View source for Kinase Group RGC

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[[kinase classification|Kinase Classification]]: [[Kinase_Group_RGC|RGC Group]]

RGCs are Receptor Guanylate Cyclases that have an unusual structure: they are single-pass transmembrane receptors that have an active guanylate cyclase domain and a catlytically inactive kinase domain on the intracellular side. The guanylate cyclase domain makes the second messenger cGMP, and the kinase domain may have a regulatory role and may bind ATP.

The RGC group has the following family:

====[[Kinase_Family_RGC|Family RGC]]====

===Evolution===
RGCs are seen in animals and choanoflagellates.

===Families===
No families have yet been defined within the RGC group, though several conserved classes are clear.

===Kinase Domain Function===
The kinase domains of animal RGCs lack the catalytic HRD motif and are classified as pseudokinases. However, some are known to bind ATP <cite>Jaleel</cite> and this is thought to cause conformational change and to regulate the activity of the guanylate cyclase domain <cite>Duda</cite>.

===References===
<biblio>
#Jaleel pmid=16460035
#Duda pmid=21222471
</biblio>