Gene IRAK-0_aa-2 (S.moellendorffii)

IRAK-0_aa-2

Species: S.moellendorffii
Alias: IRAK-0_aa-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_aa-2.AA Protein None 351 None Fasta, JSON
IRAK-0_aa-2.NA RNA None 1056 None Fasta, JSON
IRAK-0_aa-2.kin_dom Protein Kinase Domain None 198 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_aa-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-0_aa-2.AA TKL 21-283 21 1.2e-65 224.46 In-house 1-364 (364) Show / Hide 
Range on Protein: 21-283
Range on HMM: 1-364/364
Sequence Identity: 21% (83 aa)

LGGGGFSTVYQGKLPD---------GRIVAVKKLNQGNKQGI---------------------------QQFQNEVNILSQVRHPNLVQLLGYCLEGRD-
.| |||..||.||.           |. |||||... | .                             ... .|....|. ||||.||..|||..... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LLLVYEFVLNGTLADHLHGEKGNGLSLETRITIALETAQALAYLHFYV-----KPPIYHRDVKTSNILLDKDFK--------------
            | .|.|.. .|.| ..||        .. |. .||..|....|||        |||| ||| |..|||.|....              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

AKVADFGLSRLTHLDATHISTA------------------PQGTPGYLDPDYHE----------------SYQLTDKSDVYSFGVVLLELISRKKAVDMT
.|..||||||  . .     |.                  . |||... |   .                ... . |.||||||.|| |...|..     
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-----

RDKKEINLASMALA----RIHSGALHELFDPDLS--------VKYWK--LLTRLVEVAFRCLAAEKDDRPSMVEVVREL
   ....  .| ..     . ... ..   | .         . ..    .... . . .| ... ..|||. |.. .|
-PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKM-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-0_aa-2.AA IRAK 15-216 36 2.1e-58 200.33 In-house 1-225 (317) Show / Hide 
Range on Protein: 15-216
Range on HMM: 1-225/317
Sequence Identity: 36% (83 aa)

FAESRLLGGGGFSTVYQGKLPDGR-IVAVKKLNQGNKQGI----QQFQN---EVNILSQVRHPNLVQLLGYCLEGRDLLLVYEFVLNGTLADHLHGEKG-
|......| ||| .||.|..     |.||||| ....  .    |.||    |. ...  ||||.| |.|||.|. .. |||..  ||.| | |.. .| 
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

NG---LSLETRITIALETAQALAYLHFYV-KPPIYHRDVKTSNILLDKDFKAKVADFGLSRLT----HLDATHI----STAPQGTPGYLDPDYHE--SYQ
.    ||  .|. |.. || .. .||    . || |.|.|..|||||..| .| .|||| |      |. .. .        .||  |. |..    . |
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LTDKSDVYSFGVVLLELISRKKAVD
|| |.||||||.||||...  .||.
LTKKTDVYSFGIVLLEVLTGCRAVY
Kinase IRAK-0_aa-2.AA TKL-Unique 18-212 31 1.7e-51 177.42 In-house 2-225 (290) Show / Hide 
Range on Protein: 18-212
Range on HMM: 2-225/290
Sequence Identity: 31% (71 aa)

SRLLGGGGFSTVYQGKLPDGRIVAVKKLNQ---GNKQGIQQFQNEVNILSQVR-HPNLVQLLGYCL----EGRDLLLVYEFVLNGTLADHLHG-------
. ..|.||...||.|| . | .||.|...     ... .| | ||||...  . |||.|.. |||        .. .| |..  |.| |.||        
WNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-EKGNGLSLETRITIALETAQALAYLHFYVKPPIYHRDVKTSNILLDKD-----FKAKVADFGLSRLTHLDATHIST--------APQGTPGYLDPDYHE
 .. . |... |...|.  ||.. |||.. .| |.||| |.||.|.| .     ...|..|||||..   . . ...         ..|.. .. |   .
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR

S--YQLTDKSDVYSFGVVLLELISRK
.  .| . ||||||||.|| |...||
MNFCQYSEKSDVYSFGIVLWEIATRK
Kinase IRAK-0_aa-2.AA Dicty4-Unclassified 18-209 38 1.4e-44 150.58 In-house 4-202 (263) Show / Hide 
Range on Protein: 18-209
Range on HMM: 4-202/263
Sequence Identity: 38% (80 aa)

SRLLGGGGFSTVYQGKLPDGRIVAVKKLNQGN-KQG---IQQFQNEVNILSQVRHPNLVQLLGYCLEG----RDLLLVYEFVLNGTLADHLH---GEKGN
 . .| | || |. |    |. |||||.| .  |     || |  || ||  . |||||.. |||.        .  | ||   |.|    |    |.  
DQFIGKGHFSKVHKGNW-KGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQ

GLSLET--RITIALETAQALAYLHFYVKPPIYHRDVKTSNILLDKDFKAKVADFGLSRLTHLDATHISTAPQGTPGYLDPD--YHESYQLTDKSDVYSFG
 ..|.    | .|.. || ...||      . |||.| ||||.||.| .|.||||.|| .  | .   |.  |||    |    ||||  . ||||||..
PIKLDDTLIIKYAFDIAQGMQHLHTR---NFIHRDIKSSNILMDKHFNIKIADFGISRVI--DFNFNMTTIAGTPKWESPECLMHESY--NQKSDVYSYA

VVLLELI
..| ||.
MMLYELA
Kinase IRAK-0_aa-2.AA Dicty4 15-208 32 1.5e-44 146.63 In-house 1-210 (277) Show / Hide 
Range on Protein: 15-208
Range on HMM: 1-210/277
Sequence Identity: 32% (71 aa)

FAESRLLGGGGFSTVYQGKLPDGRIVAVKKL--NQGN--KQGIQQFQNEVNILSQVRHPNLVQLLGYCL----EGRDLLLVYEFVLNGTLADHLHG----
 .   ..|.|.|..|| |.   | .||||||  .. |     .. | .||.|... ||||.....|.|.    .  ... | |..  |.|.  ||     
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

---EKGNGLSLETR-ITIALETAQALAYLHFYVK--PPIYHRDVKTSNILLDKDFKAKVADFGLSR--LTHLDATHISTAPQGTPGYLDPD--YHESYQL
   ..   ..| .| . .|. .|. ...||      | | ||| |..|.| ||....||.|||||.   .| | .   ... |||..  |    |..|  
QQQSIKLDWPLIKRAMRMAFDAARGMNWLH---CCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPY--

TDKSDVYSFGVVLLEL
. |.|||||| || |.
NEKADVYSFGIVLWEI
Kinase IRAK-0_aa-2.AA Pkinase 15-212 24 4.8e-44 156.81 Pfam 1-209 (293) Show / Hide 
Range on Protein: 15-212
Range on HMM: 1-209/293
Sequence Identity: 24% (53 aa)

FAESRLLGGGGFSTVYQGKLPDGRI-VAVKKLNQGNKQGIQQFQN-----EVNILSQVRHPNLVQLLGYCLEGRDLLLVYEFVLNG----TLADHLHGEK
.   | .| |.|..||...  . .. ||||...   ..  .. |.     |. |.  ..||| |.|.... ..... .| |.. .|     |.|......
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

GNGL--SLETRITIALETAQALAYLHFYVKPPIYHRDVKTSNILLDKDFKA----KVADFGLSR-LTHLDATHISTAPQGTPGYLDPDYHE-SYQLTDKS
....  | .. . ........|.|.|      | |||.| .|||.|..       |..||||.. .  .   .  | . |||.|. |  .  .   . |.
HGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVYSFGVVLLELISRK
|..|.|..| |.....
DMWSCGCILYEMLCGR
Kinase IRAK-0_aa-2.AA S_TKc 15-286 22 1.2e-42 148.87 SMART 1-231 (231) Show / Hide 
Range on Protein: 15-286
Range on HMM: 1-231/231
Sequence Identity: 22% (65 aa)

FAESRLLGGGGFSTVYQGKLPD-GRIVAVKKLNQGNKQGIQQFQNEVNILSQVRHPNLVQLLGYCLEGRDLLLVYEFVLN--GTLADHLHGEKGNG----
.   |..| |.|..||...  . |||||.|...       .....|..||.. .|||.|.|.... .  .| .| |.. .  |.| |...  ...|    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LSLETRITIALETAQALAYLHFYVKPPIYHRDVKTSNILLDKDFKAKVADFGLSRLTHLDATHISTAPQGTPGYLDPDYHESYQLTD-KSDVYSFGVVLL
..  .   .. ....||.|.|   .  | |||.| .|||||.    |..||||.|.         |   ||| |. |      . .  |.|..|.|..| 
FPE-HARFYMYQICCALEYCHSH-G--IIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELISRKKAVDMTRDKKEINLASMALARIHSGALHELFDPDLSVKYWKLLTRLVEVAFRCLAAEKDDRPSMVEVVR-E-----LEQL
|.....   .   ... ...                               . .   .||  . ..||.  |. . |      . .
EMLCGYPPFP--QMQMMFKKIG--------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_aa-2.AA TK 15-211 15 9.3e-40 130.45 In-house 1-390 (486) Show / Hide 
Range on Protein: 15-211
Range on HMM: 1-390/486
Sequence Identity: 15% (62 aa)

FAESRLLGGGGFS---TVYQGKLPDGR--------------------------IVAVKKLNQGNKQGIQQFQN--------------EVNILSQVR----
    . || | |    .||.|.. ...                           |||| |  |. .  ..|.               |...... .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNLVQLLGYCLEGRD------------LLLVYEFVLNGT----LADHLH--GEKGNG-----------------------------------------
 |||.|.|.|.|..|.             ...| |.. .|     | |.|.   .|..                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LSLETRITIALETAQALAYLHFY----VKPPIYHRDVKTSNILLDKDFK-----------AKVADFG--
                               |...... ...  |....|||      . . . |||. . |.|.... .           .|.||||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LSRLTHLDATHISTAPQGTPG-------------------------YLDPDYHESYQ------------LTDKSDVYSFGVVLLELISR
      |.|  . |    .. ..||..                         .. |   |. .             | ||||.||||.. |. ..
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAP---ECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTY
Kinase IRAK-0_aa-2.AA LRRK 15-216 27 1.1e-39 138.02 In-house 1-284 (351) Show / Hide 
Range on Protein: 15-216
Range on HMM: 1-284/351
Sequence Identity: 27% (80 aa)

FAESRLLGGGGFS-TVYQGKLPD---------------------------GRIVAVKKLNQG---------NKQG-------------------------
. . ...| |||  .||..|. .                           .  ||.||.| .         |  .                         
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

IQQFQNEVNILSQVRHPNLVQLLGYCLEGRDLLLVYEFVLNGTLADHLHGEKGNG-------LSLETRITIALETAQALAYLHFYVKPPIYHRDVKTSNI
 . |..|| |.|  .|||.|.|.|.|.  . | .| |.. .|.| ..|| .| .|       .|  ... |||. | ...|||   .||| ||| |. ||
FREFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH-SHNPPIIHRDLKSPNI

LL---D---------KDFKAKVADFGLSR-LTHLDATHISTAPQGTPGYLDP---DYH--ESYQLTDKSDVYSFGVVLLELISRK-KAVD
||   .          . .||.||||.||     . . .     |.||.. |    |   |.|  |.|.|.||||..| ||..|.  . |
LLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEY--TEKVDCYSFGMILWELLTRQHHPFD
Kinase IRAK-0_aa-2.AA MLK 15-212 27 5.5e-37 125.87 In-house 1-233 (291) Show / Hide 
Range on Protein: 15-212
Range on HMM: 1-233/291
Sequence Identity: 27% (65 aa)

FAESRLLGGGGFSTVYQGKLPDGR----IVAVKKLN---QGNKQG----IQQFQNEVNILSQVRHPN----LVQLLGYCLE-GRDLLLVYEFVLNGTLAD
. ... .| |.|  |. |.    .    |||||. .      |.     ...|. |...|. ..|||     .|..| ||. . ....| |.. .| |..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

HLHGEKG------------NGLSLETRITIALETAQALAYLHFYVKPPIYHRDVKTSNILLD------KDFKAKVADFGLSR-LTHLDATHISTAPQGTP
 |||...               ...  ...||  |....|||   ..|| ||| | .|||.|      .. ..|..|||.|| ... .... |.|  ||.
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNA--GTY

GYLDPDY---HESYQLTDKSDVYSFGVVLLELISRK
 .  |      .. . . |.||.|.|||| |...|.
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase IRAK-0_aa-2.AA DRK 22-212 34 4.3e-35 116.3 In-house 8-199 (258) Show / Hide 
Range on Protein: 22-212
Range on HMM: 8-199/258
Sequence Identity: 34% (68 aa)

GGGGFSTVYQGKLPDGRIVAVKKLNQGNKQ---GIQQFQNEVNILSQVRHPNLVQLLGYCLEGRDLLLVYEFVLNGTLADHLHGEKGNGLSLETRITIAL
| |..  |. |    | .||||.|   |      .. |. |.|...| |||| .| .| |..  | . . |.   | |.  || |.   ..   .. ...
GRGNYGEVFRGTW-RGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIE-MDWPLMKQMMF

ETAQALAYLHFYVKPPIYHRDVKTSNILLDKDFKAKVADFGLSRLT----HLDATHISTAPQGTPGYLDPDYHESYQLTDKSDVYSFGVVLLELISRK
  |  . |||    | | ||| |. | | |  .. ||||||||  |    |.. .   |.  |||.   |    .   | | |||||..|| |.. |.
DCAKGMIYLH-CCNPIIIHRDLKSHNLLVDEHWQVKVADFGLS--TRFKKHKQHKFAMTM-CGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVTRQ
Kinase IRAK-0_aa-2.AA Pkinase_Tyr 15-167 28 1.4e-33 114.4 Pfam 1-164 (270) Show / Hide 
Range on Protein: 15-167
Range on HMM: 1-164/270
Sequence Identity: 28% (47 aa)

FAESRLLGGGGFSTVYQGKLP-----DGRIVAVKKLNQGNKQG---IQQFQNEVNILSQV-RHPNLVQLLGYCL-EGRD--LLLVYEFVLNGTLADHLHG
    . || | | .||.|..      ..  ||||.|..|  .    .. | .|..|..|  .|||.|.|.| |. .|.   ...| |.. .| | |.|. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

E--KGNGLSLETRITIALETAQALAYLHFYVKPPIYHRDVKTSNILLDKDFKAKVADFGLSRLTHLD
    .. |.... . .... |....||.      . |||. . |.|.......|..||||.|. . |
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYND
Kinase IRAK-0_aa-2.AA TK-Unique 15-210 23 1.4e-30 102.73 In-house 1-234 (294) Show / Hide 
Range on Protein: 15-210
Range on HMM: 1-234/294
Sequence Identity: 23% (55 aa)

FAESRLLGGGGFSTVYQGKLPD-------GRIVAVKKLNQGNKQG-IQQFQNEVNILSQVR-HPNLVQLLGYCLEGR-DLLLVYEFVLNGTLADHLHGEK
.   ...| | |..|. |..          ..||||.|. .. .   |.| .| ......  |||.||.||.| .   . ....|.. .|.| ..|.  .
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

GN------------------------GLSLETRITIALETAQALAYLHF--Y-VKPPIYHRDVKTSNILLDKDFKAKVADFGLSRLTHLDATHISTAPQG
..                         .|... ...| . |....||.   . .     |||. ..|.||  |...|..|||..| .. .  ....  ||
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKI----VHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQG

TPG--YLDPDYHE--SYQL-TDKSDVYSFGVVLLELIS
.    .. |..      .  | ||||.||||.. |. .
RIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase IRAK-0_aa-2.AA TyrKc 15-283 22 1.3e-24 88.98 SMART 1-280 (280) Show / Hide 
Range on Protein: 15-283
Range on HMM: 1-280/280
Sequence Identity: 22% (67 aa)

FAESRLLGGGGFSTVYQGKLPDGRIVAVKKLNQGNKQGIQQFQNEVNILSQV--RHPNLVQLLGYCLEG-------RDLLLVYEFVLNGTLADHLHGEKG
    . || | | .||.|..   . ||||.|. .    .. | .| .|....  .|||.|.|.|.|...         |..| |.. .| | |.|.  ..
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

NGLSLETRITIALETAQALAYLHFYVKPPIYHRDVKTSNILLDKDFKAKVADFGLSRLTHLD--------ATHISTAPQGT---------PGYLDPDYHE
. |.... . ...  |.  .|||     .. |||  . |.|..... .|..||||||  . |          . ..  .|          |  .      
K-LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-----N

SYQLTDKSDVYSFGVVLLELISR--KKAVDMTRDKKEINLASMALARIHSGALHELFDPDLSVKYWK-----LLTRLVEVAFRCLAAEKDDRPSMVEVVR
 .  | ||||.||||.. |. ..  .   .|.        .. ..... .|   .  . |.             . . ..  .| ... .|||.. |...
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ---MMSNQEVIEYVKQGYRMPQPPNDY-----PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHE

EL
..
CF
Kinase IRAK-0_aa-2.AA TK 264-283 25 0.001137 7.33 In-house 467-486 (486) Show / Hide 
Range on Protein: 264-283
Range on HMM: 467-486/486
Sequence Identity: 25% (5 aa)

RCLAAEKDDRPSMVEVVREL
.| ... .|||.. .....|
QCWHYDPEDRPTFSQLHEQL
Kinase IRAK-0_aa-2.AA IRAK 258-283 23 0.002498 7.85 In-house 292-317 (317) Show / Hide 
Range on Protein: 258-283
Range on HMM: 292-317/317
Sequence Identity: 23% (6 aa)

LVEVAFRCLAAEKDDRPSMVEVVREL
.  .| .|... .  |..| .|. .|
MCQCACCCGHHRANRRCDMAWVMQQL
Kinase IRAK-0_aa-2.AA Pkinase_Tyr 193-211 52 0.005414 10.76 Pfam 192-210 (270) Show / Hide 
Range on Protein: 193-211
Range on HMM: 192-210/270
Sequence Identity: 52% (10 aa)

TDKSDVYSFGVVLLELISR
| ||||.||||.. |....
TTKSDVWSFGVLMWEIFTY
Kinase IRAK-0_aa-2.AA Dicty4 273-285 40 0.015009 4.52 In-house 263-277 (277) Show / Hide 
Range on Protein: 273-285
Range on HMM: 263-277/277
Sequence Identity: 40% (6 aa)

RPSMVEVVRE--LEQ
|||. |.. .  || 
RPSFEEIIQRRILEH
Kinase IRAK-0_aa-2.AA DRK 264-285 36 0.022096 3.92 In-house 237-258 (258) Show / Hide 
Range on Protein: 264-285
Range on HMM: 237-258/258
Sequence Identity: 36% (8 aa)

RCLAAEKDDRPSMVEVVRELEQ
.|.  .   |||| |..  || 
DCWNEDPQHRPSMQECLERLEA
Kinase IRAK-0_aa-2.AA Pkinase_Tyr 264-283 30 0.028829 8.3 Pfam 251-270 (270) Show / Hide 
Range on Protein: 264-283
Range on HMM: 251-270/270
Sequence Identity: 30% (6 aa)

RCLAAEKDDRPSMVEVVREL
.| ... .|||.. |....|
QCWHYDPEDRPTFSEIHEQL
Kinase IRAK-0_aa-2.AA MLK 264-283 30 0.067724 2.52 In-house 272-291 (291) Show / Hide 
Range on Protein: 264-283
Range on HMM: 272-291/291
Sequence Identity: 30% (6 aa)

RCLAAEKDDRPSMVEVVREL
.|  ..  .|||. ..| .|
QCWNQDPHKRPSFRQIVQHL
Kinase IRAK-0_aa-2.AA TKL-Unique 264-283 30 0.08438 2.35 In-house 271-290 (290) Show / Hide 
Range on Protein: 264-283
Range on HMM: 271-290/290
Sequence Identity: 30% (6 aa)

RCLAAEKDDRPSMVEVVREL
.| . . ..|||  |.. .|
QCWHHDPSQRPSFDEIIHRL
Kinase IRAK-0_aa-2.AA TK-Unique 265-283 31 0.094105 1.97 In-house 276-294 (294) Show / Hide 
Range on Protein: 265-283
Range on HMM: 276-294/294
Sequence Identity: 31% (6 aa)

CLAAEKDDRPSMVEVVREL
|.  | ..|||  ... .|
CWQWEPEERPSFRQIKHRL
Kinase IRAK-0_aa-2.AA LRRK 265-285 28 0.115611 1.64 In-house 331-351 (351) Show / Hide 
Range on Protein: 265-285
Range on HMM: 331-351/351
Sequence Identity: 28% (6 aa)

CLAAEKDDRPSMVEVVRELEQ
| ... ..||.. ..|  |.|
CWQHDPKKRPHFSQIVKRLSQ