RHOK_Hsap_GRK M-DFGSLETVVANSAFIAARGSFDGSSSQPSRDKKYLAKLKLPPLSKCE--SLRDSLSLE
GPRK7_Hsap_GRK MVDMGALDNLIANTAYLQARKPS--DCDSKELQRR-RRSLALPGLQGCA--ELRQKLSLN
GPRK6_Hsap_GRK M----ELENIVANTVLLKAREGG--GGNRKGKSKKWRQMLQFPHISQCE--ELRLSLERD
GPRK5_Hsap_GRK M----ELENIVANTVLLKAREGG--GGKRKGKSKKWKEILKFPHISQCE--DLRRTIDRD
GPRK4_Hsap_GRK M----ELENIVANSLLLKARQGG--YGKKSGRSKKWKEILTLPPVSQCS--ELRHSIEKD
Gprk1_Dmel_BARK MA---DLEAVLADVSYLMAMEKS--KCTPAARASK-KLNLPDPSVRSVMYKYLEKEGELN
Gprk2_Dmel_GRK M----ELENIVANTVYLKAREGG--SDSNKGKSKKWRKILQFPHISQCI--NLKDKLDIS
GPRK6_Mmus_GRK M----ELENIVANTVLLKAREGG--GGNRKGKSKKWRQMLQFPHISQCE--ELRLSLERD
GPRK5_Mmus_GRK M----ELENIVANTVLLKAREGG--GGKRKGKSKKWKEILKFPHISQCE--DLRRTIDRD
GPRK4_Mmus_GRK M----ELENFVANNLLLKARLGF---NKQTGRSKKWRELLKFPPVSMCT--ELRWSIEKD
BARK2_Mmus_BARK MA---DLEAVLADVSYLMAMEKS--KTAPAARASK-KVVLPEPSIRSVMQRYLAERNEIT
BARK1_Mmus_BARK MA---DLEAVLADVSYLMAMEKS--KATPAARASK-KILLPEPSIRSVMQKYLEDRGEVT
F19C6.1_Cele_GRK M----EIENIVANTVYIKARESG--G-QKKGKSKKWKNYLQFPHYTECL--PLKTEIEVT
BARK1_Hsap_BARK MA---DLEAVLADVSYLMAMEKS--KATPAARASK-KILLPEPSIRSVMQKYLEDRGEVT
BARK2_Hsap_BARK MA---DLEAVLADVSYLMAMEKS--KATPAARASK-RIVLPEPSIRSVMQKYLAERNEIT
RHOK_Mmus_GRK M-DFGSLETVVANSAFIAARGSFDGSSTPSSRDKKYLAKLRLPPLSKCE--GLRDNLSLE
W02B3.2_Cele_BARK MA---DLEAVLADVSYLMAMEKS--RSQPAARASK-RIVLPDPSVRSIMQKFLEKSGDMK
BARK_Spur_BARK MA---DLEAVLADVSYLMAMEKS--KSTPAARASK-KLVLPDPSVRTVMYKYLEERKEIT
GPRK_Spur_GRK ------------------------------------------------------------
AqueK007_Aque_BARK MA---DLESVLADVSYLMTIEKS--R-NPGAKTLK-KIVLPDNSVHDVVHKWLSFKNELN
AqueK008_Aque_GRK --------------------------------------MLKLPPVGTCL--PLRDKIDHT
RHOK_Hsap_GRK FESVCLEQPIGKKLFQQFLQSA-EKHLPALELWKDIEDYDTADN-DLQPQ--KA-QTILA
GPRK7_Hsap_GRK FHSLCEQQPIGRRLFRDFLATV-PTFRKAATFLEDVQNWELAEE-GPTKD--SALQGLVA
GPRK6_Hsap_GRK YHSLCERQPIGRLLFREFCATR-PELSRCVAFLDGVAEYEVTPD-DKRKA--CG-RQLTQ
GPRK5_Hsap_GRK YCSLCDKQPIGRLLFRQFCETR-PGLECYIQFLDSVAEYEVTPD-EKLGE--KG-KEIMT
GPRK4_Hsap_GRK YSSLCDKQPIGRRLFRQFCDTK-PTLKRHIEFLDAVAEYEVADD-EDRSD--CG-LSILD
Gprk1_Dmel_BARK FHKNF-NEVLGYLLFKDFCENDSEEPIQQLKFFEQIKLFEKTECYDERKK--MA-RDIYD
Gprk2_Dmel_GRK YGYVIDQQPIGRELFRLFCENKRPVYFRYITFLDEVVKYEIEYI-SNRIF--IG-HDIGR
GPRK6_Mmus_GRK YHSLCERQPIGRLLFREFCATR-PELTRCTAFLDGVSEYEVTPD-EKRKA--CG-RRLMQ
GPRK5_Mmus_GRK YYSLCDKQPIGRLLFRQFCETR-PGLECYIQFLDLVAEYEITPD-ENLGA--KG-KEIMT
GPRK4_Mmus_GRK FSSLCDKQPIGRLLFRQFCDTK-PDLKRCIEFLDAVAEYEVTIE-EEQRE--FG-LAIFS
BARK2_Mmus_BARK FDKIF-NQKIGFLLFKDFCLNEIGEAVPQVKFYEEIKEYEKLDNEEDRLR--RS-RQMYD
BARK1_Mmus_BARK FEKIF-SQKLGYLLFRDFCLNHLEEAKPLVEFYEEIKKYEKLETEEERVV--RS-REIFD
F19C6.1_Cele_GRK YAFVVEKQPIGKLLFHEFCQATNSQYHQCCQFLTKVEEYETSDD-DGQSRRDLA-SSIVS
BARK1_Hsap_BARK FEKIF-SQKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVA--RS-REIFD
BARK2_Hsap_BARK FDKIF-NQKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLC--RS-RQIYD
RHOK_Mmus_GRK FESLCSEQPIGKRLFQQFLKTD-ERHVPALELWKDIEDYDTADD-DLRPQ--KA-QAILA
W02B3.2_Cele_BARK FDKIF-NQKLGFLLLKDYAENVSESPCPQIKFYEAIKEYEKMETPDERLT--KA-REIYD
BARK_Spur_BARK FEKIF-GQKLGYLLFKDYCENCADVQVQQLQFYEAIKDYEKLDTLDERLE--EA-RRIFD
GPRK_Spur_GRK ------------------------------------------------------------
AqueK007_Aque_BARK FHRIH-KQRMGTYFLEKFI----PPLCVTYSFLKAILDYEKTSSIVSRQK--KA-KQIYD
AqueK008_Aque_GRK FEFIVEQQPIGHKLFLLFCEKD-LKLSRCMQFLHAVDELKIVVE-GKRLA--HA-QTVFD
RHOK_Hsap_GRK QYLDP---------------------QAKL------------------------------
GPRK7_Hsap_GRK TCASA---------------------PAPG------------------------------
GPRK6_Hsap_GRK NFLSH---------------------TGPD------------------------------
GPRK5_Hsap_GRK KYLTP---------------------KSPV------------------------------
GPRK4_Hsap_GRK RFFND---------------------KLAA------------------------------
Gprk1_Dmel_BARK NFIME---------------------EMLS------------------------------
Gprk2_Dmel_GRK RFLDVEAQLELRNGSGGDALDAETQEELLLNSSNANPTETAETEHCNNTTANNCNNINNS
GPRK6_Mmus_GRK NFLSH---------------------TGPD------------------------------
GPRK5_Mmus_GRK KYLTP---------------------KSPV------------------------------
GPRK4_Mmus_GRK RFFKE---------------------KSEV------------------------------
BARK2_Mmus_BARK AYIMR---------------------ELLS------------------------------
BARK1_Mmus_BARK SYIMK---------------------ELLA------------------------------
F19C6.1_Cele_GRK LLHSKPEDNPSGSQDEQEFWCSFLSDEVI-------------------------------
BARK1_Hsap_BARK SYIMK---------------------ELLA------------------------------
BARK2_Hsap_BARK AYIMK---------------------ELLS------------------------------
RHOK_Mmus_GRK EYLDP---------------------QGTL------------------------------
W02B3.2_Cele_BARK HHIMV---------------------EMLA------------------------------
BARK_Spur_BARK NYIMK---------------------EVLS------------------------------
GPRK_Spur_GRK ------------------------------------------------------------
AqueK007_Aque_BARK KYIYA---------------------DMLA------------------------------
AqueK008_Aque_GRK DFLSL---------------------DSPQDQA---------------------------
RHOK_Hsap_GRK ------------------------------------------------------------
GPRK7_Hsap_GRK ------------------------------------------------------------
GPRK6_Hsap_GRK ------------------------------------------------------------
GPRK5_Hsap_GRK ------------------------------------------------------------
GPRK4_Hsap_GRK ------------------------------------------------------------
Gprk1_Dmel_BARK ------------------------------------------------------------
Gprk2_Dmel_GRK NNSQHSSDINHKKLDTRNHNGDDATGNGSSHQDDGDESVKCQEGHDDAEKGGGGEGGGGG
GPRK6_Mmus_GRK ------------------------------------------------------------
GPRK5_Mmus_GRK ------------------------------------------------------------
GPRK4_Mmus_GRK ------------------------------------------------------------
BARK2_Mmus_BARK ------------------------------------------------------------
BARK1_Mmus_BARK ------------------------------------------------------------
F19C6.1_Cele_GRK ------------------------------------------------------------
BARK1_Hsap_BARK ------------------------------------------------------------
BARK2_Hsap_BARK ------------------------------------------------------------
RHOK_Mmus_GRK ------------------------------------------------------------
W02B3.2_Cele_BARK ------------------------------------------------------------
BARK_Spur_BARK ------------------------------------------------------------
GPRK_Spur_GRK ------------------------------------------------------------
AqueK007_Aque_BARK ------------------------------------------------------------
AqueK008_Aque_GRK ------------------------------------------------------------
RHOK_Hsap_GRK ------------F-------C-SFLDEGIVAKFKEGPV--EIQDGLFQPLLQATLAHLGQ
GPRK7_Hsap_GRK ------------N-------PQPFLSQAVATKCQAATTE-EERVAAVTLAKAEAMAFLQE
GPRK6_Hsap_GRK ------------L-------I-PEVPRQLVTNCTQRLEQ-GPCKDLFQELTRLTHEYLSV
GPRK5_Hsap_GRK ------------F-------I-AQVGQDLVSQTEEKLLQ-KPCKELFSACAQSVHEYLRG
GPRK4_Hsap_GRK ------------P-------L-PEIPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRG
Gprk1_Dmel_BARK ------------H-------T-YEYSKHAVASVQKYLLKNEVPVDLFEPYLEEIFTQLKG
Gprk2_Dmel_GRK KCVPVGGYPDELV-------L-DVLNDDLIAQVRNKL--NSGGKDIFAQCVNAVKAFLAG
GPRK6_Mmus_GRK ------------L-------I-PEVPRQLVSNCAQRLEQ-GPCKDLFQELTRLTHEYLST
GPRK5_Mmus_GRK ------------F-------I-AQVGQDLVSQTEKKLLQ-SPCKELFSACAQSVHDYLKG
GPRK4_Mmus_GRK ------------P-------L-PEIPPDIVKECKWNLKQNSPSQNVFEECAGIVCKYLSE
BARK2_Mmus_BARK ------------S-------T-HQFSKQAVEHVQSHLSKKQVTATLFQPYIEEICESLRG
BARK1_Mmus_BARK ------------C-------S-HPFSKNATEHVQGHLVKKQVPPDLFQPYIEEICQNLRG
F19C6.1_Cele_GRK --------------------------STCITTADSATHDDEPRSDIFTEPYRLTCQYLTD
BARK1_Hsap_BARK ------------C-------S-HPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRG
BARK2_Hsap_BARK ------------C-------S-HPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRG
RHOK_Mmus_GRK ------------F-------C-NFLDQGMVTRVKEGPT--GSQDGLFQPLLQATMEHLSQ
W02B3.2_Cele_BARK ------------H-------A-HNYSKESLQHVQYHLLKQNVPPDLFHRYVLEICDQLRG
BARK_Spur_BARK ------------C-------T-HQFSKSAVENVRQRLTNQEAKPDLFSDYITEILNSLKG
GPRK_Spur_GRK ------------------------------------------------------------
AqueK007_Aque_BARK ------------M-------S-SKIPKEITDKVTVSLKANEVSTKLYGEIKEYLYDELTG
AqueK008_Aque_GRK ------------SKFLGAGKL-ECVSDELATKTQEKLKG-IVPVDVFEECRQAVRDFLSG
RHOK_Hsap_GRK APFQEYLGSLYFLRFLQWKWLEAQ---PMGEDWFLDFRVLGKGGFGEVSACQMKATGKLY
GPRK7_Hsap_GRK QPFKDFVTSAFYDKFLQWKLFEMQ---PVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMY
GPRK6_Hsap_GRK APFADYLDSIYFNRFLQWKWLERQ---PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMY
GPRK5_Hsap_GRK EPFHEYLDSMFFDRFLQWKWLERQ---PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMY
GPRK4_Hsap_GRK EPFEEYQESSYFSQFLQWKWLERQ---PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMY
Gprk1_Dmel_BARK KPFKKFLESDKFTRFCQWKNLELNI--QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMY
Gprk2_Dmel_GRK EPFREFESSMYFHRYLQWKWLEAQ---PITYKTFRMYRVLGKGGFGEVCACQVRATGKMY
GPRK6_Mmus_GRK APFADYLDSIYFNRFLQWKWLERQ---PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMY
GPRK5_Mmus_GRK DPFHEYLDSMYFDRFLQWKWLERQ---PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMY
GPRK4_Mmus_GRK TPFEEYQESTYFNRFLQWKWLERR---PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMY
BARK2_Mmus_BARK DIFQKFMESDKFTRFCQWKNVELNI--HLSMNDFSVHRIIGRGGFGEVYGCRKADTGKMY
BARK1_Mmus_BARK DVFQKFIESDKFTRFCQWKNVELNI--HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMY
F19C6.1_Cele_GRK APFKEFAESMYFHRFLQWKWLEKR---PVDKHTFRLYRVLGKGGFGEVCACQVRASGKMY
BARK1_Hsap_BARK DVFQKFIESDKFTRFCQWKNVELNI--HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMY
BARK2_Hsap_BARK DIFQKFMESDKFTRFCQWKNVELNI--HLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMY
RHOK_Mmus_GRK APFQEYLESLYFLRFLQWKWLEAQ---PIGEDWFLDFRVLGKGGFGEVSACQMKATGKMY
W02B3.2_Cele_BARK DIFQRFLESDKFTRFCQWKNLELNM--QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMY
BARK_Spur_BARK EIFQKFLESDKFTRFCQWKNVELNINGMLSMNDFSVHRIIGRGGFGEVYGCRKADTGKMY
GPRK_Spur_GRK ------------------------------------------------------------
AqueK007_Aque_BARK LYMKDFIHSSHYVRYCQWKYIELSVPHTISLSDFNVHRIIGRGGFGEVFGCRKDDSGKMF
AqueK008_Aque_GRK QPLIDFVESPFYWRFLQWKTLERM---IITKDHFRQYRVLGKGGFGLVFACQSKFTGKMY
RHOK_Hsap_GRK ACKKLNKKRLKKRKGYQGAMVEKKILMKVH----SRFIVSLAYAFETKADLCLVMTIMNG
GPRK7_Hsap_GRK ACKKLDKKRLKKKGGEKMALLEKEILEKVS----SPFIVSLAYAFESKTHLCLVMSLMNG
GPRK6_Hsap_GRK ACKKLEKKRIKKRKGEAMALNEKQILEKVN----SRFVVSLAYAYETKDALCLVLTLMNG
GPRK5_Hsap_GRK ACKRLEKKRIKKRKGESMALNEKQILEKVN----SQFVVNLAYAYETKDALCLVLTIMNG
GPRK4_Hsap_GRK ACKKLQKKRIKKRKGEAMALNEKRILEKVQ----SRFVVSLAYAYETKDALCLVLTIMNG
Gprk1_Dmel_BARK AMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCPFIVCMTYAFHTPDKLCFILDLMNG
Gprk2_Dmel_GRK ACKKLEKKRIKKRKGESMVLIEKQILQKIN----SPFVVNLAYAYETKDALCLVLTIMNG
GPRK6_Mmus_GRK ACKKLEKKRIKKRKGEAMALNEKQILEKVN----SRFVVSLAYAYETKDALCLVLTLMNG
GPRK5_Mmus_GRK ACKRLEKKRIKKRKGESMALNEKQILEKVN----SQFVVNLAYAYETKDALCLVLTIMNG
GPRK4_Mmus_GRK ACKKLEKKRIKKRKGEAMALNEKRILEKLH----SRFVVSLAYTYETKDALCLVLTIMNG
BARK2_Mmus_BARK AMKCLDKKRVKMKQGETLALNERIMLSLVSTG-DCPFIVCMTYAFHTPDKLCFILDLMNG
BARK1_Mmus_BARK AMKCLDKKRIKMKQGETLALNERIMLSLVSTG-DCPFIVCMSYAFHTPDKLSFILDLMNG
F19C6.1_Cele_GRK ALKKLEKKRVKKRHAETLSLNEKQILQRIN----SPFVVSLAYAYETKDALCLVLTLMNG
BARK1_Hsap_BARK AMKCLDKKRIKMKQGETLALNERIMLSLVSTG-DCPFIVCMSYAFHTPDKLSFILDLMNG
BARK2_Hsap_BARK AMKCLDKKRIKMKQGETLALNERIMLSLVSTG-DCPFIVCMTYAFHTPDKLCFILDLMNG
RHOK_Mmus_GRK ACKKLNKKRLKKRKGYQGAIVEKRILTKVH----SRFIVSLAYAFETKTDLCLVMTIMNG
W02B3.2_Cele_BARK AMKCLDKKRIKMKQGETLALNERIMLSLVSTGQDCPFIVCMTYAFQSPDKLCFILDLMNG
BARK_Spur_BARK AMKCLDKKRIKMKSGETLALNERIMLSLVSET-DCPFIVCMTYAFQTPDKLCFILDLMNG
GPRK_Spur_GRK --------------------------------------VSLAYAFEMKEALCLVLTIMNG
AqueK007_Aque_BARK AMKLLDKKRIKVKRGELLALNERNMLAKVN----SPFVVNLYYAFQTPEKLCFILDLMNG
AqueK008_Aque_GRK ALKKLEKKRVKKRKGEKLALNEKEVLEKVD----SRFVVTLAYAYQSKDSLCMVLTLMNG
* : *::. *.::: :***
RHOK_Hsap_GRK GDIRYHIYNVNEENPGFPEPRALFYTAQIICGLEHLHQRRIVYRDLKPENVLLDNDGNVR
GPRK7_Hsap_GRK GDLKFHIYNVG--TRGLDMSRVIFYSAQIACGMLHLHELGIVYRDMKPENVLLDDLGNCR
GPRK6_Hsap_GRK GDLKFHIYHMG--QAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIR
GPRK5_Hsap_GRK GDLKFHIYNMG--NPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIR
GPRK4_Hsap_GRK GDLKFHIYNLG--NPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIR
Gprk1_Dmel_BARK GDLHYHLSQHG----IFSEDEMKFYAAEVILGLEHMHKRCIVYRDLKPANILLDENGHIR
Gprk2_Dmel_GRK GDLKFHIYNMG-GEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVR
GPRK6_Mmus_GRK GDLKFHIYHMG--QAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIR
GPRK5_Mmus_GRK GDLKFHIYNMG--NPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIR
GPRK4_Mmus_GRK GDLKYHIYNLG--DPGFEEPRAVFYAAELCCGLEDLQRKRIVYRDLKPENILLDDHGHIR
BARK2_Mmus_BARK GDMHYHLSQHG----VFSEKEMRFYASEIILGLEHMHTCFVVYRDLKPANILLDEYGHVR
BARK1_Mmus_BARK GDLHYHLSQHG----VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVR
F19C6.1_Cele_GRK GDLKFHLYNLM--PGGFDEKRVQFYAAEITLGLQHLHSERILYRDLKPENILLDDFGHVR
BARK1_Hsap_BARK GDLHYHLSQHG----VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVR
BARK2_Hsap_BARK GDLHYHLSQHG----VFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHAR
RHOK_Mmus_GRK GDVRYHIYNVDEDNPGFSEPRAIYYTAQIISGLEHLHQRRIVYRDLKPENVLLDNDGNIR
W02B3.2_Cele_BARK GDLHYHLSQHG----VFTEQEMIFYASEVILGLEHMHNRFVVYRDLKPANILLDENGHVR
BARK_Spur_BARK GDLHYHLSQHG----VFSEEEVGFYAAEIILGLEHMHVRNVVYRDLKPANILLDENGHVR
GPRK_Spur_GRK GDLKFHIHNMG--SPGFEEERARFYAAEILCGLEDLHRLRIVYRDMKPENILLDDHGHVR
AqueK007_Aque_BARK GDLHYHLTQHG----VFNEAEVRFYAAELILALEHIHSQLIVYRDLKPSNVLLDEAGHIR
AqueK008_Aque_GRK GDLRFHIYSIG--SPGLEPERVVFYAAEIACGLHHLHTARIAYRDMKPDNILLDDAGHIR
**:::*: : :*:::: .: .:: *** ** *:***: *: *
RHOK_Hsap_GRK ISDLGLAVELLDGQSKTKGYAGTPGFMAPELLQ---------------------------
GPRK7_Hsap_GRK LSDLGLAVEMKGGK-PITQRAGTNGYMAPEILME--------------------------
GPRK6_Hsap_GRK ISDLGLAVHVPEGQ-TIKGRVGTVGYMAPEVVK---------------------------
GPRK5_Hsap_GRK ISDLGLAVKIPEGD-LIRGRVGTVGYMAPEVLN---------------------------
GPRK4_Hsap_GRK ISDLGLATEIPEGQ-RVRGRVGTVGYMAPEVVN---------------------------
Gprk1_Dmel_BARK ISDLGLACDFSKKK--PHASVGTHGYMAPEVLSK--------------------------
Gprk2_Dmel_GRK ISDLGLAVEIPEGE-MVRGRVGTVGYMAPEVID---------------------------
GPRK6_Mmus_GRK ISDLGLAVHVPEGQ-TIKGRVGTVGYMAPEVVR---------------------------
GPRK5_Mmus_GRK ISDLGLAVKIPEGD-LIRGRVGTVGYMAPEVLN---------------------------
GPRK4_Mmus_GRK ISDLGLAMEVPEGE-MVRGRVGTVGYMAPEIIN---------------------------
BARK2_Mmus_BARK ISDLGLACDFSKKK--PHASVGTHGYMAPEVLQK--------------------------
BARK1_Mmus_BARK ISDLGLACDFSKKR--PHASVGTHGYMAPEVLQK--------------------------
F19C6.1_Cele_GRK ISDLGLAVEIKDNE-PIKGRVGTVGYMAPEIVK---------------------------
BARK1_Hsap_BARK ISDLGLACDFSKKK--PHASVGTHGYMAPEVLQK--------------------------
BARK2_Hsap_BARK ISDLGLACDFSKKK--PHASVGTHGYMAPEVLQK--------------------------
RHOK_Mmus_GRK ISDLGLAVELKEGQNKTKGYAGTPGFMAPELLR---------------------------
W02B3.2_Cele_BARK VSDLGLACDYSKKK--PHASVGTHGYMAPEVLAK--------------------------
BARK_Spur_BARK ISDLGLACDFSSKK--PHASVGTHGYMAPEVLSKGTAYDSSADWFSLGCMLFKLLHGGTH
GPRK_Spur_GRK ISDLGLAVEIPEND-TIRGRVGTVGYMAPEVVK---------------------------
AqueK007_Aque_BARK LSDLGLACEFSDRK--PSSCVGTHGYMAPEVIQK--------------------------
AqueK008_Aque_GRK ISDLGLAVHIPEGQ-SVRGRVGTPGYMAPEVID---------------------------
:****** . .** *:****::
RHOK_Hsap_GRK ----------GEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKY
GPRK7_Hsap_GRK ----------KVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKF
GPRK6_Hsap_GRK ----------NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEY
GPRK5_Hsap_GRK ----------NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVY
GPRK4_Hsap_GRK ----------NEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEY
Gprk1_Dmel_BARK ----------GTSYDSCADWFSFGCMLYKLLKGHSPFRQHKTKDK-LEIDKMTLTMNVEL
Gprk2_Dmel_GRK ----------NEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKEKVKREEVDRRVKEDPEKY
GPRK6_Mmus_GRK ----------NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVAEEY
GPRK5_Mmus_GRK ----------NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVY
GPRK4_Mmus_GRK ----------HEKYTFSPDWWGLGCLIYEMIAGHSPFRKYKEKVNREELERRVKNETEEY
BARK2_Mmus_BARK ----------GTCYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTVNVQL
BARK1_Mmus_BARK ----------GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVEL
F19C6.1_Cele_GRK ----------NERYSYGVDWWGVGCLIYEMIEGKAPFRQRKEKVKREEVERRVREDQEKY
BARK1_Hsap_BARK ----------GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVEL
BARK2_Hsap_BARK ----------GTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTVNVEL
RHOK_Mmus_GRK ----------GEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRIISEPVKY
W02B3.2_Cele_BARK ----------GVAYDSSADWFSLGCMLYKLLKGHSPFRQHKSKDK-NEIDKMTLTQDIEL
BARK_Spur_BARK GYMAPEVLSKGTAYDSSADWFSLGCMLFKLLHGHSPFRQHKTKDK-HEIDRMTLTMDVEF
GPRK_Spur_GRK ----------NERYTFSPDYWGLGCLIYEMIEGRAPFRARKEKVKREEVDRRVKEDDEKY
AqueK007_Aque_BARK ----------GVHYDKSADWFSLGCVLYKLLRGHSPFRSQ---NK-DEVDQITLTKEVTM
AqueK008_Aque_GRK ----------GHRYTFAPDWWGMGCLIYEMICGRTPFRKHKERVSREDIERRIKDDRVCL
* *::..* ::::: .: **: . ::.:
RHOK_Hsap_GRK P-DKFSQASKDFCEALLEKDPEKRLGFRD-----ETCDKLRAHPLFKD---------LNW
GPRK7_Hsap_GRK QHDNFTEEAKDICRLFLAKKPEQRLGSRE-----K-SDDPRKHHFFKT---------INF
GPRK6_Hsap_GRK S-ERFSPQARSLCSQLLCKDPAERLGCRG-----GSAREVKEHPLFKK---------LNF
GPRK5_Hsap_GRK S-HKFSEEAKSICKMLLTKDAKQRLGCQE-----EGAAEVKRHPFFRN---------MNF
GPRK4_Hsap_GRK S-EKFSEDAKSICRMLLTKNPSKRLGCRG-----EGAAGVKQHPVFKD---------INF
Gprk1_Dmel_BARK -PESFSLELKNLLEMLLQRDVSKRLGCMG-----NGADEVKMHNFFCG---------IDW
Gprk2_Dmel_GRK S-SKFNDEAKSMCQQLLAKSIKQRLGCRNGR---MGGQDVMAHPFFHST-------QLNW
GPRK6_Mmus_GRK T-DRFSSQARSLCSQLLSKDPAERLGCRG-----GGAREVKEHPLFKK---------LNF
GPRK5_Mmus_GRK S-SKFSEEAKSICNMLLTKDSKQRLGCQE-----EGAAEVKRHPFFRN---------MNF
GPRK4_Mmus_GRK S-ERFSEDAKSICSMLLIKDPSKRLGCQR-----DGVSAVKQHPIFKD---------INF
BARK2_Mmus_BARK -PDAFSPELRSLLEGLLQRDVSQRLGCGG-----GGARELKEHIFFKG---------IDW
BARK1_Mmus_BARK -PDSFSPELRSLLEGLLQRDVNRRLGCLG-----RGAQEVKESPFFRS---------LDW
F19C6.1_Cele_GRK S-EKFSEAARTLCRGLLHKEPGFRLGCRRVGRPEDGAEEIRAHPFFNTADTVTGREPVPW
BARK1_Hsap_BARK -PDSFSPELRSLLEGLLQRDVNRRLGCLG-----RGAQEVKESPFFRS---------LDW
BARK2_Hsap_BARK -PDTFSPELKSLLEGLLQRDVSKRLGCHG-----GGSQEVKEHSFFKG---------VDW
RHOK_Mmus_GRK P-EKFSQASKDFCEQLLEKDPEKRLGFRD-----GTCDALRANVLFKD---------ISW
W02B3.2_Cele_BARK PNEGLSKDCRDLLEGLLKRDVPDRLGCRG-----KGPTEVKEHPFFKD---------VDW
BARK_Spur_BARK -PDKMSDEMRALLAGLLQREVASRLGCEG-----RGATEVREHPFFKT---------TDW
GPRK_Spur_GRK S-QKFSTEAQDICKKLLQKDPALRMGFEN-----GTAQTVKDHSFFNS---------ISF
AqueK007_Aque_BARK -PSSFSPGVSQLLTGLLEKDPTKRLGCLD-----TGVDAIKELPFFSD---------LNW
AqueK008_Aque_GRK DNSAFTEDSRSICDQFLDKVHATRLGCCG-----EMFEDVKAHPFFQT---------IDF
:. : :* : *:* .* :
RHOK_Hsap_GRK RQLEAGMLMPPFIPDSKTVYAKDIQDVGAFS--TVKGVAFDKTDTEFFQEFATGNCPIPW
GPRK7_Hsap_GRK PRLEAGLIEPPFVPDPSVVYAKDIAEIDDFS--EVRGVEFDDKDKQFFKNFATGAVPIAW
GPRK6_Hsap_GRK KRLGAGMLEPPFKPDPQAIYCKDVLDIEQFS--TVKGVELEPTDQDFYQKFATGSVPIPW
GPRK5_Hsap_GRK KRLEAGMLDPPFVPDPRAVYCKDVLDIEQFS--TVKGVNLDHTDDDFYSKFSTGSVSIPW
GPRK4_Hsap_GRK RRLEANMLEPPFCPDPHAVYCKDVLDIEQFS--VVKGIYLDTADEDFYARFATGCVSIPW
Gprk1_Dmel_BARK HQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEEDTKGIKLNDADQDLYKMFSL-TISERW
Gprk2_Dmel_GRK RRLEAGMLEPPFVPDPHAVYAKDVLDIEQFS--TVKGVNIDESDTNFYTKFNTGSVSISW
GPRK6_Mmus_GRK KRLGAGMLEPPFKPDPQAIYCKDVLDIEQFS--TVKGVDLEPTDQDFYQKFATGSVSIPW
GPRK5_Mmus_GRK KRLEAGMLDPPFVPDPRAVYCKDVLDIEQFS--TVKGVNLDHTDDDFYSKFSTGSVPIPW
GPRK4_Mmus_GRK SRLEANMLDPPFIPDPQAIYCRNILDIGQFS--VVKGVNLDTNDEIFYAEFATGSVTIPW
BARK2_Mmus_BARK QHVYLRKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQDLYKNFPL-VISERW
BARK1_Mmus_BARK QMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERW
F19C6.1_Cele_GRK KKMEAGKVTPPFCPDPRAVYAKDVLDIEQFS--TVKGVRLDATDTQFYGKFNTGCVSIPW
BARK1_Hsap_BARK QMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERW
BARK2_Hsap_BARK QHVYLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPL-VISERW
RHOK_Mmus_GRK RQLEAGMLIPPFIPDSRTVYAKNIQDVGAFS--TVKGVVFDKADTEFFQEFASGNCSIPW
W02B3.2_Cele_BARK QTVYLRRMTPPLIPPRGEVNAADAFDIGNFDDDEVKGVKLQDGDSDLYKNFNI-VISERW
BARK_Spur_BARK NQVYYQKVQPPLIPPRGEVNAADAFDIGSFDEDDVKGIKVRNLPFLTF------------
GPRK_Spur_GRK SRLEAGKLDPPFEPDKRAVYAKDVLDIEQFS--TVKGVNLDQNDDRFYTKFNSGSVAIPW
AqueK007_Aque_BARK DDVMEKKYAPPLIPPRGEVNAADAFDIGSFDSDETRGVKLNDEDQKMYSRFNV-VVSDRW
AqueK008_Aque_GRK AHLEAGLIPPPFIPNSRAVYAKDVLDIDQFS--SVRGVEIEKADEDFADKFATGIVPKPW
: **: * : . : :: *. .:*: .
RHOK_Hsap_GRK QEEMIETGIFGELNVWRS-DGQMPDDMKG-------------------------------
GPRK7_Hsap_GRK QEEIIETGLFEELNDPNR----------P-------------------------------
GPRK6_Hsap_GRK QNEMVETECFQELNVFGL-DGSVPPDLDWK------------------------------
GPRK5_Hsap_GRK QNEMIETECFKELNVFGP-NGTLPPDLNR-------------------------------
GPRK4_Hsap_GRK QNEMIESGCFKDINKSES-EEALPLDLDKN------------------------------
Gprk1_Dmel_BARK QQEVSET-VFDTVNTETDK-LEQKRKLKQKQHF---DAD--EKESDCILHGYIKKLGG-S
Gprk2_Dmel_GRK QNEMMETECFRELNVFGP-EECPTPDLQIN------------------------------
GPRK6_Mmus_GRK QNEMVETECFQELNVFGL-DGSVPPDLDWK------------------------------
GPRK5_Mmus_GRK QNEMIETECFKELNVFGP-NGTLSPDLNR-------------------------------
GPRK4_Mmus_GRK QNEMIESGCFKDLNENED-DLSSLEKY-KM------------------------------
BARK2_Mmus_BARK QQEVVET-IYDAVNADTDK-IEARRKAKNKQL---GQEEDYAMGKDCIMHGYMLKLGN-P
BARK1_Mmus_BARK QQEVAET-VFDTINAETDR-LEARKKAKNKQL---GHEEDYALGKDCIVHGYMSKMGN-P
F19C6.1_Cele_GRK QSEMIETECFAELNTFHDEDGNVMWNLRPD------------------------------
BARK1_Hsap_BARK QQEVAET-VFDTINAETDR-LEARKKAKNKQL---GHEEDYALGKDCIMHGYMSKMGN-P
BARK2_Hsap_BARK QQEVTET-VYEAVNADTDK-IEARKRAKNKQL---GHEEDYALGKDCIMHGYMLKLGN-P
RHOK_Mmus_GRK QEEMIETGLFGDLNVWRA-DGQMPDDMKG-------------------------------
W02B3.2_Cele_BARK QNEIAET-IFEVVNQDADK-AESKKRSKQKIKV--AVEE---KDSDVIVHGYIKKLGG-P
BARK_Spur_BARK ------------------------------------------------------------
GPRK_Spur_GRK QMEMIETQVFLELNVFGP-NGTLTADLMPD------------------------------
AqueK007_Aque_BARK QAEMMES-VFDSVNQDKEK-QEGKERSKSKNGILPFYTADGSFTDDSLLQGYGSKQSTAA
AqueK008_Aque_GRK QEEVSS------------------------------------------------------
RHOK_Hsap_GRK -------------------ISG--------------------------------------
GPRK7_Hsap_GRK -------------------TGC--------------------------------------
GPRK6_Hsap_GRK --------------------GQP-PAPPK-------------------------------
GPRK5_Hsap_GRK --------------------NHP-PEPPK-------------------------------
GPRK4_Hsap_GRK -------------------IHTP-VSRPN-------------------------------
Gprk1_Dmel_BARK FASLWQTKYAKLYPNRLELHSESGNNKPELIFM---DQVEDISSDFILHKNENCIQIRIN
Gprk2_Dmel_GRK ---------------------AA-PEPDK-------------------------------
GPRK6_Mmus_GRK --------------------GQP-TAPPK-------------------------------
GPRK5_Mmus_GRK --------------------SQP-PEPPK-------------------------------
GPRK4_Mmus_GRK --------------------CSS-ILRPK-------------------------------
BARK2_Mmus_BARK FLTQWQRRYFYLFPNRLEWRGEG-ESRQSLLTM---EQIMSV--EETQIKDRKCILLRIK
BARK1_Mmus_BARK FLTQWQRRYFYLFPNRLEWRGEG-EAPQSLLTM---EEIQSV--EETQIKERKCLLLKIR
F19C6.1_Cele_GRK ---------------GINMDERR-NGTSK-------------------------------
BARK1_Hsap_BARK FLTQWQRRYFYLFPNRLEWRGEG-EAPQSLLTM---EEIQSV--EETQIKERKCLLLKIR
BARK2_Hsap_BARK FLTQWQRRYFYLFPNRLEWRGEG-ESRQNLLTM---EQILSV--EETQIKDKKCILFRIK
RHOK_Mmus_GRK -------------------ITT--------------------------------------
W02B3.2_Cele_BARK FTSAWQTKYGKLYPSRLELYPESLTAKPELVFM---DQIEDVCAEMQTIKGETAIIVKLR
BARK_Spur_BARK ------------------------------------------------------------
GPRK_Spur_GRK ---------------------LP-PPPPK-------------------------------
AqueK007_Aque_BARK MFTHWQRKYFKLYPNRLDIGDSFTSMSKGLVSISFTESSILV--ESKQIKGTDIIRLQPI
AqueK008_Aque_GRK ------------------------------------------------------------
RHOK_Hsap_GRK ------------------------------------------------------------
GPRK7_Hsap_GRK ------------------------------------------------------------
GPRK6_Hsap_GRK -------------------------------------------------------KGLLQ
GPRK5_Hsap_GRK -------------------------------------------------------KGLLQ
GPRK4_Hsap_GRK -------------------------------------------------------RGFFY
Gprk1_Dmel_BARK DGTRDGRIILTNS-----------------------DEIGLKEWSSSLRSAHKISQDLLG
Gprk2_Dmel_GRK -------------------------------------------------------AGCFP
GPRK6_Mmus_GRK -------------------------------------------------------KGLLQ
GPRK5_Mmus_GRK -------------------------------------------------------KGLFH
GPRK4_Mmus_GRK -------------------------------------------------------RNFFR
BARK2_Mmus_BARK GGKQ---FVLQCE-----------------------SDPEFAQWLKELTCTFNEAQRLLR
BARK1_Mmus_BARK GGKQ---FVLQCD-----------------------SDPELVQWKKELRDAYREAQQLVQ
F19C6.1_Cele_GRK -------------------------------------------------------PGFFS
BARK1_Hsap_BARK GGKQ---FILQCD-----------------------SDPELVQWKKELRDAYREAQQLVQ
BARK2_Hsap_BARK GGKQ---FVLQCE-----------------------SDPEFVQWKKELNETFKEAQRLLR
RHOK_Mmus_GRK ------------------------------------------------------------
W02B3.2_Cele_BARK DGFK---EPKICLTNSVSENVLKYKTEKKNCRSVYLDEISLKEWHTSLRTAHKVSQELLQ
BARK_Spur_BARK ------------------------------------------------------------
GPRK_Spur_GRK -------------------------------------------------------QGFFR
AqueK007_Aque_BARK GTRR--ETCIKFE-----------------------SQLEHQMWFRFLRDAIHKHD----
AqueK008_Aque_GRK ------------------------------------------------------------
RHOK_Hsap_GRK ----------------------------------------------------G--SSSSS
GPRK7_Hsap_GRK ----------------------------------------------------E--EGNSS
GPRK6_Hsap_GRK RLFSRQRIAVETA------------ATA---R----------KS-SP--P---A-SSPQP
GPRK5_Hsap_GRK RLFKRQHQNNSKS------------SPS---S----------KT-SFNHH---I-NSNHV
GPRK4_Hsap_GRK RLFRRGGCLTM--------------V-------------------------------PSE
Gprk1_Dmel_BARK SMAKKAGKIYGSE-----------R-----------------DV-NKS---MYIFGGNCS
Gprk2_Dmel_GRK --FRRKK-----------------KQPA---R----------TQPIPIPE-HLL-TTSHS
GPRK6_Mmus_GRK RLFSRQRIAVGTA------------ATV---R----------KS-SP--P---A-SSPQA
GPRK5_Mmus_GRK RLFRRQHQSNSKS------------SPT---P----------KT-SCNHR---I-NSNHI
GPRK4_Mmus_GRK RLFRRTGCLNI----------------------------------------------ALS
BARK2_Mmus_BARK RAPK--------------------------FL----------NK-PRAAI-LEFSKPPLC
BARK1_Mmus_BARK RVPK--------------------------MK----------NK-PRSPV-VELSKVPLI
F19C6.1_Cele_GRK RLFRKKNIEVTKSLHDLSHLGVEQQQPP---K----------TS-TQTPA-VRS-SRAAS
BARK1_Hsap_BARK RVPK--------------------------MK----------NK-PRSPV-VELSKVPLV
BARK2_Hsap_BARK RAPK--------------------------FL----------NK-PRSGT-VELPKPSLC
RHOK_Mmus_GRK ----------------------------------------------------EE-AAPTA
W02B3.2_Cele_BARK RMGRKAIKIYGVN-----------HDPM--LS----------ES-ERPGS-VTRAFLNRA
BARK_Spur_BARK ------------------------------------------------------------
GPRK_Spur_GRK RIFRIKDIKEKDG-----------KNKS---T----------KG-LQSEKIFEY-RKSKE
AqueK007_Aque_BARK -----------ST-----------KDPSGPIALEDGGLIQRRQI-SDSPA-R--RARELG
AqueK008_Aque_GRK ------------------------------------------------------------
RHOK_Hsap_GRK KSGMCLVS
GPRK7_Hsap_GRK KSGVCLLL
GPRK6_Hsap_GRK EAPTSSWR
GPRK5_Hsap_GRK SSNSTGSS
GPRK4_Hsap_GRK KEVEPKQC
Gprk1_Dmel_BARK TKTSNGSN
Gprk2_Dmel_GRK VSSTTVES
GPRK6_Mmus_GRK EAPTGGWR
GPRK5_Mmus_GRK NSNSTGSS
GPRK4_Mmus_GRK EEREPTEH
BARK2_Mmus_BARK H-RNSSGL
BARK1_Mmus_BARK QRGSANGL
F19C6.1_Cele_GRK ASGRTLVI
BARK1_Hsap_BARK QRGSANGL
BARK2_Hsap_BARK H-RNSNGL
RHOK_Mmus_GRK KSGMCLIS
W02B3.2_Cele_BARK -SSVDSGV
BARK_Spur_BARK ---LNLKT
GPRK_Spur_GRK IYGVHNTP
AqueK007_Aque_BARK YTRSVPIL
AqueK008_Aque_GRK -------T