Gene CR4L_d (S.moellendorffii)

CR4L_d

Species: S.moellendorffii
Alias: CR4L_d
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: CR4L

Sequence

Name Sequence Type Origin Length Description Download
CR4L_d.AA Protein None 765 None Fasta, JSON
CR4L_d.NA RNA None 2298 None Fasta, JSON
CR4L_d.kin_dom Protein Kinase Domain None 135 None Fasta, JSON

Protein domain

Protein domains of CR4L_d.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
TNFR_c6 CR4L_d.AA TNFR_c6 352-377 29 0.000618 16.88 Pfam 16-41 (41) Show / Hide 
Range on Protein: 352-377
Range on HMM: 16-41/41
Sequence Identity: 29% (8 aa)

CAPCASDCSN-GSFVSAPCGANDNRRC
| .| . |.. |.....|| ...|. |
CLSC-TRCHPMGQYMVQPCTWTQNTVC
Kinase CR4L_d.AA IRAK 509-641 35 2.2e-42 147.1 In-house 1-148 (317) Show / Hide 
Range on Protein: 509-641
Range on HMM: 1-148/317
Sequence Identity: 35% (53 aa)

FKEVNELGRGSYGFVYKAVLGDGQ-LVAVK--RANAAQRIHGSSRDFDA---ELEILCKLRHANIVNLVGYCGEMGERLLIYEFMPHGTLRDHLHGGL--
| . | .| | .| ||....      .|||  ...|   . .. . |..   ||...|..||.||| | ||| | ..  |.|..|| |.|.| |..    
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

-SP--LGWGLRLRVAAQAARGLEFLHKED----VIHRDVKSANILLDA
 .|  | |  |. ..  .|.|..|||  .    .||.|.||||||||.
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQ
Kinase CR4L_d.AA TKL 515-648 23 3.6e-40 139.77 In-house 1-196 (364) Show / Hide 
Range on Protein: 515-648
Range on HMM: 1-196/364
Sequence Identity: 23% (47 aa)

LGRGSYGFVYKAVLGD---------GQLVAVKRANAAQRIHGSS-------------------------RDFDAELEILCKLRHANIVNLVG--------
.|.|..| |||...           |. ||||. .  .    ..                           .  |. .. .||| ||| ..|        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-YCGE----MGERLLIYEFMPHGTLRDHLHGGLSPLGWGLRLRVAAQAARGLEFLHKED--------VIHRDVKSANILLDAEWS--------------A
 .|..     |.  ...|..|.|.|...||       | .|.| | ..|||...|| ..        .|||| ||.|||.|  |               .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

RVA
 ..
KIC
Kinase CR4L_d.AA TKL-Unique 512-648 29 1.8e-36 126.17 In-house 2-159 (290) Show / Hide 
Range on Protein: 512-648
Range on HMM: 2-159/290
Sequence Identity: 29% (47 aa)

VNELGRGSYGFVYKAVLGDGQLVAVKRANA-AQRIHGSSRDFDAELEILCKLR-HANIVNLVGYCG----EMGERLLIYEFMPHGTLRDHLH--------
.| .|.|.|| |||.. . |  ||.|. .  .     ....|  |. .. ||. |.||| ..|||       ... .. |..|.|.|.|.||        
WNKIGEGGYGQVYKGK-WRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-GGLSPLGWGLRLRVAAQAARGLEFLHKED--VIHRDVKSANILLDAE-----WSARVA
    ..| . .|.. | ..|.|...|| ..  .|||| || |.|.| .     |.....
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKIC
Kinase CR4L_d.AA LRRK 509-639 26 1.3e-33 116.3 In-house 1-199 (351) Show / Hide 
Range on Protein: 509-639
Range on HMM: 1-199/351
Sequence Identity: 26% (54 aa)

FKEVNELGRGSYG-FVYKAVLGD---------------------------GQLVAVKRANA--------------------------------AQRIHGS
.|. ...|||..| |||.| . .                           .| ||.|  |                                 ..  . .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

SRDFDAELEILCKLRHANIVNLVGYCGEMGERLLIYEFMPHGTLRDHLH----GGL----SPLGWGLRLRVAAQAARGLEFLHKED--VIHRDVKSANIL
 | |  |. |...|.| |||.|.|.|  .  . .. |..|||.| ..||     |.      ..|.|.|..| | |.|.|.||. .  .|||| || |||
FREFRHEVWIMSHLNHPNIVSLKGFC--IHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNIL

L
|
L
Kinase CR4L_d.AA Pkinase_Tyr 509-640 31 3.1e-30 103.02 Pfam 1-145 (270) Show / Hide 
Range on Protein: 509-640
Range on HMM: 1-145/270
Sequence Identity: 31% (46 aa)

FKEVNELGRGSYGFVYKAVLG-----DGQLVAVKRANAAQRIHGS--SRDFDAELEILCKL-RHANIVNLVGYCG-EMGE--RLLIYEFMPHGTLRDHLH
 .   .||.|..| |||...      ... ||||     .  |    ..|| .|..|...| .| |||.|.| |  . .    ... |.|||| |.|.|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

GG---LSPLGWGLRLRVAAQAARGLEFLHKEDVIHRDVKSANILLD
       ||     |  ..| |.|.|.|.    ||||.   |.|..
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVT
Kinase CR4L_d.AA Pkinase 509-640 28 1.2e-28 102.37 Pfam 1-142 (293) Show / Hide 
Range on Protein: 509-640
Range on HMM: 1-142/293
Sequence Identity: 28% (41 aa)

FKEVNELGRGSYGFVYKAV-LGDGQLVAVKRANAAQRIHGSS-----RDFDAELEILCKLRHANIVNLVGYCGEMGERLLIYEFMPHG----TLRDHLH-
.. .  .|.||.| |||..  |.|..||||. .   . ..       .   .|..|. .|.| ||| | ... . ..  .. |....|     | |... 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL---SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

---GGLSPLGWGLRLRVAAQAARGLEFLHKEDVIHRDVKSANILLD
   |... . .    ... | .||||..|.. .||||.|..|||.|
WRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID
Kinase CR4L_d.AA TK 509-648 15 2.2e-28 91.61 In-house 1-293 (486) Show / Hide 
Range on Protein: 509-648
Range on HMM: 1-293/486
Sequence Identity: 15% (45 aa)

FKEVNELGRGSYG---FVYKAVL--------------------------GDGQLVAVKRANAAQRIHGS-SRD--------------FDAELEILC--KL
 . ...||.| .|    |||. .                          |  . ||||   .    .    .|              . .|....|  ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHANIVNLVGYCGEM------------GERLLIYEFMPHGT----LRDHLH--GG---------------------------------------------
.| |||.|.|.| .             .  ... |.||||     |||.|.   .                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------------------------LSPLGWGLRLRVAAQAARGLEFLHKEDV------IHRDVKSANILLDAEWS-----------ARVA
                             ..|    .|  ..|.|.|.|.||.  .      .|||.   |.|.. .             ...|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIA
Kinase CR4L_d.AA MLK 509-640 28 6.1e-28 94.09 In-house 1-161 (291) Show / Hide 
Range on Protein: 509-640
Range on HMM: 1-161/291
Sequence Identity: 28% (47 aa)

FKEVNELGRGSYGFVYKAVLGDGQL-----VAVKRANAAQRIHGSS-----RDFDAELEILCKLRHAN----IVNLVGYCGEMGE-RLLIYEFMPHGTLR
...   .| ||.| |.|..   ...     |||||..|  .   |.     .||. | ..| .|.| |    |. ..| | . .   ... |....| | 
IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY

DHLHGGLS-------------PLGWGLRLRVAAQAARGLEFLHKED---VIHRDVKSANILLD
. |||. |                 .. .. | | |||...||...   .|||| || |||.|
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILID
Kinase CR4L_d.AA Dicty4 509-648 34 9.2e-25 79.66 In-house 1-156 (277) Show / Hide 
Range on Protein: 509-648
Range on HMM: 1-156/277
Sequence Identity: 34% (54 aa)

FKEVNELGRGSYGFVYKAVLGDGQLVAVKRANAAQRIHGSSR--DFDAELEILCKLRHANIVNLVGYCG----EMGERLLIYEFMPHGTLRDHLHG----
 .  ...|.||.| |||.    |. |||| .|. .    ...  .| .| .|.||.|| ||. . |.|     . |. .   |.|| |.|   ||     
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

--GLSPLGWGLRLR---VAAQAARGLEFLHK--EDVIHRDVKSANILLDAEWSARVA
     .| |.|..|    |  ||||.  ||    ..|||| ||.|.| |. | . |.
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVC
Kinase CR4L_d.AA LISK 514-648 29 1.1e-24 77.02 In-house 1-147 (296) Show / Hide 
Range on Protein: 514-648
Range on HMM: 1-147/296
Sequence Identity: 29% (44 aa)

ELGRGSYGFVYKAVLG-DGQLVAVKRANA-----AQRIHGSSRDFDAELEILCKLRHANIVNLVGYCGE-MGERLLIYEFMPHGTLRDHLHGGLS---PL
|.|.|..| |||  .  .|| .|.|           .     . .. |.... .||| |||. .| | .  |.  .. |..  |.|.. |.   .   ||
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPE--YQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPL

GWGLRLRVAAQAARGLEFLHKEDVIHRDVKSANILLDAE----WSARVA
 | .|.. |   |.|...||  ..|||| || |.|..      |...|.
PWPQRVKIALDIACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVC
Kinase CR4L_d.AA STE 509-639 22 1.1e-23 80.54 In-house 1-185 (359) Show / Hide 
Range on Protein: 509-639
Range on HMM: 1-185/359
Sequence Identity: 22% (42 aa)

FKEVNELGRGSYGFVYKAVLGD----------------GQLVAVKRAN---------------AAQRIHGSSRDFDAELEILCKLR--HANIVNLVGYCG
.. . ..|.|..| ||||.  .                |...|.|. |                 .. |    ..  |..|. |..  | |||.  |.. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EMG-------ERLLIYEFMPHGTLRDHLHGGLSPLG-------------WGLRLRVAAQAARG-LEFLHKEDVIHRDVKSANILL
  |       |  .. |.|. |.|.| ..   ....               .  ... |  .| |..||.  .||||.|.|||||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL
Kinase CR4L_d.AA RIPK 515-642 26 1.7e-23 76.87 In-house 1-145 (290) Show / Hide 
Range on Protein: 515-642
Range on HMM: 1-145/290
Sequence Identity: 26% (39 aa)

LGRGSYGFVYKAVLGDGQLVAVKRANAAQRIHGS-----SRDFDAELEILCKLRHANIVNLVGYCGEM-----GE-RLLIYEFMPHGTLRDHLHGGL---
.|.|. | |.||.  .   ...| .     .|       . .   | ... |||. .|| . | | .      ..   .  |.|..| | . ||      
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

-SPLGWGLRLRVAAQAARGLEFLHKED--VIHRDVKSANILLDAE
  |. | || |   . ..|  .||  .  .|||| | .|||.|..
HHPDPWPLRCRMIHEISCGMCYLHSMNPPIIHRDLKPENILVDNN
Kinase CR4L_d.AA S_TKc 509-755 18 2.3e-22 81.52 SMART 1-231 (231) Show / Hide 
Range on Protein: 509-755
Range on HMM: 1-231/231
Sequence Identity: 18% (51 aa)

FKEVNELGRGSYGFVYKAVLGD-GQLVAVKRANAAQRIHGSSRDFDAELEILCKLRHANIVNLVGYCGEMGERLLIYEFMPH--GTLRDHLHGGLSP---
.. ....|.|..| |||..  . |..||.|. .         ...  |..|| | .| |||.| ... . ..  .. |....  |.|.|...   ..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LGWGLRLRVAAQAARGLEFLHKEDVIHRDVKSANILLDAEWSARVA------------------PPDAGYRDPEYSTAPRMTA-ADDVYGFGVVLLEL
  .      ....| ...||..|.  .||||.| .|||||      ..                  .|               .  . |.. .|..| |.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQLTTFCGTPWYMAPEVL----------GYGKCKCDWWSCGCILYEM

LSGRKAYDCEFEPAGVAEWAGPLIRTGRWAEVVDRAVEGPRSVEPVARLAEIAEKCVRVRAEERPPMGQVAV---------WL
|.|.  ..   ... . .  |                           . .. .|| ..  |.||   ..           |.
LCGYPPFP---QMQMMFKKIG------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CR4L_d.AA TyrKc 509-755 22 1.3e-17 62.32 SMART 1-280 (280) Show / Hide 
Range on Protein: 509-755
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

FKEVNELGRGSYGFVYKAVLGDGQLVAVKRANAAQRIHGSSRDFDAELEILCKL--RHANIVNLVGYCGEM-------GERLLIYEFMPHGTLRDHLHGG
 .   .||.| .| |||...   . ||||  ..        .||  |..|.|||  .| |||.|.|.| .        .  ... |.|||| |.|.|.  
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

LSPLGWGLRLRVAAQAARGLEFLHKEDVIHRDVKSANILLDAEWSARVAPP---DAGYRD-------PEYST----APRM-----------------TAA
   | .   |  . |.|.| |.||.  .||||    |.|....  ....      ..| |         |..      ..                 | .
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

DDVYGFGVVLLELLSGRKAYDCE-----FEPAGVAEWAGPLIRTGRWAE----VVDRAVEGPRSVEPVARLAEIAEKCVRVRAEERPPMGQVAVWL
 ||. |||.. |...  .    .      ... | |.     |  . ..              .|.  . . .| ..| .  .|.|| . ..   .
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------FVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase CR4L_d.AA TKL 670-755 18 2e-06 19.1 In-house 271-364 (364) Show / Hide 
Range on Protein: 670-755
Range on HMM: 271-364/364
Sequence Identity: 18% (18 aa)

DVYGFGVVLLELLSGRKAYDCEFEP------------AGVAEWAGPLIRTGRWAEVVDRAVEGPRSVEPVA--RLAEIAEKCVRVRAEERPPMGQVAVWL
||| ||.|| |.|.... |... ..            ..|..   .. .  .| ..     . . . .| .  ........|    .|.|| . ..  .|
DVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHH----K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase CR4L_d.AA IRAK 657-689 44 3e-06 18.37 In-house 191-226 (317) Show / Hide 
Range on Protein: 657-689
Range on HMM: 191-226/317
Sequence Identity: 44% (16 aa)

PEYST--APRMTAADDVYGFGVVLLELLSGR-KAYD
||. .    . |   ||| ||.||||.|.|.  .||
PEFIRDPQGQLTKKTDVYSFGIVLLEVLTGCRAVYD
Kinase CR4L_d.AA RIPK 670-688 42 0.00076 8.95 In-house 210-228 (290) Show / Hide 
Range on Protein: 670-688
Range on HMM: 210-228/290
Sequence Identity: 42% (8 aa)

DVYGFGVVLLELLSGRKAY
||| |..|. |.|.....|
DVYSFAIVMWEVLTQKHPY
Kinase CR4L_d.AA LISK 670-687 50 0.004535 5.59 In-house 221-238 (296) Show / Hide 
Range on Protein: 670-687
Range on HMM: 221-238/296
Sequence Identity: 50% (9 aa)

DVYGFGVVLLELLSGRKA
||. ||.||.|.  ..||
DVFSFGIVLCEIITRVKA
Kinase CR4L_d.AA LRRK 670-690 40 0.006078 6.23 In-house 264-285 (351) Show / Hide 
Range on Protein: 670-690
Range on HMM: 264-285/351
Sequence Identity: 40% (9 aa)

DVYGFGVVLLELLSGR-KAYDC
|.| ||..| |||...  ..|.
DCYSFGMILWELLTRQHHPFDE
Kinase CR4L_d.AA MLK 670-685 50 0.010821 5.32 In-house 218-233 (291) Show / Hide 
Range on Protein: 670-685
Range on HMM: 218-233/291
Sequence Identity: 50% (8 aa)

DVYGFGVVLLELLSGR
||. .|||| |.|...
DVWSWGVVLWEMLTRE
Kinase CR4L_d.AA TK 725-755 22 0.023224 2.86 In-house 456-486 (486) Show / Hide 
Range on Protein: 725-755
Range on HMM: 456-486/486
Sequence Identity: 22% (7 aa)

EPVARLAEIAEKCVRVRAEERPPMGQVAVWL
.| . ....  .| .  .|.|| . |.   |
CPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase CR4L_d.AA TKL-Unique 670-684 53 0.255721 0.63 In-house 210-224 (290) Show / Hide 
Range on Protein: 670-684
Range on HMM: 210-224/290
Sequence Identity: 53% (8 aa)

DVYGFGVVLLELLSG
||| ||.|| |....
DVYSFGIVLWEIATR
Kinase CR4L_d.AA IRAK 727-755 27 0.273441 0.53 In-house 289-317 (317) Show / Hide 
Range on Protein: 727-755
Range on HMM: 289-317/317
Sequence Identity: 27% (8 aa)

VARLAEIAEKCVRVRAEERPPMGQVAVWL
.. ..  |  |.  || .|..| .|   |
EKEMCQCACCCGHHRANRRCDMAWVMQQL
Kinase CR4L_d.AA Pkinase 666-685 35 0.376569 5.15 Pfam 190-209 (293) Show / Hide 
Range on Protein: 666-685
Range on HMM: 190-209/293
Sequence Identity: 35% (7 aa)

TAADDVYGFGVVLLELLSGR
. . |....|..| |.|.||
GPKVDMWSCGCILYEMLCGR