . ..  ..|     |. |  | .  |....  . . ...|.   ..  ...| |. | | ||| 
RKYFFNSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSW--KSVLKGCEDENFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase SRPK_a.AA DyrkP 284-384 38 7.6e-21 64.77 In-house 148-242 (323) Show / Hide 
Range on Protein: 284-384
Range on HMM: 148-242/323
Sequence Identity: 38% (39 aa)

KIVDLGNACWTYKQFTNDIQTRQYRSPEVLLGCKYSTPVDIWSFACLVFELATGDVLFDPHSGDQFDKDEDHLALMIELLGRMPRKVSLGGRFSREFFNR
||.| | .|.        .| | || |||..||||   .|.||  |.. || || |||      | |     || .| ..| .|  .   ||  . || |
KIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWTGNVLF------QNDNIQGLLARVIGIIGPFPEWMMQEGRLVQNFFTR

Q
.
K
Kinase SRPK_a.AA DYRK1 284-386 34 2.8e-17 56.79 In-house 146-242 (321) Show / Hide 
Range on Protein: 284-386
Range on HMM: 146-242/321
Sequence Identity: 34% (36 aa)

KIVDLGNACWTYKQFTNDIQTRQYRSPEVLLGCKYSTPVDIWSFACLVFELATGDVLFDPHSGDQFDKDEDHLALMIELLGRMPRKVSLGGRFSREFFNR
||.| | .| . .   . || | ||||||||| .|.. .|.||  |.. |. ||. ||   || .   . | .  ..| ||  |...   .  .. .|..
KIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLF---SGSN---EVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEK

QGD
. |
DPD
Kinase SRPK_a.AA DyrkP 81-220 31 2.3e-16 49.73 In-house 1-139 (323) Show / Hide 
Range on Protein: 81-220
Range on HMM: 1-139/323
Sequence Identity: 31% (45 aa)

YVVQRKVGWGHFSTVWLAWDTQQKRYVALKVQKSAKHYTEAAFDEISILKQIADGDPSNSKCVVKLLDHFKHSGPNGQHVCMVFEFLGDNLLTIIKLY--
| .   .|   ||      | |  . . .|.    | | . . ||| .|. |        | |..  | | |      |. .. | | |||    |    
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHK----EHLFIITELLKDNLYEFYKFNRE

--NYRGLPLPMVKQLSMQILIGLDYLHRQLSIIHTDLKPENVLL
    |   .  ....  ||||.|||.|  | .|| ||||||.|.
NEQQRYFTVGRLQKITQQILIALDYIH-SLRLIHCDLKPENILM
Kinase SRPK_a.AA CDK4 81-221 30 5.7e-16 51.08 In-house 1-144 (290) Show / Hide 
Range on Protein: 81-221
Range on HMM: 1-144/290
Sequence Identity: 30% (45 aa)

YVVQRKVGWGHFSTVWLAWDTQQKRYVALK-VQKSAKHY----TEAAFDEISILKQIADGDPSNSKCVVKLLDHFKHSGPNG--QHVCMVFEFLGDNLLT
|.    .| | . ||. | |... . |||| |  . .            |||.... .  .  |   .|||.| .. . . .    . ||||     | |
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPN---IVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHT

IIKLYNYRGLPLPMVKQLSMQILIGLDYLHRQLSIIHTDLKPENVLLT
 .      |.| . .|... |.| |.|.||   .||| ||||.|.|.|
YLDKCPPPGMPPCTIKHMMHQLLRGVDFLHSH-RIIHRDLKPQNILVT
Kinase SRPK_a.AA CDK4 307-334 57 1.5e-12 39.21 In-house 175-202 (290) Show / Hide 
Range on Protein: 307-334
Range on HMM: 175-202/290
Sequence Identity: 57% (16 aa)

YRSPEVLLGCKYSTPVDIWSFACLVFEL
||.|||||   | ||||.|| .| ..|.
YRAPEVLLQSYYNTPVDMWSVGCIFAEM
Kinase SRPK_a.AA TyrKc 81-443 14 1.6e-09 -68.5 SMART 1-280 (280) Show / Hide 
Range on Protein: 81-443
Range on HMM: 1-280/280
Sequence Identity: 14% (56 aa)

YVVQRKVGWGHFSTVWLAWDTQQKRYVALKVQKSAKHYTEAAFDEISILKQI-ADGDPSNSKCVVKLLDHFKHSGPNG---QHVCMVFEFL-GDNLLTII
 .  .| | |.| .|...  .   . || |. |. .   |.  .|..|....       . ...|.|.    ..| |    . ...|.|.  . .|.  .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGG-----HHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KLYNYRGLPLPMVKQLSMQILIGLDYLHRQLSIIHTDLKPENVLLTLPLDPSKDPLNDGAPRHENHKIHADEATGAADAQAPGEAPRLANKHEKRLKVTD
. .  . |...   . . ||  | .|||..  .|| ||   |.|.. ..                                                   
RKHRPK-LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENH---------------------------------------------------

LGELDLRCKIVDLGNACWTYKQ----FTNDIQTR----QYR--------SPEVLLGCKYSTPVDIWSFACLVFELAT-GDVLFDP---HSGDQFDKDEDH
      ..|| | | .   |         |  .     . .        .||..  .|..|  |.|||  . .|. | |.        .    . .... 
------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ----MMSNQEV

LALMIELLGRMPRKV----SLGGRFSREFFNRQGDLRHIKKLRYWPLDKVLHDKYSFPAQDAQELAEFLCPLLDFVADKRPTAGQCLLHPWV
...  .   ... .     |                                    |     .|. .      .. ...|||  ..  |   
IEYVKQGYRMPQPPNDYPMS------------------------------------F-VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase SRPK_a.AA Pkinase 398-443 20 5.2e-07 25.87 Pfam 227-293 (293) Show / Hide 
Range on Protein: 398-443
Range on HMM: 227-293/293
Sequence Identity: 20% (14 aa)

LDKVLHDKYSFPAQDA---------------------QELAEFLCPLLDFVADKRPTAGQCLLHPWV
...... ...|. .                       .|. .|.. .|..   ||||| |.| |||.
ICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase SRPK_a.AA CDK4 417-443 37 9.2e-05 12.03 In-house 264-290 (290) Show / Hide 
Range on Protein: 417-443
Range on HMM: 264-290/290
Sequence Identity: 37% (10 aa)

AEFLCPLLDFVADKRPTAGQCLLHPWV
...|   | .  .||..| ||| ||. 
DDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase SRPK_a.AA Pkinase_Tyr 309-336 39 0.000289 15.07 Pfam 182-209 (270) Show / Hide 
Range on Protein: 309-336
Range on HMM: 182-209/270
Sequence Identity: 39% (11 aa)

SPEVLLGCKYSTPVDIWSFACLVFELAT
.||..  .|..|  |.|||  | .|. |
APECINYGKFTTKSDVWSFGVLMWEIFT
Kinase SRPK_a.AA DyrkP 430-443 57 0.002936 5.82 In-house 310-323 (323) Show / Hide 
Range on Protein: 430-443
Range on HMM: 310-323/323
Sequence Identity: 57% (8 aa)

KRPTAGQCLLHPWV
.||||   | |||.
RRPTAKEALQHPWF
Kinase SRPK_a.AA CLK 430-443 42 0.014953 2.66 In-house 337-350 (350) Show / Hide 
Range on Protein: 430-443
Range on HMM: 337-350/350
Sequence Identity: 42% (6 aa)

KRPTAGQCLLHPWV
||.|... | ||. 
KRITCKDALQHPFF