CG7236_Dmel YEKLSRLGEGSYGVVYKCRDRETGALVAVKRFVESED--DPAIRKIALREIRLLKNLKHP
CDKL5_Mmus FEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEE--NEEVKETTLRELKMLRTLKQE
CDKL4_Mmus YEKLAKIGEGSYGVVFKCRNKSSGQVVAIKKFVESED--DRVVRKIALREIRMLKQLKHP
CDKL3_Mmus YETLGKVGEGSYGTVMKCKHKDTGRIVAIKIFYEKPE---KSVNKIATREIKFLKQFRHE
CDKL2_Mmus YENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFLESDD--DKMVKKIAMREIKLLKQLRHE
CDKL1_Mmus YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKRFLETED--DPVIKKIALREIRMLKQLKHP
CDKL1_Hsap YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESED--DPVIKKIALREIRMLKQLKHP
CDKL2_Hsap YENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDD--DKMVKKIAMREIKLLKQLRHE
CDKL5_Hsap FEILGVVGEGAYGVVLKCRHKATHEIVAIKKFKDSEE--NEEVKETTLRELKMLRTLKQE
CDKL4_Hsap YEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESED--DPVVKKIALREIRMLKQLKHP
CDKL3_Hsap YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPE---QSVNKIAMREIKFLKQFHHE
Y42A5A.4_Cele YDRLSKLGEGSYGVVYKCKNRDTGQIVAIKKFVETED--DPHIKKIALREIRMLKQLKHQ
10873_Tthe YEILGVNGEGAYGVVLKCRNKETQEIVAIKKFKETED--DEIAKKNIQREVKMLRQLRHK
17811_Tthe -------------KLYKCLNKETQKIIAIKAYKLNIN--QVEEKKRIEREVKIKKMLHHK
29899_Tthe YEVKGVVGEGAYGVVLKCMNKENGEYVAIKKFKESDE--DEVVKKTTLREVKILRMLKQE
7414_Tthe YEILGVVGEGAYGVVLKCRNRETNEILAIKKFKETED--DELVRKNIQREVKMLKTLKHK
CDKL2_Spur YESFGLVGEGSYGQVLKCRHKETNQVVAIKKFLEGED--DKMVKKIAMREVRMLKQLRHE
CDKL1_Spur YERLGKIGEGSYGVVFKCRHKDTGTIVAIKRFVESED--DPLIKKIALREIRMLKQLKHE
CDKL5_Spur ----------------------------IMKPECGKY--NEDVRRTILRELKLLRQLKQE
AqueK106_Aque YEKISKIGEGSYGVVFKCRNKDTGQIVAIKKFVESED--DPIIKKIALREIRMLRQLKHG
AqueK107_Aque YENLGLVGEGSYGMVMKCRHKDSSQLVAIKKFLETEN--DRMVKKIALREVRMLKQLRHE
GK026_Glam YEILGVSGEGAYGVVLKCRNKETNELVAIKKFKDTDDPEDSTFKKTTLREVKILKNAQHP
: .. **::: : ::
CG7236_Dmel NLVSLLEVFRRKRRLHLVFEFCELTVLHELERH--PQGCPEHLTKQICYQTLLGVAYCHK
CDKL5_Mmus NIVELKEAFRRRGKLYLVFEYVEKNMLELLEEM--PNGVPPEKVKSYIYQLIKAIHWCHK
CDKL4_Mmus NLVNLIEVFRRKRKMHLVFEYCDHTLLNELERN--PNGVSDGVIKSVLWQTLQALNFCHK
CDKL3_Mmus NLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHY--CHGLESKRLRKYLFQILRAIEYLHN
CDKL2_Mmus NLVNLLEVCKKKKRWYLVFEFVDHTILDDLKLF--PNGLDYQVVQKYLFQIINGIGFCHS
CDKL1_Mmus NLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRY--QRGVPEPLVKNITWQTLQAVNFCHK
CDKL1_Hsap NLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRY--QRGVPEHLVKSITWQTLQAVNFCHK
CDKL2_Hsap NLVNLLEVCKKKKRWYLVFEFVDHTILDDLELF--PNGLDYQVVQKYLFQIINGIGFCHS
CDKL5_Hsap NIVELKEAFRRRGKLYLVFEYVEKNMLELLEEM--PNGVPPEKVKSYIYQLIKAIHWCHK
CDKL4_Hsap NLVNLIEVFRRKRKMHLVFEYCDHTLLNELERN--PNGVADGVIKSVLWQTLQALNFCHI
CDKL3_Hsap NLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHY--CHGLESKRLRKYLFQILRAIDYLHS
Y42A5A.4_Cele NLVGLIEVFKRNRKLHLVFELCDRTVLHELEKN--PHGVNDELIKKIIYQLLEALKFCHS
10873_Tthe NIVDLIEAFKRKGRIYLVFEYVEKNLLEVLEEK--PTGLDHEVIRIIMYQLLKALHQCHK
17811_Tthe NIVDIIEICQKNNEIYIVEEYVEISLSNYLKQGSQQKGLDQNVIPNIMYQVLSSINQCHK
29899_Tthe NIVQLREAFRRKGKLYLVFEYVENNLLEILEER--PNGLDQDDVRKYIYQLCKSISYCNS
7414_Tthe NIVGLVEAFKRKGRIYLVFEYVEKNLLEVLEEK--PSGLD----------LLKALDHCHK
CDKL2_Spur NLVNLIEVFRRKKRLYLVFEFMDHTVLDELEKY--PMGLDESLVRKYMWQILKGIEFCHI
CDKL1_Spur NLVNLKEVFRRKKKLHLVFEYCDYTVLNTLEAN--VNGVPEGQGMNIVYQTLEAVNFCHQ
CDKL5_Spur NIVELKEAFRRRGKLYLVFEYVEKNMLELLEEN--PKGVPPEKVR---------------
AqueK106_Aque NLVNLLEVFRRKRKLHLVFEYCDHTVLNELEAH--PRGLDETSAKRIIWQTLQGVNYCHH
AqueK107_Aque NLVNLIEVFRRKKRLYLVFEFVDHTALDELDKY--PSGADESLVKKIMWQVLKGVEFCHQ
GK026_Glam HIVCLKEAFKRKQRLYLVFEYCEKTLLELIEDS--PGGIPIETVKLLTFQMLRGVEFLWE
::* : * ::. . ::* * : . . :. *
CG7236_Dmel -QGCLHRDIKPENILLTAQ---GQVKLCDFGFARMLS-----------PGENYTDYVATR
CDKL5_Mmus -NDIVHRDIKPENLLISHN---DVLKLCDFGFARNLSEG---------NNANYTEYVATR
CDKL4_Mmus -HNCIHRDVKPENILITKQ---GMIKICDFGFARILI-----------PGDAYTDYVATR
CDKL3_Mmus -NNIIHRDIKPENILVSQS---GITKLCDFGFARTLAA----------PGDVYTDYVATR
CDKL2_Mmus -HNIIHRDIKPENILVSQS---GVVKLCDFGFARTLAA----------PGEVYTDYVATR
CDKL1_Mmus -HNCIHRDVKPENILITKQ---SAIKLCDFGFARLLTG----------PGDYYTDYVATR
CDKL1_Hsap -HNCIHRDVKPENILITKH---SVIKLCDFGFARLLTG----------PSDYYTDYVATR
CDKL2_Hsap -HNIIHRDIKPENILVSQS---GVVKLCDFGFARTLAA----------PGEVYTDYVATR
CDKL5_Hsap -NDIVHRDIKPENLLISHN---DVLKLCDFGFARNLSEG---------NNANYTEYVATR
CDKL4_Hsap -HNCIHRDIKPENILITKQ---GIIKICDFGFAQILI-----------PGDAYTDYVATR
CDKL3_Hsap -NNIIHRDIKPENILVSQS---GITKLCDFGFARTLAA----------PGDIYTDYVATR
Y42A5A.4_Cele -HKCIHRDVKPENIFLTRN---DQVKLGDFGFARIIN-----------TTEMYTDYVATR
10873_Tthe -QDVIHRDVKPENLLVNPYN--YELKLCDFGFARTLPSK---------QGEIITDYVATR
17811_Tthe -YDIIHQNIKPMHIYINPSN--YELKLNGFRLARQLPQ----------KGEIVTDYVEAR
29899_Tthe -MDIIHRDIKPENLLISKD---GTLKLCDFGFARVLPQ----------KGGNLTDYVATR
7414_Tthe -HNIIHRDIKPENLLVNSD---GTLKLCDFGFARHMPPK---------QNEILTDYVATR
CDKL2_Spur -NNIIHRDIKPENILVSKS---KVVKLCDFGFARTIAG----------PGEIYTDYVATR
CDKL1_Spur -HNCIHRDVKPENILITKD---GRIKLCDFGFARILTG----------PDDEYTDYVATR
CDKL5_Spur -NDVIHRDIKPENLLISAK---DTLKLCDFGFARNLDGN---------SSANYTDYVATR
AqueK106_Aque -QN---------------------------------------------------------
AqueK107_Aque -HNVIHRDVKPENILISKR---GVVKICDFGFARAIAP----------PGEAYTDYVATR
GK026_Glam FMEICHRDLKPENLLLVKKHGEWTLKLCDFGFARHINGAQTAGAAGNFPQSNLTDYVATR
CG7236_Dmel WYRAPELLVGDTQYGTPVDVWAIGCLFAELVRGEALWPGRSDVDQLYLIRKTLGDLLPRH
CDKL5_Mmus WYRSPELLLGA-PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQ
CDKL4_Mmus WYRAPELLVGDTKYGSSVDVWAVGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRH
CDKL3_Mmus WYRAPELVLKDTSYGKPVDIWALGCMIIEMATGHPFLPSSSDLDLLHKIVLKVGNLTPHL
CDKL2_Mmus WYRAPELLVGDVKYGKAVDIWAIGCLVIEMLMGQPLFPGESDIDQLHHIMTCLGNLIPRH
CDKL1_Mmus WYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRH
CDKL1_Hsap WYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRH
CDKL2_Hsap WYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRH
CDKL5_Hsap WYRSPELLLGA-PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQ
CDKL4_Hsap WYRAPELLVGDTQYGSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRH
CDKL3_Hsap WYRAPELVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHL
Y42A5A.4_Cele WYRSPELLVGDVQYGPPVDIWAVGCVYAELLTGEALWPGRSDIDQLYHIRKTLGEFLPRH
10873_Tthe WYRAPELLLKYPKYSKPVDIWAVACIMGELIDGQPLFPGQNEIDQLYLIQKTLGPLTPEQ
17811_Tthe WYKSPEYLLDYRKYGKPEDIWAAACVMAELIDGEPLFPGQGEIDQFYRIVQVIGPLTNQY
29899_Tthe WYRAPELLLGYTDYGKEVDMWAVGCIMGELTDGQPLFPGQNEIDQLYVIQKVLGPLTAEQ
7414_Tthe WYRSPELLLSDPGYSFPVDNWAIACIMGELIDGQPLFPGENEIDQLYLIQKLLGPLTPDQ
CDKL2_Spur WYRAPELLVGDTKYGKAIDLWAVGCLQAEMLTGEPLFPGDSDIDQLYHIIRCFGTLIQRH
CDKL1_Spur WYRAPELLVGDMVYGPPVDVWAIGCVTAELIAGEALWPGRSDVDQLYLIKQTLGDLIDRH
CDKL5_Spur WYRSPELLLGS-AYGKAVDVWAIGCILGELSDGNAIFPGESEIDQLYM------------
AqueK106_Aque ----------------------------------PLWPGRSDVDQLHLIIQTQGDLIPYH
AqueK107_Aque WYRAPELLVGDTNYGRAVDVWAIGCLFSEMLTGEPLFPGESDIDQLYLITKCFGNLIARH
GK026_Glam WYRSPELLLNATDYNQTVDIWAAALIISEMITSEPLFAGDSDVDQLYLIQRVLGNLTRKQ
. .. .::* :.
CG7236_Dmel IQIFGQNEYFKGITLPVPPT--LEPLEDKMP-AKSQQNPLTIDFL-KKCLDKDPTKRWSC
CDKL5_Mmus MKLFYSNPRFHGLRFPAVNH--PQSLERRYLGIL---NSVLLDLM-KNLLKLDPADRYLT
CDKL4_Mmus QSIFRSNQFFRGISIPEPED--METLEEKFS-NV---QPVALSFM-KGCLKMNPDERLTC
CDKL3_Mmus HNIFSKSPIFAGVVLPQVQH--PKTARKKYP-KL---NGLLADIV-HACLQIDPAERTSS
CDKL2_Mmus QELFYKNPVFAGVRLPEVKDAEAEPLESRYP-KL---PEAVISLA-KKCLHIDPDKRPFC
CDKL1_Mmus QQVFSMNQYFSGVKIPDPED--METLELKFP-NI---SYSALGFL-KGCLHMDPAERLTC
CDKL1_Hsap QQVFSTNQYFSGVKIPDPED--MEPLELKFP-NI---SYPALGLL-KGCLHMDPTQRLTC
CDKL2_Hsap QELFNKNPVFAGVRLPEIKE--REPLERRYP-KL---SEVVIDLA-KKCLHIDPDKRPFC
CDKL5_Hsap MKLFYSNPRFHGLRFPAVNH--PQSLERRYLGIL---NSVLLDLM-KNLLKLDPADRYLT
CDKL4_Hsap QSIFKSNGFFHGISIPEPED--METLEEKFS-DV---HPVALNFM-KGCLKMNPDDRLTC
CDKL3_Hsap QNIFSKSPIFAGVVLPQVQH--PKNARKKYP-KL---NGLLADIV-HACLQIDPADRISS
Y42A5A.4_Cele ISIFRTNQFFFGLSIPEPEH--LEPLPSKLP-NA---SSAQLDFL-QKCFEMSPDRRFSC
10873_Tthe KELFIKNPRFIGTKFPEINK--PETIERRYLGKL---SKKALNIM-KLMLKMDPDERITA
17811_Tthe ENLFKKK--YKDLKFPIIKN--FNSIELRYQGKI---NAEGLDLM-KMMLKMNPDERITA
29899_Tthe QEVFLKHPGFLGVKLPEISK--PETIEKRYLGKL---SKKALSFM-KNLLKMDPSQRMSA
7414_Tthe KEMFIKNPRYVGLKFPEIPK--PETIERRYLGKL---SKKALTFM-KGLLKMDPRERMNV
CDKL2_Spur KEIFLKNPLFVGMRLPEVKN--VEPLEKRFP-TL---SGLSISMM-KSCLHLDPDQRPTC
CDKL1_Spur SKIFSTNHFFKGMSIPEPER--RIPLKDKVR-NL---NSTALTFL-EACLQMDPADRLSC
CDKL5_Spur ------------------------------------------------------------
AqueK106_Aque VKIFQESTYFKDTSIPCPDK--REPISALYP-QF---SQQILSFLEQGCLAMDPIARQTA
AqueK107_Aque REVFSRNPLFIGMRLPEARE--IQPFERRYH-RL---SPAAMDII-KWSLRLDPADRPTC
GK026_Glam MEKFLRNPKFIGVEFPTS-R--PEGLEKKLTGKIK--DKQAISLL-KMMLKMDPAERPSA
CG7236_Dmel EKLTKHSYF
CDKL5_Mmus EQCLNHPTF
CDKL4_Mmus AQLLDSAYF
CDKL3_Mmus TDLLRHDYF
CDKL2_Mmus ADLLRHDFF
CDKL1_Mmus EQLLQHPYF
CDKL1_Hsap EQLLHHPYF
CDKL2_Hsap AELLHHDFF
CDKL5_Hsap EQCLNHPTF
CDKL4_Hsap SQLLESSYF
CDKL3_Hsap SDLLHHEYF
Y42A5A.4_Cele SELMLHGIF
10873_Tthe EEAMKHPYF
17811_Tthe EQSLSHPFF
29899_Tthe DEALQHPYF
7414_Tthe QEAMAHPLF
CDKL2_Spur TQFLKHEFF
CDKL1_Spur QELMEMPFF
CDKL5_Spur --------I
AqueK106_Aque EELLDHPVF
AqueK107_Aque TQLLKHELF
GK026_Glam TQCLDHEFF
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