Gene CR4L_c (S.moellendorffii)
CR4L_c
Species: S.moellendorffii
Alias: CR4L_c
External Links:
Annotation:
Sequence
Protein domains of CR4L_c.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | CR4L_c.AA | TKL | 43-300 | 21 | 4e-59 | 202.74 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 43-300 Range on HMM: 1-364/364 Sequence Identity: 21% (81 aa) LGRGSYGSVYKAVLKN---------GQLAAVKRATCTT----------------------ANPSTSKERF-------ILSQIECPHVVNLLGFCERNDE- .|.|..| |||..... |. |||. . .| .|..|| ..|.. .|..| ..|.| ... IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG ------------VLLVVEFMANGSLHDVLHSKLSSSSLSWSRRVRIAVQTARALHALHSST------PQIIHRDVKSSNVLIDANWN------------- .| |.. .|||...|| |..|.|.| ..||... |||.. |.||||| ||.|.|.| ||. CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW -ARLGDFGLALRGDTKD--------------------IMCTPAGTLGYVDPRY-----DKPEKVG-----------PKIDVFSFGVLLLELISGRQVIDD . ..||||. . ... .|. ||... | . .|||| .|.||.|||..| |...... CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR--PY RMSPVRMVDWALPLIKQGRALAI-CDPRVRIP---------EGEAAGIKRMAVLAARCVRR-ESKRPCMGDIVLTL . | ...... | ... .... | || . ..|. |. .| .||| . .|. .| YDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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Kinase | CR4L_c.AA | IRAK | 37-300 | 24 | 5.7e-45 | 155.73 | In-house | 1-317 (317) | Show / Hide |
Range on Protein: 37-300 Range on HMM: 1-317/317 Sequence Identity: 24% (79 aa) FAEENLLGRGSYGSVYKAVLKNGQ-LAAVKRATCTTANPSTSKERFILS---------QIECPHVVNLLGFCERNDEVLLVVEFMANGSLHDVLHSKLSS |...|..| | .| ||....|| |||. . ...... .. . |..| |.|.| ... || ..|.||||.| |. . FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ SS---LSWSRRVRIAVQTARALHALHSSTPQ--IIHRDVKSSNVLIDANWNARLGDFGLALRG----DTKDIMC------TPAGTLGYVDPRYDK--PEK . ||| .|. |. ||.... ||. | |||.|.||.|.| |.. .. ..||||. | . .. . . ||. | | . . . CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ VGPKIDVFSFGVLLLELISGRQVIDDRMSPVRMVDWALPLIKQGRA-LAICDP---------------RV---------RIPEGEAAGIKRMAVLAARCV .| ||.|||. |||...|. . .|. .... . . |.. .. | | . |. |.| . . | |. .| .|. LTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEMCQCACCCG -RRESKRPCMGDIVLTL .| .|. | . .| HHRANRRCDMAWVMQQL |
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Kinase | CR4L_c.AA | Pkinase | 37-230 | 28 | 3.7e-41 | 146.61 | Pfam | 1-209 (293) | Show / Hide |
Range on Protein: 37-230 Range on HMM: 1-209/293 Sequence Identity: 28% (61 aa) FAEENLLGRGSYGSVYKAVLKNGQL-AAVKRATCTTANPSTSK------ERFILSQIECPHVVNLLGFCERNDEVLLVVEFMANG----SLHDVLH--SK . . .|.||.|.|||.. |. . |||. ..... . | |. . .|..| |....|..|.. .| |.. .| .|.|... .. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH LSSSSLSWSRRVRIAVQTARALHALHSSTPQIIHRDVKSSNVLIDANWNA----RLGDFGLALR--GDTKDIMCTPAGTLGYVDPRYDK-PEKVGPKIDV . . .|. ... |..|.| .|| |||||.|..|.||| | . ...||||| . | |..||..|. | . .. |||.|. GCFY-FSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM FSFGVLLLELISGR .|.|..| |...|| WSCGCILYEMLCGR |
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Kinase | CR4L_c.AA | RIPK | 43-236 | 28 | 2e-39 | 132.0 | In-house | 1-231 (290) | Show / Hide |
Range on Protein: 43-236 Range on HMM: 1-231/290 Sequence Identity: 28% (65 aa) LGRGSYGSVYKAVLKNGQLAAVKRA----TCTTA-----NPSTSKERFILSQIECPHVVNLLGFCERNDE------VLLVVEFMANGSLHDVLHSKL--S .|.|. | |.||. . ..| . | |. . . |. .. .. | |.| ..|||. . . .| |.|.|||| ..||.| VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ SSSLSWSRRVRIAVQTARALHALHSSTPQIIHRDVKSSNVLIDANWNARLGDFGLALRGDTKDIMC--------------TPAGTLGYVDP---RYDKPE . |. | |. ...... . ||| .| ||||| | .|.|.|.| .. . ||||| . . . ||| | .| | | . HHPDPWPLRCRMIHEISCGMCYLHSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKK K---VGPKIDVFSFGVLLLELISGRQVIDDR |.|| || ||.... |. ..... || PIKVVTPKYDVYSFAIVMWEVLTQKHPYEDR |
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Kinase | CR4L_c.AA | S_TKc | 37-279 | 22 | 4.6e-33 | 117.08 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 37-279 Range on HMM: 1-231/231 Sequence Identity: 22% (61 aa) FAEENLLGRGSYGSVYKAVLKN-GQLAAVKRATCTTANPSTSKERFILSQIECPHVVNLLGFCERNDEVLLVVEFMAN--GSLHDVLHSKLSS---SSLS . ...|.|..|.|||.. |. |.. |.|. .. .|. ||.. .|..|.|..... |.. .| |.. . |.|.|..... . . .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP WSRRVRIAVQTARALHALHSSTPQIIHRDVKSSNVLIDANWNARLGDFGLALRGDTKDIMCTPAGTLGY-----VDPRYDKPEKVGP-KIDVFSFGVLLL . ... |...|| .|| .|||||.| .|.|.| . ..||||| . | ||. | . . |. |.|. |.|..| E-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL--------GYGKCKCDWWSCGCILY ELISGRQVIDDRMSPVRMVDWALPLIKQGRALA------IC-DPRVRIPEGEAAG----IKRMAVL |...|. . . .| . . . . . ||. |. || || . . EMLCGYPPFP---QMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | CR4L_c.AA | MLK | 37-181 | 27 | 1.6e-31 | 106.63 | In-house | 1-180 (291) | Show / Hide |
Range on Protein: 37-181 Range on HMM: 1-180/291 Sequence Identity: 27% (49 aa) FAEENLLGRGSYGSVYKAVLKNGQL-----AAVKRATCTTANPSTS------KERFI--LSQIECPH----VVNLLGFCERNDE-VLLVVEFMANGSLHD . .. .| ||.|.|.|.. .| .. ||||.. .. | . .|... |. . | .. ..| | .. ...| |....|||.. IQFHEWIGSGSFGKVWKGRWRN-KDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN VLHSKLSSSS-----------LSWSRRVRIAVQTARALHALHSSTP-QIIHRDVKSSNVLIDA------NWNARLGDFGLA |||.. | .. . . ...|.| ||..| ||| | .||||| ||.|.|||. . ... |||.. VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTS |
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Kinase | CR4L_c.AA | TK | 37-182 | 13 | 2.6e-31 | 101.61 | In-house | 1-305 (486) | Show / Hide |
Range on Protein: 37-182 Range on HMM: 1-305/486 Sequence Identity: 13% (42 aa) FAEENLLGRGSYG---SVYKAVLKNG--------------------------QLAAVKRATCTTANPSTS----------------KERFILSQIE---- .. ||.| .| |||. .... . ||| . ..|. .. .| .... ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG -CPHVVNLLGFCERNDE------------VLLVVEFMANGS----LHDVLH------------------------------------------------- .|..|.|.| | .... ...|.|.|..|. |.| |. HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY ----SKLSSSSLSWSRRVR-------------------IAVQTARALHALHSSTP----QIIHRDVKSSNVLIDANWN-----------ARLGDFGLA-- .|.....|. . .. ...| |... ||| ...|||. |.|.. | . ....||||. DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ ----L | GSGVL |
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Kinase | CR4L_c.AA | Dicty4 | 82-200 | 32 | 3.8e-29 | 94.49 | In-house | 51-184 (277) | Show / Hide |
Range on Protein: 82-200 Range on HMM: 51-184/277 Sequence Identity: 32% (44 aa) ILSQIECPHVVNLLGFCE----RNDEVLLVVEFMANGSLHDVLHS----KLSSSSLSWSRRVR---IAVQTARALHALHSSTPQIIHRDVKSSNVLIDAN |...| |... ..| | ... | |.| |.|. .||. . .| .|.|... | .| .|| . ||...| ||||| ||.| |.|.| IMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKN WNARLGDFGLAL----RGDTKDIMCTPAGTLGYV |.. .||||. | || . |..|| ... WRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWM |
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Kinase | CR4L_c.AA | LRRK | 37-180 | 23 | 6.3e-29 | 99.45 | In-house | 1-224 (351) | Show / Hide |
Range on Protein: 37-180 Range on HMM: 1-224/351 Sequence Identity: 23% (52 aa) FAEENLLGRGSYG-SVYKAVLKN---------------------------GQLAAVKRATCT------------------------------------TA . .|...|||..| .||.| ... .| .|.| . . .| LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA NPSTSKERFILSQIECPHVVNLLGFCERNDEVLLVVEFMANGSLHDVLHSKLSSS------SLSWSRRVRIAVQTARALHALHSSTPQIIHRDVKSSNVL . .| .|.| . |..|.|.||| . .| |.. .|.|...||.| ... ..||. . .||.| |... |||..| ||||| || |.| FREFRHEVWIMSHLNHPNIVSLKGFCIH--PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNIL I---D---------ANWNARLGDFGL . . |. .| ..|||. LWSSPQNHSPNYPNAHVCAKIADFGI |
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Kinase | CR4L_c.AA | STE | 37-230 | 20 | 2.5e-28 | 97.19 | In-house | 1-265 (359) | Show / Hide |
Range on Protein: 37-230 Range on HMM: 1-265/359 Sequence Identity: 20% (57 aa) FAEENLLGRGSYGSVYKAVLKN----------------GQLAAVKRATCTTANP-------------------STSKERFILSQIE--CPHVVNLLGFCE . .|.|..|.||||. .. |.. |.|. . |. . || |... .|..|. .| .. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF RN-------DEVLLVVEFMANGSLHDVLHSKLSS-SSLS----------WSRRVRIAVQTARA-LHALHSSTPQIIHRDVKSSNVLIDANWNARLGDFGL .. ||. .. |.|..||| |....| . .|. | .|..|. .. |. ||| |||||.|..|.|. . | |||. KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL-----VKLCDFGV ALRGD----------------TKDIMC-TPAGTLGYVDP-RYDK-----PEKVGPKIDVFSFGVLLLELISGR . . . | . .. | .|| . | . .. . . | |. |.| ...|.. |. CGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK |
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Kinase | CR4L_c.AA | TKL-Unique | 41-181 | 31 | 2.1e-27 | 93.76 | In-house | 3-164 (290) | Show / Hide |
Range on Protein: 41-181 Range on HMM: 3-164/290 Sequence Identity: 31% (51 aa) NLLGRGSYGSVYKAVLKNGQLAAVKRATCTTANPSTSKER------FILSQIE-CPHVVNLLGFCE----RNDEVLLVVEFMANGSLHDVLH-------S |..|.|.||.|||.. .| |.|. . .| .... ... .. | .| . |.| . . .|.|.. |||.|||| NKIGEGGYGQVYKGKW-RGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN KLSSSSLSWSRRVRIAVQTARALHALHSSTPQIIHRDVKSSNVLIDAN-----WNARLGDFGLA ... |....||..| . |.... ||.. | ||||| ||||.|.| | ||... ||||. NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLS |
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Kinase | CR4L_c.AA | Pkinase_Tyr | 37-181 | 26 | 2.8e-26 | 89.64 | Pfam | 1-158 (270) | Show / Hide |
Range on Protein: 37-181 Range on HMM: 1-158/270 Sequence Identity: 26% (43 aa) FAEENLLGRGSYGSVYKAVLK-----NGQLAAVKRATCTTANPS------TSKERFILSQI-ECPHVVNLLGFCE-RNDE--VLLVVEFMANGSLHDVLH ||.|..|.|||...| ... ||| .. . . | |..|. .|..|.|.| | . . ...|.|.|..|.|.| |. ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR SK-LSSSSLSWSRRVRIAVQTARALHALHSSTPQIIHRDVKSSNVLIDANWNARLGDFGLA .. . .|. .. . ...| |... |.| .||||. |.|.. | .. .||||| KHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLA |
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Kinase | CR4L_c.AA | LISK | 42-181 | 29 | 1.1e-25 | 80.3 | In-house | 1-152 (296) | Show / Hide |
Range on Protein: 42-181 Range on HMM: 1-152/296 Sequence Identity: 29% (46 aa) LLGRGSYGSVYKAVLK-NGQLAAVKRAT-------CTTANPSTSKERFILSQIECPHVVNLLGFCER-NDEVLLVVEFMANGSLHDVLHSKLS-SSSLSW .|.|..|.||| .. || |.| . . . .| .. .. |..|. | |.. ... .| |.. | ||. |... . .. |.| EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW SRRVRIAVQTARALHALHSSTPQIIHRDVKSSNVLIDAN----WNARLGDFGLA . ||.||. |... ||| .||||| || |.|.. | |.....|||.| PQRVKIALDIACGMSYLHSM--NIIHRDLKSKNCLVRENDNNQWRIKVCDFGFA |
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Kinase | CR4L_c.AA | TyrKc | 37-300 | 21 | 5.2e-17 | 52.35 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 37-300 Range on HMM: 1-280/280 Sequence Identity: 21% (66 aa) FAEENLLGRGSYGSVYKAVLKNGQLAAVKRATCTTANPSTSKERF-----ILSQI--ECPHVVNLLGFCERN-------DEVLLVVEFMANGSLHDVLHS . ||.| .| |||...| . ||| . .| | |.... . |..|.|.| | . ...|.|.|..|.|.| |.. ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK KLSSSSLSWSRRVRIAVQTARALHALHSSTPQIIHRDVKSSNVLIDANWNARLGDFGLALRGDTKDIMCTPAGTLGYVDPRYDKP--EKVGP-------- . |... . ...| |. ||| ..|||| |.|...| .. .||||. .. .| . . | .. .| | HRPK--LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG--------ESKDYYRKKEHKGGKTMLPIRWM ------------KIDVFSFGVLLLELISGRQVIDDR-----MSPVRMVDWALPLIKQGRALAICDPRVRIPEGEAA----GIKRMAVLAARCVRR-ESKR | ||.||||.. |. . | ||. .. . ..|||. . . . . . | . .| .. ..| APECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEV----IEYVKQGYRMPQPPNDY-----P-MSFVCCPDEMYQIMKQCWHEDPEDR PCMGDIVLTL |.. .|. . PTFSEIHECF |
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Kinase | CR4L_c.AA | LISK | 213-232 | 45 | 5e-06 | 15.29 | In-house | 219-238 (296) | Show / Hide |
Range on Protein: 213-232 Range on HMM: 219-238/296 Sequence Identity: 45% (9 aa) KIDVFSFGVLLLELISGRQV . ||||||..|.|.| .... SCDVFSFGIVLCEIITRVKA |
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Kinase | CR4L_c.AA | Dicty4 | 37-54 | 44 | 6.8e-05 | 12.44 | In-house | 1-18 (277) | Show / Hide |
Range on Protein: 37-54 Range on HMM: 1-18/277 Sequence Identity: 44% (8 aa) FAEENLLGRGSYGSVYKA . |...|.||.|.|||. INIEQRIGKGSFGEVYKG |
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Kinase | CR4L_c.AA | LRRK | 213-230 | 44 | 0.001286 | 8.65 | In-house | 262-279 (351) | Show / Hide |
Range on Protein: 213-230 Range on HMM: 262-279/351 Sequence Identity: 44% (8 aa) KIDVFSFGVLLLELISGR |.|..|||..| ||.... KVDCYSFGMILWELLTRQ |
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Kinase | CR4L_c.AA | MLK | 215-230 | 43 | 0.002337 | 7.66 | In-house | 218-233 (291) | Show / Hide |
Range on Protein: 215-230 Range on HMM: 218-233/291 Sequence Identity: 43% (7 aa) DVFSFGVLLLELISGR ||.|.||.| |..... DVWSWGVVLWEMLTRE |
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Kinase | CR4L_c.AA | TK | 215-228 | 57 | 0.038011 | 2.13 | In-house | 376-389 (486) | Show / Hide |
Range on Protein: 215-228 Range on HMM: 376-389/486 Sequence Identity: 57% (8 aa) DVFSFGVLLLELIS ||.|||||. |. . DVWSFGVLMWEIFT |
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Kinase | CR4L_c.AA | TKL-Unique | 213-231 | 42 | 0.064364 | 2.77 | In-house | 208-226 (290) | Show / Hide |
Range on Protein: 213-231 Range on HMM: 208-226/290 Sequence Identity: 42% (8 aa) KIDVFSFGVLLLELISGRQ |.||.|||. | |.... . KSDVYSFGIVLWEIATRKI |
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Kinase | CR4L_c.AA | Pkinase_Tyr | 215-231 | 55 | 0.474601 | 4.18 | Pfam | 196-213 (270) | Show / Hide |
Range on Protein: 215-231 Range on HMM: 196-213/270 Sequence Identity: 55% (10 aa) DVFSFGVLLLELIS-GRQ || |||||. |... |.| DVWSFGVLMWEIFTYGEQ |