Gene IRAK-0_h (S.moellendorffii)

IRAK-0_h

Species: S.moellendorffii
Alias: IRAK-0_h
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_h.AA Protein None 218 None Fasta, JSON
IRAK-0_h.NA RNA None 657 None Fasta, JSON
IRAK-0_h.kin_dom Protein Kinase Domain None 153 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_h.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-0_h.AA IRAK 40-200 37 1.1e-47 164.71 In-house 46-222 (317) Show / Hide 
Range on Protein: 40-200
Range on HMM: 46-222/317
Sequence Identity: 37% (67 aa)

QFLN---EVKAISSVQHRNLVKLLGCSMEGTERLLVYELLKNNSLENALFGPV-EKP---LSWETRHNILLGTARGLAYLHEDS-QIRIVHRDIKPSNIL
.|.    |.|. .. .| |.| |.| . |. .  |||....| |||  | .     |   ||| .|. |..|||.|. .||...  . | |.|||..|||
RFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANIL

LDEFYEAKIADFGLARLF---ESSHQLEV---LTTKAAGTYGYMAPEYAL--NGQLSDKIDVYSYGIVILKTVSGKR
||.  ..||.||||.|     ... . ..    | .  ||  ||.||.     |||. | |||| |||.| ...| |
LDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDVYSFGIVLLEVLTGCR
Kinase IRAK-0_h.AA TKL 40-192 24 2.4e-44 153.67 In-house 71-279 (364) Show / Hide 
Range on Protein: 40-192
Range on HMM: 71-279/364
Sequence Identity: 24% (54 aa)

QFLNEVKAISSVQHRNLVKLLGCSMEGTE-------------RLLVYELLKNNSLENALFGPVEKPLSWETRHNILLGTARGLAYLHEDS-----QIRIV
.. .|.. .|. .| |.|...|......                .|.|. .. ||.. |         |. |... |..|||..||| .         |.
FEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPII

HRDIKPSNILLDEFYE--------------AKIADFGLAR-LFESSHQLEV---------------LTTKAAGTYGYMAPEYALNG--------------
|||.|..|||.|| ..              .||.||||.| ...|...                   | .  ||...||||   .               
HRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCK

--QLSDKIDVYSYGIVI
  . | |.||||.|||.
GFEYSEKCDVYSFGIVL
Kinase IRAK-0_h.AA Pkinase 40-199 26 6.4e-36 128.08 Pfam 44-209 (293) Show / Hide 
Range on Protein: 40-199
Range on HMM: 44-209/293
Sequence Identity: 26% (45 aa)

QFLN--EVKAISSVQHRNLVKLLGCSMEGTERLLVYELLKNN----SLENALFGPVEKPL--SWETRHNILLGTARGLAYLHEDSQIRIVHRDIKPSNIL
. ..  |..   ...| | |.|... .....  .| |.. .     .|   . .  ....  |...  .... ..|||.|.|.    .|.|||.||.|||
THRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENIL

LDEFYEA----KIADFGLARLFESSHQLEVLTTKAAGTYGYMAPEYAL-NGQLSDKIDVYSYGIVILKTVSGK
.|. ..     ||.|||||..|.  .   . .|  .||..|||||  . .   . |.|..|.|...   ..|.
IDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR
Kinase IRAK-0_h.AA TKL-Unique 41-191 30 1.8e-29 101.16 In-house 42-217 (290) Show / Hide 
Range on Protein: 41-191
Range on HMM: 42-217/290
Sequence Identity: 30% (54 aa)

FLNEVKAISSVQ-HRNLVKLLGCSM----EGTERLLVYELLKNNSLENALFG--------PVEKPLSWETRHNILLGTARGLAYLHEDSQIRIVHRDIKP
| |||. ..  . | |.|.. | .|       .. .| | .  .|| . |          . ...|... | .. .  |.|. |||  .   | |||.|.
FENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKS

SNILLDEF-----YEAKIADFGLARLFESSHQLEVLTTK-------AAGTYGYMAPEYALNG---QLSDKIDVYSYGIV
||.|.|..     . .||.||||.. | |.   . ....         |.. .||||  |..   | | |.||||.|||
SNFLVDNNSNIAEWNIKICDFGLSK-FNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV-LRMNFCQYSEKSDVYSFGIV
Kinase IRAK-0_h.AA MLK 22-192 26 3e-29 98.7 In-house 1-226 (291) Show / Hide 
Range on Protein: 22-192
Range on HMM: 1-226/291
Sequence Identity: 26% (60 aa)

LRRKHKLGEGGFGAVYKLQFLNEV-----KAISSVQ---------------------------HRN-----LVKLLGCSMEGTERLLVYELLKNNSLENA
.. ....|.|.||.|.| .. |.       |.  |                            |.|      . . .|. .. . ..| | . . || | 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LFG-PVEKP-----------LSWETRHNILLGTARGLAYLHEDSQIRIVHRDIKPSNILLDE------FYEAKIADFGLARLFESSHQLEVL-TTKAAGT
| | . .              . .   |. |  |||..|||.. .  |.|||.|..|||.||         .||.|||..| .   || .    ...|||
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDW---HQMC-TNMMSNAGT

YGYMAPEY---ALNGQLSDKIDVYSYGIVI
| .||||    . ... | | ||.|.|.|.
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVL
Kinase IRAK-0_h.AA Dicty4 41-191 27 5.5e-27 87.18 In-house 45-206 (277) Show / Hide 
Range on Protein: 41-191
Range on HMM: 45-206/277
Sequence Identity: 27% (45 aa)

FLNEVKAISSVQHRNLVKLLGCSM----EGTERLLVYELLKNNSLENALFG-----PVEKPLSWETRHN---ILLGTARGLAYLHEDSQIRIVHRDIKPS
|..||.  .. .| |.....| .     .  . . | |..   .|.. |         ...|.|...     . . .|||...||. .  .|.|||.|..
FRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSH

NILLDEFYEAKIADFGLARLFESSHQLEVLTTKAAGTYGYMAPEYALNGQLSDKIDVYSYGIV
|.| |. . .|..||||....    ..   .. |.|| ..||||   .     | ||||.|||
NLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIV
Kinase IRAK-0_h.AA CAMKK 101-172 34 1.4e-25 77.79 In-house 181-280 (396) Show / Hide 
Range on Protein: 101-172
Range on HMM: 181-280/396
Sequence Identity: 34% (35 aa)

ILLGTARGLAYLH-EDS-----------------QIRIVHRDIKPSNILLDEFY---EAKIADFGLARLFESSHQL--------EVLTTKAAGTYGYMAP
.... . || ||| .                   | .|.||||||.|||.||      .|||||| .  ||...|.        . .  | |||. .|||
YFRDCIKGLEYLHNYQKACSYIIIYINEFIIDHFQ-DIIHRDIKPQNILIDEEGCGEHVKIADFGVSHIFEGQDQTLSNCESCFQRELNKTAGTPAFMAP

E
|
E
Kinase IRAK-0_h.AA STE 22-193 22 9.7e-25 84.35 In-house 1-259 (359) Show / Hide 
Range on Protein: 22-193
Range on HMM: 1-259/359
Sequence Identity: 22% (59 aa)

LRRKHKLGEGGFGAVYKL-------------------------------------------------------QFLNEVKAISSVQ--HRNLVKLLGCSM
...  |.|.|.|| |||                                                        |.|.|.|  .  .  | | || .|| .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EG-------TERLLVYELLKNNSLENALFG--PVEKPLSW---------ETRH-NILLGTARG-LAYLHEDSQIRIVHRDIKPSNILLDEFYEAKIADFG
 .       .|  .. |.. . ||.  .     . |||.          |.    |.  . .| |.|||.     |.||||||.||||     .|..|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LARLFESSHQ------------LEV-LTTKAAGTYGYMAPEYALN------GQLSDKIDVYSYGIVIL
..  ...|.               .  ..  .||  .||||  ..      .. . | |..| |..|.
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTII
Kinase IRAK-0_h.AA RIPK 42-199 27 1e-24 81.17 In-house 44-225 (290) Show / Hide 
Range on Protein: 42-199
Range on HMM: 44-225/290
Sequence Identity: 27% (51 aa)

LNEVKAISSVQHRNLVKLLGCSMEG-----TE-RLLVYELLKNNSLENALFGPVE---KPLSWETRHNILLGTARGLAYLHEDSQIR--IVHRDIKPSNI
. |.|.  . .... |...|   .       .   .| |  .| ||.. |    .   .|. |  |  ..  ...|  |||    .   | ||| ||.||
KEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQHHPDPWPLRCRMIHEISCGMCYLHS---MNPPIIHRDLKPENI

LLDEFYEAKIADFGLARLFESSHQLE--------VLTTKAA--GTYGYMAPEYALNGQLSD------KIDVYSYGIVILKTVSGK
|.|  . .||||||||   . ||.            ....   ||  ||.||  .... .       | ||||..||.    ..|
LVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQK
Kinase IRAK-0_h.AA Ciliate-E2 22-200 18 5.6e-24 79.18 In-house 1-294 (365) Show / Hide 
Range on Protein: 22-200
Range on HMM: 1-294/365
Sequence Identity: 18% (55 aa)

LRRKHKLGEGGFGAVYKL------------------------------------------QFLNEVKAIS-----------------SVQHRNLVKLLGC
     |.|.|.|| |||                                           .... .. |                  ...| |..|.  |
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

SMEGTE--RLLVYELLKNNSLEN-----ALFGPVE----KPLSWETRHNILLGTAR---------------GLAYLHEDSQIRIVHRDIKPSNILLDEFY
  | ..    || |... ..|.       .. . |    |..... . .|    ..               .| |||.     |.||||||.|||.    
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN--IIHRDIKPENILF----

EAKIADFGLAR-----------------LFESSHQLEVLTTKA------------AGTYGYMAPEYALNGQ---------LSDKIDVYSYGIVILKTVSG
  ||.||||..                 . . . . .. ...             .||.||||||   ...          . |.|..| |...   ..|
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

KR
|.
KP
Kinase IRAK-0_h.AA LRRK 43-192 28 1.3e-22 76.77 In-house 106-272 (351) Show / Hide 
Range on Protein: 43-192
Range on HMM: 106-272/351
Sequence Identity: 28% (50 aa)

NEVKAISSVQHRNLVKLLGCSMEGTERLLVYELLKNNSLENALFGPVEKP-------LSWETRHNILLGTARGLAYLHEDSQIR--IVHRDIKPSNILL-
.||  .|. .| |.|.|.| ...   . .| |.. . .|   |. . . .       .|| ... | |  |.|..|||     .  |.||| |. |||| 
HEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH---SHNPPIIHRDLKSPNILLW

--D---------EFYEAKIADFGLARLFESSHQLEVLTTKAAGTYGYMAPEYALNG---QLSDKIDVYSYGIVI
  .         ... |||||||. |.|  .  .. .. .  |. |.||||   ..   . ..|.|.||.|...
SSPQNHSPNYPNAHVCAKIADFGISRMF--QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMIL
Kinase IRAK-0_h.AA Pkinase_Tyr 41-192 27 1.5e-19 66.86 Pfam 50-204 (270) Show / Hide 
Range on Protein: 41-192
Range on HMM: 50-204/270
Sequence Identity: 27% (43 aa)

FLNEVKAISSV-QHRNLVKLLGCSM-EGTE--RLLVYELLKNNSLENALFGP--VEKPLSWETRHNILLGTARGLAYLHEDSQIRIVHRDIKPSNILLDE
|..|.|  ..  .| |.|.|.|. . .|     ..| |. .. .| . |  .   ..||. ..  .. .  |.|..||..   ....|||.   |.|..|
FMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLES---KNCIHRDLAARNCLVTE

FYEAKIADFGLARLF-ESSHQLEVLTTKAAGTYGYMAPEYALNGQLSDKIDVYSYGIVI
   .||.||||||.  . .    . ....      ||||   .|  . | ||.|.|...
NNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLM
Kinase IRAK-0_h.AA S_TKc 22-218 23 3.7e-15 45.41 SMART 1-231 (231) Show / Hide 
Range on Protein: 22-218
Range on HMM: 1-231/231
Sequence Identity: 23% (59 aa)

LRRKHKLGEGGFGAVYKLQFLN----------------EVKAISSVQHRNLVKLLGCSMEGTERLLVYELLKN--NSLENALFGPVE----KPLSWETRH
 .   |.|.|.|| ||| .  .                |..  .. .| |.|||...  . ..  .| |.. .   .|   .         .|..  .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HAR

NILLGTARGLAYLHEDSQIRIVHRDIKPSNILLDEFYEAKIADFGLARLFESSHQLEVLTTKAAGTYGYMAPEYALNGQLSD-KIDVYSYGIVILKTVSG
 ..  ....|.|.|  |. .|.|||.||.||||||  . ||.||||||..          |   ||  |||||     . .  |.|..| |...   ..|
FYMYQICCALEYCH--SH-GIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCG

KR---------------------------N-RDRSLVDEVLE-----KISVCI
.                            . ..|  . |.|.     |.   .
YPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_h.AA TyrKc 22-214 19 3.6e-14 6.39 SMART 1-280 (280) Show / Hide 
Range on Protein: 22-214
Range on HMM: 1-280/280
Sequence Identity: 19% (55 aa)

LRRKHKLGEGGFGAVYK-----------------LQFLNEVKAISSV--QHRNLVKLLGCSMEG-------TERLLVYELLKNNSLENALFGPVEKPLSW
.. ..||||| || |||                   |..| .  ...  .| |.|.|.|. ...          ..| |. .. .| . |  . .| |..
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-LCM

ETRHNILLGTARGLAYLHEDSQIRIVHRDIKPSNILLDEFYEAKIADFGLARLFESS------HQLEVL----TTKAAGTYGYMAPEYALNGQLSDKIDV
.. ... .  |.| .|||.    ...|||.   |.|..| . .||.||||.|  ..       ..  .      .|.   .  ||||    |  . | ||
KDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV

YSYGIVI-----------------------LKTVSGKRNRDRSLVD--------------------------------EVLEKI
.|.|...                       .     ...| .   .                                |. |..
WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK-0_h.AA LRRK 22-38 44 0.00066 9.69 In-house 1-18 (351) Show / Hide 
Range on Protein: 22-38
Range on HMM: 1-18/351
Sequence Identity: 44% (8 aa)

LRRKHKLGEGGFG-AVYK
|..  ..|.||||  ||.
LKIEEQIGRGGFGTFVYR
Kinase IRAK-0_h.AA IRAK 23-38 50 0.000724 9.78 In-house 2-17 (317) Show / Hide 
Range on Protein: 23-38
Range on HMM: 2-17/317
Sequence Identity: 50% (8 aa)

RRKHKLGEGGFGAVYK
 . ...|||||| ||.
HKDNRIGEGGFGCVYR
Kinase IRAK-0_h.AA Dicty4 22-38 41 0.001027 8.46 In-house 1-17 (277) Show / Hide 
Range on Protein: 22-38
Range on HMM: 1-17/277
Sequence Identity: 41% (7 aa)

LRRKHKLGEGGFGAVYK
. .  ..|.|.|| |||
INIEQRIGKGSFGEVYK
Kinase IRAK-0_h.AA TKL 28-38 72 0.002157 8.09 In-house 1-11 (364) Show / Hide 
Range on Protein: 28-38
Range on HMM: 1-11/364
Sequence Identity: 72% (8 aa)

LGEGGFGAVYK
.|.|||| |||
IGSGGFGEVYK
Kinase IRAK-0_h.AA RIPK 28-38 63 0.005567 5.96 In-house 1-11 (290) Show / Hide 
Range on Protein: 28-38
Range on HMM: 1-11/290
Sequence Identity: 63% (7 aa)

LGEGGFGAVYK
.| |||| |.|
VGGGGFGEVFK
Kinase IRAK-0_h.AA Pkinase 22-38 47 0.006265 11.44 Pfam 1-17 (293) Show / Hide 
Range on Protein: 22-38
Range on HMM: 1-17/293
Sequence Identity: 47% (8 aa)

LRRKHKLGEGGFGAVYK
.... |.|.|.|| |||
YHIGRKIGSGSFGCVYK
Kinase IRAK-0_h.AA Pkinase_Tyr 22-38 58 0.054254 7.37 Pfam 1-17 (270) Show / Hide 
Range on Protein: 22-38
Range on HMM: 1-17/270
Sequence Identity: 58% (10 aa)

LRRKHKLGEGGFGAVYK
..  .||||| || |||
ITFGKKLGEGAFGEVYK
Kinase IRAK-0_h.AA TKL-Unique 26-38 69 0.055137 3.01 In-house 3-15 (290) Show / Hide 
Range on Protein: 26-38
Range on HMM: 3-15/290
Sequence Identity: 69% (9 aa)

HKLGEGGFGAVYK
 |.||||.|.|||
NKIGEGGYGQVYK