Gene IRAK-0_af-2 (S.moellendorffii)

IRAK-0_af-2

Species: S.moellendorffii
Alias: IRAK-0_af-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_af-2.AA Protein None 1022 None Fasta, JSON
IRAK-0_af-2.NA RNA None 3069 None Fasta, JSON
IRAK-0_af-2.kin_dom Protein Kinase Domain None 220 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_af-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRR_1 IRAK-0_af-2.AA LRR_1 139-160 37 0.004463 15.08 Pfam 1-26 (26) Show / Hide 
Range on Protein: 139-160
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLVTLDLNN-N--NLQGPIPR--CIGI
.| .|||.. |  ||.| ||   . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_af-2.AA LRR_1 164-187 32 30.91858 1.46 Pfam 1-26 (26) Show / Hide 
Range on Protein: 164-187
Range on HMM: 1-26/26
Sequence Identity: 32% (9 aa)

RLKRLGMAGGA--GNL-GTIPEE-LGSL
.|..| . |     || |.||.. . .|
NLQHLDLSG-CNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_af-2.AA LRR_1 189-211 40 0.000431 18.68 Pfam 1-26 (26) Show / Hide 
Range on Protein: 189-211
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

SLEQLYLDN-T--NLTGPIPSS-FGGM
.|. |.|.. .  |||| ||.| | ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_af-2.AA LRR_1 213-235 37 0.000315 19.16 Pfam 1-26 (26) Show / Hide 
Range on Protein: 213-235
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLQQLDIRY-N--RLSGRIPLE-LGRL
.|| ||... |  .|.| || . .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_af-2.AA LRR_1 237-258 29 55.053107 0.57 Pfam 1-26 (26) Show / Hide 
Range on Protein: 237-258
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

NLVELGIQV-N--SLEGGIEA--VASL
|| .| ..  |  .|.| |      .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_af-2.AA LRR_1 260-283 29 0.082928 10.58 Pfam 1-26 (26) Show / Hide 
Range on Protein: 260-283
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

RLEILTAFN-N--HFSGNLSLSIFRNL
.|..|   . |  ...|... |.| ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_af-2.AA LRR_1 285-306 33 0.520988 7.75 Pfam 1-26 (26) Show / Hide 
Range on Protein: 285-306
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLRVLNLKL-N--NFTGGIPE--LDER
.|..|.|   |  |.|| ||.  .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_af-2.AA LRR_1 309-331 48 0.000386 18.85 Pfam 1-26 (26) Show / Hide 
Range on Protein: 309-331
Range on HMM: 1-26/26
Sequence Identity: 48% (13 aa)

NLTHLDLSF-N--QLSRGIPGS-LVRL
||.|||||  |  .|.. || | .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_af-2.AA LRR_1 333-351 50 0.03854 11.76 Pfam 1-22 (26) Show / Hide 
Range on Protein: 333-351
Range on HMM: 1-22/26
Sequence Identity: 50% (11 aa)

SLTHLFLGH-N--NLSGAIPSS
.|.|| |.. |  ||.| ||.|
NLQHLDLSGCNCCNLTGHIPPS
LRR_1 IRAK-0_af-2.AA LRR_1 355-377 37 0.003204 15.59 Pfam 1-26 (26) Show / Hide 
Range on Protein: 355-377
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

ALQVLDVSH-N--SLSGSLPNL-PQQL
 ||.||.|. |  .|.|..|.    .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
Malectin IRAK-0_af-2.AA Malectin 419-577 26 1.3e-20 79.64 Pfam 1-181 (202) Show / Hide 
Range on Protein: 419-577
Range on HMM: 1-181/202
Sequence Identity: 26% (49 aa)

TSFAVRVGSSQN-LTNRDGTLFRSDGFARNSTG--LHYLEADRNWALELSSEFSSTV-------TVPATISGVPPEDD--PSLYQTMRWSSSYLAYHGGN
.|...  |..    | .||...  | .    .     |  .. .|.   .  |.          .. ...| . ..||  | |||| ||| | ..| .  
YSWHINCGGPEHYTTDSDGITYEADNHFTGGSAASDYYVSRNNWWGYS-TGDFMDDDNNQYYYGYITTNSSIFYTTDDVDPELYQTERWSPSSFRYYIPC

LAPGTYSVSLYFCETVFTN-------ASYRAMDVVVQGEVIARQLDVVREVGP--RTAYKITRNATVTDGSLS--IEFIFTG
|. |.|.| |.|.|. |..       .  |  || .||... . .|.. |.|   ..|.|   |.|||.| |.  | |  .|
LENGNYTVILHFAEIYFQDTDQTWNSPGRRVFDVYIQGKLVLKDFDIWKEAGGKGKAAHKEFINVTVTNGTLEYVIHFYWAG
Kinase IRAK-0_af-2.AA TKL 687-850 24 2e-49 170.5 In-house 1-242 (364) Show / Hide 
Range on Protein: 687-850
Range on HMM: 1-242/364
Sequence Identity: 24% (60 aa)

LGQGGFGSVYVGNLQDQT---------LVAVKQLLHQ---------------------------TQQGREAFRKEIRILSSVQHRNLVAVRGYCLEAEH-
.|.|||| || |... ..          ||||..  .                           ... |. ...||...|. .| |.|   |||.. .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------PMLVCDYMRNGSLDQFLHGSRGFLTWNQRRKIAIDTAFGLAYLHDES-----KHRIIHCDLKPPNILLDDDMM--------------P
            ...| .|. .|||  .||       |.|| ..|.|.| |..||| .      |  |||.|||..|||.|...               .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

RIADFGMARLYEEGK-----------------SHVTATKMGGTIGYLAP
 |.||| .|  .. .                 .. |  . .||....||
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAP
Kinase IRAK-0_af-2.AA IRAK 681-850 33 1.3e-43 151.19 In-house 1-191 (317) Show / Hide 
Range on Protein: 681-850
Range on HMM: 1-191/317
Sequence Identity: 33% (64 aa)

FNPTKKLGQGGFGSVYVGNLQDQT-LVAVKQLLH----QTQQGREAFRK---EIRILSSVQHRNLVAVRGYCLEAEHPMLVCDYMRNGSLDQFLHGSRG-
|..  ..|.|||| || | .. .|  .||| |      .. . .. |.    |...... .| |.|.. |||.| . . || .||.||||   |..  | 
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

-F---LTWNQRRKIAIDTAFGLAYLHDES-KHRIIHCDLKPPNILLDDDMMPRIADFGMARLY----EEGKSHV---TATKMGGTIGYLAP
     |.| || .|.. || |. .||. . .  ||| | |. |||||....| |.|||..|      .  |. .    . .  ||  |..|
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPP
Pkinase IRAK-0_af-2.AA Pkinase 681-900 25 2.5e-43 154.3 Pfam 1-209 (293) Show / Hide 
Range on Protein: 681-900
Range on HMM: 1-209/293
Sequence Identity: 25% (60 aa)

FNPTKKLGQGGFGSVYVG-NLQDQTLVAVKQLLHQTQQG--REAFRK--EIRILSSVQHRNLVAVRGYCLEAEHPMLVCDYMRNG----SLDQFLH-GSR
.   .|.|.|.||.|| . .  .. .||||..  ...    ... |.  ||.|. ...| | |  .... .  |. .| .|...|    .|  ...  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GFL--TWNQRRKIAIDTAFGLAYLHDESKHRIIHCDLKPPNILLDDDMMP----RIADFGMARLYEEGKSHVTATKMGGTIGYLAPGKKKELICRILELG
| .  .... ....  .. ||.|.|..   .|||.|||| |||.|... .    .|.||| |....   . . .|   ||..|.||    |.|       
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAP----EVIR------

FIDNSSLAEYAMHYQLSDKADVYSYGVVLLEIISGR
            .   . |.|..|.|..| | ..||
-----------GGQYYGPKVDMWSCGCILYEMLCGR
Kinase IRAK-0_af-2.AA MLK 681-900 25 1.8e-42 145.16 In-house 1-233 (291) Show / Hide 
Range on Protein: 681-900
Range on HMM: 1-233/291
Sequence Identity: 25% (66 aa)

FNPTKKLGQGGFGSVYVGNLQDQT----LVAVKQLLH------QTQQGREAFRKEIRILSSVQHRN----LVAVRGYCLEAEH-PMLVCDYMRNGSLDQF
..  ...| |.||.|. |. . ..     ||||.  .      .|   ...|..|.|.|. ..|.|     ....| ||. ..   .|  |...|||  .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHGSRG-------------FLTWNQRRKIAIDTAFGLAYLHDESKHRIIHCDLKPPNILLDD------DMMPRIADFGMAR-LYEEGKSHVTATKMGGTI
||| |.               .  .  ..| . | |..||| . .. ||| |||..|||.|.      ..  .|.||| .| ... . .  . ... || 
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-T--NMMSNAGTY

GYLAPGKKKELICRILELGFIDNSSLAEYAMHYQLSDKADVYSYGVVLLEIISGR
 . ||    | | .               . . . | |.||.|.|||| |.....
AWMAP----EVIQQ---------------FRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase IRAK-0_af-2.AA TKL-Unique 683-899 27 4.2e-35 121.3 In-house 1-224 (290) Show / Hide 
Range on Protein: 683-899
Range on HMM: 1-224/290
Sequence Identity: 27% (69 aa)

PTKKLGQGGFGSVYVGNLQDQTLVAVKQLLH---QTQQGREAFRKEIRILSSVQ-HRNLVAVRGYCL----EAEHPMLVCDYMRNGSLDQFLH-------
. .|.|.||.|.|| |    .. ||.||.     .  . .. |..|.....  . | |.|   |||      . .  .|..|.  |||.  ||       
FWNKIGEGGYGQVYKG-KWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

--GSRGFLTWNQRRKIAIDTAFGLAYLHDESKHRIIHCDLKPPNILLDDD-----MMPRIADFGMARLYEEGKSHVTATKMG-----------GTIGYLA
   .   |...|| |.||| | |. ||| ...  |||.|||..|.|.| .     .  .|.||| ...    .|  .... .           |.. ..|
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKF----NSKINKMTNNEHKGTRNQTRCGSFRWMA

PGKKKELICRILELGFIDNSSLAEYAMHYQLSDKADVYSYGVVLLEIISG
|    |....                  .| | |.||||.|.|| ||...
P----EVLRMNF----------------CQYSEKSDVYSFGIVLWEIATR
Kinase IRAK-0_af-2.AA LRRK 681-850 25 5.8e-34 117.53 In-house 1-248 (351) Show / Hide 
Range on Protein: 681-850
Range on HMM: 1-248/351
Sequence Identity: 25% (64 aa)

FNPTKKLGQGGFG-SVYVGNLQDQ---------------------------TLVAVKQLLHQ-----------------------------------TQQ
.   ...|.|||| .|| .....|                           . ||.|...                                     .  
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

GREAFRKEIRILSSVQHRNLVAVRGYCLEAEHPMLVCDYMRNGSLDQFLHGSR--GF------LTWNQRRKIAIDTAFGLAYLHDESKHR--IIHCDLKP
 || ||.|. |.|. .| |.|   |.|.  .....| .|...|.|..||| ..  ||      ..|. . |||.. | |..|||   .|.  |||.|||.
FRE-FRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH---SHNPPIIHRDLKS

PNILLDDDMMP------------RIADFGMARLYEEGKSHVTATKMGGTIGYLAP
|||||   ...             |||||  |..     .  | ...|..|..||
PNILLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAP
Kinase IRAK-0_af-2.AA Pkinase_Tyr 681-828 30 1.4e-33 114.34 Pfam 1-160 (270) Show / Hide 
Range on Protein: 681-828
Range on HMM: 1-160/270
Sequence Identity: 30% (50 aa)

FNPTKKLGQGGFGSVYVGNLQ-----DQTLVAVKQLLHQTQQG---REAFRKEIRILSSV-QHRNLVAVRGYCL-EAEH--PMLVCDYMRNGSLDQFLHG
    ||||.| ||.|| | .      ... |||| | ... .    ||.| .|..|...  .| |.|   | |. . |.  ...|  || .|.|. .|. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

S---RGFLTWNQRRKIAIDTAFGLAYLHDESKHRIIHCDLKPPNILLDDDMMPRIADFGMARL
    .. ||  .  ..... | |..||..   ...|| ||   |.|.....  .|.|||.||.
HREDKQPLTMKDLLQMCWQIAKGMEYLES---KNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase IRAK-0_af-2.AA TK 681-839 16 9.3e-33 106.56 In-house 1-319 (486) Show / Hide 
Range on Protein: 681-839
Range on HMM: 1-319/486
Sequence Identity: 16% (54 aa)

FNPTKKLGQGGFG---SVYVGNLQDQ--------------------------TLVAVKQLL---HQTQQGREA--------------FRKEIRILSS--V
    ||||.| ||    || | ....                          | ||||.|    ...|. ...              .  |. ....   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHRNLVAVRGYCLEA------------EHPMLVCDYMRNGS----LDQFLHGSRG---------------------------------------------
.| |.|   |.|..             |..|.|  || .|.    |...|. .|.                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------FLTWNQRRKIAIDTAFGLAYLHDESKH-----RIIHCDLKPPNILLDDDMM-----------PRIADFG-
                              .||  |.  .. . | |..|||  ||.     ...| ||   |.|.....             .||||| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLH--SKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGL

-------MARLYEEGKSHVTAT
       .||  ....  ....
SRQGSGVLARDIYSDDDYYRKS
Kinase IRAK-0_af-2.AA Dicty4 681-850 29 1.5e-32 106.01 In-house 1-186 (277) Show / Hide 
Range on Protein: 681-850
Range on HMM: 1-186/277
Sequence Identity: 29% (55 aa)

FNPTKKLGQGGFGSVYVGNLQDQTLVAVKQL--LHQT--QQGREAFRKEIRILSSVQHRNLVAVRGYCL----EAEHPMLVCDYMRNGSLDQFLHG----
 | ....|.|.||.|| |.   .. |||| |  . |.  .   ..||||. |... .| |..   |.|.    . . .. |  ||  |.|   ||     
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

--SRGFLTWNQRRK---IAIDTAFGLAYLHDESKHRIIHCDLKPPNILLDDDMMPRIADFGMARLYEEGKSHVT-ATKMGGTIGYLAP
  ..  | |  ...   .|.|.| |...|| ..  .||| |||. |.| |...   ..||| ...  ....| . .. . || .. ||
QQQSIKLDWPLIKRAMRMAFDAARGMNWLH-CCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAP
Kinase IRAK-0_af-2.AA UTK 681-828 30 2.3e-30 101.06 In-house 1-177 (296) Show / Hide 
Range on Protein: 681-828
Range on HMM: 1-177/296
Sequence Identity: 30% (55 aa)

FNPTKKLGQGGFGSVYVGNLQD------QTLVAVKQLL--HQTQQGRE---AFRKEIR---ILSSVQ-HRNLVAVRGYCLEAEHPMLVCDYMRNGSLDQF
  . ..|||| || |... ...      . .||||..   . .|| .|    |..| |   ... .. |.|.. . |.|.  | .|.|  ||.||.|...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LHGSRG-------FLTWNQRRKIAIDTAFGLAYLHDESKHRIIHCDLKPPNILLDDD-------MMPRIADFG---MARL
|  .|        .||  || . | | | |..|||    ....|.||   |.|....       |  .|||||   |.|.
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLH---SCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRR
Kinase IRAK-0_af-2.AA S_TKc 681-977 20 3.9e-30 107.34 SMART 1-231 (231) Show / Hide 
Range on Protein: 681-977
Range on HMM: 1-231/231
Sequence Identity: 20% (66 aa)

FNPTKKLGQGGFGSVYVGNLQD-QTLVAVKQLLHQTQQGREAFRKEIRILSSVQHRNLVAVRGYCLEAEHPMLVCDYMRN--GSLDQFLHGSRGF-----
.   .|.|.|.||.|| .   . . .||.|..        | .|.||.||.. .| |.|   ... . .|  .| .|. .  |.| ....  ..      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LTWNQRRKIAIDTAFGLAYLHDESKHRIIHCDLKPPNILLDDDMMPRIADFGMARLYEEGKSHVTATKMGGTIGYLAPGKKKELICRILELGFIDNSSLA
..  . |...  .. .|.|.|   .|.|||.|||| |||||.     |.|||.||..         | . ||  |.||    |..               
FPE-HARFYMYQICCALEYCH---SHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAP----EVL---------------

EYAMHYQLSD-KADVYSYGVVLLEIISGRRAIDSAAPREEVVLVDFAQSLASISTLELVTLLDKKLEGEGGEISVAEVVDMARVAVLCTLE-NPSLRPRM
      . .  |.|..| |..| | ..|.   .     .. .. .                                  . |.  .   |. .|. ||  
------GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG------------------------------SPEAKDFIRKCLQKDPEKRPTA

RAVWL---------ML
  .            .
-EALQDEWDIKCHPWF
Kinase IRAK-0_af-2.AA Src 681-832 36 5.4e-26 85.27 In-house 1-150 (255) Show / Hide 
Range on Protein: 681-832
Range on HMM: 1-150/255
Sequence Identity: 36% (57 aa)

FNPTKKLGQGGFGSVYVGNLQDQTLVAVKQLLHQTQQGREAFRKEIRILSSVQHRNLVAVRGYCLEAEHPML-VCDYMRNGSLDQFLH-GSRGF-LTWNQ
.   .||||| || |. |  ...| |||| |   |    ||| .|. |. ...| .||.    | . | | . |  ||..||| ..|.  ..|  |  .|
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGT-MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEE-PIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQ

RRKIAIDTAFGLAYLHDESKHRIIHCDLKPPNILLDDDMMPRIADFGMARLYEEG
   .|   | | |||   .. ..|| ||   |.| ... .  .|||| ||| .|.
LIDMAAQVAEGMAYL---ESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKED
Kinase IRAK-0_af-2.AA RIPK 687-850 29 8.7e-26 84.83 In-house 1-191 (290) Show / Hide 
Range on Protein: 687-850
Range on HMM: 1-191/290
Sequence Identity: 29% (56 aa)

LGQGGFGSVYVGNLQDQTLVAVKQL---LHQT----QQGREAFRKEIRILSSVQHRNLVAVRGYCLEAEH------PMLVCDYMRNGSLDQFLHGSRGF-
.| |||| |.     ..  ...|     .|      .| |..   |  .. . .... | . | | . |       . .|  || ||||  |||    . 
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

---LTWNQRRKIAIDTAFGLAYLHDESKH-RIIHCDLKPPNILLDDDMMPRIADFGMARLYEEGKSHV----------TATKM-GGTIGYLAP
   . |  |  .   .. |  |||  |.   ||| |||| |||.| ..   ||||| |   .  .||           .. |  .||. |..|
HHPDPWPLRCRMIHEISCGMCYLH--SMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPP
Kinase IRAK-0_af-2.AA TyrKc 681-977 22 9.2e-24 86.19 SMART 1-280 (280) Show / Hide 
Range on Protein: 681-977
Range on HMM: 1-280/280
Sequence Identity: 22% (74 aa)

FNPTKKLGQGGFGSVYVGNLQDQTLVAVKQLLHQTQQGREAFRKEIRILSSV--QHRNLVAVRGYCLEA-------EHPMLVCDYMRNGSLDQFLHGSRG
    |||| | || || | .   . |||| | . .   ||.|..|.||....  .| |.|.  |.|..        | .|.|  || .|.|...|. .|.
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

FLTWNQRRKIAIDTAFGLAYLHDESKHRIIHCDLKPPNILLDDDMMPRIADFGMARLYEEG------KSHVTA----TKMG-GTIGYLAPGKKKELICRI
 |.. .  ..... | | .|||.    ..|| ||   |.|....   .|.|||..|  ...      |.  ..     . .   |  .||    | |   
KLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP----ECI---

LELGFIDNSSLAEYAMHYQLSDKADVYSYGVVLLEIISGRRAIDSAAPREE-----VVLVDFAQSLASISTLELVTL----LDKKLEGEGGEISVAEVVD
               ...  . | ||.|.||.. || .     . . | ..     .   .  . . .   ..                    .|    .
---------------NYGKFTTKSDVWSFGVCMWEIFT-----YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------FVCCPDE

MARVAVLCTLENPSLRPRMRAVWLML
| ..   |  |.|. ||.....   .
MYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK-0_af-2.AA IRAK 871-977 18 1.2e-10 34.08 In-house 189-317 (317) Show / Hide 
Range on Protein: 871-977
Range on HMM: 189-317/317
Sequence Identity: 18% (25 aa)

LAEYAMH---YQLSDKADVYSYGVVLLEIISGRRAIDSAAPR---EEVVLVDFAQSLAS-ISTLE-------------------LVTLLDKKLEGEGGEI
... ..     ||. | |||| |.||||...|.|| ..  |.       . . ... ..  |..                     . ..|.. .. ..  
MPPEFIRDPQGQLTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPP--

SVAEVVDMARVAVLCTLENPSLRPRMRAVWLML
  ... .|. .|. |...   .|. |. |   |
--NMEKEMCQCACCCGHHRANRRCDMAWVMQQL
Kinase IRAK-0_af-2.AA TKL 876-901 46 1e-06 20.17 In-house 262-287 (364) Show / Hide 
Range on Protein: 876-901
Range on HMM: 262-287/364
Sequence Identity: 46% (12 aa)

MHYQLSDKADVYSYGVVLLEIISGRR
.... | |.||||.|.|| ||....|
KGFEYSEKCDVYSFGIVLWEILTRCR
Kinase IRAK-0_af-2.AA LRRK 881-904 32 5.3e-05 13.62 In-house 260-284 (351) Show / Hide 
Range on Protein: 881-904
Range on HMM: 260-284/351
Sequence Identity: 32% (8 aa)

SDKADVYSYGVVLLEIISGR-RAID
..|.|.||.|..| |..... .. |
TEKVDCYSFGMILWELLTRQHHPFD
Kinase IRAK-0_af-2.AA Dicty4 883-896 78 0.000741 8.94 In-house 197-210 (277) Show / Hide 
Range on Protein: 883-896
Range on HMM: 197-210/277
Sequence Identity: 78% (11 aa)

KADVYSYGVVLLEI
||||||.| || ||
KADVYSFGIVLWEI
Kinase IRAK-0_af-2.AA RIPK 881-902 31 0.006982 5.62 In-house 206-227 (290) Show / Hide 
Range on Protein: 881-902
Range on HMM: 206-227/290
Sequence Identity: 31% (7 aa)

SDKADVYSYGVVLLEIISGRRA
. | ||||...|. |. ... .
TPKYDVYSFAIVMWEVLTQKHP
Kinase IRAK-0_af-2.AA TK 883-898 50 0.008496 4.35 In-house 374-389 (486) Show / Hide 
Range on Protein: 883-898
Range on HMM: 374-389/486
Sequence Identity: 50% (8 aa)

KADVYSYGVVLLEIIS
| ||.|.||.. || .
KSDVWSFGVLMWEIFT
Kinase IRAK-0_af-2.AA Src 883-900 52 0.023428 3.76 In-house 180-198 (255) Show / Hide 
Range on Protein: 883-900
Range on HMM: 180-198/255
Sequence Identity: 52% (10 aa)

KADVYSYGVVLLEIIS-GR
|.|| |.|. | ||.. ||
KSDVWSFGILLTEIVTYGR
Kinase IRAK-0_af-2.AA Pkinase_Tyr 876-898 34 0.048662 7.53 Pfam 187-209 (270) Show / Hide 
Range on Protein: 876-898
Range on HMM: 187-209/270
Sequence Identity: 34% (8 aa)

MHYQLSDKADVYSYGVVLLEIIS
...  . | ||.|.||.. ||..
NYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAK-0_af-2.AA UTK 885-899 53 0.076573 2.09 In-house 222-236 (296) Show / Hide 
Range on Protein: 885-899
Range on HMM: 222-236/296
Sequence Identity: 53% (8 aa)

DVYSYGVVLLEIISG
||.|.|||. || ..
DVWSFGVVCWEIWTW