Gene IRAK-0_am (S.moellendorffii)

IRAK-0_am

Species: S.moellendorffii
Alias: IRAK-0_am
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_am.AA Protein None 222 None Fasta, JSON
IRAK-0_am.NA RNA None 669 None Fasta, JSON
IRAK-0_am.kin_dom Protein Kinase Domain None 155 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_am.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-0_am.AA IRAK 44-204 38 9e-50 171.67 In-house 46-222 (317) Show / Hide 
Range on Protein: 44-204
Range on HMM: 46-222/317
Sequence Identity: 38% (68 aa)

QFLN---EVKAISSVQHRNLVKLLGCSMEGTERLLVYEFLKNNSLENALFGAV-EKP---LSWETRHNILLGTARGLAYLHEDS-QIRIVHRDIKPSNIL
.|.    |.|. .. .| |.| |.| . |. .  |||....| |||  | .     |   ||| .|. |..|||.|. .||...  . | |.|||..|||
RFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANIL

LDEFYEAKIADFGLARLF---ESSHQLEV---LTTKAAGTYGYMTPEYAL--NGQLSDKIDVYSYGIVILETVSGKR
||.  ..||.||||.|     ... . ..    | .  ||  || ||.     |||. | |||| |||.||...| |
LDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDVYSFGIVLLEVLTGCR
Kinase IRAK-0_am.AA TKL 44-204 24 8.3e-46 158.5 In-house 71-287 (364) Show / Hide 
Range on Protein: 44-204
Range on HMM: 71-287/364
Sequence Identity: 24% (55 aa)

QFLNEVKAISSVQHRNLVKLLGCSMEGTE-------------RLLVYEFLKNNSLENALFGAVEKPLSWETRHNILLGTARGLAYLHEDS-----QIRIV
.. .|.. .|. .| |.|...|......                .|.|. .. ||.. |         |. |... |..|||..||| .         |.
FEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPII

HRDIKPSNILLDEFYE--------------AKIADFGLAR-LFESSHQLEV---------------LTTKAAGTYGYMTPEYALNG--------------
|||.|..|||.|| ..              .||.||||.| ...|...                   | .  ||...| ||   .               
HRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCK

--QLSDKIDVYSYGIVILETVSGKR
  . | |.||||.|||. | ....|
GFEYSEKCDVYSFGIVLWEILTRCR
Kinase IRAK-0_am.AA Pkinase 44-203 26 7.1e-36 127.93 Pfam 44-209 (293) Show / Hide 
Range on Protein: 44-203
Range on HMM: 44-209/293
Sequence Identity: 26% (45 aa)

QFLN--EVKAISSVQHRNLVKLLGCSMEGTERLLVYEFLKNN----SLENALFGAVEKPL--SWETRHNILLGTARGLAYLHEDSQIRIVHRDIKPSNIL
. ..  |..   ...| | |.|... .....  .| |.. .     .|   . .  ....  |...  .... ..|||.|.|.    .|.|||.||.|||
THRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENIL

LDEFYEA----KIADFGLARLFESSHQLEVLTTKAAGTYGYMTPEYAL-NGQLSDKIDVYSYGIVILETVSGK
.|. ..     ||.|||||..|.  .   . .|  .||..|| ||  . .   . |.|..|.|... | ..|.
IDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR
Kinase IRAK-0_am.AA TKL-Unique 45-204 29 2.1e-30 104.48 In-house 42-226 (290) Show / Hide 
Range on Protein: 45-204
Range on HMM: 42-226/290
Sequence Identity: 29% (55 aa)

FLNEVKAISSVQ-HRNLVKLLGCSM----EGTERLLVYEFLKNNSLENALFG--------AVEKPLSWETRHNILLGTARGLAYLHEDSQIRIVHRDIKP
| |||. ..  . | |.|.. | .|       .. .| |..  .|| . |          . ...|... | .. .  |.|. |||  .   | |||.|.
FENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKS

SNILLDEF-----YEAKIADFGLARLFESSHQLEVLTTK-------AAGTYGYMTPEYALNG---QLSDKIDVYSYGIVILETVSGKR
||.|.|..     . .||.||||.. | |.   . ....         |.. .| ||  |..   | | |.||||.|||  | ...|.
SNFLVDNNSNIAEWNIKICDFGLSK-FNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV-LRMNFCQYSEKSDVYSFGIVLWEIATRKI
Kinase IRAK-0_am.AA MLK 26-196 26 1.7e-29 99.51 In-house 1-226 (291) Show / Hide 
Range on Protein: 26-196
Range on HMM: 1-226/291
Sequence Identity: 26% (61 aa)

FDESHKLGEGGFGAVYKLQFLNEV-----KAISSVQ---------------------------HRN-----LVKLLGCSMEGTERLLVYEFLKNNSLENA
.......|.|.||.|.| .. |.       |.  |                            |.|      . . .|. .. . ..| |.. . || | 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LFGA---------VEK---PLSWETRHNILLGTARGLAYLHEDSQIRIVHRDIKPSNILLDE------FYEAKIADFGLARLFESSHQLEVL-TTKAAGT
| ||         ..|     . .   |. |  |||..|||.. .  |.|||.|..|||.||         .||.|||..| .   || .    ...|||
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDW---HQMC-TNMMSNAGT

YGYMTPEY---ALNGQLSDKIDVYSYGIVI
| .| ||    . ... | | ||.|.|.|.
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVL
Kinase IRAK-0_am.AA RIPK 46-203 28 1.4e-26 87.58 In-house 44-225 (290) Show / Hide 
Range on Protein: 46-203
Range on HMM: 44-225/290
Sequence Identity: 28% (52 aa)

LNEVKAISSVQHRNLVKLLGCSMEG-----TE-RLLVYEFLKNNSLENALFGAVE---KPLSWETRHNILLGTARGLAYLHEDSQIR--IVHRDIKPSNI
. |.|.  . .... |...|   .       .   .| |. .| ||.. |    .   .|. |  |  ..  ...|  |||    .   | ||| ||.||
KEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQHHPDPWPLRCRMIHEISCGMCYLHS---MNPPIIHRDLKPENI

LLDEFYEAKIADFGLARLFESSHQLE--------VLTTKAA--GTYGYMTPEYALNGQLSD------KIDVYSYGIVILETVSGK
|.|  . .||||||||   . ||.            ....   ||  || ||  .... .       | ||||..||. |  ..|
LVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQK
Kinase IRAK-0_am.AA Dicty4 45-195 26 2.3e-25 81.7 In-house 45-206 (277) Show / Hide 
Range on Protein: 45-195
Range on HMM: 45-206/277
Sequence Identity: 26% (44 aa)

FLNEVKAISSVQHRNLVKLLGCSM----EGTERLLVYEFLKNNSLENALFG-----AVEKPLSWETRHN---ILLGTARGLAYLHEDSQIRIVHRDIKPS
|..||.  .. .| |.....| .     .  . . | |..   .|.. |         ...|.|...     . . .|||...||. .  .|.|||.|..
FRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSH

NILLDEFYEAKIADFGLARLFESSHQLEVLTTKAAGTYGYMTPEYALNGQLSDKIDVYSYGIV
|.| |. . .|..||||....    ..   .. |.|| ..| ||   .     | ||||.|||
NLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIV
Kinase IRAK-0_am.AA Ciliate-E2 26-204 18 6.7e-25 82.4 In-house 1-294 (365) Show / Hide 
Range on Protein: 26-204
Range on HMM: 1-294/365
Sequence Identity: 18% (55 aa)

FDESHKLGEGGFGAVYKL------------------------------------------QFLNEVKAIS-----------------SVQHRNLVKLLGC
..   |.|.|.|| |||                                           .... .. |                  ...| |..|.  |
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

SMEGTE--RLLVYEFLKNNSLEN-----ALFGAVE----KPLSWETRHNILLGTAR---------------GLAYLHEDSQIRIVHRDIKPSNILLDEFY
  | ..    || |... ..|.       ..   |    |..... . .|    ..               .| |||.     |.||||||.|||.    
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN--IIHRDIKPENILF----

EAKIADFGLAR-----------------LFESSHQLEVLTTKA------------AGTYGYMTPEYALNGQ---------LSDKIDVYSYGIVILETVSG
  ||.||||..                 . . . . .. ...             .||.||| ||   ...          . |.|..| |... | ..|
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

KR
|.
KP
Kinase IRAK-0_am.AA STE 26-198 20 1.9e-23 79.72 In-house 1-260 (359) Show / Hide 
Range on Protein: 26-198
Range on HMM: 1-260/359
Sequence Identity: 20% (56 aa)

FDESHKLGEGGFGAVYKL-------------------------------------------------------QFLNEVKAISSVQ--HRNLVKLLGCSM
..   |.|.|.|| |||                                                        |.|.|.|  .  .  | | || .|| .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EG-------TERLLVYEFLKNNSLENALFGAVEKPLSW-----------ETRH-NILLGTARG-LAYLHEDSQIRIVHRDIKPSNILLDEFYEAKIADFG
 .       .|  .. |.. . ||.  .    ... .            |.    |.  . .| |.|||.     |.||||||.||||     .|..|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LARLFESSHQ------------LEV-LTTKAAGTYGYMTPEYALN------GQLSDKIDVYSYGIVILE
..  ...|.               .  ..  .||  .| ||  ..      .. . | |..| |..|.|
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIE
Kinase IRAK-0_am.AA Dicty4-Unclassified 45-202 30 1.2e-22 74.3 In-house 45-204 (263) Show / Hide 
Range on Protein: 45-202
Range on HMM: 45-204/263
Sequence Identity: 30% (51 aa)

FLNEVKAISSVQHRNLVKLLGCSMEG----TERLLVYEFLKNNSLENALF---GAVEKPLSWET--RHNILLGTARGLAYLHEDSQIRIVHRDIKPSNIL
|. ||    |.|| ||||. | ..           | ||.    |           ..|.. .      . .  |.|...||      ..||||| ||||
FKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLH---TRNFIHRDIKSSNIL

LDEFYEAKIADFGLARLFESSHQLEVLTTKAAGTYGYMTPEYALNGQLSDKIDVYSYGIVILETVSG
.|  . .||||||..|  .    .    |  |||     ||         | |||||...  | . |
MDKHFNIKIADFGISRVIDFNFNM----TTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATG
Kinase IRAK-0_am.AA LRRK 47-204 27 3.6e-21 71.62 In-house 106-281 (351) Show / Hide 
Range on Protein: 47-204
Range on HMM: 106-281/351
Sequence Identity: 27% (50 aa)

NEVKAISSVQHRNLVKLLGCSMEGTERLLVYEFLKNNSLENALFGAVEKP-------LSWETRHNILLGTARGLAYLHEDSQIR--IVHRDIKPSNILL-
.||  .|. .| |.|.|.| ...   . .| |.. . .|   |.   . .       .|| ... | |  |.|..|||     .  |.||| |. |||| 
HEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH---SHNPPIIHRDLKSPNILLW

--D---------EFYEAKIADFGLARLFESSHQLEVLTTKAAGTYGYMTPEYALNG---QLSDKIDVYSYGIVILETVSGK-R
  .         ... |||||||. |.|  .  .. .. .  |. |.| ||   ..   . ..|.|.||.|... | .... .
SSPQNHSPNYPNAHVCAKIADFGISRMF--QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHH
Kinase IRAK-0_am.AA Pkinase_Tyr 45-152 28 4.7e-18 61.76 Pfam 50-160 (270) Show / Hide 
Range on Protein: 45-152
Range on HMM: 50-160/270
Sequence Identity: 28% (33 aa)

FLNEVKAISSV-QHRNLVKLLGCSM-EGTE--RLLVYEFLKNNSLENALFGA--VEKPLSWETRHNILLGTARGLAYLHEDSQIRIVHRDIKPSNILLDE
|..|.|  ..  .| |.|.|.|. . .|     ..| |. .. .| . |      ..||. ..  .. .  |.|..||..   ....|||.   |.|..|
FMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLES---KNCIHRDLAARNCLVTE

FYEAKIADFGLARL
   .||.||||||.
NNVVKICDFGLARD
Kinase IRAK-0_am.AA S_TKc 26-222 23 5.9e-15 42.45 SMART 1-231 (231) Show / Hide 
Range on Protein: 26-222
Range on HMM: 1-231/231
Sequence Identity: 23% (59 aa)

FDESHKLGEGGFGAVYKLQFLN----------------EVKAISSVQHRNLVKLLGCSMEGTERLLVYEFLKN--NSLENALFGAVE----KPLSWETRH
..   |.|.|.|| ||| .  .                |..  .. .| |.|||...  . ..  .| |.. .   .|   .         .|..  .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HAR

NILLGTARGLAYLHEDSQIRIVHRDIKPSNILLDEFYEAKIADFGLARLFESSHQLEVLTTKAAGTYGYMTPEYALNGQLSD-KIDVYSYGIVILETVSG
 ..  ....|.|.|  |. .|.|||.||.||||||  . ||.||||||..          |   ||  || ||     . .  |.|..| |... | ..|
FYMYQICCALEYCH--SH-GIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCG

KR---------------------------N-RDRSLVDEVLE-----KISVCI
.                            . ..|  . |.|.     |.   .
YPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_am.AA TyrKc 26-222 19 1.5e-13 -3.67 SMART 1-280 (280) Show / Hide 
Range on Protein: 26-222
Range on HMM: 1-280/280
Sequence Identity: 19% (54 aa)

FDESHKLGEGGFGAVYK-----------------LQFLNEVKAISSV--QHRNLVKLLGCSMEG-------TERLLVYEFLKNNSLENALFGAVEKPLSW
    .||||| || |||                   |..| .  ...  .| |.|.|.|. ...          ..| |. .. .| . |    .| |..
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-LCM

ETRHNILLGTARGLAYLHEDSQIRIVHRDIKPSNILLDEFYEAKIADFGLARLFESS------HQLEVL----TTKAAGTYGYMTPEYALNGQLSDKIDV
.. ... .  |.| .|||.    ...|||.   |.|..| . .||.||||.|  ..       ..  .      .|.   .  | ||    |  . | ||
KDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV

YSYGIVILET---------------VSGKRNRDRSLVDEVLEKISV------------------------------------CI
.|.|... |                .| .. . .    . ...                                       |.
WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK-0_am.AA IRAK 26-42 52 7.6e-07 20.48 In-house 1-17 (317) Show / Hide 
Range on Protein: 26-42
Range on HMM: 1-17/317
Sequence Identity: 52% (9 aa)

FDESHKLGEGGFGAVYK
|......|||||| ||.
FHKDNRIGEGGFGCVYR
Kinase IRAK-0_am.AA LRRK 26-42 38 0.000387 10.52 In-house 1-18 (351) Show / Hide 
Range on Protein: 26-42
Range on HMM: 1-18/351
Sequence Identity: 38% (7 aa)

FDESHKLGEGGFG-AVYK
. .  ..|.||||  ||.
LKIEEQIGRGGFGTFVYR
Kinase IRAK-0_am.AA TKL 32-42 72 0.002157 8.09 In-house 1-11 (364) Show / Hide 
Range on Protein: 32-42
Range on HMM: 1-11/364
Sequence Identity: 72% (8 aa)

LGEGGFGAVYK
.|.|||| |||
IGSGGFGEVYK
Kinase IRAK-0_am.AA RIPK 32-42 63 0.005567 5.96 In-house 1-11 (290) Show / Hide 
Range on Protein: 32-42
Range on HMM: 1-11/290
Sequence Identity: 63% (7 aa)

LGEGGFGAVYK
.| |||| |.|
VGGGGFGEVFK
Kinase IRAK-0_am.AA Pkinase 26-42 47 0.019582 9.69 Pfam 1-17 (293) Show / Hide 
Range on Protein: 26-42
Range on HMM: 1-17/293
Sequence Identity: 47% (8 aa)

FDESHKLGEGGFGAVYK
.    |.|.|.|| |||
YHIGRKIGSGSFGCVYK
Kinase IRAK-0_am.AA TKL-Unique 29-42 64 0.019909 4.59 In-house 2-15 (290) Show / Hide 
Range on Protein: 29-42
Range on HMM: 2-15/290
Sequence Identity: 64% (9 aa)

SHKLGEGGFGAVYK
. |.||||.|.|||
WNKIGEGGYGQVYK
Kinase IRAK-0_am.AA Dicty4 26-42 41 0.034202 3.31 In-house 1-17 (277) Show / Hide 
Range on Protein: 26-42
Range on HMM: 1-17/277
Sequence Identity: 41% (7 aa)

FDESHKLGEGGFGAVYK
 .   ..|.|.|| |||
INIEQRIGKGSFGEVYK
Kinase IRAK-0_am.AA Pkinase_Tyr 26-42 58 1.528161 2.46 Pfam 1-17 (270) Show / Hide 
Range on Protein: 26-42
Range on HMM: 1-17/270
Sequence Identity: 58% (10 aa)

FDESHKLGEGGFGAVYK
    .||||| || |||
ITFGKKLGEGAFGEVYK