Gene WNK_b-2 (S.moellendorffii)

WNK_b-2

Species: S.moellendorffii
Alias: WNK_b-2
External Links:
Annotation:

Classification

Group: Other
Family: WNK

Sequence

Name Sequence Type Origin Length Description Download
WNK_b-2.AA Protein None 682 None Fasta, JSON
WNK_b-2.NA RNA None 2049 None Fasta, JSON
WNK_b-2.kin_dom Protein Kinase Domain None 259 None Fasta, JSON

Protein domain

Protein domains of WNK_b-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase WNK_b-2.AA WNK 54-311 47 7e-134 434.9 In-house 2-261 (261) Show / Hide 
Range on Protein: 54-311
Range on HMM: 2-261/261
Sequence Identity: 47% (126 aa)

RYKELLGKGAFKTVYKAFDEIDGIEVAWNQVKLHDVLRSPEDLERLYSEVHLLKSLKHKNIIKFYNSWVDT---KNNNVNFITEIFTSGNLRQYRRKHKH
.. | .|.|.|||||...|   ..||||. ...  . ..  .  |.  |. .|| |.| ||..||..|  .   |  ..  .||  ||| |. | .  |.
KFDEEVGRGSFKTVYRGLDTETWVEVAWCELQDQKLSKN--ERQRFKEEAEMLKKLQHPNIVRFYDYWESVLCGKK-CIVLVTELMTSGTLKTYLKRFKK

VDLKAVKHWARQILRGLLYLHSHDP-PIIHRDLKCDNIFVNGNHGEVKIGDLGLAGILRQAHGAHSVIGTPEFMAPELYEEDYNELVDIYSFGMCLLEMV
.  |  . | ||||.|| .||.  | |||||||||||||..|  |.|||||||||  |...  | ||||||||||||.||| | | ||.|.||||.|||.
MKPKVLRSWCRQILKGLHFLHTRQPHPIIHRDLKCDNIFITGTTGSVKIGDLGLAVTLKNSSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMA

TFEYPYSECMNAAQIYKKVTSGKKPAALNKVQDPQMRAFVEQCLAKAC-RRLPARELLMDPFL
| |||||||.||||||.|||.| ||....|.|.|. . ..|.|. .    |  ...|| . |.
TSEYPYSECQNAAQIYRKVTQGIKPNSFQKIQNPEVKEIIEKCIRHNKEERPSIQQLLNHDFF
S_TKc WNK_b-2.AA S_TKc 53-311 27 7.2e-65 222.73 SMART 1-231 (231) Show / Hide 
Range on Protein: 53-311
Range on HMM: 1-231/231
Sequence Identity: 27% (76 aa)

GRYKELLGKGAFKTVYKAFDEIDGIEVAWNQVKLHDVLRSPEDLERLYSEVHLLKSLKHKNIIKFYNSWVDTKNNNVNFITEIFTS--GNLRQYRRKHKH
 .  ...||||| .|||. .  .| .||  ..|           |....|. .||. .|.||.|.| ...|   ... ...|      |.|..| .|...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGR

------VDLKAVKHWARQILRGLLYLHSHDPPIIHRDLKCDNIFVNGNHGEVKIGDLGLAGILRQAHGAHSVIGTPEFMAPELYEEDYNE-LVDIYSFGM
       .   ......||...| |.|||   ||||||| .||...    ..||.| ||| .|      ....|||..||||.    |.   .|..|.| 
HGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGC

CLLEMVTFEYPYSECMNAAQIYKKVTSGKKPAALNKVQDPQMRAFVEQCLA-KACRRLPARELLM-------DPFL
.| ||.. . |..   . ....||.             .|... |...||     .|. | |.|        .|..
ILYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase WNK_b-2.AA Pkinase 53-311 25 1.1e-56 199.49 Pfam 1-293 (293) Show / Hide 
Range on Protein: 53-311
Range on HMM: 1-293/293
Sequence Identity: 25% (77 aa)

GRYKELLGKGAFKTVYKAFDEIDGIEVAWNQVKLHDVLRSPEDLERLYSEVHLLKSLKHKNIIKFYNSWVDTKNNNVNFITEIFTSG----NLRQYRR--
 . .. .|.|.| .|||. .  .|..||  ..|...   . .   |. ||....|.|.|.||...| .. |  .... ...|    |     |  | .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW

KHKHV--DLKAVKHWARQILRGLLYLHSHDPPIIHRDLKCDNIFVNGNHGEV----KIGDLGLAGI--LRQAHGAHSVIGTPEFMAPEL--YEEDYNELV
.|. .  . . .|....|||||| |.||.   ||||||| .||... |.|..    ||.| |||    .   . .... |||..||||.    ..|   |
RHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DIYSFGMCLLEMVTFEYPYSEC-----MNAAQIYKKVTSGKKPAALNKVQD-------------------PQMRAFVEQCLAKACRRLP-ARELLMDPFL
|..|.|  | ||.. . |....     ..  |..... ... .    .  .                   . .. |.. ||.| . . | |...| .|..
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase WNK_b-2.AA STE 54-311 22 1.5e-53 184.19 In-house 1-359 (359) Show / Hide 
Range on Protein: 54-311
Range on HMM: 1-359/359
Sequence Identity: 22% (84 aa)

RYK-ELLGKGAFKTVYKAFDEI---------------DGIEVAWNQVKLHDVL-------------RSPEDLERLYSEVHLLKSLK--HKNIIKFYNSWV
  . | .||||| ||||| .                  |  .|  |..| .               . .|.....  |. ..| ..  |.||.|.| . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

D----TKN-NNVNFITEIFTSGNLRQYRR-KHKHVD-------------LKAVKHWARQILRG-LLYLHSHDPPIIHRDLKCDNIFVNGNHGEVKIGDLG
.    .|| .... . |    | |..  . |... .              . ... .||||.| | |||||   |||||.|..||..      ||. | |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL------VKLCDFG

LAGILRQ---------------AHG--AHSVIGTPEFMAPELYEED-------YNELVDIYSFGMCLLEMVTFEYPY---SEC--MNAAQIYKKVTS---
..|.| .                 .    ...||| .||||  . .       |.. .||.|.| ...||.| ..|.   .    | .... ... .   
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFE

------GKKPAALNKVQD------------------PQMRAFVEQCLAKACR-RLPARELLM--DPFL
      |. |   .....                  | .. |...|| |  . |  | .||    ||.
QLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase WNK_b-2.AA Ciliate-E2 53-255 21 8.6e-49 165.61 In-house 1-296 (365) Show / Hide 
Range on Protein: 53-255
Range on HMM: 1-296/365
Sequence Identity: 21% (64 aa)

GRYKELLGKGAFKTVYKAFDEIDGIEVA---------------WNQVKLHDVLRS-PEDLERLYSEVHLLK----------------SLKHKNIIKFYNS
    ...|.|.| .|||. .  .. ..|                ...|.  . .  . ..| . .| |...                .|.|.||||.| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

WVDTKNNNVNFITEIFTSGNLRQYRRKHKH-----------VDLKAVKHWARQILR---------------GLLYLHSHDPPIIHRDLKCDNIFVNGNHG
. ....||. ...| .  |.|..| ...|.            ..| .|.  .|||.               .| ||||  . |||||.| .||..     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF-----

EVKIGDLGLAGILRQA--------------------------------HGAHSVIGTPEFMAPELYE----------EDYNELVDIYSFGMCLLEMVTFE
 .|| |.||. .. .                                 . .....|||..|||| ..          ..|.. .||.|.|..| ||.. .
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

YPY
.|.
PPF
Kinase WNK_b-2.AA NRBP 56-312 37 3e-46 159.98 In-house 2-261 (261) Show / Hide 
Range on Protein: 56-312
Range on HMM: 2-261/261
Sequence Identity: 37% (101 aa)

KELLGKGAFKTVYKAFDEIDGIEVAWNQVKLHDVLRSPEDLERLYSEVHLLKSLKHKNIIKFYNSWVDTKNNN--VNFITEIFTSGNLRQY----RRKHK
... |    ...| | |. .|.|| || |.  .      . |..      |  |.|.||.||   |.|||..   | ||||   || ..|.    ...||
RDVPG---IDCAYLAMDTEEGVEVVWNEVQFSERKNFKAQEEKIRQVFDNLIQLDHQNIVKFHKYWTDTKEEKPRVIFITEYMSSGSMKQFLKKTKKNHK

HVDLKAVKHWARQILRGLLYLHSHDPPIIHRDLKCDNIFVNGNHGEVKIGDLGLAGILRQAHGAHSVIGTPEFMAPELYEEDYNEL---VDIYSFGMCLL
....|| |.|. |||  | |||| ||||||  | || ||.  | | .|||      | .. . .        |.|||    . ..|   ||||||||| |
NMNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHN-GLIKIGCVWPDAIHHHVRTCREEMRNMHFFAPEYGILEVTDLTTAVDIYSFGMCAL

EMVTFEYPYSECMNAAQIYKKVTSGKKPAALNKVQDPQMRAFVEQCLAKACRRLP-ARELLMDPFLQ
||  .|   | | |.   |  ||      | . ..|| .| |...||.|   | | |||||  . | 
EMAVLEI-QSGCQNGESEY--VTEEAIQRAIHSLEDPMQRDFIRKCLQKDPARRPSARELLFHQILF
Kinase WNK_b-2.AA CAMK 58-311 16 5.1e-46 145.85 In-house 1-425 (425) Show / Hide 
Range on Protein: 58-311
Range on HMM: 1-425/425
Sequence Identity: 16% (70 aa)

LLGKGAFKTVYKAFDEIDG------------IEVAWNQVKLHDVLR------------------------SPEDLERLYSEVHLLKS-------LKHKNI
 ||.|.| .|.....  ..             .||   ..   .                          .|.|......|....|.       |.|.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKFYNSWVD-----------TKNN-------NVNFIT---EIFTSG----NLRQYRRKHKH---------------VDLKAVKHWARQILRGLLYLHSHD
||.|  . |           | ..       .. ...   |  . |     | .| ..|..               .. . .... |||. .. |.|||.
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

PPIIHRDLKCDNIFVNGNH----------------GEVKIGDLGLAGILRQAHG------------------------AHSVIGTPEFMA-PELYE----
  |.|||||..|| .. |.                . .|| | |.| .... ..                         . . ||||.|| ||. .    
--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

-----------EDYNELVDIYSFGMCLLEMVTFEYPYSEC------------MNAAQIYKKVTSGKKPAALNKVQD----------------------PQ
           . |.. .|. | |  |  |.. ..|. .             ||  ....|...||      .. .                      ..
CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQE

MRAFVEQCLAK-ACRRLPARELLMDPFL
 . .. ..| .   .|. . . | .|..
CKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase WNK_b-2.AA NEK 54-311 28 1.6e-42 147.62 In-house 2-286 (286) Show / Hide 
Range on Protein: 54-311
Range on HMM: 2-286/286
Sequence Identity: 28% (82 aa)

RYKELLGKGAFKTVYKAFDEIDGIE-----VAWNQVKLHDVLRSPEDLERLY-SEVHLLKSLKHKNIIKFYNSWVDTKNNNVNFITEIFT-SGNLRQY--
.. . .|.|.| .|||. . .|| .     ..| ....     |... . .. .||..||.||| ||.|.|.|... .||  . . |     |.| |   
EIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNM--SEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIK

-RRKHK----HVDLKAVKHWARQILRGLLYLHSH-DP--PIIHRDLKCDNIFVNGNHGE---VKIGDLGLAGILR-QAHGAHS-VIGTPEFMAPELY-EE
   |.|    . . . . .|  |.. .| |.|..  |   |.|||.|. ||| . |. .   |||||.|.. .|   .  |.. ..||| .|.||.  ..
SIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNK

DYNELVDIYSFGMCLLEMVTF--EYP-YS-ECMNAAQIYKKVTSGKKPAALNKV--QDPQMRAFVEQCLAK-ACRRLPARELLMDPFL
 ||. .|| |.| .| ||.|.  . | ..   ||  . |.|.. |.... ...     .... ...|.| |    |  ....| .||.
PYNNKSDIWSLGCVLYEMCTLKPKHPFEAWD-MNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase WNK_b-2.AA STE11 53-311 27 2.1e-42 147.18 In-house 1-303 (303) Show / Hide 
Range on Protein: 53-311
Range on HMM: 1-303/303
Sequence Identity: 27% (85 aa)

GRYKELLGKGAFKTVYKAFDEIDGIEVAWNQVKLHDVL----RSPEDLER------LYSEVHLLKSLKHKNIIKFYNSWV-DTKNNNVNFITEIFTSGNL
 . .|..||||| ||||...   | ..|  |.....         . ..       . .|. |.| |.||||...| . . | .|..|| . |    | |
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

RQYRR-KHKH--VDLKAVKHWARQILRGLLYLHSHDPPIIHRDLKCDNIFVNGNHGEVKIGDLGLAGILRQAH--GAH---------SVIGTPE------
..  | |      | . ...  .|||.|| |||||   |||||.| .||... . . .|..| | |  | . .  ...         |. |||       
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHG--IIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGT

--FMAPELYE-ED---YNELVDIYSFGMCLLEMVTFEYPYSECMN--AAQIYKKVTS-GKKPAALNKVQD-----PQMRAFVEQCLAKACR-RLPARELL
  .|||| .  |    |   .|| |.| . .||.|   |.... .  .|...| ... .  |    ...      .. |.|. .|. . .  |  |..||
PMWMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLL

MDPFL
..||.
QHPFI
Kinase WNK_b-2.AA TKL 59-274 21 5.8e-39 135.77 In-house 1-317 (364) Show / Hide 
Range on Protein: 59-274
Range on HMM: 1-317/364
Sequence Identity: 21% (70 aa)

LGKGAFKTVYKA-FDEID-------GIEVAWNQVKLHDVLRSPE-----------------------DLERLYSEVHLLKSLKHKNIIKFYNSWVDTKNN
.|.|.| .|||. .  ..       | .||  . | |..  . .                         ...  |. ....|.| ||..|. .  . ...
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------NVNFITEIFTSGNLRQYRRKHKHVDLKAVKHWARQILRGLLYLHSHD------PPIIHRDLKCDNIFVNGN-------------HGEVK
           .  ...|    |.|. |        .    .||..| ||. ||||..      ||||||||| .||.|. |             .. .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

IGDLGLAGIL--------------------RQAHGAHSVIGTPEFMAPELYE-----------------EDYNELVDIYSFGMCLLEMVTFEYPYSECMN
|.|.||.  .                    ...   ....||| .||||. .                 ..|.| .|.||||..| |..| . ||.. ..
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY

AAQI---------YKKVTSGKKP
  .|         .. .  |..|
MPMIFQDPFEEMFMMVCDKGLRP
Kinase WNK_b-2.AA Ciliate-E2-Unclassified 54-256 21 7.9e-39 132.31 In-house 2-271 (352) Show / Hide 
Range on Protein: 54-256
Range on HMM: 2-271/352
Sequence Identity: 21% (58 aa)

RYKELLGKGAFKTVYKAFDEIDGIEV-----AWNQVKLHDVLRSPEDLERLYSEVHLLKS----------------LKHKNIIKFYNSWVDTKNNNVNFI
.  . .|.|.| .|||. .. .. ..     .  . . .. .   .| | . .. .. .                 | |..... .  ..... .|. ..
KIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

TEIFTSGNLRQYRRKHKH-----------------VDLKAVK-----HWARQILRGLLYLHSHDPPIIHRDLKCDNIFVNGNHG--EVKIGDLGLAGILR
.| .  |.|.|| .| |.                 .. ...|     ....||| || |||.    |||||.|..||... |..  ..|| |.|..  . 
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

QAHG----------------AHSVIGTPEFM----APELYEE-DYN----ELVDIYSFGMCLLEMVTFEYPYS
|  .                .....|||..|    |||....  |.    . .||.|.|..| ||.. .||..
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFY
Kinase WNK_b-2.AA ULK 56-258 26 5.2e-38 130.3 In-house 4-259 (329) Show / Hide 
Range on Protein: 56-258
Range on HMM: 4-259/329
Sequence Identity: 26% (69 aa)

KELLGKGAFKTVYKAFDEID----GIEVAWNQVKLHDVLRSPED------LERLYSEVHLLKSLK----HKN----IIKFYNSWVDTKN-NNVNFITEIF
.. ||||.| .|||......    .. ||  .. .    ... .      .. | .|. ..| ||    |||    |.|.|  |  |.| ||. .|.|  
NHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYD-WFETSNHNNIYIIMEYC

TSGNLRQYRRKHKHVDLKA----------VKHWARQILRGLLYLHSHDPPIIHRDLKCDNIFVNGN-----------HGEVKIGDLGLAGILRQA----H
  |.|.||  |.|.  ..           ...  .||| |. .||.|   |||||.| .|| .. .           .| .||.| |.|  .        
NGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHN--IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

GAHSVI------GTPEFMAPELYEED-----YNEL-VDIYSFGMCLLEMVTFEYPYSEC
 ...        ||| .|||.. ..      |..  .||.|.|. . ||.. ..|....
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW
Kinase WNK_b-2.AA TyrKc 53-310 23 1.6e-17 60.51 SMART 1-280 (280) Show / Hide 
Range on Protein: 53-310
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

GRYKELLGKGAFKTVYKAFDEIDGIEVAWNQVKLHDVLRSPEDLERLYSEVHLLKSL--KHKNIIKFYNSWVDTKN-----NNVNFITEIFTSGNLRQYR
 . .. || ||| .|||.      |.||   .| .        .| ...|  ....|  .|.||...|   .. .        .  ..|    |.|..| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RKHKH-VDLKAVKHWARQILRGLLYLHSHDPPIIHRDLKCDNIFVNGNHGEVKIGDLGLAGILRQA------HGAHSV---IGTPE-----FMAPELYEE
|||.. . .|   ... || .|  ||||.  ..||||| . |. |. ||  |||.| ||.  .         .   ..    |.        ||||   .
RKHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

D-YNELVDIYSFGMCLLEMVTFEYPYSEC-----MNAAQIYKKVTSGKKPAALNKV-------QDPQMRAFVEQCLAK-ACRRLPARELLMDPF
  ...  |..||| |. |. |.  .  .      |........| .|. .     .         . |    .|| .  .  |   .|.  . |
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase WNK_b-2.AA Pkinase_Tyr 139-204 40 4.2e-09 31.47 Pfam 92-158 (270) Show / Hide 
Range on Protein: 139-204
Range on HMM: 92-158/270
Sequence Identity: 40% (28 aa)

GNLRQYRRKH----KHVDLKAVKHWARQILRGLLYLHSHDPPIIHRDLKCDNIFVNGNHGEVKIGDLGLA
|.|. | |||    .....|   ....|| .|. ||.|.   .||||| . |. |. |.  |||.| |||
GDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENN-VVKICDFGLA
Kinase WNK_b-2.AA Pkinase_Tyr 92-118 30 0.022417 8.67 Pfam 41-70 (270) Show / Hide 
Range on Protein: 92-118
Range on HMM: 41-70/270
Sequence Identity: 30% (9 aa)

SPED--LERLYSEVHLLKSL-KHKNIIKFY
..|.  .| . .|. ..|.| .|.||...|
MHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase WNK_b-2.AA Pkinase_Tyr 223-271 27 0.113063 6.29 Pfam 181-232 (270) Show / Hide 
Range on Protein: 223-271
Range on HMM: 181-232/270
Sequence Identity: 27% (15 aa)

MAPE--LYEEDYNELVDIYSFGMCLLEMVTFE-YP-YSECMNAAQIYKKV-TSG
||||   | . ...  |..||| .. |..|.   | | ..   ...|...  .|
MAPECINYGK-FTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDG
FRWNK_Wnk1 WNK_b-2.AA FRWNK_Wnk1 402-451 30 0.000167 13.61 In-house 43-92 (92) Show / Hide 
Range on Protein: 402-451
Range on HMM: 43-92/92
Sequence Identity: 30% (15 aa)

IHFPFDVEADTALCVASEMVAELDLSDQDVTTIADMIDAEIVLLVPHWRP
| | || | |..  || |||.   . ..|. ..| .| . . |   . . 
IEFSFDLEKDVPEEVAQEMVESGFFCEADYKIVAKSIRDRVALIKWKRER