View source for Kinase Subfamily AlphaK1

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[[kinase classification|Kinase Classification]]: [[Kinase_Group_PKL|Group PKL]]: [[Kinase_Family_Alpha|Family Alpha]]: [[Kinase_Subfamily_AlphaK1|Subfamily AlphaK1]]

====Domain Structure====
Members have a helical N-terminal region followed by a poorly conserved linker and an alpha kinase domain.

====Evolution====
AlphaK1 (ALPK1) is a single-copy gene in vertebrates. Clear orthologs have also been detected in the chordate Branchiostoma floridae (lancelet) and the sea anemone, Nematostella, as well as several lophotrochozoa, suggesting that the gene was born in early metazoan evolution, but then lost from many lineages. Multiple invertebrate orthologs conserve the kinase domain and N-terminal helical domain, and have poor conservation of the intervening region.

====Functions====
ALPK1 has been implicated in vesicle transport from the Golgi to the plasma membrane <cite>Heine</cite>, perhaps by myosin phosphorylation. Mouse ALPK1 mutants were associated with motor co-ordination defects <cite>Chen</cite>, and the gene has been associated with both gout and kidney disease. Human ALPK1 has also been shown to be a receptor for the bacterial ADP-heptose<cite>Zhou</cite>. ADP-heptose binding causes ALPK1 to phosphorylate TIFA and activate NFkB signaling.

====References====
<biblio>
#Chen pmid=21208416
#Heine pmid=15883161
#Zhou pmid=30111836
</biblio>