Gene IRAK-0_ac (S.moellendorffii)

IRAK-0_ac

Species: S.moellendorffii
Alias: IRAK-0_ac
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_ac.AA Protein None 822 None Fasta, JSON
IRAK-0_ac.NA RNA None 2469 None Fasta, JSON
IRAK-0_ac.kin_dom Protein Kinase Domain None 184 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_ac.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRR_1 IRAK-0_ac.AA LRR_1 10-23 35 34.522179 1.29 Pfam 11-26 (26) Show / Hide 
Range on Protein: 10-23
Range on HMM: 11-26/26
Sequence Identity: 35% (6 aa)

N--KLSGPLPSS-LGRL
|  .|.| .|.| .  |
NCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_ac.AA LRR_1 25-47 25 0.376545 8.25 Pfam 1-26 (26) Show / Hide 
Range on Protein: 25-47
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

NLVSIGFGS-N--DFSGTLPRE-IGNL
|| .. ... |   ..|..| . . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_ac.AA LRR_1 49-71 33 0.015128 13.2 Pfam 1-26 (26) Show / Hide 
Range on Protein: 49-71
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLRKIYMDAC---NLGGELPEE-FGNL
.|...... |   || |..|.. | ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_ac.AA LRR_1 73-95 29 0.022628 12.58 Pfam 1-26 (26) Show / Hide 
Range on Protein: 73-95
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLEILWMAG-N--NFNGTFPEF-IGRL
.|..| . | |  |. |..|.  .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_ac.AA LRR_1 121-142 33 0.032552 12.02 Pfam 1-26 (26) Show / Hide 
Range on Protein: 121-142
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

GINKLMLRNC---ELSGSIPD--LGNL
 . .| |..|    |.|.||.  . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_ac.AA LRR_1 144-166 51 0.000222 19.7 Pfam 1-26 (26) Show / Hide 
Range on Protein: 144-166
Range on HMM: 1-26/26
Sequence Identity: 51% (14 aa)

TLAHLDLSF-N--NLTGVIPSS-LWAF
.| |||||  |  |||| ||.| . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_ac.AA LRR_1 168-187 38 0.339386 8.41 Pfam 1-26 (26) Show / Hide 
Range on Protein: 168-187
Range on HMM: 1-26/26
Sequence Identity: 38% (10 aa)

SLQNLLLGS-N--RLTGPLPS---QL
.|| | |.. |  .||| .|.   .|
NLQHLDLSGCNCCNLTGHIPPSCFNL
Malectin IRAK-0_ac.AA Malectin 249-411 35 2.4e-43 155.1 Pfam 1-179 (202) Show / Hide 
Range on Protein: 249-411
Range on HMM: 1-179/202
Sequence Identity: 35% (64 aa)

YQFAINCGGPQI--TSSSGTMFSEDTAMFTMGT----FTSNDQAWVVGSTGYSDGFVRA----FENTTVPVLGTVDR---GLYQTSRSAPSSLRYIGLGM
| ..|||||| .  |.|.|...  |..    ..    . | .. | . .  ..|    .    .  |......| |     |||| | .|||.|| ....
YSWHINCGGPEHYTTDSDGITYEADNHFTGGSAASDYYVSRNNWWGYSTGDFMDDDNNQYYYGYITTNSSIFYTTDDVDPELYQTERWSPSSFRYYIPCL

VNGAYTLEFHFAEIQLDN-STTWLGITRRLFDIYLQGTQRVKDFNIQNEAGGSSRALVRTFRNVEVTNNVLD--MHFVW
 || ||.. |||||.  . . || .  || ||.|.||   .|||.|  ||||...| .. | ||.|||..|.   || |
ENGNYTVILHFAEIYFQDTDQTWNSPGRRVFDVYIQGKLVLKDFDIWKEAGGKGKAAHKEFINVTVTNGTLEYVIHFYW
Kinase IRAK-0_ac.AA TKL 498-746 20 2.2e-60 206.9 In-house 1-364 (364) Show / Hide 
Range on Protein: 498-746
Range on HMM: 1-364/364
Sequence Identity: 20% (77 aa)

LGQGGFGAVYKGVLPN---------GTVVAIKELSSKS--------------------------QQGSREFLNEVT-VISSVQHRNLVKLHGCCIDGDH-
.|.|||| ||||.. .         |..||.| ..|..                          ..  |.|..|.. ..|. .| |.|.. |.|..... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLLVYEFLENNSLHHVLL------ICLGIARGLSYLHEDS-----KPKIVHRDIKAHNVLLDRNMT--------------PKIADFGL
              .|.|. .. ||.|.|.      ..|.||||..||| .      ||.|.|||.| .|.|.|.|.|              .||.||||
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLHWHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGL

AKLFQDHETHVSTR------------------VAGTIGYLSPEYAM----------------RGQLTEKADVYSFGVLALEIVSGRSNLDTSLPADMVYL
.. .. ..    |                   . ||.....||  .                 .. .||.||||||..  ||....       | .    
SRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR------PYYDYPY

LEWAWN----LYERKQEMDMVDKELTDVSQE---------EAARVIKVALLCSHAVASSRPAMSHVVAML
 .. ..    ..  .   .    .. .. |.            ...| .  | .. ...|| .. ..  |
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-0_ac.AA TK 492-673 17 1.5e-45 150.16 In-house 1-389 (486) Show / Hide 
Range on Protein: 492-673
Range on HMM: 1-389/486
Sequence Identity: 17% (69 aa)

FSSENKLGQGGFG---AVYKGVLPNG--------------------------TVVAIKELSSKSQQGSRE--------------FLNEVTVISSVQ----
   ..|||.| ||    |||| . ..                          | ||.| | ... . ..|              ||.|. ...  .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HRNLVKLHGCCIDG------------DHRLLVYEFLENNS----LHHVLL-------------------------------------------------
 | |.|.|.|.| .|             . ..| |. .. .    |.. |                                                  
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

--------------------------------------ICLGIARGLSYLHED----SKPKIVHRDIKAHNVLLDRNMT-----------PKIADFG---
                                      .|. ||.|..|||.       ...||||. |.|.|...|..            ||||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LAKLFQDHETHVSTRVAGTIG-------------------------YLSPEYAM---------RGQLTEKADVYSFGVLALEIVS
     ||.  ....  ....  || .                         ...||  .          |  |.| ||.|||||  ||..
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Pkinase IRAK-0_ac.AA Pkinase 492-675 28 1.1e-43 155.54 Pfam 1-209 (293) Show / Hide 
Range on Protein: 492-675
Range on HMM: 1-209/293
Sequence Identity: 28% (61 aa)

FSSENKLGQGGFGAVYKGVLPNGTV-VAIKELSSKSQQGSRE--FLN--EVTVISSVQHRNLVKLHGCCIDGDHRLLVYEFLENN----SLH-------H
.  . |.|.|.|| |||..  .    ||.|... ...  . .   ..  |. .  ...| | |.|.... |.||  .| |..|.     .|.       |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

VLL---------ICLGIARGLSYLHEDSKPKIVHRDIKAHNVLLDRNMTP----KIADFGLAKLFQDHETHVSTRVAGTIGYLSPEYAM-RGQLTEKADV
  .         ... |.||| |.|.    .|.|||.|  |.|.|.|...    ||.||||||.|.    .  | ..||..|..||  . .   . |.|.
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

YSFGVLALEIVSGR
.|.|..  | ..||
WSCGCILYEMLCGR
Kinase IRAK-0_ac.AA MLK 492-675 26 2.5e-42 144.68 In-house 1-233 (291) Show / Hide 
Range on Protein: 492-675
Range on HMM: 1-233/291
Sequence Identity: 26% (63 aa)

FSSENKLGQGGFGAVYKGVLPNGT----VVAIKELS----SKSQQG--SREFLNEVTVISSVQHRN----LVKLHGCCID-GDHRLLVYEFLENNSLHHV
.  . ..| |.||.|.||.  | .    .||.|.      .||. .  ...|  |.   . ..|.|     ... |.|.. . | ..| |..|. ||..|
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

L--------------------------LICLGIARGLSYLHEDSKPKIVHRDIKAHNVLLDR------NMTPKIADFGLAKLFQDH-ETHVSTRVAGTIG
|                           ..| .|||..|||.. ...|.|||.| ||.|.|.      ..| ||.|||... .... ... |.  |||  
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSN--AGTYA

YLSPEY---AMRGQLTEKADVYSFGVLALEIVSGR
. .||    .  .. .||.||.|.||.  |.....
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase IRAK-0_ac.AA STE 492-675 21 6.2e-39 135.14 In-house 1-265 (359) Show / Hide 
Range on Protein: 492-675
Range on HMM: 1-265/359
Sequence Identity: 21% (59 aa)

FSSENKLGQGGFGAVYKGVLPN----------------GTVVAIKELSSKSQQG-----------------SREFLNEVTVISSVQ--HRNLVKLHGCCI
.    |.|.|.|| |||..  .                |...|||... ....                    ..|.|. . .  .  | | || .||..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DG-------DHRLLVYEFLENNSLHHVLL--------------------------ICLGIARG-LSYLHEDSKPKIVHRDIKAHNVLLDRNMTPKIADFG
..       |.  .. |.... ||  ..                           ||  | .| |.|||.     |.|||||. |.||      |..|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LAKLFQDH-------------ETHVSTR--VAGTIGYLSPEYAMR------GQLTEKADVYSFGVLALEIVSGR
... ..|.             || .. |  ..||  . .||  ..      .. ..|.|..|.| ...| . |.
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAK-0_ac.AA TKL-Unique 496-666 31 3.2e-36 125.27 In-house 3-216 (290) Show / Hide 
Range on Protein: 496-666
Range on HMM: 3-216/290
Sequence Identity: 31% (67 aa)

NKLGQGGFGAVYKGVLPNGTVVAIKELSS---KSQQGSREFLNEVTVISSVQ-HRNLVKLHGCCI----DGDHRLLVYEFLENNSLHHVLL---------
||.|.||.|.||||.  .|. |||| ..    .| . ..|| |||....  . | |.|.. | |.    .  .. .| |... .||. ||          
NKIGEGGYGQVYKGKW-RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNN

-------------ICLGIARGLSYLHEDSKPKIVHRDIKAHNVLLDRN-----MTPKIADFGLAKLFQ-DHETHVS-------TRVAGTIGYLSPEYAMR
             . . ||.|. |||  ..| | |||.|  |.|.|.|     .  ||.||||.|.   . .. ..       . . |.. ...||  ..
NNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

--GQLTEKADVYSFGV
   | .||.||||||.
NFCQYSEKSDVYSFGI
Kinase IRAK-0_ac.AA S_TKc 492-744 22 1.4e-35 125.42 SMART 1-231 (231) Show / Hide 
Range on Protein: 492-744
Range on HMM: 1-231/231
Sequence Identity: 22% (63 aa)

FSSENKLGQGGFGAVYKGVLPN-GTVVAIKELSSKSQQGSREFLNEVTVISSVQHRNLVKLHGCCIDGDHRLLVYEFLEN--NSLHHVLL----------
.   .|.|.|.|| |||..  . | .||||...       . ...|. . .. .| |.|||.... | ||  .| |....   .|....           
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

-------ICLGIARGLSYLHEDSKPKIVHRDIKAHNVLLDRNMTPKIADFGLAKLFQDHETHVSTRVAGTIGYLSPEYAMRGQLTE-KADVYSFGVLALE
       ..  |...| |.|  |. .|.|||.|  |.|||.  . ||.|||||...        | . ||  |..||     . .  |.|..|.|..  |
FPEHARFYMYQICCALEYCH--SH-GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

IVSGRSNLDTSLPADMVYLLEWAWNLYERKQEMDMVDKELTDVSQEEAARVIKVALLCSHAV--ASSRPAMS-------HVVA
 ..|.   .   .. |  ..                          . |. .   .|.       .   |.        |   
MLCGYPPFP--QMQMMFKKIG------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_ac.AA Ciliate-E2 492-675 19 2e-35 119.04 In-house 1-293 (365) Show / Hide 
Range on Protein: 492-675
Range on HMM: 1-293/365
Sequence Identity: 19% (58 aa)

FSSENKLGQGGFGAVYKG-VLPNGTVVA--------------------IKELSSKSQQGSREFLNEVTVI----------------SSVQHRNLVKLHGC
.   .|.|||.|| |||. |  ..  .|                    |... ...... .....|  ..                ....| |..|.. |
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

CI--DGDHRLLVYEFLENNSLHH-----------------------VLLICLGIAR---------------GLSYLHEDSKPKIVHRDIKAHNVLLDRNM
 .  | ..  || |... ..| .                       .. |   |..               .| |||.  .  |.|||||  |.|.    
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN--IIHRDIKPENILF----

TPKIADFGLAKLFQDH-----------------ETHVSTR-------------VAGTIGYLSPEYAMRGQ---------LTEKADVYSFGVLALEIVSGR
 .||.||||.| ..|                  .|.....             ..|| ||..||  ....          ..|.|..|.||.  | ..|.
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK
Kinase IRAK-0_ac.AA IRAK 579-746 28 1.9e-34 119.52 In-house 114-317 (317) Show / Hide 
Range on Protein: 579-746
Range on HMM: 114-317/317
Sequence Identity: 28% (59 aa)

ICLGIARGLSYLHEDS-KPKIVHRDIKAHNVLLDRNMTPKIADFGLAKLF---QDHETHVS-----TRVAGTIGYLSPEYAM--RGQLTEKADVYSFGVL
||.|.|.|. .||... .  | |.|||  |.||| ..||||.||||.      .. | ...      .| ||  |. ||.     |||| | ||||||. 
ICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDVYSFGIV

ALEIVSGR-SNLDTSLPADMVYLLEWAWNLYERKQE--------------------MDM------VDKELTDVSQEEAARVIKVALLCSHAVASSRPAMS
 ||...|.   .| .  .   ||..   .. |                          |      .|.  ...  ....    .|. | |. |  |..| 
LLEVLTGCRAVYDDR--PEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEMCQCACCCGHHRANRRCDMA

HVVAML
 |.. |
WVMQQL
Kinase IRAK-0_ac.AA LRRK 492-675 24 2.1e-32 111.97 In-house 1-279 (351) Show / Hide 
Range on Protein: 492-675
Range on HMM: 1-279/351
Sequence Identity: 24% (69 aa)

FSSENKLGQGGFG-AVYKGVLPN---------------------------GTVVAIKELSSK---SQQGS------------------------------
. .|...|.||||  ||.. . .                           .. |||| .      .   .                              
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTID-NDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCR

--REFLNEVTVISSVQHRNLVKLHGCCIDGDHRLLVYEFLENNSLHHVLL---------------------ICLGIARGLSYLHEDSKPKIVHRDIKAHN
  ||| .||...|. .| |.|.| | ||  ... .| |.. . .|.|.|                      | | ||.|. ||| ...|.|.||| | .|
AFREFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH-SHNPPIIHRDLKSPN

VLL---D---------RNMTPKIADFGLAKLFQDHETHVSTRVAGTIGYLSPEYAMRG---QLTEKADVYSFGVLALEIVSGR
.||   .          ... ||||||.  .||   . |  .. |..|...||    .   . |||.|.||||..  |.....
ILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQ
Kinase IRAK-0_ac.AA TyrKc 492-746 23 2.8e-31 111.13 SMART 1-280 (280) Show / Hide 
Range on Protein: 492-746
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

FSSENKLGQGGFGAVYKGVLPNGTVVAIKELSSKSQQGSREFLNEVTVISSV--QHRNLVKLHGCCIDG-------DHRLLVYEFLENNSLHHVL-----
 . . ||| | || ||||..   . ||.| | . .    ..|..|  . ...  .| |.|.|.|.|...       .  ..| |. .. .|.. |     
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

--------LICLGIARGLSYLHEDSKPKIVHRDIKAHNVLLDRNMTPKIADFGLAKLFQDH--------ETHV----STRVAGTIGYLSPEYAMRGQLTE
         .|. ||.| .|||.    ...|||. | |.|...| | ||.||||..   |.          ..    ...    |  ..||  . |  |.
KLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

KADVYSFGVLALEIVSGRSNLDTSLPADMVYL--LEWAWNLYERKQEMDMVDKELTDVSQE-----EAARVIKVALLCSHAVASSRPAMSHVVAML
| ||.||||.  || .     .   |   . .  ....  ..|. .. .. ..   |   .       . . .. . | |. ...|| .| ..  .
KSDVWSFGVCMWEIFT-----YGQQPYPGMIQQMMSNQ-EVIEYVKQGYRMPQPPNDY--PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK-0_ac.AA Dicty4 577-665 41 5e-30 97.46 In-house 115-204 (277) Show / Hide 
Range on Protein: 577-665
Range on HMM: 115-204/277
Sequence Identity: 41% (38 aa)

LLICLGIARGLSYLHEDSKPKIVHRDIKAHNVLLDRNMTPKIADFGLAKLFQDHETHVS--TRVAGTIGYLSPEYAMRGQLTEKADVYSFG
..... .|||. .||. . | |.|||.|.|| | | |.. |..||||..... ||.|    . ..|| .. .||  |    .|||||||||
MRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFG
Kinase IRAK-0_ac.AA TK-Unique 579-673 36 1.2e-23 78.55 In-house 136-234 (294) Show / Hide 
Range on Protein: 579-673
Range on HMM: 136-234/294
Sequence Identity: 36% (37 aa)

ICLGIARGLSYLHE--DSKPKIVHRDIKAHNVLLDRNMTPKIADFGLAKLFQDHETHVSTR--VAGTIGYLSPEYAM--RGQL-TEKADVYSFGVLALEI
.. .||.|..||..  .   ||||||. |.|||| .. . ||.|||.|.  .... .....      | ...||.    .|.  |.| ||.|||||  ||
FAWQIACGMEYLASQRK---KIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEI

VS
..
FT
Kinase IRAK-0_ac.AA Pkinase_Tyr 492-575 27 2.1e-21 73.13 Pfam 1-96 (270) Show / Hide 
Range on Protein: 492-575
Range on HMM: 1-96/270
Sequence Identity: 27% (26 aa)

FSSENKLGQGGFGAVYKGVLP-----NGTVVAIKELSSKSQQG---SREFLNEVTVISSV-QHRNLVKLHGCCI-DGDH--RLLVYEFLENNSLHH
 .   |||.| || ||||..      ... ||.| |  .. .    ...|..|. . ..  .| |.|.|.|.|. .|..   ..| |. .. .|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD
Kinase IRAK-0_ac.AA IRAK 492-574 31 7.4e-20 67.17 In-house 1-91 (317) Show / Hide 
Range on Protein: 492-574
Range on HMM: 1-91/317
Sequence Identity: 31% (29 aa)

FSSENKLGQGGFGAVYKGVLPNGT-VVAIK----ELSSKSQQGSREFLN---EVTVISSVQHRNLVKLHGCCIDGDHRLLVYEFLENNSLH
|. .|..|.|||| ||.|.. | | ..|.|    . ...  .  ..|.    |. | .. .| |.| | | |....   |||... | ||.
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLE
Kinase IRAK-0_ac.AA TK-Unique 492-577 25 2.6e-16 52.83 In-house 1-96 (294) Show / Hide 
Range on Protein: 492-577
Range on HMM: 1-96/294
Sequence Identity: 25% (24 aa)

FSSENKLGQGGFGAVYKGVLPNGT-------VVAIKELS-SKSQQGSREFLNEVTVISSVQ-HRNLVKLHGCCIDGD-HRLLVYEFLENNSLHHVL
.  ....|.| || |..| . ...       .||.| |  . ...  ..||.|  . ...  | |.|.. |||.. |   ....|.... .| | |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYL
Kinase IRAK-0_ac.AA Pkinase_Tyr 577-667 36 3e-14 48.88 Pfam 114-203 (270) Show / Hide 
Range on Protein: 577-667
Range on HMM: 114-203/270
Sequence Identity: 36% (34 aa)

LLICLGIARGLSYLHEDSKPKIVHRDIKAHNVLLDRNMTPKIADFGLAKLFQDHETH-VSTRVAGT-IGYLSPEYAMRGQLTEKADVYSFGVL
| .|. ||.|..||..     ..|||. | |.|...|.. ||.|||||.. .. ..  ...  .   |  ..||  . |  |.| ||.|||||
LQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVL
Kinase IRAK-0_ac.AA Dicty4 492-556 32 5.8e-08 22.82 In-house 1-68 (277) Show / Hide 
Range on Protein: 492-556
Range on HMM: 1-68/277
Sequence Identity: 32% (23 aa)

FSSENKLGQGGFGAVYKGVLPNGTVVAIKELSSKSQQGS-----REFLNEVTVISSVQHRNLVKLHGCCI
   |...|.|.|| ||||    |. ||.| | .. .|..      ||..||.  .. .| |.... | |.
INIEQRIGKGSFGEVYKGTW-RGKEVAVKKLNNH-NQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACT