Gene IRAK-0_au-1 (S.moellendorffii)

IRAK-0_au-1

Species: S.moellendorffii
Alias: IRAK-0_au-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_au-1.AA Protein None 1023 None Fasta, JSON
IRAK-0_au-1.NA RNA None 3072 None Fasta, JSON
IRAK-0_au-1.kin_dom Protein Kinase Domain None 199 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_au-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRR_1 IRAK-0_au-1.AA LRR_1 102-120 40 44.166397 0.91 Pfam 6-26 (26) Show / Hide 
Range on Protein: 102-120
Range on HMM: 6-26/26
Sequence Identity: 40% (9 aa)

DLFG-N-QLLNGTLPEA-LCNL
|| | |   | |..|.  . ||
DLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_au-1.AA LRR_1 122-145 33 1.530993 6.09 Pfam 1-26 (26) Show / Hide 
Range on Protein: 122-145
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLRILDLGL-Q--RLSGQIPGCIGSRL
.|..|||.     .|.|.||  .   |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_au-1.AA LRR_1 147-169 29 0.008433 14.1 Pfam 1-26 (26) Show / Hide 
Range on Protein: 147-169
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

GLQILRIGD-N--RFNGSIPEE-LGEL
 ||.| ... |  .. |.||.. .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_au-1.AA LRR_1 171-193 37 0.111074 10.13 Pfam 1-26 (26) Show / Hide 
Range on Protein: 171-193
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLQQLFLDT-T--NISGPIPAS-LGRL
.|| | |.  .  |..| || | .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_au-1.AA LRR_1 195-217 33 0.000715 17.9 Pfam 1-26 (26) Show / Hide 
Range on Protein: 195-217
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

NLTNLNLRS-N--ALEGDLPEE-IGQL
||. |.|.. |   |.|..|.. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_au-1.AA LRR_1 219-241 44 0.010863 13.71 Pfam 1-26 (26) Show / Hide 
Range on Protein: 219-241
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

NLVELSLQV-N--RLTGSIPDS-YGDL
|| .|.|.  |  .|||.||.|    |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_au-1.AA LRR_1 243-266 29 0.335006 8.43 Pfam 1-26 (26) Show / Hide 
Range on Protein: 243-266
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

NLQTFRLFN-N--ELSGGVSSSVLQGM
|||.  | . |   |.| ...| . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_au-1.AA LRR_1 268-288 26 0.063132 11.0 Pfam 1-26 (26) Show / Hide 
Range on Protein: 268-288
Range on HMM: 1-26/26
Sequence Identity: 26% (7 aa)

SLTDLNLRH-N--RFSGPVPDF--GL
.|. |.|.. |  ...| .|.   .|
NLQHLDLSGCNCCNLTGHIPPSCFNL
LRR_1 IRAK-0_au-1.AA LRR_1 291-313 29 0.047442 11.44 Pfam 1-26 (26) Show / Hide 
Range on Protein: 291-313
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

RLSTVDLGF-N--EFSGPLPGS-LGGL
.| . ||.  |   ..| .| | . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_au-1.AA LRR_1 315-337 29 0.001369 16.9 Pfam 1-26 (26) Show / Hide 
Range on Protein: 315-337
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLTSLFIGH-N--RLNGSIPDN-FGSF
.|..| ... |  .| |.||.. | ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_au-1.AA LRR_1 339-360 25 0.616812 7.49 Pfam 1-26 (26) Show / Hide 
Range on Protein: 339-360
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

ALAQLDISH-N--MLAGSLQS--LGGN
 |  ||.|. |   | |....  . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_au-1.AA LRR_1 362-396 15 3.272747 4.92 Pfam 1-26 (26) Show / Hide 
Range on Protein: 362-396
Range on HMM: 1-26/26
Sequence Identity: 15% (6 aa)

QLTQLDVSF-N--FFN-ISSAPTPVPQQPNLGSNAYFNC
.|. ||.|  |   .               . ...  |.
NLQHLDLSGCNCCNLTGH------------IPPSCF-NL
Malectin IRAK-0_au-1.AA Malectin 483-567 41 1.8e-21 82.49 Pfam 73-169 (202) Show / Hide 
Range on Protein: 483-567
Range on HMM: 73-169/202
Sequence Identity: 41% (40 aa)

GNTEQ---ELYRSMRWSSSYIAYHGYSLRPGNYTVMLYFAELVFTE-------PGYRIFDVVLQGRVVLENLDIAREAGA--RAAYVMSRNITINNS
..|..   |||.. ||| |  .| .  |. ||||| |.|||. |..       || |.||| .|| .||...||  |||.  .||.  . |.|..|.
YTTDDVDPELYQTERWSPSSFRYYIPCLENGNYTVILHFAEIYFQDTDQTWNSPGRRVFDVYIQGKLVLKDFDIWKEAGGKGKAAHKEFINVTVTNG
Kinase IRAK-0_au-1.AA IRAK 689-957 29 3.7e-66 226.11 In-house 4-317 (317) Show / Hide 
Range on Protein: 689-957
Range on HMM: 4-317/317
Sequence Identity: 29% (95 aa)

SDKLGEGGFGAVYKGTLPSGT-VIAVKQLVKH----TQQIEDDFKR---EISIISKVRHRNLLAVIGYSLESDVPMLVCEFIPNGSLDKWLFRRR-ENA-
. ..|||||| ||.| .   | . ||| | ..    . ...  |     |. . .. || |.... ||..|.. . || ...|||||   |  .   .. 
DNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQCPP

--LSWEARRAVAIGVACGLAYLHDES-KPSIIHLDVKPGNILLDEDFNPRLADFGLARLY---DEKESHVT----ATRLKGTAGYLAPEYAM--HLQLSD
  |||  |  ...| |||. .||. . . .||| |.|. |||||..|.| ..||||.|      .||...     . ...||. |..||.      ||. 
KPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTK

KVDVYSFGVVLLELLSGRRAVELSAPSEQIVLVDWAHKEAEIPDN----------------------------LLDIVDRKLHGDFVAEEARDMASIAIL
|.||||||.||||.|.|.||| ..  .| . |.|    ..|                                ..|    .. .. . ... .|.. |. 
KTDVYSFGIVLLEVLTGCRAV-YDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFID----HRMPPCPPNMEKEMCQCACC

CTQRSAALRPKMQAVWLML
|. . |..|..|  |   |
CGHHRANRRCDMAWVMQQL
Kinase IRAK-0_au-1.AA TKL 692-885 24 3.7e-61 209.5 In-house 1-287 (364) Show / Hide 
Range on Protein: 692-885
Range on HMM: 1-287/364
Sequence Identity: 24% (72 aa)

LGEGGFGAVYKGTLPS---------GTVIAVKQLVK---------------------------HTQQIEDDFKREISIISKVRHRNLLAVIGYSLESDV-
.|.|||| ||||..           |...|||.. .                           ....... ...|| ..|. || |..  .||.....  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------PMLVCEFIPNGSLDKWLFRRRENALSWEARRAVAIGVACGLAYLHDES-----KPSIIHLDVKPGNILLDEDFN--------------
            ...| |..|.|||   |         |. |   |...|.|..||| .      || ||| | |. |||.||...              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

PRLADFGLARLYDEKE-----------------SHVTATRLKGTAGYLAPEYAMHL----------------QLSDKVDVYSFGVVLLELLSGRR
. ..||||.|  ....                 .. |  .  || ...|||  .                  . | |.||||||.|| |.|...|
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR
Kinase IRAK-0_au-1.AA Pkinase 688-884 29 1.5e-49 175.75 Pfam 3-209 (293) Show / Hide 
Range on Protein: 688-884
Range on HMM: 3-209/293
Sequence Identity: 29% (63 aa)

FSDKLGEGGFGAVYKGTLPSGTV-IAVKQLVKHTQQIEDD--FKR--EISIISKVRHRNLLAVIGYSLESDVPMLVCEFIPNG----SLDKWLFRRRENA
.  |.|.|.|| |||..  .     |||.. |...  . |    |  ||.|  ...| | .  ...  ..| . .| |. ..|    .|  .. ..|...
IGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGC

L--SWEARRAVAIGVACGLAYLHDESKPSIIHLDVKPGNILLDEDFNP----RLADFGLARLYDEKESHVTATRLKGTAGYLAPEYAM-HLQLSDKVDVY
.  |..  . ..  ...||.|.|..   .||| |.|| |||.|.. ..    ...|||||...|   . . .| . || .|.|||  . .   . |||..
FYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SFGVVLLELLSGR
|.|..| |.|.||
SCGCILYEMLCGR
Kinase IRAK-0_au-1.AA TKL-Unique 688-883 31 2.1e-48 167.11 In-house 1-224 (290) Show / Hide 
Range on Protein: 688-883
Range on HMM: 1-224/290
Sequence Identity: 31% (71 aa)

FSDKLGEGGFGAVYKGTLPSGTVIAVKQLVK---HTQQIEDDFKREISIISKVR-HRNLLAVIGYSL--ESDVP--MLVCEFIPNGSLDKWLFR------
|. |.||||.|.||||. . |. .|.||. .      .....|..|.....| . | |..  .||.     . |   .|.|..| |||.. | .      
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

--RRENALSWEARRAVAIGVACGLAYLHDESKPSIIHLDVKPGNILLDED-----FNPRLADFGLARLYDEKESHVTATRL--------KGTAGYLAPEY
  .... |... |   || .| |. ||| ...| |||.| |. |.|.|..     .| ...||||... . |..  |....        .|.. ..||| 
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNS-KINKMTNNEHKGTRNQTRCGSFRWMAPEV

AMH--LQLSDKVDVYSFGVVLLELLSG
 .    | | |.||||||.|| |....
LRMNFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAK-0_au-1.AA Dicty4 688-881 32 3.2e-40 131.96 In-house 3-211 (277) Show / Hide 
Range on Protein: 688-881
Range on HMM: 3-211/277
Sequence Identity: 32% (68 aa)

FSDKLGEGGFGAVYKGTLPSGTVIAVKQL--VKHT--QQIEDDFKREISIISKVRHRNLLAVIGYSL----ESDVPMLVCEFIPNGSLDKWLFR-----R
. ...|.|.|| |||||   |.  ||| |   . .  . .  .|..|..| .| || |..   |...    ..  .. | |. | |.| . |        
IEQRIGKGSFGEVYKGTW-RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQ

RENALSWEARRA---VAIGVACGLAYLHDESKPSIIHLDVKPGNILLDEDFNPRLADFGLARLYDEKESHVT-ATRLKGTAGYLAPEYAMHLQLSDKVDV
 .  |.|. ...    |. .| |...|| .. | |||.| |. |.| |....   .||||...  . |.| . ..  .||... |||  ||     |.||
QSIKLDWPLIKRAMRMAFDAARGMNWLH-CCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADV

YSFGVVLLELL
|||| || |.|
YSFGIVLWEIL
Kinase IRAK-0_au-1.AA MLK 688-884 26 3.7e-37 126.47 In-house 3-233 (291) Show / Hide 
Range on Protein: 688-884
Range on HMM: 3-233/291
Sequence Identity: 26% (62 aa)

FSDKLGEGGFGAVYKGTLPSGT----VIAVKQLV------KHTQQIEDDFKREISIISKVRHRN----LLAVIGYSLESDV-PMLVCEFIPNGSLDKWLF
|. ..|.|.||.|.||.    .    ..|||.          |  . .||..|. . ....|.|      .. | .|..     .| |....|||   | 
FHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLH

R-RRENA-----------LSWEARRAVAIGVACGLAYLHDESKPSIIHLDVKPGNILLDE------DFNPRLADFGLARLYDEKESHVTATRLKGTAGYL
  | . .            . .     |  .| |..||| . .. ||| | |. |||.||      . . . .|||..|   ...   . .  .||. . 
GARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC--TNMMSNAGTYAWM

APEY---AMHLQLSDKVDVYSFGVVLLELLSGR
|||    . . . | |.||.|.|||| |.|...
APEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase IRAK-0_au-1.AA LISK 691-888 25 3.8e-37 118.1 In-house 1-240 (296) Show / Hide 
Range on Protein: 691-888
Range on HMM: 1-240/296
Sequence Identity: 25% (63 aa)

KLGEGGFGAVYKGTLP-SGTVIAVKQLVK-----HTQQIEDDFKREISIISKVRHRNLLAVIGYSLE-SDVPMLVCEFIPNGSLDKWLFRR--RENALSW
..|.|.|| |||||.  .|.|.|.|.. .          .  ..||. .. . ||.| .  .| . . ..  ..| |.|  | |   |...  .   |.|
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

EARRAVAIGVACGLAYLHDESKPSIIHLDVKPGNILLD----EDFNPRLADFGLARLYDEKE--------------------------SHVTATRLK---
. |   | ..|||..|||.     ||| | |  |.|..    .... ...|||.||. |...                              . . |   
PQRVKIALDIACGMSYLHSM---NIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRM

---GTAGYLAPEYAMHLQLSDKVDVYSFGVVLLELLSGRRAVE
   ||.   |||     . ....||.|||.||.|.  ...| .
TICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKADP
Kinase IRAK-0_au-1.AA LRRK 686-888 21 1e-35 123.81 In-house 1-284 (351) Show / Hide 
Range on Protein: 686-888
Range on HMM: 1-284/351
Sequence Identity: 21% (63 aa)

QGFSDKLGEGGFG-AVYKGTLPS---------------------------GTVIAVKQLVKH----------------------------------TQQI
. .  ..|.||||  ||.... .                           .. .|.|.. ..                                  .  .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

EDDFKREISIISKVRHRNLLAVIGYSLESDVPMLVCEFIPNGSLDKWLFRRRENA-------LSWEARRAVAIGVACGLAYLHDESKPSIIHLDVKPGNI
   | .|..|.|. .| |..  .|....   ...| |..|.|.|.. |. .....       .||  .  .|. .| |..|||. ..|.||| | |. ||
FREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS-HNPPIIHRDLKSPNI

LL---D---------EDFNPRLADFGLARLYDEKESHVT-ATRLKGTAGYLAPEYAM---HLQLSDKVDVYSFGVVLLELLSGR-RAVE
||   .         .. .  .||||. |..  .  | . | .. |. |..|||        . ..|||.||||..| |||... .. .
LLWSSPQNHSPNYPNAHVCAKIADFGISRMF--QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD
Kinase IRAK-0_au-1.AA S_TKc 688-935 25 1.6e-33 118.65 SMART 3-231 (231) Show / Hide 
Range on Protein: 688-935
Range on HMM: 3-231/231
Sequence Identity: 25% (68 aa)

FSDKLGEGGFGAVYKGTLPS-GTVIAVKQLVKHTQQIEDDFKREISIISKVRHRNLLAVIGYSLESDVPMLVCEFIPN--GSLDKWLFRRRENA----LS
. .|.|.|.|| |||..  . | . |.|..        ....|||.| .| .| |.   ...  . |   .| |....  |.| . . .|. .     ..
ILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

WEARRAVAIGVACGLAYLHDESKPSIIHLDVKPGNILLDEDFNPRLADFGLARLYDEKESHVTATRLKGTAGYLAPEYAMHLQLSD-KVDVYSFGVVLLE
    | ..  ..|.|.|.|.  .  ||| |.|| ||||||  .  ..||||||..         | . ||  |.|||     . .  |.|..|.|..| |
E-HARFYMYQICCALEYCHSH-G--IIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LLSGRRAVELSAPSEQIVLVDWAHKEAEIPDNLLDIVDRKLHGD----FVAEEARD-------MASI
.|.|.   .     .. .. .        .. ..|.... |. |      | ||         .  .
MLCGYPPFP-----QMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_au-1.AA RIPK 692-899 28 1.4e-32 108.34 In-house 1-240 (290) Show / Hide 
Range on Protein: 692-899
Range on HMM: 1-240/290
Sequence Identity: 28% (68 aa)

LGEGGFGAVYKGT-LPSGTVIAVKQ---LVKHTQ---QIEDDFKREISIISKVRHRNLLAVIGYSLESDV------PMLVCEFIPNGSLDKWLFRRRE--
.| |||| |.| .    |...|.|    . .||.   | . . |.|  .  | |... . . |   . .       . .| |. .|||| . | .. .  
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

-NALSWEARRAVAIGVACGLAYLHDESKPSIIHLDVKPGNILLDEDFNPRLADFGLARLYDEKESHV----------TATRLK-GTAGYLAPEYAMHLQL
   . |  |      ..||  |||.  .| |||.| ||.|||.| .|.  .||||||      .||           .. ... ||  |..||     . 
HHPDPWPLRCRMIHEISCGMCYLHSM-NPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNK

SD------KVDVYSFGVVLLELLSGRRAVELSAPSEQIVLV
.       | |||||..|. |.|... . |   ....|...
KPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMMC
Kinase IRAK-0_au-1.AA Pkinase_Tyr 688-882 28 1.8e-30 103.84 Pfam 3-209 (270) Show / Hide 
Range on Protein: 688-882
Range on HMM: 3-209/270
Sequence Identity: 28% (60 aa)

FSDKLGEGGFGAVYKGTLP-----SGTVIAVKQLVKHTQQIE---DDFKREISIISKV-RHRNLLAVIGYSL-ESDV--PMLVCEFIPNGSLDKWLFRR-
|  ||||| || |||||.       ..  ||| |  .. . .   .|| ||..| ..  .| |..  .|  . ...   ...| |. |.|.|.. | .. 
FGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR

-RENALSWEARRAVAIGVACGLAYLHDESKPSIIHLDVKPGNILLDEDFNPRLADFGLARLYDEKESH-VTATRLKGTAGYLAPEYAMHLQLSDKVDVYS
  ...|. .     .. .|.|..||..     .|| |.   |.|..|..  . .||||||.  ...   ....  |     .|||  ..   . | ||.|
EDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

FGVVLLELLS
|||.. |...
FGVLMWEIFT
Kinase IRAK-0_au-1.AA Dicty4-Unclassified 688-883 29 1.9e-29 98.02 In-house 3-204 (263) Show / Hide 
Range on Protein: 688-883
Range on HMM: 3-204/263
Sequence Identity: 29% (62 aa)

FSDKLGEGGFGAVYKGTLPSGTVIAVKQLVKHTQQIE----DDFKREISIISKVRHRNLLAVIGYSLES----DVPMLVCEFIPNGSLDKWLF---RRRE
    .|.| |  |.||    |  .||| .     .      .|||.|. |   . | ||. . ||..         . | ||.. | |          ..
IDQFIGKGHFSKVHKGNW-KGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQ

NALSWEA--RRAVAIGVACGLAYLHDESKPSIIHLDVKPGNILLDEDFNPRLADFGLARLYDEKESHVTATRLKGTAGYLAPEYAMHLQLSDKVDVYSFG
  .. .     ..|. .| |...||      .|| |.|  |||.| .|| . ||||..|  |      . |   ||    .||  ||     | ||||..
QPIKLDDTLIIKYAFDIAQGMQHLHTR---NFIHRDIKSSNILMDKHFNIKIADFGISRVIDFN---FNMTTIAGTPKWESPECLMHESYNQKSDVYSYA

VVLLELLSG
..| ||. |
MMLYELATG
Kinase IRAK-0_au-1.AA STE 686-884 20 3.7e-29 100.18 In-house 1-265 (359) Show / Hide 
Range on Protein: 686-884
Range on HMM: 1-265/359
Sequence Identity: 20% (56 aa)

QGFSDKLGEGGFGAVYKGTLP----------------SGTVIAVKQLVKHTQ-----------------QIEDDFKREISIISKVR--HRNLLAVIGYSL
. . .|.|.|.|| |||.                   .|...|.||. . ..                 ........||.| .| .  | |    .|. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

ES-------DVPMLVCEFIPNGSLDKWLFR--RRENALS----------WEARRAVAIGVACG-LAYLHDESKPSIIHLDVKPGNILLDEDFNPRLADFG
         |   .. |....||||. . .   . . |.           .  ....  .  | |.|||.     ||| |.||.||||       |.|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LARLYDEK--------------ESHVTATRLKGTAGYLAPEYAMH------LQLSDKVDVYSFGVVLLELLSGR
..   ...               .    . . ||  . |||  .        . . |.|..|.| ...|.. |.
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAK-0_au-1.AA TyrKc 688-957 24 4.8e-26 93.77 SMART 3-280 (280) Show / Hide 
Range on Protein: 688-957
Range on HMM: 3-280/280
Sequence Identity: 24% (71 aa)

FSDKLGEGGFGAVYKGTLPSGTVIAVKQLVKHTQQIEDDFKREISIISKV--RHRNLLAVIGYSLES-------DVPMLVCEFIPNGSLDKWLFRRRENA
. .||||| || |||||.   .  ||| | ...   . || ||..| .|.  .| |... .|. ...       . .|.| |. |.|.|.. | ..|.. 
LGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-

LSWEARRAVAIGVACGLAYLHDESKPSIIHLDVKPGNILLDEDFNPRLADFGLARLYDEK-------ESHVTAT--RLK--GTAGYLAPEYAMHLQLSDK
|...     .. .||| .|||.     .|| |    |.|..|..  . .||||.|  ...       .  ....    |       .|||  ..   . |
LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

VDVYSFGVVLLELLSGRRAVELS-----APSEQIVLVDWAHKEAEIPDNLLDIVDRKLHGDFVAEEARDMASIAILCTQRSAALRPKMQAVWLML
 ||.||||.. |...              . ....    . .  ..|.| . .        |  .   .| .|   | .. .. || ....   .
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------F-VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF