Gene IRAK-0_i-1 (S.moellendorffii)

IRAK-0_i-1

Species: S.moellendorffii
Alias: IRAK-0_i-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_i-1.AA Protein None 329 None Fasta, JSON
IRAK-0_i-1.NA RNA None 990 None Fasta, JSON
IRAK-0_i-1.kin_dom Protein Kinase Domain None 199 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_i-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-0_i-1.AA TKL 19-280 18 1.4e-62 214.22 In-house 1-364 (364) Show / Hide 
Range on Protein: 19-280
Range on HMM: 1-364/364
Sequence Identity: 18% (73 aa)

LGRGAFGTVFKGVLKD---------GSEVAVKQLDLHSKQGQ---------------------------REFVNELSIITSIQHKNLAKLRGYCLDRDD-
.|.|.||.|.||...          | .||||..  |. .                              ....|. .. ...| |. .. |||.. .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RILVYEFLENKS-LDQLLFESTTGILLDWPTRFQIVLGVANGLAYLHE-----GSQKQIIHRDIKASNILLDHRLH------------
              .|.|. .. | |..|.          |. |....|..| |..|||      .  ..|||||.| .|||.|  ..            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--PKISDFGISKLFNQEKG------------------FTSTVIAGTMGYLAPEYVLGG----------------LLTVKADVYSFGVLTLEIVSGQRCSD
  .||.|||.|. ..|...                   |.  . || ...|||   |                   . |.||||||..  ||....|   
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR---

RKDGRLLVYSAWILHENNSE------------LEIADERLDLEHN------------SEEILRVIQVALACTHENSASRPSMGDAVAML
              ......              ..|..| ..              .    .... .  | ...  .|||. . .  |
------------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-0_i-1.AA IRAK 13-212 35 2.7e-57 196.65 In-house 1-222 (317) Show / Hide 
Range on Protein: 13-212
Range on HMM: 1-222/317
Sequence Identity: 35% (78 aa)

FSDDNKLGRGAFGTVFKGVLKDGS-EVAVK----QLDLHSKQGQREFVN---ELSIITSIQHKNLAKLRGYCLDRDDRILVYEFLENKSL-DQLLFESTT
|. ||..| |.||.|..|..|     .|||      |.  ..  ..|     || . ....|.|.  | |||..|..  |||... | || |.|    ..
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

GIL--LDWPTRFQIVLGVANGLAYLHEGSQK-QIIHRDIKASNILLDHRLHPKISDFGISKL--FNQEKGFTST------VIAGTMGYLAPEYVL--GGL
. .  | |..|. | .| |.|. .||. . .  |||.||| .||||| .. |||.|||      . ..|  ..       .. ||  |..||.     | 
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LTVKADVYSFGVLTLEIVSGQR
||.| ||||||.  ||...|.|
LTKKTDVYSFGIVLLEVLTGCR
Kinase IRAK-0_i-1.AA Pkinase 13-211 27 1.6e-46 165.56 Pfam 1-209 (293) Show / Hide 
Range on Protein: 13-211
Range on HMM: 1-209/293
Sequence Identity: 27% (59 aa)

FSDDNKLGRGAFGTVFKGVLKDGSE-VAVKQLDLHSKQG--QREFVN--ELSIITSIQHKNLAKLRGYCLDRDDRILVYEFLENK----SLDQLLF-EST
.    |.|.|.||.|.|.. |. .. ||||.......    ... ..  |..|  ...|.|  .|.... |.|.  .| |..|.     .|  ..  .. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TGILLDWPTRFQIVLGVANGLAYLHEGSQKQIIHRDIKASNILLDHRLHP----KISDFGISKLF-NQEKGFTSTVIAGTMGYLAPEYVL-GGLLTVKAD
....... .   ... .. ||.|.|.     |||||.| .|||.|.. |.    ||.|||..|.| .  ..   |...|| .|.||| .. |   . |.|
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVD

VYSFGVLTLEIVSGQ
..|.|..  | ..|.
MWSCGCILYEMLCGR
Kinase IRAK-0_i-1.AA STE 13-211 21 5.4e-41 142.5 In-house 1-265 (359) Show / Hide 
Range on Protein: 13-211
Range on HMM: 1-265/359
Sequence Identity: 21% (59 aa)

FSDDNKLGRGAFGTVFKGVLKD----------------GSEVAVKQLDLHSKQG-----------------QREFVNELSIITSIQ--HKNLAKLRGYCL
. .  |.|.||||||.|.. ..                |  .|.||..| ...                  . .. .|..|    .  |.|  |  |...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

D-------RDDRILVYEFLENKSLDQLLFES-TTGILLD----------WPTRFQIVLGVANG-LAYLHEGSQKQIIHRDIKASNILLDHRLHPKISDFG
.       .|.  .. |.... |||... .   .|  |.           .    |.  .  | |.|||.     |||||||..||||      |..|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

ISKLFNQ---------------EKGFTSTVIAGTMGYLAPEYVLG------GLLTVKADVYSFGVLTLEIVSGQ
... ...                 .  .. ..||  . ||| ...      .  ..|.|..|.| . .| . |.
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAK-0_i-1.AA TK 13-209 16 2.4e-39 129.02 In-house 1-389 (486) Show / Hide 
Range on Protein: 13-209
Range on HMM: 1-389/486
Sequence Identity: 16% (65 aa)

FSDDNKLGRGAFG---TVFKGVLKDGS--------------------------EVAVKQLDLHSKQGQREFVN--------------ELSIITSIQ----
    .|||.|.||   .|.|| .....                          .||||.| ... . |.||                |....   .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HKNLAKLRGYCLDRDD------------RILVYEFLENKS----LDQLLFES-----------------------------------------------
 |.|. .| |.|.. .              ..| |. .. .    |.. | ..                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------TTGILLD--------------WPTRFQIVLGVANGLAYLHEGSQK-----QIIHRDIKASNILLDHRLH-----------PKISDFGI
            ||  ||.               ...  . . .|.|..|||  |..     ...|||. | |.|......            ||.||| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLH--SKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGL

S--------KLFNQEKGFTSTVIAGTMG-------------------------YLAPEYVLGGL---------LTVKADVYSFGVLTLEIVS
|        .  ....  ...   ||..                         ..||| ....           | | ||.|||||  ||..
SRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAK-0_i-1.AA TKL-Unique 15-212 28 4e-39 135.64 In-house 1-226 (290) Show / Hide 
Range on Protein: 15-212
Range on HMM: 1-226/290
Sequence Identity: 28% (66 aa)

DDNKLGRGAFGTVFKGVLKDGSEVAVKQLDL---HSKQGQREFVNELSIITSIQ-HKNLAKLRGYCL----DRDDRILVYEFLENKSLDQLLF----ES-
. ||.|.|..|.|.||. . |..||.||. .    |..  .|| ||....  .. |.|. .. |||     .  ....| |...  ||. .|      . 
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

--TTGILLDWPTRFQIVLGVANGLAYLHEGSQKQIIHRDIKASNILLDHR-----LHPKISDFGISKLFNQE-KGFTS-------TVIAGTMGYLAPEYV
     . |..  | .... .| |. |||  . . |||||.| ||.|.| .     .  ||.|||.||. ... |....       ..  |.  ..|||  
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

LG--GLLTVKADVYSFGVLTLEIVSGQR
 .   . . |.||||||.   ||.....
RMNFCQYSEKSDVYSFGIVLWEIATRKI
Kinase IRAK-0_i-1.AA Dicty4-Unclassified 16-210 34 4.7e-37 124.41 In-house 4-204 (263) Show / Hide 
Range on Protein: 16-210
Range on HMM: 4-204/263
Sequence Identity: 34% (71 aa)

DNKLGRGAFGTVFKGVLKDGSEVAVKQLDLHSKQGQ----REFVNELSIITSIQHKNLAKLRGYCLDR----DDRILVYEFLENKSLDQLLF----ESTT
|  .|.|.|  | ||. | | .|||| .   . .       .|  |  |  |||| || |..|||.         . | ||.    |  .      |   
DQFIGKGHFSKVHKGNWK-GKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQ

GILLDWPTRFQIVLGVANGLAYLHEGSQKQIIHRDIKASNILLDHRLHPKISDFGISKLFNQEKGFTSTVIAGTMGYLAPEYVLGGLLTVKADVYSFGVL
 | ||      . . .| |...||    . .||||||.||||.|     || |||||        |. | ||||    .||   .   . |.||||....
PIKLDDTLIIKYAFDIAQGMQHLH---TRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFN--FNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMM

TLEIVSG
  | . |
LYELATG
Kinase IRAK-0_i-1.AA S_TKc 13-284 22 5.3e-37 130.17 SMART 1-231 (231) Show / Hide 
Range on Protein: 13-284
Range on HMM: 1-231/231
Sequence Identity: 22% (65 aa)

FSDDNKLGRGAFGTVFKGVLKD-GSEVAVKQLDLHSKQGQREFVNELSIITSIQHKNLAKLRGYCLDRDDRILVYEFLEN--KSLDQLLFESTTG---IL
.   .|.|.||||.|.|.. |. | .||.|...       . . .|..|  . .|.|. || ... | |.  .| |....   .| ... .  ..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LDWPTRFQIVLGVANGLAYLHEGSQKQIIHRDIKASNILLDHRLHPKISDFGISKLFNQEKGFTSTVIAGTMGYLAPEYVLGGLLTV-KADVYSFGVLTL
..  .   ..  ....|.|.|.   ..|||||.| .|||||.  | ||.|||.....        | . ||  |.||| .     .  |.|..|.|..  
FPE-HARFYMYQICCALEYCHS---HGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EIVSGQR-CSDRKDGRLLVYSAWILHENNSELEIADERLDLEHNSEEILRVIQVALACTHENSASRPSMGDAVA-----MLSGYK
| ..|.   .      . .    |.                   |.| .  |.    | . . . ||.  .| .     ..  . 
EMLCGYPPFP-----QMQMMFKKIG-------------------SPEAKDFIR---KCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_i-1.AA MLK 13-211 27 5.7e-36 122.3 In-house 1-233 (291) Show / Hide 
Range on Protein: 13-211
Range on HMM: 1-233/291
Sequence Identity: 27% (65 aa)

FSDDNKLGRGAFGTVFKGVLKDGS----EVAVKQLD---LHSKQG----QREFVNELSIITSIQHKN----LAKLRGYCLDR-DDRILVYEFLENKSLDQ
.    ..| |.|| |.||. .       .||||. .     .|.     |..|  |  .   ..|.|      ...| ||.   .  .| |..|. ||  
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

LLFESTTGIL-----------LDWPTRFQIVLGVANGLAYLHEGSQKQIIHRDIKASNILLDH------RLHPKISDFGISKLFNQEKGFTSTVIAGTMG
.| . ....             |    ... | .|.|..|||.  .|.|||||.| .|||.|.       .. ||.|||.|. ..| .  . .  |||  
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYA

YLAPEYVL----GGLLTVKADVYSFGVLTLEIVSGQ
. ||| |.    ..  . |.||.|.||.  |.....
WMAPE-VIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase IRAK-0_i-1.AA LRRK 13-212 22 1.3e-34 119.92 In-house 1-281 (351) Show / Hide 
Range on Protein: 13-212
Range on HMM: 1-281/351
Sequence Identity: 22% (66 aa)

FSDDNKLGRGAFG-TVFKGVLKD---------------------------GSEVAVKQLDLH----------------------------------SKQG
.   ...|||.|| .|... ...                           ...||.|.....                                  .   
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

QREFVNELSIITSIQHKNLAKLRGYCLDRDDRILVYEFLENKSLDQLLFEST-TG-----ILLDWPTRFQIVLGVANGLAYLHEGSQK-QIIHRDIKASN
 ||| .|..|. . .| |. .| |.|.  . ...| |.. . .|...|...  .|     . ..| .. .|.| .| |..|||  |..  ||||| |  |
FREFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH--SHNPPIIHRDLKSPN

ILL---D---------HRLHPKISDFGISKLFNQEKGFT-STVIAGTMGYLAPEYVLGG----LLTVKADVYSFGVLTLEIVSGQ-R
|||   .            . ||.||||| .| |  . .      |. |..||| ....      | |.|.||||..  |....| .
ILLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPE-IMRYNGEEEYTEKVDCYSFGMILWELLTRQHH
Kinase IRAK-0_i-1.AA Pkinase_Tyr 13-162 29 7.6e-34 115.25 Pfam 1-160 (270) Show / Hide 
Range on Protein: 13-162
Range on HMM: 1-160/270
Sequence Identity: 29% (48 aa)

FSDDNKLGRGAFGTVFKGVLK-----DGSEVAVKQL-DLHSKQG--QREFVNELSIITSI-QHKNLAKLRGYCLDRDDR---ILVYEFLENKSLDQLLFE
 . . |||.||||.|.||..|     .. .|||| | . ....   ...| .|..| ... .|.|. .| | |.|...    ..| |. .. .|.  | .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

S-TTGILLDWPTRFQIVLGVANGLAYLHEGSQKQIIHRDIKASNILLDHRLHPKISDFGISKL
  . .  |. ..  |. . .|.|..||..   |..||||. | |.|... .. ||.||| ...
HREDKQPLTMKDLLQMCWQIAKGMEYLES---KNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase IRAK-0_i-1.AA Ciliate-E2-Unclassified 13-213 21 1.7e-33 113.55 In-house 1-269 (352) Show / Hide 
Range on Protein: 13-213
Range on HMM: 1-269/352
Sequence Identity: 21% (58 aa)

FSDDNKLGRGAFGTVFKGVLKDGSEV-------AVKQLDLHSK-QGQREFVNELSIITSIQ-----------------HKNLAKLRGYCLDRDD--RILV
.    ..|.|.||.|.| . |.  ..        ... . ... . . |..||. .. ...                 |... ... .  ..|.   ..|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

YEFLENKSLDQLLFESTT---------------GILLDWPTRF----QIVLGVANGLAYLHEGSQKQ-IIHRDIKASNILLDHRL---HPKISDFGISK-
.|..|...| | . .. .                |. .  ..     ..   . .|| |||   .|. ||||||| .|||.|      ..||.|||||| 
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLH---HKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKK

--LFNQEKGFT------------STVIAGTMGYL----APEYVLGGLLT----VKADVYSFGVLTLEIVSGQRC
   .|... ..            .. ..|| .|.    |||.  |         |.|..|.||.  |.. |...
YQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYP
Kinase IRAK-0_i-1.AA TK-Unique 13-209 23 2e-33 112.66 In-house 1-234 (294) Show / Hide 
Range on Protein: 13-209
Range on HMM: 1-234/294
Sequence Identity: 23% (56 aa)

FSDDNKLGRGAFGTVFKGVLKDGS-------EVAVKQLD-LHSKQGQREFVNELSIITSIQ-HKNLAKLRGYCLDRD-DRILVYEFLENKSLDQLLFEST
.  ....|.||||.|..| .. ..        ||||.|   .... ...| .|...  ..  |.|. .. |.| . | .  ...|.... .|. .| .. 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

TG-----------IL------------LDWPTRFQIVLGVANGLAYLHEGSQ--KQIIHRDIKASNILLDHRLHPKISDFGISKLFNQEKGFTSTVIAGT
 .           .             ..  . ...  ..|.|..||.   .  |.|.|||. |.|.|| ...  ||.|||...  . ..   ..   |.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLA---SQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGR

MG--YLAPEYVL--GGLL-TVKADVYSFGVLTLEIVS
.   ..|||. .  .|   | | ||.|||||  ||..
IPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase IRAK-0_i-1.AA TyrKc 13-280 24 3.7e-27 97.45 SMART 1-280 (280) Show / Hide 
Range on Protein: 13-280
Range on HMM: 1-280/280
Sequence Identity: 24% (73 aa)

FSDDNKLGRGAFGTVFKGVLKDGSEVAVKQLDLHSKQGQREFVNELSIITSI--QHKNLAKLRGYCLDR-------DDRILVYEFLENKSLDQLL-FEST
 . . |||.||||.|.||..|   .|||| |  ..   ...| .|..| ...  .|.|. .| |.|..        .   .| |. .. .|.. |     
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

TGILLDWPTRFQIVLGVANGLAYLHEGSQKQIIHRDIKASNILLDHRLHPKISDFGISKLFNQE--KGFTSTVIA-----GTMG-----YLAPEYVLGGL
.   | ...  .. . .|.| .|||.    ..||||. | |.|...... |||||| |.    .  .|  . ..      |. .      .|||    | 
K---LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

LTVKADVYSFGVLTLEIVSGQRCSDRKDGRLLVYS-AW--ILHENNSELEIADERLDLEHN--------SEEILRVIQVALACTHENSASRPSMGDAVAM
 | | ||.||||.  || .        .|    .  .   .  .   |.  . .|..  .|          . .    . . | ||. ..||.. . .  
FTTKSDVWSFGVCMWEIFT--------YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ--IMKQCWHEDPEDRPTFSEIHEC

L
.
F
Kinase IRAK-0_i-1.AA Pkinase_Tyr 181-209 51 0.001728 12.44 Pfam 181-209 (270) Show / Hide 
Range on Protein: 181-209
Range on HMM: 181-209/270
Sequence Identity: 51% (15 aa)

LAPEYVLGGLLTVKADVYSFGVLTLEIVS
.|||    |  |.| ||.|||||  ||..
MAPECINYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAK-0_i-1.AA TK 257-280 20 0.005629 4.96 In-house 463-486 (486) Show / Hide 
Range on Protein: 257-280
Range on HMM: 463-486/486
Sequence Identity: 20% (5 aa)

QVALACTHENSASRPSMGDAVAML
.. . | |.. . ||.. . . .|
DLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK-0_i-1.AA IRAK 257-280 29 0.040953 3.49 In-house 294-317 (317) Show / Hide 
Range on Protein: 257-280
Range on HMM: 294-317/317
Sequence Identity: 29% (7 aa)

QVALACTHENSASRPSMGDAVAML
|.|. |.|.  . |..|  ... |
QCACCCGHHRANRRCDMAWVMQQL