Gene VPS15-1 (S.moellendorffii)

VPS15-1

Species: S.moellendorffii
Alias: VPS15-1
External Links:
Annotation:

Classification

Group: Other
Family: VPS15

Sequence

Name Sequence Type Origin Length Description Download
VPS15-1.AA Protein None 1376 None Fasta, JSON
VPS15-1.NA RNA None 4128 None Fasta, JSON
VPS15-1.kin_dom Protein Kinase Domain None 203 None Fasta, JSON

Protein domain

Protein domains of VPS15-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase VPS15-1.AA VPS15 27-295 47 2e-128 432.95 In-house 1-293 (296) Show / Hide 
Range on Protein: 27-295
Range on HMM: 1-293/296
Sequence Identity: 47% (140 aa)

LVLKEVIGKSERFFKAILCVHDEGLLLVKVYFKRGDVLDLREHARKLNEIREQFRNVENSHVWPFQRWHETDKAAYLLRQYFFSNLHERLSTRPFLSTIQ
 . ..  | | ||.|     |.||.  |||. |. | . |. .  .. ||. ...     .. |.|.  |||||||. |||.  ||  |.||||||. | 
CHYVKNLG-STRFMKVCKAKHHEGYIVVKVFVKHDDTYSLEPYKQRIEEIKKNLMQHPAFNCCPYQKVIETDKAAYMMRQYVKHNLYDRISTRPFLQMIE

KKWLAFQLLHAVKQSHDRG-VCHGDIKCENVLVTSWNWIYLTDFASFKPTYIPDDNPADFSFFFDTGGRRRCYLAPERFY-----DPKTES---------
||| |||.| |..|.| .| ||||||| ||.|||||||.||||||.|||.|.| ||||||.||||| .|| ||.|||||.     | . .          
KKWIAFQTLCALEQCHKQGNVCHGDIKSENILVTSWNWCYLTDFACFKPCYLPEDNPADFTFFFDTSRRRTCYIAPERFVSNTEQDQDSNNGNMRDIHTD

----PVSP--GGALKPSMDMFSLGCVIAELFLEG-QALFDLSQLLGYRKRLYDPL--PSLEKISDTGIKNMILQMIHVV-PESRLSCDDYLETW
       |  .| |.|.||.||.||||||||.|| |..||.|||. ||.  |.|.    .||| |. |.|....||. . |. |.||..||  |
SIDRQQNPWLFGELTPAMDIFSAGCVIAELFCEGDQPPFDYSQLCKYRSGEYHPNREQIMEKIQDEHIRNLCHHMIQKDNPMKRMSCEEYLNKW
Kinase VPS15-1.AA S_TKc 27-296 17 1.2e-12 8.39 SMART 1-231 (231) Show / Hide 
Range on Protein: 27-296
Range on HMM: 1-231/231
Sequence Identity: 17% (51 aa)

LVLKEVIGKSERFFKAILCVHDE--GLLLVKVYFKRGDVLDLREHARKLNEIREQFRNVENSHVWPFQRWHETDKAAYLLRQYFFS---NLHERLSTRPF
  . ..|||   | |  .|.| .   .  .|.              . ..||.   .     ..  .  . .. .  |.   |      .|....  |. 
YEILRKIGK-GAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

------LSTIQKKWLAFQLLHAVKQSHDRGVCHGDIKCENVLVTSWNWIYLTDF--ASFKPTYIPDDNPADFSFFFDTGGRRRC----YLAPERFYDPKT
      ..  . . .. |.. |..  |..|..| |.| ||.|...   | ..||  | .                     .  |    |.||| .     
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------------TTFCGTPWYMAPEVL-----

ESPVSPGGALKPSMDMFSLGCVIAELFLEGQALFDLSQLLGYRKRLYDPLPSLEKISDTGIKNMILQMIHVVPESRLSCDDYLE--------TWA
       |  |.. |. |.||...|..  |. .|.  |.    |..          |. ..  .| .. .. || |... . |.         | 
-------GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG---------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase VPS15-1.AA CMGC 111-169 15 3.2e-09 25.47 In-house 140-248 (513) Show / Hide 
Range on Protein: 111-169
Range on HMM: 140-248/513
Sequence Identity: 15% (17 aa)

NLHERLSTRPF---------LSTIQ------------KKWLA------FQLLHAVK--QSHDRG--VCHGDIKCENVLVTSWNW----------------
.|.. .   .|         ||  .            .| .       .|.| ..|    | ..  ..| |.| ||.|... .                 
DLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQ

----IYLTDF
    . . ||
KNGRLKICDF
Kinase VPS15-1.AA Ciliate-E2-Unclassified 111-232 16 8e-09 26.76 In-house 107-260 (352) Show / Hide 
Range on Protein: 111-232
Range on HMM: 107-260/352
Sequence Identity: 16% (29 aa)

NLHERLSTRPF-----------------LSTIQKK-----WLAFQLLHAVKQSHDRG-VCHGDIKCENVLVTSWN---WIYLTDFASFK-----------
.|.. .. |..                 ..  | |      .. |.| . .. |  . ..| |||.||.|... .    | ..|| ..|           
DLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTN

-------------------PTYIPDDNPADFSFFFDTGGRRRCYLAPERFYDPKTESPVSPGGALKPSMDMFSLGCVI
                   | |.|                   |.||| .   . . . .       . |..|||...
QQQKMQIWKQQMMWTFCGTPNYMP-Q-----------------YTAPEVLQGQNYDHSKA------YKCDIWSLGVIL
Kinase VPS15-1.AA NIM1 133-169 48 8.7e-09 21.96 In-house 108-144 (258) Show / Hide 
Range on Protein: 133-169
Range on HMM: 108-144/258
Sequence Identity: 48% (18 aa)

QLLHAVKQSHDRGVCHGDIKCENVLVTSWNWIYLTDF
|.. |||  | |.. | ||| |||. || | . . ||
QIVSAVKHMHSRNIVHRDIKAENVMYTSNNCVKVGDF
Kinase VPS15-1.AA CAMK 133-169 25 1.2e-07 19.99 In-house 187-240 (425) Show / Hide 
Range on Protein: 133-169
Range on HMM: 187-240/425
Sequence Identity: 25% (14 aa)

QLLHAVKQSHDRGVCHGDIKCENVLVTSWN----------------W-IYLTDF
|.. ||.  |.....| |.|.||.|... |                . | ..||
QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDF
Kinase VPS15-1.AA Ciliate-C3 133-169 40 3.1e-07 22.29 In-house 104-140 (140) Show / Hide 
Range on Protein: 133-169
Range on HMM: 104-140/140
Sequence Identity: 40% (15 aa)

QLLHAVKQSHDRGVCHGDIKCENVLVTSWNWIYLTDF
|.| |.   |.  . ||||| .|.|. | . | . ||
QILQAIDYLHEHNIVHGDIKFSNILINSKDEIKIIDF
Kinase VPS15-1.AA MARK 133-158 42 3.2e-07 19.83 In-house 112-137 (262) Show / Hide 
Range on Protein: 133-158
Range on HMM: 112-137/262
Sequence Identity: 42% (11 aa)

QLLHAVKQSHDRGVCHGDIKCENVLV
|...||.  |.....| |||.||.|.
QIVSAVNYCHSKNIVHRDIKPENILI
Kinase VPS15-1.AA CDKL 132-169 38 1e-06 18.49 In-house 105-143 (286) Show / Hide 
Range on Protein: 132-169
Range on HMM: 105-143/286
Sequence Identity: 38% (15 aa)

FQLLHAVKQSHDRGVCHGDIKCENVLVT-SWNWIYLTDF
.|.| |... |   . | ||| || |.| .   . | ||
WQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDF
Kinase VPS15-1.AA CDK 128-169 25 2e-06 16.21 In-house 111-157 (284) Show / Hide 
Range on Protein: 128-169
Range on HMM: 111-157/284
Sequence Identity: 25% (12 aa)

KWLAFQLLHAVKQSHDRGVCHGDIKCENVLVTSWNW-----IYLTDF
|.. .||| ..   |.... | |.|. | |...        . ..||
KCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADF
Kinase VPS15-1.AA CMGC 221-248 24 4e-06 15.26 In-house 314-363 (513) Show / Hide 
Range on Protein: 221-248
Range on HMM: 314-363/513
Sequence Identity: 24% (12 aa)

PSMDMFSLGCVIAELFLE-------GQALFD---------------LSQL
...|| |.||..||...        |. ||                . ||
TPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQL
Kinase VPS15-1.AA ERK7 98-169 31 3.8e-05 13.21 In-house 73-144 (292) Show / Hide 
Range on Protein: 98-169
Range on HMM: 73-144/292
Sequence Identity: 31% (23 aa)

DKAAYLLRQYFFSNLHERLSTRPFLSTIQKKWLAFQLLHAVKQSHDRGVCHGDIKCENVLVTSWNWIYLTDF
|.  ||   .  . ||        |  | |.   .||| |.|  |   | | |.|  |.|. |   . . ||
DRDIYLVFEFMETDLHAVIRKGNILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDF
Kinase VPS15-1.AA ERK7 224-243 45 0.001682 7.48 In-house 189-207 (292) Show / Hide 
Range on Protein: 224-243
Range on HMM: 189-207/292
Sequence Identity: 45% (9 aa)

DMFSLGCVIAELFLEGQALF
|| |.||...|. | |...|
DMWSIGCILGEM-LRGKPMF
Kinase VPS15-1.AA Pkinase 224-295 15 0.002722 12.72 Pfam 194-293 (293) Show / Hide 
Range on Protein: 224-295
Range on HMM: 194-293/293
Sequence Identity: 15% (16 aa)

DMFSLGCVIAELFLEGQALFD-L------SQLLGYRKRLYDPLPSLEKISD--------------------TGIKNMILQMIHVVPESRLSCDDYLET--
||.|.||...|... |. .|.        .|.  ...... ||.. .  ..                       |  |  .... |..|..... |.   
DMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

W
.
F
Kinase VPS15-1.AA CDK 224-243 45 0.00314 6.0 In-house 204-225 (284) Show / Hide 
Range on Protein: 224-243
Range on HMM: 204-225/284
Sequence Identity: 45% (10 aa)

DMFSLGCVIAELFL--EGQALF
|| |.||..||.|.   ...||
DMWSVGCIFAEMFTDVTRKPLF
Kinase VPS15-1.AA CDKL 221-243 39 0.009543 5.22 In-house 179-200 (286) Show / Hide 
Range on Protein: 221-243
Range on HMM: 179-200/286
Sequence Identity: 39% (9 aa)

PSMDMFSLGCVIAELFLEGQALF
.. |. ..|||.||. . ||.|.
KPVDIWAIGCVMAEM-IDGQPLW
Kinase VPS15-1.AA Pkinase 142-169 34 0.059631 7.98 Pfam 125-156 (293) Show / Hide 
Range on Protein: 142-169
Range on HMM: 125-156/293
Sequence Identity: 34% (11 aa)

HDRGVCHGDIKCENVLVTSWNWI----YLTDF
|..|..| |.| ||.|. . . |     ..||
HSMGIIHRDLKPENILIDNNGHIDACVKICDF
HEAT VPS15-1.AA HEAT 473-503 29 1.5e-05 23.1 Pfam 1-31 (31) Show / Hide 
Range on Protein: 473-503
Range on HMM: 1-31/31
Sequence Identity: 29% (9 aa)

IVPFVAALLSDSAAIVRCAALQTLCNVLSMV
|.|..  .|.|. . ||.||...|..... .
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT VPS15-1.AA HEAT 518-548 25 0.692321 6.93 Pfam 1-31 (31) Show / Hide 
Range on Protein: 518-548
Range on HMM: 1-31/31
Sequence Identity: 25% (8 aa)

IFPLLSMLPDDPEESVRICYADCIHKIAGTA
|.|.|  . .||...||   . |. ...  .
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT VPS15-1.AA HEAT 625-655 29 2.291404 5.13 Pfam 1-31 (31) Show / Hide 
Range on Protein: 625-655
Range on HMM: 1-31/31
Sequence Identity: 29% (9 aa)

LLPVLPAFLNDRDKQLRALFFEQIVHVCIFV
.||.|   ||| | . |.  .. ....| ..
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT VPS15-1.AA HEAT 664-694 32 0.036877 11.34 Pfam 1-31 (31) Show / Hide 
Range on Protein: 664-694
Range on HMM: 1-31/31
Sequence Identity: 32% (10 aa)

LLPYLEQALSNVEEPVIVNALECLAALCVYK
.||.| ..|.  .. |  .|..||..|| . 
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT VPS15-1.AA HEAT 711-734 25 5.0214 3.95 Pfam 8-31 (31) Show / Hide 
Range on Protein: 711-734
Range on HMM: 8-31/31
Sequence Identity: 25% (6 aa)

LLCHPSQWVRRAAITLVAASGSNL
.|..|.  ||.||.  ...  ...
CLNDPDWEVREAACWCLGQLCEHC
WD40 VPS15-1.AA WD40 974-1012 27 4.8e-13 40.16 Pfam 1-39 (39) Show / Hide 
Range on Protein: 974-1012
Range on HMM: 1-39/39
Sequence Identity: 27% (11 aa)

GVLVSHLHEHQRAVNQVAVSSD-NSFFTSASDDGTVKVWD
. ... . .|. .|. .|.. |  ... |.|.|||...||
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD
WD40 VPS15-1.AA WD40 973-1012 25 6.3e-11 43.55 SMART 1-46 (46) Show / Hide 
Range on Protein: 973-1012
Range on HMM: 1-46/46
Sequence Identity: 25% (12 aa)

RGVLVSHLHEHQR--AVNQVAVSSDN------SFFTSASDDGTVKVWD
   .|. .. |.   .|. |....|.      ... |.| |||...||
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 VPS15-1.AA WD40 1021-1061 18 0.062299 7.97 SMART 1-46 (46) Show / Hide 
Range on Protein: 1021-1061
Range on HMM: 1-46/46
Sequence Identity: 18% (9 aa)

SFRSKLTYSFGQNE--RVLCLAMLSPD------QQVAAASSAGEIRVLC
. .   |.. | .   .|.|..  . .      ...|..|  | ||.  
T-KCVHTFK-GHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 VPS15-1.AA WD40 1024-1059 26 12.534535 1.55 Pfam 1-37 (39) Show / Hide 
Range on Protein: 1024-1059
Range on HMM: 1-37/39
Sequence Identity: 26% (10 aa)

SKLTYSFGQN-ERVLCLAMLSP-DQQVAAASSAGEIRV
.|....|      | |.|   .  . .| .|  | ||.
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRI
WD40 VPS15-1.AA WD40 1077-1114 16 1.025854 0.29 SMART 1-46 (46) Show / Hide 
Range on Protein: 1077-1114
Range on HMM: 1-46/46
Sequence Identity: 16% (8 aa)

GISNVRRTDAQEG--SVLALQAFGG-------MLLYSTQKNG-LHLWD
  . |.  .. .|  .|....            .|.|   .| ...||
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 VPS15-1.AA WD40 1120-1158 18 0.007453 13.79 SMART 1-46 (46) Show / Hide 
Range on Protein: 1120-1158
Range on HMM: 1-46/46
Sequence Identity: 18% (9 aa)

DAWLLKAKP-EQG--YVSALAADPSR------HWLVSGTSRGVLTLWD
.  ...  .  .|  .|.... .|.       ..|.||   | . .||
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 VPS15-1.AA WD40 1130-1158 33 0.038225 8.79 Pfam 10-39 (39) Show / Hide 
Range on Protein: 1130-1158
Range on HMM: 10-39/39
Sequence Identity: 33% (10 aa)

QGYVSALAADPS-RHWLVSGTSRGVLTLWD
.. |...| .|. .|.|.||   | . .||
THWVTCCAWHPDMGHYLASGSRDGTIRIWD
WD40 VPS15-1.AA WD40 1279-1292 42 0.001403 12.92 Pfam 26-39 (39) Show / Hide 
Range on Protein: 1279-1292
Range on HMM: 26-39/39
Sequence Identity: 42% (6 aa)

VITGGTDCRIRLWD
...|. |. ||.||
LASGSRDGTIRIWD
WD40 VPS15-1.AA WD40 1257-1292 16 0.08557 7.1 SMART 1-46 (46) Show / Hide 
Range on Protein: 1257-1292
Range on HMM: 1-46/46
Sequence Identity: 16% (8 aa)

LSDPPPRIP------GVRALLPTTAG------ASVITGGTDCRIRLWD
   .   ..      .|...     |        ...|. |. ||.||
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 VPS15-1.AA WD40 1349-1376 38 1.8e-08 27.0 Pfam 9-39 (39) Show / Hide 
Range on Protein: 1349-1376
Range on HMM: 9-39/39
Sequence Identity: 38% (12 aa)

HRDSITSLAAASQ---LLISSSRDGTIKVWK
| ...|..| .     .|.|.||||||..|.
HTHWVTCCAWHPDMGHYLASGSRDGTIRIWD
WD40 VPS15-1.AA WD40 1336-1376 19 9.3e-05 23.06 SMART 1-46 (46) Show / Hide 
Range on Protein: 1336-1376
Range on HMM: 1-46/46
Sequence Identity: 19% (10 aa)

SEVALAAVDMAGCHRD--SITSLAAASQ--------LLISSSRDGTIKVWK
.   ..  .   .|..  ..|...  .         .|.|.| ||||..|.
T-KCVHTFK---GHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD