Gene IRAK-0_be (S.moellendorffii)

IRAK-0_be

Species: S.moellendorffii
Alias: IRAK-0_be
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_be.AA Protein None 302 None Fasta, JSON
IRAK-0_be.NA RNA None 909 None Fasta, JSON
IRAK-0_be.kin_dom Protein Kinase Domain None 139 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_be.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-0_be.AA TKL 57-192 22 1.9e-29 103.17 In-house 1-205 (364) Show / Hide 
Range on Protein: 57-192
Range on HMM: 1-205/364
Sequence Identity: 22% (48 aa)

ISRGRRACVYRAKLPDE---------QQVVVKKTKL-----------------------------------ARDELLVISSASHFNIVGVTGYCFNRKE-
| .|. ..||..|.  .         . |.||| |                                     . |....|. .| |||   |||.. .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------NFLVLEYVPNGSLADHLFSNASTLAWSSRLRIAVQVSSALEFLHSYV-----EPSITHGHVSSDNILLDKSWN--------------A
             ..| ||.|.||| ..|        |. |.|.| ........|||        | | |    |.|||.|. |.              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KLAGFGSSRRSC
|.. || ||. .
KICDFGLSRFMS
Kinase IRAK-0_be.AA TKL-Unique 85-186 28 1.3e-20 69.59 In-house 43-162 (290) Show / Hide 
Range on Protein: 85-186
Range on HMM: 43-162/290
Sequence Identity: 28% (35 aa)

RDELLVISSAS-HFNIVGVTGYCF----NRKENFLVLEYVPNGSLADHLF---------SNASTLAWSSRLRIAVQVSSALEFLHSYVEPSITHGHVSSD
..|. ...    | |||   |||.      .. ..|.||.| ||| |.|          .| ..| .. |...| ........||..  | |.|.   | 
ENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSS

NILLDKS-----WNAKLAGFG
|.|.|       ||.|...||
NFLVDNNSNIAEWNIKICDFG
Kinase IRAK-0_be.AA IRAK 87-186 37 4.3e-17 57.26 In-house 53-158 (317) Show / Hide 
Range on Protein: 87-186
Range on HMM: 53-158/317
Sequence Identity: 37% (40 aa)

ELLVISSASHFNIVGVTGYCFNRKENFLVLEYVPNGSLADHLFSNAS--T---LAWSSRLRIAVQVSSALEFLHSYV-EPSITHGHVSSDNILLDKSWNA
|| | ..  | ||| ..|||. | .  || .| ||||| | |   .   .   | |  |. |.   . ...|||.     .| || ..| |||||.  ..
ELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTP

KLAGFG
|.. ||
KICDFG
Kinase IRAK-0_be.AA TK 51-191 12 2.7e-16 50.38 In-house 1-306 (486) Show / Hide 
Range on Protein: 51-191
Range on HMM: 1-306/486
Sequence Identity: 12% (38 aa)

FSSSNLISRGRRA---CVYRAKLPDE--------------------------QQVVVKKTKL--ARDELL--------------------VISSAS----
    . . .|       ||.... ..                          ..| ||  |.  | ..                      ...  .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HFNIVGVTGYCFNR------------KENFLVLEYVPNGS----LADHLFSNAST--------------------------------------------
 | |||   |.|.              .   .|.||.|.|.    | |.| ..  .                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LAWSSRLRIAVQVSSALEFLHSY----VEPSITHGHVSSDNILLDKSWN-----------AKLAGFGSS
                               |    .| ...|.....|.|||     . . . |. .   |.|.... .           .|.| || |
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

R-----RS
|     ..
RQGSGVLA
Kinase IRAK-0_be.AA TK-Unique 51-190 19 1e-14 47.26 In-house 1-182 (294) Show / Hide 
Range on Protein: 51-190
Range on HMM: 1-182/294
Sequence Identity: 19% (36 aa)

FSSSNLISRGRRACVYRAKLP------DEQ-QVVVKKTK-----L----ARDELLVISSAS-HFNIVGVTGYCFNRK-ENFLVLEYVPNGSLADHLFSNA
.   ..| .|.  .|.|...       |.| .|.||. |     .      .|. . ..   | |||   |.|       ....||.|.|.| ..| ...
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

ST-------------------------LAWSSRLRIAVQVSSALEFLHS--Y-VEPSITHGHVSSDNILLDKSWNAKLAGFGSSRR
 .                         .   . ...|.|. ...|.|.|  . .    .|..... |.||    ..|...|| .|.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKI----VHRDLCARNVLLTEDKVCKICDFGMARD
Kinase IRAK-0_be.AA LRRK 83-192 31 1.2e-14 48.28 In-house 103-231 (351) Show / Hide 
Range on Protein: 83-192
Range on HMM: 103-231/351
Sequence Identity: 31% (41 aa)

LARDELLVISSASHFNIVGVTGYCFNRKENFLVLEYVPNGSLADHLFSNAST--------LAWSSRLRIAVQVSSALEFLHSYVEPSITHGHVSSDNILL
..| |. ..|.  | |||   |.|..     .|.||.|.|.| ..|......        . |. .|.||.|.....|.|||   |.| |    |.||||
EFRHEVWIMSHLNHPNIVSLKGFCIH--PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS-HNPPIIHRDLKSPNILL

DKS------------WNAKLAGFGSSR--RSC
 .|             .||.| || ||   ..
WSSPQNHSPNYPNAHVCAKIADFGISRMFQCF
Kinase IRAK-0_be.AA UTK 41-190 20 5.2e-14 44.32 In-house 51-177 (296) Show / Hide 
Range on Protein: 41-190
Range on HMM: 51-177/296
Sequence Identity: 20% (34 aa)

PQVLREATDKFSSSNLISRGRRACVYRAKLPDEQQVVVKKTKLARDELLVISSAS-HFNIVGVTGYCFNRKENFLVLEYVPNGSLADHLFSNASTLA---
|....||.                                      || . .  . | |.... |.|.. .   .|.|| .||.|.. | ... |.    
PDFMEEAR--------------------------------------ELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACP

-WSS---RLRIAVQVSSALEFLHSYVEPSITHGHVSSDNILLDKS-------WNAKLAGFG---SSRR
 | .   ||  |.........|||     . |. .   |.|....       . .|.|.||    |||
HWLTLHQRLCMAWDIARGMQYLHSC---GFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRR
Kinase IRAK-0_be.AA Dicty5 108-189 32 6.2e-13 40.85 In-house 70-152 (260) Show / Hide 
Range on Protein: 108-189
Range on HMM: 70-152/260
Sequence Identity: 32% (28 aa)

NRKENFLVLEYVPNGSLADHLFSNAS----TLAWSSRLRIAVQVSSALEFLHSYVEPSITHGHVSSDNILLDKSWNAKLAGFGSSR
| |  | | ||. |||| . |          .|.  .| .|. .  ....|||    .| |  . | |.|. . | .|.  || ||
NDKYPFHVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHSM---NIIHRDLKSMNFLITENWKIKIIDFGTSR
Kinase IRAK-0_be.AA Pkinase 51-189 20 2.7e-12 44.57 Pfam 1-160 (293) Show / Hide 
Range on Protein: 51-189
Range on HMM: 1-160/293
Sequence Identity: 20% (34 aa)

FSSSNLISRGRRACVYRAKLPDEQQ-VVVKKTKLARD------------ELLVISSASHFNIVGVTGYCFNRKENFLVLEYVPNG----SLADHLF-SNA
.     | .|  .|||...  .... |.||. |. ..            |. .  . .| |||   ... ....  .|.||...|    .|.|..  .. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

STL--AWSSRLRIAVQVSSALEFLHSYVEPSITHGHVSSDNILLDKSWNA----KLAGFGSSR
 ..   .    ... |. ..||..||    .| |  . ..|||.|.  .     |.. ||...
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAK
Kinase IRAK-0_be.AA MLK 51-189 20 4.1e-12 38.45 In-house 1-181 (291) Show / Hide 
Range on Protein: 51-189
Range on HMM: 1-181/291
Sequence Identity: 20% (38 aa)

FSSSNLISRGRRACVYRAKLPDEQ----QVVVKKTK--------------LARDELLVISSASHFN----IVGVTGYCFNR-KENFLVLEYVPNGSLADH
.  .  |  |    |....   .      | ||. .                . |    .  || |    |. . | | .  .. ..|.||...|||.. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LFSNAS-------------TLAWSSRLRIAVQVSSALEFLHSYVEPSITHGHVSSDNILLD------KSWNAKLAGFGSSR
| .. |             .   .. ...|.|.......|||   . | | .  | |||.|      .  ..| . || ||
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR
Kinase IRAK-0_be.AA HH498 95-189 25 3.9e-11 31.14 In-house 60-172 (284) Show / Hide 
Range on Protein: 95-189
Range on HMM: 60-172/284
Sequence Identity: 25% (29 aa)

SHFNIVGVTGYCFNRKENF-LVLEYVPNGSLADHL--------------FSNA---STLAWSSRLRIAVQVSSALEFLHSYVEPSITHGHVSSDNILLDK
.|.. |   . | .    | .|..|. ||||   |                .      .   |...|.| |    ..||.   . | |    | |||...
NHPCVVQFVYACCDDPSQFAIVTQYCDNGSLFSILNTIPIGGAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHE

SWNAKLAGFGSSR
   |. | || ||
DGHAVVADFGESR
Kinase IRAK-0_be.AA S_TKc 51-294 17 9.9e-11 -19.55 SMART 1-231 (231) Show / Hide 
Range on Protein: 51-294
Range on HMM: 1-231/231
Sequence Identity: 17% (48 aa)

FSSSNLISRGRRACVYRAKLPD-EQQVVVKKTK-LARDELLVISSASHFNIVGVTGYCFNRKENFLVLEYVPN--GSLADHLFSNAS-----TLAWSSRL
.   ..| .|  ..||...  .  ..| .|. |  .| |. . ..  | |||   ... . .. ..|.||...  |.| |.. .. .      .      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HAR

RIAVQVSSALEFLHSYVEPSITHGHVSSDNILLDKSWNAKLAGFGSSRRSCVKRVGSHNFGLKAEEVYRFGG----------LVMELVTGDR--SSSKAR
... |. .|||..||     | |  .  .|||||.  . |.. ||..|.     .|. .. .  | .  .|.          .. |...|    .     
FYMYQICCALEYCHSH---GIIHRDLKPENILLDE--HIKICDFGLARQL-TTFCGTPWY-MAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQ

RACEVIESGKEEMLGLVLDRRCGSNDVTDKRAVLKLAEVGAWCMTKEAKERPTMVEVAS-----ALRQVL
.  ..|                             . .    |..|. ..|||  |.       .. . .
MMFKKIG-------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_be.AA TyrKc 51-290 18 3.2e-10 -57.48 SMART 1-280 (280) Show / Hide 
Range on Protein: 51-290
Range on HMM: 1-280/280
Sequence Identity: 18% (55 aa)

FSSSNLISRGRRACVYRAKLPDEQQVVVKKTKLA-----RDELLVISSA--SHFNIVGVTGYCFNR-------KENFLVLEYVPNGSLADHLFSNASTLA
 .    . .|    ||....   .|| ||. |       ..|. . ..   .| |||   |.|          .  ..|.||.|.|.| |.| ..  .| 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLC

WSSRLRIAVQVSSALEFLHSYVEPSITHGHVSSDNILLDKSWNAKLAGFGSSRRSCVK-------RVGSHNF--GLK--------AEEVYRFG-------
..  | ...|...  |.|||     . |      |.|...   .| . || ||    .        . ..    | |        | |. ..|       
MKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

----GLVM-ELVT-GDRSSSK-------ARRACEVIESGKEEMLGLV-----LDRRCGSNDVTDKRAVLKLAEVGAWCMTKEAKERPTMVEVASAL
    | .| |. | |.   .        .... | ...|.  .                      ..  .. ..  .|   ....|||. |. . .
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF-----------VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK-0_be.AA Pkinase_Tyr 87-156 28 1.4e-08 29.64 Pfam 53-129 (270) Show / Hide 
Range on Protein: 87-156
Range on HMM: 53-129/270
Sequence Identity: 28% (22 aa)

ELLVISSA-SHFNIVGVTGYCFNRKEN---FLVLEYVPNGSLADHLFSN---ASTLAWSSRLRIAVQVSSALEFLHS
|. . ..  .| |||   | |  ..|    ..|.||.|.|.| |.| ..      |  .  | ...|.....|.|.|
EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLES
Kinase IRAK-0_be.AA IRAK 51-80 35 3.8e-05 14.38 In-house 1-31 (317) Show / Hide 
Range on Protein: 51-80
Range on HMM: 1-31/317
Sequence Identity: 35% (11 aa)

FSSSNLISRGRRACVYRAKLPDEQ-QVVVKK
|. .|.|. |  .||||...  .   ..|||
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKK
Kinase IRAK-0_be.AA TK 272-290 26 0.000667 8.12 In-house 468-486 (486) Show / Hide 
Range on Protein: 272-290
Range on HMM: 468-486/486
Sequence Identity: 26% (5 aa)

CMTKEAKERPTMVEVASAL
|  .....|||. .. ..|
CWHYDPEDRPTFSQLHEQL
Kinase IRAK-0_be.AA UTK 272-290 21 0.002758 7.1 In-house 278-296 (296) Show / Hide 
Range on Protein: 272-290
Range on HMM: 278-296/296
Sequence Identity: 21% (4 aa)

CMTKEAKERPTMVEVASAL
|....  |||..... ...
CWHYDPQERPDFEDLVQQM
Kinase IRAK-0_be.AA MLK 272-290 21 0.007069 5.97 In-house 273-291 (291) Show / Hide 
Range on Protein: 272-290
Range on HMM: 273-291/291
Sequence Identity: 21% (4 aa)

CMTKEAKERPTMVEVASAL
|.  ....||.. .. . |
CWNQDPHKRPSFRQIVQHL
Kinase IRAK-0_be.AA IRAK 272-290 31 0.025312 4.24 In-house 299-317 (317) Show / Hide 
Range on Protein: 272-290
Range on HMM: 299-317/317
Sequence Identity: 31% (6 aa)

CMTKEAKERPTMVEVASAL
|.   |..|..| .| . |
CGHHRANRRCDMAWVMQQL
Kinase IRAK-0_be.AA TKL 271-290 25 0.048352 3.16 In-house 345-364 (364) Show / Hide 
Range on Protein: 271-290
Range on HMM: 345-364/364
Sequence Identity: 25% (5 aa)

WCMTKEAKERPTMVEVASAL
.|.  ....||.. |. . |
DCWDHDPEKRPSFQEILKRL
Kinase IRAK-0_be.AA LRRK 271-292 27 0.066153 2.51 In-house 330-351 (351) Show / Hide 
Range on Protein: 271-292
Range on HMM: 330-351/351
Sequence Identity: 27% (6 aa)

WCMTKEAKERPTMVEVASALRQ
.| . . |.||.. .. . | |
HCWQHDPKKRPHFSQIVKRLSQ
Kinase IRAK-0_be.AA Pkinase_Tyr 272-290 31 0.079935 6.8 Pfam 252-270 (270) Show / Hide 
Range on Protein: 272-290
Range on HMM: 252-270/270
Sequence Identity: 31% (6 aa)

CMTKEAKERPTMVEVASAL
|. .....|||. |. . |
CWHYDPEDRPTFSEIHEQL
Kinase IRAK-0_be.AA TK-Unique 272-290 31 0.102519 1.84 In-house 276-294 (294) Show / Hide 
Range on Protein: 272-290
Range on HMM: 276-294/294
Sequence Identity: 31% (6 aa)

CMTKEAKERPTMVEVASAL
| ..|..|||.  .... |
CWQWEPEERPSFRQIKHRL