Gene IRAK-0_aa-1 (S.moellendorffii)

IRAK-0_aa-1

Species: S.moellendorffii
Alias: IRAK-0_aa-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_aa-1.AA Protein None 352 None Fasta, JSON
IRAK-0_aa-1.NA RNA None 1059 None Fasta, JSON
IRAK-0_aa-1.kin_dom Protein Kinase Domain None 198 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_aa-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-0_aa-1.AA TKL 22-284 21 1.2e-65 224.46 In-house 1-364 (364) Show / Hide 
Range on Protein: 22-284
Range on HMM: 1-364/364
Sequence Identity: 21% (83 aa)

LGGGGFSTVYQGKLPD---------GRIVAVKKLNQGNKQGI---------------------------QQFQNEVNILSQVRHPNLVQLLGYCLEGRD-
.| |||..||.||.           |. |||||... | .                             ... .|....|. ||||.||..|||..... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LLLVYEFVLNGTLADHLHGEKGNGLSLETRITIALETAQALAYLHFYV-----KPPIYHRDVKTSNILLDKDFK--------------
            | .|.|.. .|.| ..||        .. |. .||..|....|||        |||| ||| |..|||.|....              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

AKVADFGLSRLTHLDATHISTA------------------PQGTPGYLDPDYHE----------------SYQLTDKSDVYSFGVVLLELISRKKAVDMT
.|..||||||  . .     |.                  . |||... |   .                ... . |.||||||.|| |...|..     
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-----

RDKKEINLASMALA----RIHSGALHELFDPDLS--------VKYWK--LLTRLVEVAFRCLAAEKDDRPSMVEVVREL
   ....  .| ..     . ... ..   | .         . ..    .... . . .| ... ..|||. |.. .|
-PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKM-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-0_aa-1.AA IRAK 16-217 36 2.1e-58 200.33 In-house 1-225 (317) Show / Hide 
Range on Protein: 16-217
Range on HMM: 1-225/317
Sequence Identity: 36% (83 aa)

FAESRLLGGGGFSTVYQGKLPDGR-IVAVKKLNQGNKQGI----QQFQN---EVNILSQVRHPNLVQLLGYCLEGRDLLLVYEFVLNGTLADHLHGEKG-
|......| ||| .||.|..     |.||||| ....  .    |.||    |. ...  ||||.| |.|||.|. .. |||..  ||.| | |.. .| 
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

NG---LSLETRITIALETAQALAYLHFYV-KPPIYHRDVKTSNILLDKDFKAKVADFGLSRLT----HLDATHI----STAPQGTPGYLDPDYHE--SYQ
.    ||  .|. |.. || .. .||    . || |.|.|..|||||..| .| .|||| |      |. .. .        .||  |. |..    . |
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LTDKSDVYSFGVVLLELISRKKAVD
|| |.||||||.||||...  .||.
LTKKTDVYSFGIVLLEVLTGCRAVY
Kinase IRAK-0_aa-1.AA TKL-Unique 19-213 31 1.7e-51 177.42 In-house 2-225 (290) Show / Hide 
Range on Protein: 19-213
Range on HMM: 2-225/290
Sequence Identity: 31% (71 aa)

SRLLGGGGFSTVYQGKLPDGRIVAVKKLNQ---GNKQGIQQFQNEVNILSQVR-HPNLVQLLGYCL----EGRDLLLVYEFVLNGTLADHLHG-------
. ..|.||...||.|| . | .||.|...     ... .| | ||||...  . |||.|.. |||        .. .| |..  |.| |.||        
WNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-EKGNGLSLETRITIALETAQALAYLHFYVKPPIYHRDVKTSNILLDKD-----FKAKVADFGLSRLTHLDATHIST--------APQGTPGYLDPDYHE
 .. . |... |...|.  ||.. |||.. .| |.||| |.||.|.| .     ...|..|||||..   . . ...         ..|.. .. |   .
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR

S--YQLTDKSDVYSFGVVLLELISRK
.  .| . ||||||||.|| |...||
MNFCQYSEKSDVYSFGIVLWEIATRK
Kinase IRAK-0_aa-1.AA Dicty4-Unclassified 19-210 38 1.4e-44 150.58 In-house 4-202 (263) Show / Hide 
Range on Protein: 19-210
Range on HMM: 4-202/263
Sequence Identity: 38% (80 aa)

SRLLGGGGFSTVYQGKLPDGRIVAVKKLNQGN-KQG---IQQFQNEVNILSQVRHPNLVQLLGYCLEG----RDLLLVYEFVLNGTLADHLH---GEKGN
 . .| | || |. |    |. |||||.| .  |     || |  || ||  . |||||.. |||.        .  | ||   |.|    |    |.  
DQFIGKGHFSKVHKGNW-KGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQ

GLSLET--RITIALETAQALAYLHFYVKPPIYHRDVKTSNILLDKDFKAKVADFGLSRLTHLDATHISTAPQGTPGYLDPD--YHESYQLTDKSDVYSFG
 ..|.    | .|.. || ...||      . |||.| ||||.||.| .|.||||.|| .  | .   |.  |||    |    ||||  . ||||||..
PIKLDDTLIIKYAFDIAQGMQHLHTR---NFIHRDIKSSNILMDKHFNIKIADFGISRVI--DFNFNMTTIAGTPKWESPECLMHESY--NQKSDVYSYA

VVLLELI
..| ||.
MMLYELA
Kinase IRAK-0_aa-1.AA Dicty4 16-209 32 1.5e-44 146.63 In-house 1-210 (277) Show / Hide 
Range on Protein: 16-209
Range on HMM: 1-210/277
Sequence Identity: 32% (71 aa)

FAESRLLGGGGFSTVYQGKLPDGRIVAVKKL--NQGN--KQGIQQFQNEVNILSQVRHPNLVQLLGYCL----EGRDLLLVYEFVLNGTLADHLHG----
 .   ..|.|.|..|| |.   | .||||||  .. |     .. | .||.|... ||||.....|.|.    .  ... | |..  |.|.  ||     
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

---EKGNGLSLETR-ITIALETAQALAYLHFYVK--PPIYHRDVKTSNILLDKDFKAKVADFGLSR--LTHLDATHISTAPQGTPGYLDPD--YHESYQL
   ..   ..| .| . .|. .|. ...||      | | ||| |..|.| ||....||.|||||.   .| | .   ... |||..  |    |..|  
QQQSIKLDWPLIKRAMRMAFDAARGMNWLH---CCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPY--

TDKSDVYSFGVVLLEL
. |.|||||| || |.
NEKADVYSFGIVLWEI
Kinase IRAK-0_aa-1.AA Pkinase 16-213 24 4.8e-44 156.81 Pfam 1-209 (293) Show / Hide 
Range on Protein: 16-213
Range on HMM: 1-209/293
Sequence Identity: 24% (53 aa)

FAESRLLGGGGFSTVYQGKLPDGRI-VAVKKLNQGNKQGIQQFQN-----EVNILSQVRHPNLVQLLGYCLEGRDLLLVYEFVLNG----TLADHLHGEK
.   | .| |.|..||...  . .. ||||...   ..  .. |.     |. |.  ..||| |.|.... ..... .| |.. .|     |.|......
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

GNGL--SLETRITIALETAQALAYLHFYVKPPIYHRDVKTSNILLDKDFKA----KVADFGLSR-LTHLDATHISTAPQGTPGYLDPDYHE-SYQLTDKS
....  | .. . ........|.|.|      | |||.| .|||.|..       |..||||.. .  .   .  | . |||.|. |  .  .   . |.
HGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVYSFGVVLLELISRK
|..|.|..| |.....
DMWSCGCILYEMLCGR
Kinase IRAK-0_aa-1.AA S_TKc 16-287 22 1.2e-42 148.87 SMART 1-231 (231) Show / Hide 
Range on Protein: 16-287
Range on HMM: 1-231/231
Sequence Identity: 22% (65 aa)

FAESRLLGGGGFSTVYQGKLPD-GRIVAVKKLNQGNKQGIQQFQNEVNILSQVRHPNLVQLLGYCLEGRDLLLVYEFVLN--GTLADHLHGEKGNG----
.   |..| |.|..||...  . |||||.|...       .....|..||.. .|||.|.|.... .  .| .| |.. .  |.| |...  ...|    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LSLETRITIALETAQALAYLHFYVKPPIYHRDVKTSNILLDKDFKAKVADFGLSRLTHLDATHISTAPQGTPGYLDPDYHESYQLTD-KSDVYSFGVVLL
..  .   .. ....||.|.|   .  | |||.| .|||||.    |..||||.|.         |   ||| |. |      . .  |.|..|.|..| 
FPE-HARFYMYQICCALEYCHSH-G--IIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELISRKKAVDMTRDKKEINLASMALARIHSGALHELFDPDLSVKYWKLLTRLVEVAFRCLAAEKDDRPSMVEVVR-E-----LEQL
|.....   .   ... ...                               . .   .||  . ..||.  |. . |      . .
EMLCGYPPFP--QMQMMFKKIG--------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_aa-1.AA TK 16-212 15 9.3e-40 130.45 In-house 1-390 (486) Show / Hide 
Range on Protein: 16-212
Range on HMM: 1-390/486
Sequence Identity: 15% (62 aa)

FAESRLLGGGGFS---TVYQGKLPDGR--------------------------IVAVKKLNQGNKQGIQQFQN--------------EVNILSQVR----
    . || | |    .||.|.. ...                           |||| |  |. .  ..|.               |...... .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNLVQLLGYCLEGRD------------LLLVYEFVLNGT----LADHLH--GEKGNG-----------------------------------------
 |||.|.|.|.|..|.             ...| |.. .|     | |.|.   .|..                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LSLETRITIALETAQALAYLHFY----VKPPIYHRDVKTSNILLDKDFK-----------AKVADFG--
                               |...... ...  |....|||      . . . |||. . |.|.... .           .|.||||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LSRLTHLDATHISTAPQGTPG-------------------------YLDPDYHESYQ------------LTDKSDVYSFGVVLLELISR
      |.|  . |    .. ..||..                         .. |   |. .             | ||||.||||.. |. ..
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAP---ECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTY
Kinase IRAK-0_aa-1.AA LRRK 16-217 27 1.1e-39 138.02 In-house 1-284 (351) Show / Hide 
Range on Protein: 16-217
Range on HMM: 1-284/351
Sequence Identity: 27% (80 aa)

FAESRLLGGGGFS-TVYQGKLPD---------------------------GRIVAVKKLNQG---------NKQG-------------------------
. . ...| |||  .||..|. .                           .  ||.||.| .         |  .                         
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

IQQFQNEVNILSQVRHPNLVQLLGYCLEGRDLLLVYEFVLNGTLADHLHGEKGNG-------LSLETRITIALETAQALAYLHFYVKPPIYHRDVKTSNI
 . |..|| |.|  .|||.|.|.|.|.  . | .| |.. .|.| ..|| .| .|       .|  ... |||. | ...|||   .||| ||| |. ||
FREFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH-SHNPPIIHRDLKSPNI

LL---D---------KDFKAKVADFGLSR-LTHLDATHISTAPQGTPGYLDP---DYH--ESYQLTDKSDVYSFGVVLLELISRK-KAVD
||   .          . .||.||||.||     . . .     |.||.. |    |   |.|  |.|.|.||||..| ||..|.  . |
LLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEY--TEKVDCYSFGMILWELLTRQHHPFD
Kinase IRAK-0_aa-1.AA MLK 16-213 27 5.5e-37 125.87 In-house 1-233 (291) Show / Hide 
Range on Protein: 16-213
Range on HMM: 1-233/291
Sequence Identity: 27% (65 aa)

FAESRLLGGGGFSTVYQGKLPDGR----IVAVKKLN---QGNKQG----IQQFQNEVNILSQVRHPN----LVQLLGYCLE-GRDLLLVYEFVLNGTLAD
. ... .| |.|  |. |.    .    |||||. .      |.     ...|. |...|. ..|||     .|..| ||. . ....| |.. .| |..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

HLHGEKG------------NGLSLETRITIALETAQALAYLHFYVKPPIYHRDVKTSNILLD------KDFKAKVADFGLSR-LTHLDATHISTAPQGTP
 |||...               ...  ...||  |....|||   ..|| ||| | .|||.|      .. ..|..|||.|| ... .... |.|  ||.
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNA--GTY

GYLDPDY---HESYQLTDKSDVYSFGVVLLELISRK
 .  |      .. . . |.||.|.|||| |...|.
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase IRAK-0_aa-1.AA DRK 23-213 34 4.3e-35 116.3 In-house 8-199 (258) Show / Hide 
Range on Protein: 23-213
Range on HMM: 8-199/258
Sequence Identity: 34% (68 aa)

GGGGFSTVYQGKLPDGRIVAVKKLNQGNKQ---GIQQFQNEVNILSQVRHPNLVQLLGYCLEGRDLLLVYEFVLNGTLADHLHGEKGNGLSLETRITIAL
| |..  |. |    | .||||.|   |      .. |. |.|...| |||| .| .| |..  | . . |.   | |.  || |.   ..   .. ...
GRGNYGEVFRGTW-RGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIE-MDWPLMKQMMF

ETAQALAYLHFYVKPPIYHRDVKTSNILLDKDFKAKVADFGLSRLT----HLDATHISTAPQGTPGYLDPDYHESYQLTDKSDVYSFGVVLLELISRK
  |  . |||    | | ||| |. | | |  .. ||||||||  |    |.. .   |.  |||.   |    .   | | |||||..|| |.. |.
DCAKGMIYLH-CCNPIIIHRDLKSHNLLVDEHWQVKVADFGLS--TRFKKHKQHKFAMTM-CGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVTRQ
Kinase IRAK-0_aa-1.AA Pkinase_Tyr 16-168 28 1.4e-33 114.4 Pfam 1-164 (270) Show / Hide 
Range on Protein: 16-168
Range on HMM: 1-164/270
Sequence Identity: 28% (47 aa)

FAESRLLGGGGFSTVYQGKLP-----DGRIVAVKKLNQGNKQG---IQQFQNEVNILSQV-RHPNLVQLLGYCL-EGRD--LLLVYEFVLNGTLADHLHG
    . || | | .||.|..      ..  ||||.|..|  .    .. | .|..|..|  .|||.|.|.| |. .|.   ...| |.. .| | |.|. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

E--KGNGLSLETRITIALETAQALAYLHFYVKPPIYHRDVKTSNILLDKDFKAKVADFGLSRLTHLD
    .. |.... . .... |....||.      . |||. . |.|.......|..||||.|. . |
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYND
Kinase IRAK-0_aa-1.AA TK-Unique 16-211 23 1.4e-30 102.73 In-house 1-234 (294) Show / Hide 
Range on Protein: 16-211
Range on HMM: 1-234/294
Sequence Identity: 23% (55 aa)

FAESRLLGGGGFSTVYQGKLPD-------GRIVAVKKLNQGNKQG-IQQFQNEVNILSQVR-HPNLVQLLGYCLEGR-DLLLVYEFVLNGTLADHLHGEK
.   ...| | |..|. |..          ..||||.|. .. .   |.| .| ......  |||.||.||.| .   . ....|.. .|.| ..|.  .
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

GN------------------------GLSLETRITIALETAQALAYLHF--Y-VKPPIYHRDVKTSNILLDKDFKAKVADFGLSRLTHLDATHISTAPQG
..                         .|... ...| . |....||.   . .     |||. ..|.||  |...|..|||..| .. .  ....  ||
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKI----VHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQG

TPG--YLDPDYHE--SYQL-TDKSDVYSFGVVLLELIS
.    .. |..      .  | ||||.||||.. |. .
RIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase IRAK-0_aa-1.AA TyrKc 16-284 22 1.3e-24 88.98 SMART 1-280 (280) Show / Hide 
Range on Protein: 16-284
Range on HMM: 1-280/280
Sequence Identity: 22% (67 aa)

FAESRLLGGGGFSTVYQGKLPDGRIVAVKKLNQGNKQGIQQFQNEVNILSQV--RHPNLVQLLGYCLEG-------RDLLLVYEFVLNGTLADHLHGEKG
    . || | | .||.|..   . ||||.|. .    .. | .| .|....  .|||.|.|.|.|...         |..| |.. .| | |.|.  ..
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

NGLSLETRITIALETAQALAYLHFYVKPPIYHRDVKTSNILLDKDFKAKVADFGLSRLTHLD--------ATHISTAPQGT---------PGYLDPDYHE
. |.... . ...  |.  .|||     .. |||  . |.|..... .|..||||||  . |          . ..  .|          |  .      
K-LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-----N

SYQLTDKSDVYSFGVVLLELISR--KKAVDMTRDKKEINLASMALARIHSGALHELFDPDLSVKYWK-----LLTRLVEVAFRCLAAEKDDRPSMVEVVR
 .  | ||||.||||.. |. ..  .   .|.        .. ..... .|   .  . |.             . . ..  .| ... .|||.. |...
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ---MMSNQEVIEYVKQGYRMPQPPNDY-----PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHE

EL
..
CF
Kinase IRAK-0_aa-1.AA TK 265-284 25 0.001137 7.33 In-house 467-486 (486) Show / Hide 
Range on Protein: 265-284
Range on HMM: 467-486/486
Sequence Identity: 25% (5 aa)

RCLAAEKDDRPSMVEVVREL
.| ... .|||.. .....|
QCWHYDPEDRPTFSQLHEQL
Kinase IRAK-0_aa-1.AA IRAK 259-284 23 0.002498 7.85 In-house 292-317 (317) Show / Hide 
Range on Protein: 259-284
Range on HMM: 292-317/317
Sequence Identity: 23% (6 aa)

LVEVAFRCLAAEKDDRPSMVEVVREL
.  .| .|... .  |..| .|. .|
MCQCACCCGHHRANRRCDMAWVMQQL
Kinase IRAK-0_aa-1.AA Pkinase_Tyr 194-212 52 0.005414 10.76 Pfam 192-210 (270) Show / Hide 
Range on Protein: 194-212
Range on HMM: 192-210/270
Sequence Identity: 52% (10 aa)

TDKSDVYSFGVVLLELISR
| ||||.||||.. |....
TTKSDVWSFGVLMWEIFTY
Kinase IRAK-0_aa-1.AA Dicty4 274-286 40 0.015009 4.52 In-house 263-277 (277) Show / Hide 
Range on Protein: 274-286
Range on HMM: 263-277/277
Sequence Identity: 40% (6 aa)

RPSMVEVVRE--LEQ
|||. |.. .  || 
RPSFEEIIQRRILEH
Kinase IRAK-0_aa-1.AA DRK 265-286 36 0.022096 3.92 In-house 237-258 (258) Show / Hide 
Range on Protein: 265-286
Range on HMM: 237-258/258
Sequence Identity: 36% (8 aa)

RCLAAEKDDRPSMVEVVRELEQ
.|.  .   |||| |..  || 
DCWNEDPQHRPSMQECLERLEA
Kinase IRAK-0_aa-1.AA Pkinase_Tyr 265-284 30 0.028829 8.3 Pfam 251-270 (270) Show / Hide 
Range on Protein: 265-284
Range on HMM: 251-270/270
Sequence Identity: 30% (6 aa)

RCLAAEKDDRPSMVEVVREL
.| ... .|||.. |....|
QCWHYDPEDRPTFSEIHEQL
Kinase IRAK-0_aa-1.AA MLK 265-284 30 0.067724 2.52 In-house 272-291 (291) Show / Hide 
Range on Protein: 265-284
Range on HMM: 272-291/291
Sequence Identity: 30% (6 aa)

RCLAAEKDDRPSMVEVVREL
.|  ..  .|||. ..| .|
QCWNQDPHKRPSFRQIVQHL
Kinase IRAK-0_aa-1.AA TKL-Unique 265-284 30 0.08438 2.35 In-house 271-290 (290) Show / Hide 
Range on Protein: 265-284
Range on HMM: 271-290/290
Sequence Identity: 30% (6 aa)

RCLAAEKDDRPSMVEVVREL
.| . . ..|||  |.. .|
QCWHHDPSQRPSFDEIIHRL
Kinase IRAK-0_aa-1.AA TK-Unique 266-284 31 0.094105 1.97 In-house 276-294 (294) Show / Hide 
Range on Protein: 266-284
Range on HMM: 276-294/294
Sequence Identity: 31% (6 aa)

CLAAEKDDRPSMVEVVREL
|.  | ..|||  ... .|
CWQWEPEERPSFRQIKHRL
Kinase IRAK-0_aa-1.AA LRRK 266-286 28 0.115611 1.64 In-house 331-351 (351) Show / Hide 
Range on Protein: 266-286
Range on HMM: 331-351/351
Sequence Identity: 28% (6 aa)

CLAAEKDDRPSMVEVVRELEQ
| ... ..||.. ..|  |.|
CWQHDPKKRPHFSQIVKRLSQ