Gene IRAK-0_aq-2 (S.moellendorffii)

IRAK-0_aq-2

Species: S.moellendorffii
Alias: IRAK-0_aq-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_aq-2.AA Protein None 515 None Fasta, JSON
IRAK-0_aq-2.NA RNA None 1548 None Fasta, JSON
IRAK-0_aq-2.kin_dom Protein Kinase Domain None 202 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_aq-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-0_aq-2.AA TKL 185-450 22 1.2e-64 221.09 In-house 1-364 (364) Show / Hide 
Range on Protein: 185-450
Range on HMM: 1-364/364
Sequence Identity: 22% (83 aa)

IGEGGYGVVFKGFLPD---------GSVVAVKNLLNNTGQ---------------------------AEKEFRVEVEAIGKVRHKNLVRLLGYCAE----
||.||.|.|.|| .           | .|||| .  .  .                           .......|.  . . || |.|...||| .    
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-SCYR--------MLVYEYVDNGNLEDWLHGFSSQTQAFPWEARMKIALGTAKALTYLHEAL-----EPKVVHRDIKASNILVEGDWN------------
  |..        ..|.||...|.|.. ||          |. |...||..|... |||         |...|||.| .||||  .|.            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--AKISDFGLAKLL----GSEKSHVTTR--------------VMGTFGYVAPEYAS----------------TGLLNERSDVYSFGVLLMELITGRDPVD
  .||.||||.. .    .....  |..              . ||... |||                    .  .|..||||||..| |..|.. | .
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY

-YSRPPGEVNLVDWLK---VMVANRHSEDVADPRLHV----KPTPRILKKALLVAIRCVDPDSLRRPKMGHVVHML
 |  .| ...  . ..   .||...      .|.        | | ...     . .| |.|   || .  ... |
DYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-0_aq-2.AA IRAK 179-450 29 7.9e-59 201.75 In-house 1-317 (317) Show / Hide 
Range on Protein: 179-450
Range on HMM: 1-317/317
Sequence Identity: 29% (95 aa)

FCEDSKIGEGGYGVVFKGFLPDGS-VVAVK----NLLNNTGQAEKEFRV---EVEAIGKVRHKNLVRLLGYCAESCYRMLVYEYVDNGNLEDWLHGFS-S
| .| .|||||.|.|..| .     ..|||    .   .... ...|.    |...  . ||.|.| |.|||.|.    |||.|  || ||| |..   .
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

QT-QAFPWEARMKIALGTAKALTYLHEALEPK--VVHRDIKASNILVEGDWNAKISDFGLAKLL----GSEKSHV----TTRVMGTFGYVAPEYAS--TG
 . .. .|  | .|..|||... .||.. .|.  . |.||| .|||   . ..||.||||.       ..||. .    | .| ||  | .||.    .|
CPPKPLSWHQRCSICWGTACGIQFLHQN-HPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQG

LLNERSDVYSFGVLLMELITGRDPVDYSRPPGEVNLVDWLKVMVANRHS--------------------------EDVADPRLHVKPTPRILKKALL-VA
 |  ..||||||. |.|..||. .|.  ||. .  |.| . .    . .                          |.  |.|  . | |. . |... .|
QLTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYY-LKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHR--MPPCPPNMEKEMCQCA

IRCVDPDSLRRPKMGHVVHML
..|.     ||..|  |.  |
CCCGHHRANRRCDMAWVMQQL
Kinase IRAK-0_aq-2.AA TKL-Unique 183-377 35 2.5e-45 156.91 In-house 3-224 (290) Show / Hide 
Range on Protein: 183-377
Range on HMM: 3-224/290
Sequence Identity: 35% (79 aa)

SKIGEGGYGVVFKGFLPDGSVVAVKNLL-NNTGQAE--KEFRVEVEAIGKVR-HKNLVRLLGYCA----ESCYRMLVYEYVDNGNLEDWLH---GFS---
.||||||||.|.||  . |. ||.| .  |.    |  .||. ||  . | . |.|.|.. |||.       .. .| ||.. |.| | ||     .   
NKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNN

SQTQAFPWEARMKIALGTAKALTYLHEALEPKVVHRDIKASNILVEGD-----WNAKISDFGLAKLLGSE-KSHVT-------TRVMGTFGYVAPEYAST
..   .... |.|.|.  |... |||  .||.. |||.| ||.||  .     ||.||.||||.|.. .. |. ..       . ..|.| ..|||  . 
NNNCKLNMQQRVKMAIDIAQGMYYLHH-CEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

--GLLNERSDVYSFGVLLMELITG
   . .| |||||||. | |..|.
NFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAK-0_aq-2.AA Dicty4 182-380 34 6.9e-44 144.35 In-house 4-216 (277) Show / Hide 
Range on Protein: 182-380
Range on HMM: 4-216/277
Sequence Identity: 34% (74 aa)

DSKIGEGGYGVVFKGFLPDGSVVAVKNL-LNNTG--QAE-KEFRVEVEAIGKVRHKNLVRLLGYCA----ESCYRMLVYEYVDNGNLEDWLHG-FSSQTQ
...||.|..| |.||    |. |||| | ..|..  ... .||| ||.  .| || |.. ..|.|     ..   . | ||.  |||.  ||   | | |
EQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQ

AFPWE----AR-MKIALGTAKALTYLHEALEPKVVHRDIKASNILVEGDWNAKISDFGLAKLLGSEKSHVT--TRVMGTFGYVAPEYASTGLLNERSDVY
  . .     | |..|. .|. ...||.   | ..|||.|..|.||  .|..|..||||...   ...| .  . . || ...|||       || .|||
SIKLDWPLIKRAMRMAFDAARGMNWLHCC-NPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVY

SFGVLLMELITGRDP
||| .| |. |. .|
SFGIVLWEILTRQEP
Kinase IRAK-0_aq-2.AA TK 179-450 16 5.2e-43 141.55 In-house 1-486 (486) Show / Hide 
Range on Protein: 179-450
Range on HMM: 1-486/486
Sequence Identity: 16% (83 aa)

FCEDSKIGEGGYG---VVFKGFLPDGS--------------------------VVAVKNLLNNTGQAEKEFRV--------------EVEAIGKVR----
     |.||| .|   .|.|| . ...                           |||| |   ......||.               |.|.. . .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HKNLVRLLGYCAESCY------------RMLVYEYVDNGN----LEDWLHGFSSQTQA-----------------------------------------
 |.|.|||.|.| ..               |.| ||...|.    | |.|.  .  .|                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FPWEARMKIALGTAKALTYLHEA---LEPKVVHRDIKASNILVEGDWN-----------AKISDFG---
                               .. . .. ...  |... |||.    .....||||. | |.||  . .           .||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LAKLLGSEKSHVTTRVMGTFG-------------------------YVAPEYAS---------TGLLNERSDVYSFGVLLMELIT-GRDPVDYSR
     ||. ..|..  ....  || .                         . |||            .|   . |||.|||||. |. | |. |     
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

PP------GEVNL--VDWLKV----------MVANRHSED--VADPR----LHVKPTPRILKKAL-LVAIRCVDPDSLRRPKMGHVVHML
.       | .|   .. |.           .| .|.     .  |      . . .|.   ... ..  .| ..|  .|| .  ....|
SNQDVWKDG-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK-0_aq-2.AA LISK 184-387 27 2e-42 135.5 In-house 1-247 (296) Show / Hide 
Range on Protein: 184-387
Range on HMM: 1-247/296
Sequence Identity: 27% (70 aa)

KIGEGGYGVVFKGFLP-DGSVVAVKNLLN-----NTGQAEKEFRVEVEAIGKVRHKNLVRLLGYCAE-SCYRMLVYEYVDNGNLEDWLHGFSSQTQAFPW
.||.|..| |.|| .  .|.|.|.| . .     |   ..| .  ||. . . ||.| |.  | | . .   ..| ||.. |.|.. |.  ...   .||
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

EARMKIALGTAKALTYLHEALEPKVVHRDIKASNILVE----GDWNAKISDFGLAKLLGSEK-----------------------------------SHV
. |.||||. |....|||.    ...||| |. |.||     ..|..|. |||.|...  |.                                   .. 
PQRVKIALDIACGMSYLHSM---NIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRM

TTRVMGTFGYVAPEYASTGLLNERSDVYSFGVLLMELITGRDPVD--YSRPP
|  . ||   .|||       .|..||.|||..| |.||....    . |.|
T--ICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKADPDYWPRTP
Kinase IRAK-0_aq-2.AA Pkinase 179-378 26 1.8e-41 147.72 Pfam 1-209 (293) Show / Hide 
Range on Protein: 179-378
Range on HMM: 1-209/293
Sequence Identity: 26% (58 aa)

FCEDSKIGEGGYGVVFKGFLPDGSV-VAVKNLLNNTGQAEKEFRV-----EVEAIGKVRHKNLVRLLGYCAESCYRMLVYEYVDNG----NLEDWLHGFS
..  .|||.|..|.|.|.   . .  ||||  ..  .. ... .      |..   ...|.| |||.... .. .  .| ||...|     | |....  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVK-IIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--

SQTQAF--PWEARMKIALGTAKALTYLHEALEPKVVHRDIKASNILVEGDWNA----KISDFGLAKLL-GSEKSHVTTRVMGTFGYVAPEYASTGLLN--
..  .|  ...   .... ....| |.|.    ...|||.| .|||.  . .     ||.||||||..    .|  ||.. || .|.|||      ..  
WRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFC-GTPWYMAPEV-----IRGG

----ERSDVYSFGVLLMELITGR
     ..|..|.|..| |...||
QYYGPKVDMWSCGCILYEMLCGR
Kinase IRAK-0_aq-2.AA MLK 179-380 25 5.7e-40 136.38 In-house 1-235 (291) Show / Hide 
Range on Protein: 179-380
Range on HMM: 1-235/291
Sequence Identity: 25% (61 aa)

FCEDSKIGEGGYGVVFKGFLPDGS----VVAVKNLLNNT---GQAE---KEFRVEVEAIGKVRHKN----LVRLLGYCAES-CYRMLVYEYVDNGNLEDW
. .  .||.|..|.|.||          .||||.   ..   ....   ..|. |..   ...|.|     ....| |... |   .| ||...| | . 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHGFSSQTQ----------AFPWEARMKIALGTAKALTYLHEALEPKVVHRDIKASNILVE------GDWNAKISDFGLAKLLGSEKSHV---TTRVMGT
||| .|.              . .  |..||  |... |||. . ....|||.| .|||.       .. ..||.|||...    ....     .  .||
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR----DWHQMCTNMMSNAGT

FGYVAPEY---ASTGLLNERSDVYSFGVLLMELITGRDP
. . |||    .  .  .| .||.|.||.| |..|.. |
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase IRAK-0_aq-2.AA Pkinase_Tyr 179-380 29 6e-37 125.77 Pfam 1-214 (270) Show / Hide 
Range on Protein: 179-380
Range on HMM: 1-214/270
Sequence Identity: 29% (64 aa)

FCEDSKIGEGGYGVVFKGFLP-----DGSVVAVKNLLNNTGQAE---KEFRVEVEAIGKV-RHKNLVRLLGYCA-ESCY--RMLVYEYVDNGNLEDWLHG
   . |.||| .|.|.|| .      ..  |||| | ... . .   ..|  |..   .  .|.|.|||.| |  ..     ..| ||. .|.| | |. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

FSSQTQAFPWEARMKIALGTAKALTYLHEALEPKVVHRDIKASNILVEGDWNAKISDFGLAKLL-GSEKS-HVTTRVMGTFGYVAPEYASTGLLNERSDV
 ... |... .   ....  ||.. ||..    . .|||. | |.||. .  .||.|||||...   .   ....  .      |||  ..|  .. |||
HREDKQPLTMKDLLQMCWQIAKGMEYLESK---NCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

YSFGVLLMELIT-GRDP
.|||||. |..| |. |
WSFGVLMWEIFTYGEQP
Kinase IRAK-0_aq-2.AA LRRK 179-382 24 1.9e-36 126.48 In-house 1-284 (351) Show / Hide 
Range on Protein: 179-382
Range on HMM: 1-284/351
Sequence Identity: 24% (70 aa)

FCEDSKIGEGGYG-VVFKGFLPD---------------------------GSVVAVKNLLN-----------NTG-----------------------QA
. . ..||.||.| .|... . .                           .. ||.| ..            ...                        |
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

EKEFRVEVEAIGKVRHKNLVRLLGYCAESCYRMLVYEYVDNGNLEDWLHGFSSQTQ-----AFPWEARMKIALGTAKALTYLHEALEPKVVHRDIKASNI
  ||| ||  . . .| |.| |.|.| . .  ..| ||...|.| . || ...  .      ..|  . ||||  ||.. ||| .  |...||| |  ||
FREFRHEVWIMSHLNHPNIVSLKGFCIHPL--CMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSH-NPPIIHRDLKSPNI

LVEGD------------WNAKISDFGLAKLLGSEKSHVTTRVMGTFGYVAPEYASTG---LLNERSDVYSFGVLLMELITGR-DPVD
|...              .|||.|||.  .  . .. |. .. |..|..|||    .     .| .|.||||..| ||.|.. .| |
LLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD
Kinase IRAK-0_aq-2.AA Dicty4-Unclassified 182-380 33 1.8e-34 115.46 In-house 4-207 (263) Show / Hide 
Range on Protein: 182-380
Range on HMM: 4-207/263
Sequence Identity: 33% (71 aa)

DSKIGEGGYGVVFKGFLPDGSVVAVKNLLNNTGQAE----KEFRVEVEAIGKVRHKNLVRLLGYCAES----CYRMLVYEYVDNGNLEDWLH-GFSSQTQ
|  ||.|    | ||    |  |||| .  |  ..     ..|. |||  | . | |||.. |||          . | |    |||    |   | | |
DQFIGKGHFSKVHKGNW-KGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQ

AFPWEA--RMKIALGTAKALTYLHEALEPKVVHRDIKASNILVEGDWNAKISDFGLAKLLGSEKSHVTTRVMGTFGYVAPEYASTGLLNERSDVYSFGVL
    .    .|.|.  |. . .||      ..|||||.||||.  . |.|| |||..     .     | . ||    .||       | .|||||....
PIKLDDTLIIKYAFDIAQGMQHLHTR---NFIHRDIKSSNILMDKHFNIKIADFGISRVI--DFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMM

LMELITGRDP
| ||.||  |
LYELATGDEP
Kinase IRAK-0_aq-2.AA RIPK 185-380 27 1.3e-33 111.87 In-house 1-227 (290) Show / Hide 
Range on Protein: 185-380
Range on HMM: 1-227/290
Sequence Identity: 27% (63 aa)

IGEGGYGVVFKGFLPDGSVVAVKNLLN-----NT--GQAEKEFRVEVEAIGKVRHKNLVRLLGYCAES-----CY-RMLVYEYVDNGNLEDWLHGFSS-Q
.| || | ||| .  .  ....|   .      .   | ...   |...  | |... |...| | .      |    .| ||  ||.|.. ||  .. |
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

TQAFPWEARMKIALGTAKALTYLHEALEPKVVHRDIKASNILVEGDWNAKISDFGLAKLLGSEKSHV-----------TTRVM-GTFGYVAPEYASTGLL
 .  ||  |  .   .. .  |||    | . ||| | .|||| .. ..||.|||||. ..  .||            . .   ||  | .||   |.. 
HHPDPWPLRCRMIHEISCGMCYLHS-MNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNK

NE------RSDVYSFGVLLMELITGRDP
.        .|||||.... |. |.. |
KPIKVVTPKYDVYSFAIVMWEVLTQKHP
Kinase IRAK-0_aq-2.AA S_TKc 179-450 22 2.6e-33 117.88 SMART 1-231 (231) Show / Hide 
Range on Protein: 179-450
Range on HMM: 1-231/231
Sequence Identity: 22% (66 aa)

FCEDSKIGEGGYGVVFKGFLPD-GSVVAVKNLLNNTGQAEKEFRVEVEAIGKVRHKNLVRLLGYCAESCYRMLVYEYVDN--GNLEDWLHGFSSQT--QA
.    |||.|..|.|.|.   . | .||.| .        . .| |..   | .|.|.|.|.... .  .  .| ||.|.  |.| | ..   ..   . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

FPWEARMKIALGTAKALTYLHEALEPKVVHRDIKASNILVEGDWNAKISDFGLAKLLGSEKSHVTTRVMGTFGYVAPEYASTGLLNE-RSDVYSFGVLLM
||     ...  ...|| |.|.    ...|||.| .|||.    . ||.|||||..|        | . ||  |.|||       .  ..|..|.|..| 
FPE-HARFYMYQICCALEYCHSH---GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELITGRDPVDYSRPPGEVNLVDWLKVMVANRHSEDVADPRLHVKPTPRILKKALLVAIRCVDPDSLRRPKMGHVVH---------ML
|...|. | .        ..   .|...                      . |.    .| . |  .||    . .          .
EMLCGYPPFP--------QMQMMFKKIG---------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_aq-2.AA TyrKc 179-450 23 3.8e-31 110.7 SMART 1-280 (280) Show / Hide 
Range on Protein: 179-450
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

FCEDSKIGEGGYGVVFKGFLPDGSVVAVKNLLNNTGQAEKEFRVEVEAIGKV--RHKNLVRLLGYCAES-------CYRMLVYEYVDNGNLEDWLHGFSS
   . |.||| .|.|.|| .     |||| | ...   ...|. | .   |.  .|.|.|||.|.| ..          |.| ||...|.| | |.    
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

QTQAFPWEARMKIALGTAKALTYLHEALEPKVVHRDIKASNILVEGDWNAKISDFGLAKLLGSE------KSHVTT----RVM--GTFGYVAPEYASTGL
.   ....   ....  |.   |||.    ...|||. | |.||  .  .|||||||.. ....      |.  ..               |||   .| 
K---LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

LNERSDVYSFGVLLMELITGRDPVDYSRP----PGEVNLVDWLKVMVANRHSEDVADPRLHVKPTPRILKKALLVAIRCVDPDSLRRPKMGHVVHML
 .. |||.||||.. |. |  .   |. .         .. ..|     .  ...  | .     ..  ..   .  .| . |   || .  ... .
FTTKSDVWSFGVCMWEIFTYGQ-QPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MSF---VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK-0_aq-2.AA MLK 431-450 30 0.095828 1.99 In-house 272-291 (291) Show / Hide 
Range on Protein: 431-450
Range on HMM: 272-291/291
Sequence Identity: 30% (6 aa)

RCVDPDSLRRPKMGHVVHML
.| ..|. .||.. ..|  |
QCWNQDPHKRPSFRQIVQHL