Egfr_Dmel       LRKGGVLGMGAFGRVYKGVWVPE-GENVKIPVAIKELLKSTGAESSEEFLREAYIMASVE
ErbB4_Mmus      LKRVKVLGSGAFGTVYKGIWVPE-GETVKIPVAIKILNETTGPKANVEFMDEALIMASMD
ErbB3_Mmus      LRKLKVLGSGVFGTVHKGIWIPE-GESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLD
ErbB2_Mmus      LRKLKVLGSGAFGTVYKGIWIPD-GENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVG
EGFR_Mmus       FKKIKVLGSGAFGTVYKGLWIPE-GEKVKIPVAIKELREATSPKANKEILDEAYVMASVD
let-23_Cele     TKLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTD--QSQTDEMLEEATNMFRLR
ErbB4_Hsap      LKRVKVLGSGAFGTVYKGIWVPE-GETVKIPVAIKILNETTGPKANVEFMDEALIMASMD
ErbB3_Hsap      LRKLKVLGSGVFGTVHKGVWIPE-GESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLD
ErbB2_Hsap      LRKVKVLGSGAFGTVYKGIWIPD-GENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVG
EGFR_Hsap       FKKIKVLGSGAFGTVYKGLWIPE-GEKVKIPVAIKELREATSPKANKEILDEAYVMASVD
EGFR_Spur       LKLGPVLGSGAFGTVYKGLWIPD-GEKIRIPVAIKALREV-SPHAAEELLEEAKVMASVD
AqueK263_Aque   ------------------------------------------------------------
AqueK264_Aque   ------------------------------------------------------------
AqueK265_Aque   LEFGKELGAGAFGTVYEGYWKPA-NDENEYHVAIKVLKNT-SASASKELLQEGVVMATMD
AqueK266_Aque   LEFKKELGSGTFGTVYEGYWKPD-NDEAEYHVAIKILKST-SADASKEL-----------


Egfr_Dmel       HVNLLKLLAVCMSS-QMMLITQLMPLGCLLDYV---------------------RNNRDK
ErbB4_Mmus      HPHLVRLLGVCLSP-TIQLVTQLMPHGCLLDYV---------------------HEHKDN
ErbB3_Mmus      HAHIVRLLGLCPGS-SLQLVTQYLPLGSLLDHV---------------------RQHRET
ErbB2_Mmus      SPYVSRLLGICLTS-TVQLVTQLMPYGCLLDHV---------------------REHRGR
EGFR_Mmus       NPHVCRLLGICLTS-TVQLITQLMPYGCLLDYV---------------------REHKDN
let-23_Cele     HDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFL---------------------KLHKEN
ErbB4_Hsap      HPHLVRLLGVCLSP-TIQLVTQLMPHGCLLEYV---------------------HEHKDN
ErbB3_Hsap      HAHIVRLLGLCPGS-SLQLVTQYLPLGSLLDHV---------------------RQHRGA
ErbB2_Hsap      SPYVSRLLGICLTS-TVQLVTQLMPYGCLLDHV---------------------RENRGR
EGFR_Hsap       NPHVCRLLGICLTS-TVQLITQLMPFGCLLDYV---------------------REHKDN
EGFR_Spur       HPCLLRLLCVCIAQ-NMTLITQLMPLGAILDYV---------------------RQHKEQ
AqueK263_Aque   ------------------------------------------------------------
AqueK264_Aque   ---------------------------------------------------------RNS
AqueK265_Aque   HENVVRLYCVCMSK-QLMLVSQFVPCGALIDYI---------------------KKQQDR
AqueK266_Aque   ----LQVXGLCISR-QIMLVSQLVPLGSLIAYLKNHKNKISAQTVINFSLQIAKXXHRNS


Egfr_Dmel       IGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNE
ErbB4_Mmus      IGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKE
ErbB3_Mmus      LGPQLLLNWGVQIAKGMYYLEEHSMVHRDLALRNVMLKSPSQVQVADFGVADLLPPDDKQ
ErbB2_Mmus      LGSQDLLNWCVQIAKGMSYLEEVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETE
EGFR_Mmus       IGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKE
let-23_Cele     LGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADS
ErbB4_Hsap      IGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKE
ErbB3_Hsap      LGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQ
ErbB2_Hsap      LGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETE
EGFR_Hsap       IGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKE
EGFR_Spur       IGSHHLLNWSFQIAKGMVYLEEKHLIHRDLAARNVLVQSPAQVKITDFGLAKFLEVDSNE
AqueK263_Aque   ------------------------LVHRDLAARNALVQSHLKVLITDFGLTRFIEPDESH
AqueK264_Aque   ISAQTVINFSLQIAKGMAYLESKSLVHRDLAARNVLVQSHLKVLITDFGLTRFIEPDESH
AqueK265_Aque   LNAHTILLFSSQIANGMAYLETKHLVHRDLAARNVLVQTPVKVKITDFGLTRIIEANQSH
AqueK266_Aque   ISAQTVINFSLQIAKGMAYLESKSLVHRDLAARNILVQSHLKVLITDFGLTRFIKPDESH
                                        ::**:** ** :::.   * ::***:: ::  :

Egfr_Dmel       YKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIE
ErbB4_Mmus      YNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLE
ErbB3_Mmus      LLHSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEIPDLLE
ErbB2_Mmus      YHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLE
EGFR_Mmus       YHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASDISSILE
let-23_Cele     ITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLK
ErbB4_Hsap      YNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLE
ErbB3_Hsap      LLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLE
ErbB2_Hsap      YHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLE
EGFR_Hsap       YHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILE
EGFR_Spur       YKAQ----------------------------GVTLWELMTFGGKPYEGVKAREVPELLE
AqueK263_Aque   YEASGSKLPVRWLPPESIRQRIFTHKTDIWSFGVTVWEILTFGESPFKGKSVFELLKLLE
AqueK264_Aque   YEAPGSKLPVRWLPPESIQQRIFTHKTDVWSFGVTVWEILTFGESPFKGKSVFELLKLLE
AqueK265_Aque   YEATTSKMPVRWLPPESIRNRVFTHKTDVWSFGVTVWEILTFGARPYQGKKPYEILKMLE
AqueK266_Aque   YEASGSKLPVRWLPPESIQQRIFTHKTDVWSFGVTVWEILTFGESPFKGKSVFELLKLLE
                                                *** **::***  *. .    .: .:::

Egfr_Dmel       VGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTT---V-F
ErbB4_Mmus      KGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAA---EFS
ErbB3_Mmus      KGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELAN---E-F
ErbB2_Mmus      KGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVS---EFS
EGFR_Mmus       KGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIL---EFS
let-23_Cele     DGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYE---RFK
ErbB4_Hsap      KGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAA---EFS
ErbB3_Hsap      KGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELAN---E-F
ErbB2_Hsap      KGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVS---EFS
EGFR_Hsap       KGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELII---EFS
EGFR_Spur       RGERLPQPPICTIDIYMLMVKCWLIDEDSRPTFKQMQE---ELE
AqueK263_Aque   KGDRLKQPKTCTLVFYKSLQNCWELEPEKRPSFEDLVY---Q-F
AqueK264_Aque   KGDRLKQPKTCTLEFYKTLQNCWELEPERRPSFEDLVY---Q-F
AqueK265_Aque   GGHRLDQPVTCTIDLYAVLLECWLLEPDSRPDFVDLGRRFHEFM
AqueK266_Aque   KGDRLKQPKTCTLEFYKTLQNCWELEPEKRPSFEDLVY---Q-F
                 * :* **  *:  .*  :  **  :   ** *  :