View source for Kinase Subfamily PI3K3

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[[kinase classification|Kinase Classification]]: [[Kinase_Group_PKL|Group PKL]]: [[Kinase_Family_PIK|Family PIK]]: [[Kinase_Subfamily_PI3K3|Subfamily PI3K3]]

Class 3 Phosphatidyl Inositol Kinases

====Evolution====
A single PI3K3 is found in most or all eukaryotes <cite>Philippon</cite>. The human gene is PIK3C3 and the yeast is Vps34. Its regulatory partner, Vps15, is also pan-eukaryotic.

====Domain Structure====
PI3K3 have a N-terminal C2 domain followed by PI3Ka (accessory domain), and then a PKL kinase domain.

====Functions====
PI3K3 has a conserved role in membrane trafficking and autophagy, in yeast and mammals, as well as endocytosis and insulin signaling in mammals. 

====References====
<biblio>
#Philippon pmid=26482564
</biblio>