Gene IRAK-0_z-2 (S.moellendorffii)

IRAK-0_z-2

Species: S.moellendorffii
Alias: IRAK-0_z-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_z-2.AA Protein None 564 None Fasta, JSON
IRAK-0_z-2.NA RNA None 1695 None Fasta, JSON
IRAK-0_z-2.kin_dom Protein Kinase Domain None 198 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_z-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
DUF26 IRAK-0_z-2.AA DUF26 93-138 27 0.000426 14.46 Pfam 12-55 (55) Show / Hide 
Range on Protein: 93-138
Range on HMM: 12-55/55
Sequence Identity: 27% (13 aa)

DQPSCSECIKKAYQGI-QQNAPYTLGGTYWINETEIRCRLRYENYN-L
.  .|..|.. | ... .|  |.  ||. |      .| |||..|.  
SPSDCRDCLATAVRQMLPQCCPNRQGGRIW----YDWCYLRYSDYPNF
Kinase IRAK-0_z-2.AA IRAK 254-523 29 5.1e-63 215.67 In-house 1-317 (317) Show / Hide 
Range on Protein: 254-523
Range on HMM: 1-317/317
Sequence Identity: 29% (95 aa)

FSETNQLGQGGFGTVYKACLKDGT-QVAVKKL----SLQSSQGRQEFVN---EISIITSIQHRNLARLKGYCVERDQRLLVYEFLNNGSLDRALFSPK-T
|.. | .|.||||.||.. .|  |  .|||||    ...  . .|.|     |. . ....| |.  | ||| ||..  |||... ||||   |   . .
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

ST---LNWTSRFHIVTGVARGLAYLHEES-HIQIIHRDIKASNILLDDKMQPKISDFGISKL--FDMDKGFTST------KVAGTVGYMAPEYAT--RGR
 .   | |  |. |  | |.|. .||. .  . |||.||| .|||||. ..|||.|||      .  .|  ..       .| ||  ||.||. .   |.
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LSSKADVFSFGILALEIVSGRRCMDPTLSASQELLVQMAWNMWNAG----------------------KM---VEFVDKRLDGNYVEEEVFRVMDVAILC
|. | ||.||||  ||...|.| ..   .  . |.     .|  .|                      .|   . |.|.|  .  .....    ..|. |
LTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPP-CPPNMEKEMCQCACCC

TQEGEEYRPTMSDVVAML
. ..   |..|  |.. |
GHHRANRRCDMAWVMQQL
Kinase IRAK-0_z-2.AA TKL 260-452 22 8.8e-63 214.89 In-house 1-287 (364) Show / Hide 
Range on Protein: 260-452
Range on HMM: 1-287/364
Sequence Identity: 22% (68 aa)

LGQGGFGTVYKACLKD---------GTQVAVKKLSLQSSQGR---------------------------QEFVNEISIITSIQHRNLARLKGYCVERDQ-
.|.||||.|||. ..          |. |||||.. .... .                           .....|| .. ...| |. ...||| . .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLLVYEFLNNGS-LDRALFSPKTSTLNWTSRFHIVTGVARGLAYLHEESH-----IQIIHRDIKASNILLDDKMQ-------------
              .|.|.  .|| |.. .         |  |.... ..|||..||| .        .|||||.| .|||.|....             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-PKISDFGISKLFDMDKGFTSTK------------------VAGTVGYMAPEYAT----------------RGRLSSKADVFSFGILALEIVSGRR
 .||.|||.|. ...... . |.                  . || ..||||                    .  | |.||.||||.  ||....|
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR
Kinase IRAK-0_z-2.AA Pkinase 254-451 29 3.9e-47 167.69 Pfam 1-209 (293) Show / Hide 
Range on Protein: 254-451
Range on HMM: 1-209/293
Sequence Identity: 29% (63 aa)

FSETNQLGQGGFGTVYKACLKDGTQ-VAVKKLSLQSSQG--RQEFVN--EISIITSIQHRNLARLKGYCVERDQRLLVYEFLNNG----SLDRALF---S
.    ..|.|.||.|||.. |.  . ||||......     .|. ..  ||.|  ...| |  ||.... ..|   .| |....|    .| . .    .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

PKTSTLNWTSRFHIVTGVARGLAYLHEESHIQIIHRDIKASNILLDDKMQP----KISDFGISKLFDMDKGFTSTKVAGTVGYMAPEYAT-RGRLSSKAD
 . . . .    .... ..|||.|.|..    |||||.| .|||.|.....    ||.|||..|.||  ..   | ..|| .|||||    .   ..|.|
GCFY-FSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

VFSFGILALEIVSGR
..|.|..  | ..||
MWSCGCILYEMLCGR
Kinase IRAK-0_z-2.AA STE 254-451 21 4.8e-43 149.31 In-house 1-265 (359) Show / Hide 
Range on Protein: 254-451
Range on HMM: 1-265/359
Sequence Identity: 21% (59 aa)

FSETNQLGQGGFGTVYKACLKD----------------GTQVAVKKLSLQSSQG-----------------RQEFVNEISIITSIQ--HRNLARLKGYCV
.    ..|.|.|||||||. ..                |. .|.|...|....                  .|.. .||.|    .  | |  .  |...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

-------ERDQRLLVYEFLNNGSLDRALF---SPKT---------STLNWTSRFHIVTGVARG-LAYLHEESHIQIIHRDIKASNILLDDKMQPKISDFG
       ..|.  .. |....||||  .    ...          .... .   .|.  . .| |.|||.     |||||||..||||      |..|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

ISKLFDM---------------DKGFTSTKVAGTVGYMAPEYATRGR------LSSKADVFSFGILALEIVSGR
... ..                . .  .. ..||  .||||  ....       . |.|. |.|....| . |.
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAK-0_z-2.AA TKL-Unique 257-442 31 2.1e-42 147.21 In-house 2-216 (290) Show / Hide 
Range on Protein: 257-442
Range on HMM: 2-216/290
Sequence Identity: 31% (68 aa)

TNQLGQGGFGTVYKACLKDGTQVAVKKLSL---QSSQGRQEFVNEISIITSIQ-HRNLARLKGYCV----ERDQRLLVYEFLNNGSLDRALFS-------
 | .|.||.|.|||.  . |..||.|....   .|.. .||| ||....  .. | |. .. |||.       .. .| |... |||.  |         
WNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-PKTSTLNWTSRFHIVTGVARGLAYLHEESHIQIIHRDIKASNILLDDK-----MQPKISDFGISKLFD-MDKGFTSTK-------VAGTVGYMAPEYAT
 .. ..||.  | ...  .|.|. ||| ..   |||||.| ||.|.| .     .. ||.|||.||. . ..|......       . |.  .||||  .
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR

R--GRLSSKADVFSFGI
.     | |.||.||||
MNFCQYSEKSDVYSFGI
Kinase IRAK-0_z-2.AA TK 254-449 16 4.8e-41 134.83 In-house 1-389 (486) Show / Hide 
Range on Protein: 254-449
Range on HMM: 1-389/486
Sequence Identity: 16% (64 aa)

FSETNQLGQGGFG---TVYKACLKDG--------------------------TQVAVKKLSLQSSQGRQE-----------------FVNEISIITS--I
    ..||.| ||   .|||. ....                          |.|||| | . ...  .|                 ...|...  .   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHRNLARLKGYCVER------------DQRLLVYEFLNNGS----LDRALF--SPKTST-----------------------------------------
.| |. || |.|..                ..| |. ..|.    |.  |   .||...                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LNWTSRFHIVTGVARGLAYLHEE--SHI--QIIHRDIKASNILLDDKMQ-----------PKISDFGIS
                               |.   .  .   .|.|..|||.   .    ...|||. | |.|......            ||.||| |
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

--------KLFDMDKGFTSTKVAGTVG-------------------------YMAPEYAT---------RGRLSSKADVFSFGILALEIVS
        .  . |.  ....  || .                         .||||  .          |. ..| ||.|||.|  ||..
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAK-0_z-2.AA Pkinase_Tyr 254-443 28 2.5e-39 133.83 Pfam 1-203 (270) Show / Hide 
Range on Protein: 254-443
Range on HMM: 1-203/270
Sequence Identity: 28% (59 aa)

FSETNQLGQGGFGTVYKACLK-----DGTQVAVKKLSLQSSQG---RQEFVNEISIITSI-QHRNLARLKGYCV-ERDQ--RLLVYEFLNNGSLDRALFS
 .   .||.| ||.|||. .|     ....||||.|  ....    |..| .|..| ... .| |. || | |. ....   ..| |.  .|.|.  | .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

P--KTSTLNWTSRFHIVTGVARGLAYLHEESHIQIIHRDIKASNILLDDKMQPKISDFGISKLFDMDKGFTSTKVAG----TVGYMAPEYATRGRLSSKA
.      |.     .. . .|.|..||..   ...||||. | |.|...... ||.||| ...  ....   ....|     .  ||||    |. ..| 
HREDKQPLTMKDLLQMCWQIAKGMEYLES---KNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKS

DVFSFGIL
|| |||.|
DVWSFGVL
Kinase IRAK-0_z-2.AA Dicty4 254-443 30 3.9e-38 124.89 In-house 1-206 (277) Show / Hide 
Range on Protein: 254-443
Range on HMM: 1-206/277
Sequence Identity: 30% (65 aa)

FSETNQLGQGGFGTVYKACLKDGTQVAVKKL--SLQS--SQGRQEFVNEISIITSIQHRNLARLKGYCV----ERDQRLLVYEFLNNGSLDRALFS----
   .. .|.|.||.|||.  . |..||||||    |   .   .|| .|..|  .|.| |.  ..|.|     .    . | |..  |.| . | .    
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

--PKTSTLNWTSRFH---IVTGVARGLAYLHEESHIQIIHRDIKASNILLDDKMQPKISDFGISKLFDMDK--GF-TSTKVAGTVGYMAPEYATRGRLSS
  ... .| |. .     .   .|||...||. .   |||||.|..|.| |. .. |..|||.|...  ..  .. ..| ..||...||||     .  .
QQQSI-KLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMT-ACGTPCWMAPEVMMHQPYNE

KADVFSFGIL
||||.||||.
KADVYSFGIV
Kinase IRAK-0_z-2.AA MLK 254-451 24 9.8e-37 124.99 In-house 1-233 (291) Show / Hide 
Range on Protein: 254-451
Range on HMM: 1-233/291
Sequence Identity: 24% (58 aa)

FSETNQLGQGGFGTVYKACLKDGTQ-----VAVKKLSL------QSSQGRQEFVNEISIITSIQHRN----LARLKGYCVERDQ-RLLVYEFLNNGSLDR
. .   .| |.|| |.|.  . ..      ||||.         ...  ...|  |. .   ..|.|      ...| | .  .  ..| |.. .||| .
IQFHEWIGSGSFGKVWKGRWR-NKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

ALFS-PKTST-----------LNWTSRFHIVTGVARGLAYLHEESHIQIIHRDIKASNILLDD------KMQPKISDFGISKLFDMDKGFTSTKVAGTVG
 | . .. .                . . . . .|||..|||..   .|||||.| .|||.|.      ... ||.|||.|. .   .  . .. |||. 
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYA

YMAPEY---ATRGRLSSKADVFSFGILALEIVSGR
.||||    .  .. | |.||.|.|..  |.....
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase IRAK-0_z-2.AA S_TKc 254-527 22 1.2e-36 128.93 SMART 1-231 (231) Show / Hide 
Range on Protein: 254-527
Range on HMM: 1-231/231
Sequence Identity: 22% (65 aa)

FSETNQLGQGGFGTVYKACLKD-GTQVAVKKLSLQSSQGRQEFVNEISIITSIQHRNLARLKGYCVERDQRLLVYEFLNN--GSLDRALFSPKT----ST
.   ...|.|.||.|||.  |. | .||.|...       . . .||.|  . .| |. .|...... |   .| |....  |.| . . . ..    . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LNWTSRFHIVTGVARGLAYLHEESHIQIIHRDIKASNILLDDKMQPKISDFGISKLFDMDKGFTSTKVAGTVGYMAPEYATRGRLSS-KADVFSFGILAL
..     ...  ....|.|.|  || .|||||.| .|||||.  . ||.|||.....        | . ||  |||||       .  |.|. |.|..  
FPE-HARFYMYQICCALEYCH--SH-GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EIVSGRRCMDPTLSASQELLVQMAWNMWNAGKMVEFVDKRLDGNYVEEEVFRVMDVAILCTQEGEEYRPTMSDVVA-----MLMGYL
| ..|.   . .. .  ....                               . |    | |   | |||  .. .     ... ..
EMLCGYPPFP-QMQMMFKKIG----------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_z-2.AA Dicty4-Unclassified 257-450 32 5.6e-36 120.69 In-house 4-204 (263) Show / Hide 
Range on Protein: 257-450
Range on HMM: 4-204/263
Sequence Identity: 32% (68 aa)

TNQLGQGGFGTVYKACLKDGTQVAVKKLSLQSSQGR----QEFVNEISIITSIQHRNLARLKGYCVER----DQRLLVYEFLNNGSLDRALF---SPKTS
   .|.| |  |.|   | |  |||||.   . . |    |.|  |. |  |||| || ...|||.           | ||.  | |        | .  
DQFIGKGHFSKVHKGNWK-GKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQ

TLNWTS--RFHIVTGVARGLAYLHEESHIQIIHRDIKASNILLDDKMQPKISDFGISKLFDMDKGFTSTKVAGTVGYMAPEYATRGRLSSKADVFSFGIL
 .   .     .   .|.|...||      .||||||.||||.|     || |||||   |    |. | .|||.   .||        .|.||.|....
PIKLDDTLIIKYAFDIAQGMQHLHT---RNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFN--FNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMM

ALEIVSG
  | . |
LYELATG
Kinase IRAK-0_z-2.AA Ciliate-E2 254-452 20 3.1e-35 118.41 In-house 1-294 (365) Show / Hide 
Range on Protein: 254-452
Range on HMM: 1-294/365
Sequence Identity: 20% (61 aa)

FSETNQLGQGGFGTVYKACL-KDGTQVA--------------------VKKLSLQSSQGRQEFVNEISIIT----------------SIQHRNLARLKGY
.   ...|||.||.|||..  |.. |.|                     . .  .. .. ... .||.|.                 ...| |. ... .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

CV--ERDQRLLVYEFLNNGSLDR-----ALFSPKTST----LNWTSRFHIVTGVAR---------------GLAYLHEESHIQIIHRDIKASNILLDDKM
     ..   || |... |.|        .....  .    ...  . .| . ...               .| |||.. .  ||||||| .|||.    
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN--IIHRDIKPENILF----

QPKISDFGISKLFDMD----------KGFTSTK---------------------VAGTVGYMAPEYATRGR---------LSSKADVFSFGILALEIVSG
 .||.|||.|| .| |          | ..  |                     ..|| ||||||   ..           . |.|..|.|..  | ..|
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

RR
..
KP
Kinase IRAK-0_z-2.AA LRRK 254-455 23 7.6e-35 120.69 In-house 1-284 (351) Show / Hide 
Range on Protein: 254-455
Range on HMM: 1-284/351
Sequence Identity: 23% (69 aa)

FSETNQLGQGGFG-TVYKACLKD---------------------------GTQVAVKKLSLQ---------SSQG-------------------------
. . .|.|.|||| .||.| ...                           .. ||.||. .          .| .                         
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

RQEFVNEISIITSIQHRNLARLKGYCVERDQRLLVYEFLNNGSLDRALFSPKTST-------LNWTSRFHIVTGVARGLAYLHEESHIQ--IIHRDIKAS
 .|| .|..|. . .| |.  |||.|   . . .| |.. .|.|.. |...| .        ..|. .  |.. .|.|..|||        ||||| |  
FREFRHEVWIMSHLNHPNIVSLKGFC--IHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS---HNPPIIHRDLKSP

NILLDDKMQP------------KISDFGISKLFDMDKGFTSTKVAGTVGYMAPEYATRG---RLSSKADVFSFGILALEIVSGR-RCMD
||||   .|.            ||.||||| .|  ..     .. |. |.||||    .     . |.|..|||..  |..... . .|
NILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD
Kinase IRAK-0_z-2.AA TyrKc 254-523 26 1e-32 115.94 SMART 1-280 (280) Show / Hide 
Range on Protein: 254-523
Range on HMM: 1-280/280
Sequence Identity: 26% (78 aa)

FSETNQLGQGGFGTVYKACLKDGTQVAVKKLSLQSSQGRQEFVNEISIITSI--QHRNLARLKGYCVER-------DQRLLVYEFLNNGSLDRALFSPKT
 .   .|| | ||.|||. .|  .|||||.|   .   |..| .|..| ...  .| |. || |.|..        .. ..| |.  .|.|.  | ... 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

STLNWTSRFHIVTGVARGLAYLHEESHIQIIHRDIKASNILLDDKMQPKISDFGISKLFDMD-------KGFT-----STKVAGTVGYMAPEYATRGRLS
  |..    .. . .|.| .|||.    ..||||. | |.|.... . |||||| |.  . |       .  .     ..|    .  ||||    |. .
K-LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

SKADVFSFGILALEIVSGRRCMDPTLS-ASQELLVQMAWNMWNAGKMVEFVDKRLDGNY----VEEEVFRVMDVAILCTQEGEEYRPTMSDVVAML
.| ||.|||..  || .  ... |    . | .  | . .   .|.. .  .  .          .|....|     | .|  | |||.|...  .
TKSDVWSFGVCMWEIFT--YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MSFVCCPDEMYQIM---KQCWHEDPEDRPTFSEIHECF
Kinase IRAK-0_z-2.AA TK 513-523 45 0.054725 1.59 In-house 476-486 (486) Show / Hide 
Range on Protein: 513-523
Range on HMM: 476-486/486
Sequence Identity: 45% (5 aa)

RPTMSDVVAML
|||.|... .|
RPTFSQLHEQL
Kinase IRAK-0_z-2.AA Pkinase_Tyr 513-523 45 3.036419 1.45 Pfam 260-270 (270) Show / Hide 
Range on Protein: 513-523
Range on HMM: 260-270/270
Sequence Identity: 45% (5 aa)

RPTMSDVVAML
|||.|... .|
RPTFSEIHEQL