Gene IRAK-0_c-2 (S.moellendorffii)

IRAK-0_c-2

Species: S.moellendorffii
Alias: IRAK-0_c-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_c-2.AA Protein None 490 None Fasta, JSON
IRAK-0_c-2.NA RNA None 1473 None Fasta, JSON
IRAK-0_c-2.kin_dom Protein Kinase Domain None 202 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_c-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-0_c-2.AA TKL 146-411 21 8.7e-66 224.87 In-house 1-364 (364) Show / Hide 
Range on Protein: 146-411
Range on HMM: 1-364/364
Sequence Identity: 21% (80 aa)

LGEGGYGIVYKGKLPD---------GTPIAVKNLLNNRGQ---------------------------AEKEFRVEVEAIGRVRHKNLVRLLGYCVEGCH-
.|.||.|.|||||.           |...||| .  .  .                           .......|.  . | || |.|...||| .. . 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RMLVYEYVDNGNLEQWLHGPISRTKSLTWEARMKIVLGTAKALAYLHEAL-----EPKVVHRDIKSSNILIDSTYN------------
             ..|.||...|.|.  ||          |. |....|..|....|||         |...|||.||.|||.|. ..            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--ARISDFGLAKLLGAGKSHVTTR------------------VMGTFGYVAPEYAN----------------TGLLNERSDVYSFGVLLMEVVTGRDPVD
  . |.||||.. .   ..   |                   . ||... |||  .                 .  .|..||||||..| |..|.. | .
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY

-YSRPPSEVNLVDWLKLMVGQRRSEEVADPNLEP-------KPASRALKRALLVALRCVDPDSSKRPKMGHVVHML
 |  .| ...  . ...|  .. ..    |  .         | . ....    . .| |.| .||| .  ... |
DYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-0_c-2.AA IRAK 140-348 36 3.8e-58 199.5 In-house 1-230 (317) Show / Hide 
Range on Protein: 140-348
Range on HMM: 1-230/317
Sequence Identity: 36% (85 aa)

FADCNVLGEGGYGIVYKGKLPDGT-PIAVKNLLNNR----GQAEKEFRV---EVEAIGRVRHKNLVRLLGYCVEGCHRMLVYEYVDNGNLEQWLHGPI-S
|.  |..||||.| ||.|..   | . ||| | ...    .. ...|.    |...  | ||.|.| |.||| |.    |||.|  || ||  |..   .
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

RT-KSLTWEARMKIVLGTAKALAYLHEALEPK--VVHRDIKSSNILIDSTYNARISDFGLAKLL----GAGKSHV----TTRVMGTFGYVAPEYAN--TG
 . | |.|  | .| .|||... .||.. .|.  . |.||||.||| |   .. |.||||.       .  |. .    | .| ||  | .||. .  .|
CPPKPLSWHQRCSICWGTACGIQFLHQN-HPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQG

LLNERSDVYSFGVLLMEVVTGRDPVDYSRPP
 |  ..||||||. |.||.||. .|.  ||.
QLTKKTDVYSFGIVLLEVLTGCRAVYDDRPE
Kinase IRAK-0_c-2.AA TKL-Unique 142-338 34 1.6e-45 157.52 In-house 1-224 (290) Show / Hide 
Range on Protein: 142-338
Range on HMM: 1-224/290
Sequence Identity: 34% (77 aa)

DCNVLGEGGYGIVYKGKLPDGTPIAVKNLL-NNRGQAE--KEFRVEVEAIGRVR-HKNLVRLLGYCV----EGCHRMLVYEYVDNGNLEQWLH--GPIS-
. |..|||||| ||||| . |.|.|.| .  |.    |  .||. ||  . . . |.|.|.. |||.       .. .| ||.. |.|   ||   . . 
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

---RTKSLTWEARMKIVLGTAKALAYLHEALEPKVVHRDIKSSNILIDST-----YNARISDFGLAKLLGAG-KSHVT-------TRVMGTFGYVAPEYA
   . . |... |.|...  |... |||  .||.. |||.||||.|.|.      .|..|.||||.|..    |. ..       . ..|.| ..|||  
NNNNNCKLNMQQRVKMAIDIAQGMYYLHH-CEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

NT--GLLNERSDVYSFGVLLMEVVTG
.    . .| |||||||. | | .|.
RMNFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAK-0_c-2.AA TK 140-411 17 8.1e-45 147.71 In-house 1-486 (486) Show / Hide 
Range on Protein: 140-411
Range on HMM: 1-486/486
Sequence Identity: 17% (84 aa)

FADCNVLGEGGYG---IVYKGKLPDG--------------------------TPIAVKNLLNNRGQAEKEFRV--------------EVEAIGRVR----
    ..|||| .|    ||||.. ..                          || ||| |    .....||.               |.|..   .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HKNLVRLLGYCVEGC------------HRMLVYEYVDNGN----LEQWLHGPISRTKS-----------------------------------------
 |.|.|||.|.|..|             . |.| ||...|.    | ..|.    ...                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LTWEARMKIVLGTAKALAYLHEA---LEPKVVHRDIKSSNILIDSTYN-----------ARISDFG---
                               || . .. . .  |....|||.    .....||||.   |.|... ..           ..|.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LAKLLGAGKSHVTTRVMGTFG-------------------------YVAPEYAN---------TGLLNERSDVYSFGVLLMEVVT-GRDPVDYSR
     ||. .. ..  ....  || .                         . |||  |         .|   . |||.|||||. |..| |. |     
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

PP------SEVNLVDWLKLMVGQR-----RSEEVADPNLEPKPASRAL-------------KRALLVALRCVDPDSSKRPKMGHVVHML
.         .|     .|  |.|     . .|| . .  |.|.                 .   .. ..| ..| ..|| .  ....|
SNQDVWKDG-DNQEVMEYLRRGGRLCRSGL-NEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK-0_c-2.AA LISK 145-349 25 1.8e-41 132.37 In-house 1-248 (296) Show / Hide 
Range on Protein: 145-349
Range on HMM: 1-248/296
Sequence Identity: 25% (65 aa)

VLGEGGYGIVYKGKLP-DGTPIAVKNLLN-----NRGQAEKEFRVEVEAIGRVRHKNLVRLLGYCVE-GCHRMLVYEYVDNGNLEQWLHGPISRTKSLTW
..|.|..| |||| .  .|...|.| . .     |.  ..| .  ||. . . ||.| |.  | |..   . ..| ||.. |.|.| |. . .. . |.|
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

EARMKIVLGTAKALAYLHEALEPKVVHRDIKSSNILID----STYNARISDFGLAKLLGAGK-----------------------------------SHV
. |.|| |. |....|||.    ...||| || |.|..    . ..... |||.|...   .                                   .. 
PQRVKIALDIACGMSYLHSM---NIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRM

TTRVMGTFGYVAPEYANTGLLNERSDVYSFGVLLMEVVTGRDPVD--YSRPPS
|  . ||   .|||  .    .|..||.|||..| | .|....    . |.|.
T--ICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKADPDYWPRTPQ
Kinase IRAK-0_c-2.AA Pkinase 140-339 26 4.4e-41 146.36 Pfam 1-209 (293) Show / Hide 
Range on Protein: 140-339
Range on HMM: 1-209/293
Sequence Identity: 26% (59 aa)

FADCNVLGEGGYGIVYKGKLPDG-TPIAVKNLLNNRGQAEKEFRV-----EVEAIGRVRHKNLVRLLGYCVEGCHRMLVYEYVDNG----NLEQWLHGPI
.    ..|.|..| |||..  .     |||  .. |.. ... .      |..   |..|.| |||.... .. |  .| ||...|     |  ....  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVK-IIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--

SRTKSL--TWEARMKIVLGTAKALAYLHEALEPKVVHRDIKSSNILIDSTYNA----RISDFGLAKLL-GAGKSHVTTRVMGTFGYVAPEYANTGLLN--
.| ...  ...   .... ....|.|.|.    ...|||.|..|||||....     .|.||||||..    .|  ||.. || .|.|||      ..  
WRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFC-GTPWYMAPEV-----IRGG

----ERSDVYSFGVLLMEVVTGR
     ..|..|.|..| |...||
QYYGPKVDMWSCGCILYEMLCGR
Kinase IRAK-0_c-2.AA LRRK 140-343 24 3.7e-39 136.18 In-house 1-284 (351) Show / Hide 
Range on Protein: 140-343
Range on HMM: 1-284/351
Sequence Identity: 24% (69 aa)

FADCNVLGEGGYG-IVYKGKLPD---------------------------GTPIAVKNLLN----------------------------------NRGQA
.   . .|.||.| .||..|. .                           ....|.| ..                                   ..  |
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

EKEFRVEVEAIGRVRHKNLVRLLGYCVEGCHRMLVYEYVDNGNLEQWLHGPISRT----K-SLTWEARMKIVLGTAKALAYLHEALEPKVVHRDIKSSNI
  ||| ||  . . .| |.| |.|.| .  ....| ||...|.| . || . .      | ...|  . ||.|  ||...||| .  |...||| || ||
FREFRHEVWIMSHLNHPNIVSLKGFCIH--PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSH-NPPIIHRDLKSPNI

LI---D---------STYNARISDFGLAKLLGAGKSHVTTRVMGTFGYVAPEYANTG---LLNERSDVYSFGVLLMEVVTGR-DPVD
|.   .          ...| |.|||.  .  . .. |. .. |..|..|||  . .     .| .|.||||..| | .|.. .| |
LLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD
Kinase IRAK-0_c-2.AA Dicty4 144-341 32 7.5e-36 117.17 In-house 5-216 (277) Show / Hide 
Range on Protein: 144-341
Range on HMM: 5-216/277
Sequence Identity: 32% (69 aa)

NVLGEGGYGIVYKGKLPDGTPIAVKNL-LNNRG--QAE-KEFRVEVEAIGRVRHKNLVRLLGYCV----EGCHRMLVYEYVDNGNLEQWLHG-PISRTKS
. .|.|..| ||||.   |.  ||| | ..| .  ... .||| ||.  .  || |.. ..|.|     .    . | ||.  |||.  ||  |    .|
QRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQS

LTWE----AR-MKIVLGTAKALAYLHEALEPKVVHRDIKSSNILIDSTYNARISDFGLAKLLGAGKSHVT--TRVMGTFGYVAPEYANTGLLNERSDVYS
 . .     | |.. . .|. ...||.   | ..|||.||.|.|.|  ... ..||||...   ...| .  . . || ...|||       || .||||
IKLDWPLIKRAMRMAFDAARGMNWLHCC-NPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYS

FGVLLMEVVTGRDP
|| .| | .|. .|
FGIVLWEILTRQEP
Kinase IRAK-0_c-2.AA TyrKc 140-411 23 9.8e-36 125.95 SMART 1-280 (280) Show / Hide 
Range on Protein: 140-411
Range on HMM: 1-280/280
Sequence Identity: 23% (71 aa)

FADCNVLGEGGYGIVYKGKLPDGTPIAVKNLLNNRGQAEKEFRVEVEAIGRV--RHKNLVRLLGYCVEG-------CHRMLVYEYVDNGNLEQWLHGPIS
     .|||| .|.||||..   .. ||| | ..    ...|. | .   ..  .|.|.|||.|.|...          |.| ||...|.| . |. .  
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

RTKSLTWEARMKIVLGTAKALAYLHEALEPKVVHRDIKSSNILIDSTYNARISDFGLAKLLGAG------KSHVTT----RVM--GTFGYVAPEYANTGL
.   |...   .. .  |.  .|||.    ...|||.   |.|... . ..||||||.. .. .      |.  ..               |||  |.| 
K---LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

LNERSDVYSFGVLLMEVVTGRDPVDYSRPPSEVNLVDWLKLMVGQRRSEEVADPNLEPKPAS-------RALKRALLVALRCVDPDSSKRPKMGHVVHML
 .. |||.||||.. |. |  ..     |.... .      |  |.  | | . .  |.|..       .. .    . ..| . | ..|| .  ... .
FTTKSDVWSFGVCMWEIFTYGQQ-----PYPGMIQQ----MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK-0_c-2.AA MLK 140-341 25 5.6e-35 118.82 In-house 1-235 (291) Show / Hide 
Range on Protein: 140-341
Range on HMM: 1-235/291
Sequence Identity: 25% (60 aa)

FADCNVLGEGGYGIVYKGKLPDGTP-----IAVKNLLNNR---GQAE---KEFRVEVEAIGRVRHKN----LVRLLGYCVE-GCHRMLVYEYVDNGNLEQ
.    ..|.|..| |.||.   ..      .|||.   .    ....   ..|. |..   ...|.|     ....| | . .||  .| ||...| |  
IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

WLHG-PISRTKS---------LTWEARMKIVLGTAKALAYLHEALEPKVVHRDIKSSNILIDS------TYNARISDFGLAKLLGAGKSHVTTRVMGTFG
 ||| ..    .          . .  |.. |  |....|||. . ....|||.||.|||||         ...|.|||... .   .    .  .||. 
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYA

YVAPEY---ANTGLLNERSDVYSFGVLLMEVVTGRDP
. |||    .  .  .| .||.|.||.| |..|.. |
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase IRAK-0_c-2.AA Pkinase_Tyr 145-341 30 6.3e-35 118.92 Pfam 6-214 (270) Show / Hide 
Range on Protein: 145-341
Range on HMM: 6-214/270
Sequence Identity: 30% (64 aa)

VLGEGGYGIVYKGKLP-----DGTPIAVKNLLNNRGQAE---KEFRVEVEAIGRV-RHKNLVRLLGYCV-EGCH--RMLVYEYVDNGNLEQWLHGPISRT
.|||| .| ||||..      ...| ||| | ..  . .   ..|  |..      .|.|.|||.| |. .| .   ..| ||. .|.|   |. . .  
KLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDK

KSLTWEARMKIVLGTAKALAYLHEALEPKVVHRDIKSSNILIDSTYNARISDFGLAKLL-GAGKS-HVTTRVMGTFGYVAPEYANTGLLNERSDVYSFGV
..|| .   .. .  ||...||..    . .|||.   |.|....  ..|.|||||...   .   ....  .      |||  |.|  .. |||.||||
QPLTMKDLLQMCWQIAKGMEYLESK---NCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGV

LLMEVVT-GRDP
|. |..| |. |
LMWEIFTYGEQP
Kinase IRAK-0_c-2.AA S_TKc 140-411 21 1.3e-34 122.26 SMART 1-231 (231) Show / Hide 
Range on Protein: 140-411
Range on HMM: 1-231/231
Sequence Identity: 21% (62 aa)

FADCNVLGEGGYGIVYKGKLPD-GTPIAVKNLLNNRGQAEKEFRVEVEAIGRVRHKNLVRLLGYCVEGCHRMLVYEYVDN--GNLEQWLHGPISRT--KS
.   ...|.|..| |||..  . |   |.| .        . .| |..   . .|.|.|.|......  |  .| ||.|.  |.| . ..   ..   . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LTWEARMKIVLGTAKALAYLHEALEPKVVHRDIKSSNILIDSTYNARISDFGLAKLLGAGKSHVTTRVMGTFGYVAPEYANTGLLNE-RSDVYSFGVLLM
..     ...  ...||.|.|.    ...|||.| .|||.|.  .  |.|||||..|        | . ||  |.|||       .  ..|..|.|..| 
FPE-HARFYMYQICCALEYCHSH---GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EVVTGRDPVDYSRPPSEVNLVDWLKLMVGQRRSEEVADPNLEPKPASRALKRALLVALRCVDPDSSKRPKMGHVVH---------ML
| ..|. | .        ..   .|...                      . |.    .| . | .|||    . .          .
EMLCGYPPFP--------QMQMMFKKIG---------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_c-2.AA Dicty4-Unclassified 144-341 31 4.8e-33 110.48 In-house 5-207 (263) Show / Hide 
Range on Protein: 144-341
Range on HMM: 5-207/263
Sequence Identity: 31% (66 aa)

NVLGEGGYGIVYKGKLPDGTPIAVKNLLNNRGQAE----KEFRVEVEAIGRVRHKNLVRLLGYCVEG-CHR---MLVYEYVDNGNLEQWLH-GPISRTKS
  .|.|    |.||    |  .||| .  |. ..     ..|. |||  | . | |||.. |||.    |.   . | |    |||    |  |  . ..
QFIGKGHFSKVHKGNW-KGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQP

LTWEA--RMKIVLGTAKALAYLHEALEPKVVHRDIKSSNILIDSTYNARISDFGLAKLLGAGKSHVTTRVMGTFGYVAPEYANTGLLNERSDVYSFGVLL
.  .    .|. .  |. ...||      ..||||||||||.|  .|..| |||..           | . ||    .||       | .|||||....|
IKLDDTLIIKYAFDIAQGMQHLHTR---NFIHRDIKSSNILMDKHFNIKIADFGISRVIDF--NFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMML

MEVVTGRDP
 | .||  |
YELATGDEP
Kinase IRAK-0_c-2.AA LISK-DD1 145-347 28 8.1e-30 105.06 In-house 1-236 (290) Show / Hide 
Range on Protein: 145-347
Range on HMM: 1-236/290
Sequence Identity: 28% (68 aa)

VLGEGGYGIVYKGKLPDGTPIAVKNLLN-----NRGQAEKEFRVEVEAIGR---VRHKNLVRLLGYCVE-------------GCHRMLVYEYVDNGNLEQ
  | |..|.|||| .  |||.|.| . .     |.   .|    |....      ||.|.|. .| |..             .   ..| |... |.| .
EIGKGSFGKVYKGCYF-GTPVAIKKIHKQPNDPNDPDYWKFMQREIKMLKNLLNIRHPNIVQFIGICEHPLASPSLVNRLLNESSLYIVTEFIEGGDLHW

WLHG-P--------ISRTKSLTWEARMKIVLGTAKALAYLHEALEPKVVHRDIKSSNILIDST----YNARISDFGLAKLLGAG-----KSHVTTRVMGT
 |   |        | . . ..|. |.|| |. |.| ||||.    ...||| || |||.|      . ... |||.|. .  .     ..| |    ||
YLKNTPFDDTPEQYIHHKIPIPWKLRVKIALDIACAMAYLHSK---NIIHRDLKSKNILVDENGDSQWRIKVCDFGFARMFEQKKNQQNNRHMT--ICGT

FGYVAPEYANTGLLNERSDVYSFGVLLMEVVTGRDPVDYSRP
 . .|||       ....||.|||..| |  |...|. . ..
DNWMAPEVILGMSYDWSCDVFSFGMVLLELITRKKPDKRMWQ
Kinase IRAK-0_c-2.AA MLK 392-411 35 0.004297 6.73 In-house 272-291 (291) Show / Hide 
Range on Protein: 392-411
Range on HMM: 272-291/291
Sequence Identity: 35% (7 aa)

RCVDPDSSKRPKMGHVVHML
.| ..|..|||.. ..|  |
QCWNQDPHKRPSFRQIVQHL
Kinase IRAK-0_c-2.AA LISK 387-411 28 0.19865 0.17 In-house 272-296 (296) Show / Hide 
Range on Protein: 387-411
Range on HMM: 272-296/296
Sequence Identity: 28% (7 aa)

LLVALRCVDPDSSKRPKMGHVVHML
| ....|.. | ..||.  ..|. |
LDLCFDCCKYDPKNRPSFKEIVQWL
Kinase IRAK-0_c-2.AA TKL-Unique 392-411 35 0.265804 0.57 In-house 271-290 (290) Show / Hide 
Range on Protein: 392-411
Range on HMM: 271-290/290
Sequence Identity: 35% (7 aa)

RCVDPDSSKRPKMGHVVHML
.| ..|.|.||    ..| |
QCWHHDPSQRPSFDEIIHRL
Kinase IRAK-0_c-2.AA Pkinase_Tyr 391-411 23 3.098978 1.42 Pfam 250-270 (270) Show / Hide 
Range on Protein: 391-411
Range on HMM: 250-270/270
Sequence Identity: 23% (5 aa)

LRCVDPDSSKRPKMGHVVHML
..| ..| ..|| .  ....|
KQCWHYDPEDRPTFSEIHEQL