otk_Dmel MTARM--------ISICGLVMALMMASVLASSSRFQRVPQS-QSVVE-------------
CCK4_Mmus MGARP--------LTLLRALLLPLLAGAQ-AAIVFIKEPSS-QDALQ-------------
CCK4_Hsap MGAARGSPARPRRLPLLSVLLLPLLGGTQ-TAIVFIKQPSS-QDALQ-------------
CCK4_Spur MLAYVN-----------------------------IAGISEE------------------
AqueK250_Aque MAAFLE---------------------DE-DSVVSIKDIVDEEQALQDTANAVLGDSDDT
* * .
otk_Dmel ---------NESVKFECESTDSYSEL--------------------HYDW----------
CCK4_Mmus ---------GRRALLRCEV-EAPDPV--------------------HVYW----------
CCK4_Hsap ---------GRRALLRCEV-EAPGPV--------------------HVYW----------
CCK4_Spur ------------------------------------------------------------
AqueK250_Aque NCTYTKGYVSRQALYACST-CTPSSSVLAGFCLACSLRCHEGHDVIELYTKRNFRCDCGN
otk_Dmel -------------------------LHNG-------------------------------
CCK4_Mmus -------------------------LLNG-------------------------------
CCK4_Hsap -------------------------LLDG-------------------------------
CCK4_Spur ------------------------------------------------------------
AqueK250_Aque SKISGNPCLLCPDKDPLNSENIYNHNFNGLYCTCNRPYPDLDDEVEDEMIQCSVCEDWYH
otk_Dmel ----------------------------------H----------------------RIA
CCK4_Mmus ----------------------------------V----------------------PVQ
CCK4_Hsap ----------------------------------A----------------------PVQ
CCK4_Spur ------------------------------------------------------------
AqueK250_Aque TRHLGLHPPNSFEETVCDKCMSRLSFLYHYKIHSVSSEEPFVHQETLDACTSTTHHIESE
otk_Dmel YDK--------------------------------------------------------R
CCK4_Mmus DTE--------------------------------------------------------R
CCK4_Hsap DTE--------------------------------------------------------R
CCK4_Spur ------------------------------------------------------------
AqueK250_Aque KTETHTAKTESDSIIPNGKEAEPKTLSTDSPPLKSDPVPGPTNESQSQLRETETCVLEKR
otk_Dmel VHQIGSNLHIEAVRRT-------------------EDVGNYVCIATNLASGAREASPP--
CCK4_Mmus RFAQGSSLSFAAVDRL-------------------QDSGAFQCVARDNVTGEEVRSTN--
CCK4_Hsap RFAQGSSLSFAAVDRL-------------------QDSGTFQCVARDDVTGEEARSAN--
CCK4_Spur ------------------------------------------------------------
AqueK250_Aque KTLSSSSSNFSGPGYFTSQWRSELCSCSSCKKMYKELSVEFLLDTLDSITSYETRAKSTG
otk_Dmel -------------------------------------AKLSVIYLESASVQLLG------
CCK4_Mmus -------------------------------------ASFNIKWIEAGPVVLKHPA----
CCK4_Hsap -------------------------------------ASFNIKWIEAGPVVLKHPA----
CCK4_Spur --------------------------------LRV---------------QLNRPN----
AqueK250_Aque YIHDVGMEALSSSMGRVQQVEMINGYNHMKEELKKFLGSFASKGKVVRPRDITDFFGELE
:
otk_Dmel ---------------------SNRNELLLKCHVEGASGDLEPLEIEWYRNSEKLSTW---
CCK4_Mmus ----------------SEAEIQPQTQVTLRCHIDGHP---RP-TYQWFRDGTPLSDDQST
CCK4_Hsap ----------------SEAEIQPQTQVTLRCHIDGHP---RP-TYQWFRDGTPLSDGQSN
CCK4_Spur ----------------LPEDVEEGGKVTLICRASGNP---VP-MVTWYHDQTPVVA---G
AqueK250_Aque NQKRQSHGGASPPTVVGPPVVIEGDSVSLHCD--TGS---SE-AVQWFKDGVSVSVS--N
.: * * . *::: :
otk_Dmel KNVQLDQHRLIIRQPG-SEDDGLYRCTASNAAGRVMSKQGYVYQSS---------VKCLP
CCK4_Mmus HTVSSRERNLTLRPAS-PEHSGLYSCCAHNAFGQACSSQNFTLSVA---------DESFA
CCK4_Hsap HTVSSKERNLTLRPAG-PEHSGLYSCCAHSAFGQACSSQNFTLSIA---------DESFA
CCK4_Spur SNVDISGTRLKIKSAT-PLDSGIYSCMATNVAGSMPSTENVQFNIV---------DSNTP
AqueK250_Aque PNFDTSESNISISSANATIHSGTYACSLTSNQSEV--STPFQLTVYYFHGKLSICKVREN
... .: : . . ..* * * . . .
otk_Dmel RL----------------------------------------------------------
CCK4_Mmus RV----------------------------------------------------------
CCK4_Hsap RV----------------------------------------------------------
CCK4_Spur VV----------------------------------------------------------
AqueK250_Aque NIQVSPVDSMLYPGLSSYSVSVESDVLLTCCTPPAIPPVHNVSWIKVDGNTRPSDGGDSS
:
otk_Dmel ---------------------------------------------------PRRKNEKMM
CCK4_Mmus ---------------------------------------------------VLAPQDVVV
CCK4_Hsap ---------------------------------------------------VLAPQDVVV
CCK4_Spur ---------------------------------------------------EVAPTDAIR
AqueK250_Aque EGWSLLLSDIAVNDRGRYRCSYEHVAAGTVQSEEVELKVAVQGSTPATPVDVTVPQSTVC
. :
otk_Dmel -ESWDKQTFLCR------------------------------------------------
CCK4_Mmus -ARNEEAMFHCQFSAQPP-PSLQWVFEDETPITNRSRPPHLRR-----AVVFANGSLLLT
CCK4_Hsap -ARYEEAMFHCQFSAQPP-PSLQWLFEDETPITNRSRPPHLRR-----ATVFANGSLLLT
CCK4_Spur -VLGDSIMFHCQFSGDPT-PPVEWYTTSK---AGGEIPPQLMNDTETGTYIIGNGSLSLA
AqueK250_Aque TKPGNTVTIHCTVSGTVGNGDVSWKLGDN---TL---PSNERY-----SVDPVTNSLTIT
: : *
otk_Dmel ---------------GKRGGAAGLEALP--AAPEDLRIVQG-PIGQSIIKEGEPTALTCL
CCK4_Mmus QVRPRNAGVYRCIGQGQRGPPIVLEATLHLAEIEDM-----LPFEPRVFIAGDEERVTCP
CCK4_Hsap QVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDM-----PLFEPRVFTAGSEERVTCL
CCK4_Spur NLTAGDEGEFQCVCDSPHGRPFA-SARLTIATVNPL-----PEFEAQLIPEGDTKTINCS
AqueK250_Aque NAALSDDGVYKCTAINDLNADSA-TVHLNMTCIHSVH--VSPSFVST--GLGTSKTLACS
. . . : . : : * : *
otk_Dmel YELPDELKNQRIQLRWRKDGKLLRQVELGGS-----------------------------
CCK4_Mmus APQ----GLPTPSVWWEHAG--VP-LPAHG------RVHQKGLELVFVTIAESDTGVYTC
CCK4_Hsap PPK----GLPEPSVWWEHAG--VR-LPTHG------RVYQKGHELVLANIAESDAGVYTC
CCK4_Spur YPAGDVGGIPTPSIHWLKPS--LREVPLDGTKTKRVRVEEQKNLLVFDPIKKSDEGNYTC
AqueK250_Aque SNHDD--SLATPTYFWFTPQ--G--------------IEVQGPELVLNNLQYSDAGSYNC
*
otk_Dmel ------------------------------------------------APIPGHSFDSG-
CCK4_Mmus HASNLAGQ-RRQDVNITVATVP--TWLRKPQDSQLEEGKPGYLHCLTQ-ATPKPTVIWYR
CCK4_Hsap HAANLAGQ-RRQDVNITVATVP--SWLKKPQDSQLEEGKPGYLDCLTQ-ATPKPTVVWYR
CCK4_Spur VSSNMAGE-TTQILKVVVATAP--KITTRPVDVHIREREEATLRCNAT-GTPTPTISWTF
AqueK250_Aque TASSPNSLPVSSLVSLTVLGPPLVKITAFP-NREARLYRPLTLHCSVNVSIPDQEIEWSK
* .
otk_Dmel KDALLREDARLVLHKQNGTLSFASIIASDAGQYQCQLQLEAHAPINSSPGILEVIEQLKF
CCK4_Mmus NQMLISEDSRFEVS-KNGTLRINSVEVYDGTLYRCVSSTPAGS-IE-AQARVQVLEKLKF
CCK4_Hsap NQMLISEDSRFEVF-KNGTLRINSVEVYDGTWYRCMSSTPAGS-IE-AQARVQVLEKLKF
CCK4_Spur GTRDIT------------------------------------------NVRNHVLTILKF
AqueK250_Aque ENSTDKNFISSESF-NSNILTIRNFSVSDVGVYHCSYTSDTY--RE-VKNSVHVVLTNKI
.*: *:
otk_Dmel VPQPTSKN-L-ELDAVVAKVHCKAQG----TPTPQVQWVRDGE------NTTLPDHVEVD
CCK4_Mmus TPPPQPQQCM-EFDK-EATVPCSATG----REKPTVKWVRAD-------GSSLPEWVT-D
CCK4_Hsap TPPPQPQQCM-EFDK-EATVPCSATG----REKPTIKWERAD-------GSSLPEWVT-D
CCK4_Spur NPRPIAVTSL-DRGE-MNRLVCHATA----SIQPFIAWHKQGI------IGTWPDHISEP
AqueK250_Aque YPKFDIISRTGIVNE-ILIVTCEFLGGISSDGTLTVSWFKGGSPLRSSRNVTVSNGVVQG
* . : * . : * : . : .: :
otk_Dmel ANGTLIFRNVNSEHRGNYTCLATNS-QGQINATVAINVVVTPKFSVPPVGPIETSEQGTV
CCK4_Mmus NAGTLHFARVTRDDAGNYTCIASNEPQGQIRAHVQLTVAVFITFKVEPERTT-VYQGHTA
CCK4_Hsap NAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTT-VYQGHTA
CCK4_Spur NSGVLQFNPAEASDAGTYICIASTG-LERINTTVRIDVVVKPKFVIIPNNTI-GFEGYSL
AqueK250_Aque GVASLTINSVKMSDEGSYSCLASDG-VHEFNETFEIIVNVPGSFLEVPPSSVQYMEGEYL
. * : . .. *.* *:*: .:. . : * * .* * . :
otk_Dmel VMHCQAIGDPKPTIQWDKDLKYLSENNTDRERFRFLENGTLEIRNVQVEDEGSYGCTIGN
CCK4_Mmus LLRCEAQGDPKPLIQWKGKDRILDPTK-LGPRMHIFQNGSLVIHDVAPEDSGSYTCIAGN
CCK4_Hsap LLQCEAQGDPKPLIQWKGKDRILDPTK-LGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGN
CCK4_Spur KIDCTAHGDPEPTITWISKPIM--------------------------------------
AqueK250_Aque YLECRVAGKPLPKVTWLKELSHLES----DDRIIVDSNGSLVITSIVMSDAGDYLCFFDS
: * . *.* * : * .
otk_Dmel SAGLKREDVQLVVKTTGDGFAPEESGGDG----FLVTRAVLITMTVALAYIV-LVVGLML
CCK4_Mmus SCNIRHTEAPLLVVD---KPVMEDSEGPGSPPPYKMIQTIGLSVGAAVAYII-AVLGLMF
CCK4_Hsap SCNIKHTEAPLYVVD---KPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYII-AVLGLMF
CCK4_Spur ------------------------------------------------------------
AqueK250_Aque PDGVKEHSTVTIKVS-PRQATPTALTG--DDTILGLEQNLFISIVLAVVGVIFIILIVLL
otk_Dmel WC----RYRRQARKARLNDLSTKEAGGDQ----------------PDVAGNGKGSEQ-EP
CCK4_Mmus YC----KKRCKAKRLQ------KQPEGEE----------------PEMECLNGGPLQN--
CCK4_Hsap YC----KKRCKAKRLQ------KQPEGEE----------------PEMECLNGGPLQN--
CCK4_Spur ------------------------------------------------------------
AqueK250_Aque LCCTLCYVKCRSRE--------RSTNGHQKAVLETVSFERRPSLRGSLRKDNSGILQQNP
otk_Dmel C-LS------KQHNGHSKSRSKSSGDAQK-SDDTACSQQSRASK--------KSAHIY--
CCK4_Mmus --------------------GQPSAEIQEEVALTSLGSGPPATN--------KRHSAG--
CCK4_Hsap --------------------GQPSAEIQEEVALTSLGSGPAATN--------KRHSTS--
CCK4_Spur ------------------------------------------------------------
AqueK250_Aque SDLSSLWTFTTDN-----SNSVPMTAVSSSVAV---SPGPPVPSPIPPPPDGPTASLATE
otk_Dmel -----EQLALPRSGLSE-LIQIGRGEFGDVFVGKLKATLVTSPSDKDADTEKQHSNSENG
CCK4_Mmus -----DRMHFPRASLQP-ITTLGKSEFGEVFLAKAQGV----------------------
CCK4_Hsap -----DKMHFPRSSLQP-ITTLGKSEFGEVFLAKAQGL----------------------
CCK4_Spur --------NYPEHFTHLP---NGHGAYGEVTLSRAAGI----------------------
AqueK250_Aque LNLPHGISSFPRHKLMLSGDIMGEGEFGPVVKAIARHI----------------------
*. *.. :* * .
otk_Dmel SGGSGSGSTTLSTLNEKRRSKTSMDDIEEIKEEEQDQHNQSGLEQLVLVKALNKVKDEQA
CCK4_Mmus --------------------------------------EEGATETLVLVKSLQS-RDEQQ
CCK4_Hsap --------------------------------------EEGVAETLVLVKSLQS-KDEQQ
CCK4_Spur --------------------------------------KDGEEATTVMVKALET-KEESL
AqueK250_Aque --------------------------------------TEDSSETLVAVKVLMS-REGEE
:. * ** * . :: .
otk_Dmel C-----QEFRRQLDLLRAISHKGVVRLFGLCREKDPHYMVLEYTDWGDLKQFLLATAGKV
CCK4_Mmus Q-----LDFRREVEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKNKD
CCK4_Hsap Q-----LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKD
CCK4_Spur Q-----LDFRREIEMLGKLNHENIVKLLGVCRDTEPQLMITEYLDWGDLKQFLQATRGEN
AqueK250_Aque ALWPSLMDFSNQM----RLSSPFISKILGICADAEPYYVIYEYLDRGDLKNFLFASHP--
:* .:: :. : :::*:* : :* :: ** * ****:** :
otk_Dmel NTATAGSSSPPPLTTSQVLAVAYQIARGMDAIYRARFTHRDLATRNCVISSEFIVKVSYP
CCK4_Mmus E----KLKS-QPLSTKQKVALCSQVALGMEHLSNNRFVHKDLAARNCLISAQRQVKVSAL
CCK4_Hsap E----KLKS-QPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSAL
CCK4_Spur G----TKNVPPPLTLSQKIDIVNQVALGMETLSANRFIHGDLAARNCLLSPSMEVKICTM
AqueK250_Aque -----SPHSEPMLTQSDLLHFVSQIAEGMRYLYSQQIIHGDLATRNCLISSNFSVKIADL
*: .: : . *:* ** : :: * ***:***::*.. **:.
otk_Dmel ALCKDKYSREYHKHRNTLLPIRWLAPECIQED----EYTTKSDIFAYGVVVWELFNQATK
CCK4_Mmus GLSKDVYNSEYYHFRQAWVPLRWMSPEAVLEG----DFSTKSDVWAFGVLMWEVFTHG-E
CCK4_Hsap GLSKDVYNSEYYHFRQAWVPLRWMSPEAILEG----DFSTKSDVWAFGVLMWEVFTHG-E
CCK4_Spur SVSQDLYRPEYHEYHQKLIPVRWMPAEAIFED----ELSAKSDVWAYGIFVWEVFSQG-T
AqueK250_Aque GIGHDLYEQDYYDNGSQLLPIRWMAPELLKDSNMGPAFSLASDIWSFGVFCWEVFSYA-Q
.: :* * :*:. . :*:**:..* : :. : **::::*:. **:*. .
otk_Dmel LPHEELTNEQVVQRSQAGSLEWSVAEATPDSLREILLSCWVSNPKERPSFSQLGAALSKA
CCK4_Mmus MPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWAPNPKDRPSFSEIASTLGDS
CCK4_Hsap MPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDS
CCK4_Spur LPYTQLDNDAVMRAMIDGELMLETPPDTPEEIELMMHRCWADSPKDRHTFSEITHHLGRI
AqueK250_Aque QPYEGLSDEQVLRLVPSGHLLSLPEEGMPALLYSLLMDCWQFDPLQRPLFTEIAPAVRGI
*: :: *: * * : :: ** .* :* *::: :
otk_Dmel MQSAEK
CCK4_Mmus PADSKQ
CCK4_Hsap TVDSKP
CCK4_Spur STDSRV
AqueK250_Aque DV---D