SgK223_Hsap MHQTLCLNPESLKMSACSDFVEHI-------------WKPGSCKNCFCL-RSDHQLVAGP
SgK269_Hsap -------------MSACNTFTEHV-------------WKPGECKNCFKP-KSLHQLPPDP
SgK223_Mmus -------------MSACSDFVEHI-------------WKPGSCKNCFCL-RSDHQPTAGH
SgK269_Mmus -------------MSACNTFTEHV-------------WKPGECKNCFKP-KSLHQLPPDS
Spk390_Spur -------------MEC-------------------------HCAACSSP-----------
AqueK185_Aque -------------MNKSSTRTLQAIGHDEGDSSPEEFAIPRAATICTSALRGRRQL-SEP
*. . *
SgK223_Hsap PQPRAGSLPPPPRLPPRPENCRLEDEGVNSSP-YSKPTIAVKPTMMSSEASDVWTEANLS
SgK269_Hsap EKAPITH-GNVKTNANHSNNHRIRNTGNFRPPVAKKPTIAVKPTMIVADGQSICGELSIQ
SgK223_Mmus PKARANSLPAGTRLPARPENCRLDDEGVNGLA-YSKPTIAVKPTMMTSETSDLWTEASLS
SgK269_Mmus EKTPITH-GSGKTNANHSNNHRVRSTGNFRPPVAKKPTIAVKPTMMVADGQSVCGELSIQ
Spk390_Spur ------H-GSRKRMMNI-------------------------------------------
AqueK185_Aque PSDML-------------------------------------------------------
SgK223_Hsap AEVS--Q--VIWRRAPGKL---PLPK--QED-APVVYLGSFRGVQKPAGP----------
SgK269_Hsap EHCENKPVIIGWNRNRAALSQKPLNNNNEDD-EGISHVPKPYGNNDSAKKMSDNNNGLTE
SgK223_Mmus AEVP--K--VNWRRTPGKL---LLPK--QED-EPIVYLGSFRGLQKPASP----------
SgK269_Mmus EHCENKPVILGWNQNKTSLSQKPLNNNSEGDAEGFGSDPQQCANNDSAQKISNNNNGLTE
Spk390_Spur ---------HGANRANI-APQKPARRRQ--------------------------------
AqueK185_Aque ------------------------------------------------------------
SgK223_Hsap --------STSPD--GN---------------------SRCPPAYTMVGLHNLEPRGERN
SgK269_Hsap VLKEIAGLDTAPQIRGNETNSRETFLGRINDCYKRSLERKLPPSCMIGGIKETQG--K--
SgK223_Mmus --------LACTD--GN---------------------SRCPPAYTMVGLHNLEARVDRN
SgK269_Mmus VLKEIAGLEATPPVRGNETNARETFLGRINDCYKRSLERKIPPSCMTGSMKDSQG--K--
Spk390_Spur ---------------RNRTTGFEDLPSRVKRMAPKTPEK--PTPCDTG------------
AqueK185_Aque ------------------------------------------------------------
SgK223_Hsap IAFHPVSFPEEKAVHKEKPSFPYQDRPS---------------TQESFRQKLAAFAGTTS
SgK269_Hsap ---HVILSGSTEVISNEGGRFCYPEFSSGEESEEDVLFSNMEEEHESWDESDEELLAMEI
SgK223_Mmus TAFQPVSFQEEKAG--------REELPS---------------AHESFRQKLAAFAGMTS
SgK269_Mmus ---HVILSGSAEVISNEGGRFCYPEFSSGEESEEDVLFSNMEEEHESWDESDEELLAMEI
Spk390_Spur ------------------------------------------------------------
AqueK185_Aque ------------------------------------------------------------
SgK223_Hsap GCHQGP----------GPL-------RESLPSEDDSDQR-CSPSGDSEGGEYCSILDCCP
SgK269_Hsap RMRGQPRFANFRANTLSPVRFFVDKKWNTIPLRNKSLQRICAVDYDD---SYDEILNGYE
SgK223_Mmus SCPKGPRPC----TSPQPL-------RESLPSEDDSDQR-CSPSGDSEGGEYCSILDCCP
SgK269_Mmus RMRGQPRFANFRANTLSPVRFFVSKKWNTIPLRNKSLQRICAVDYDD---SYDEILNGYE
Spk390_Spur ---------------------------------------------D-------DVFD---
AqueK185_Aque ------------------------------------------------------------
SgK223_Hsap GSPVAKAASQTAGSRGRHGGRDCSPTCWEQGKCSGPAEQEK--RGPSFPKECCSQG-PTA
SgK269_Hsap EN-SVVSY--GQGS---IQS-MVSSDST--SPDSSLTEESRSETASSLSQKICNGGLSPG
SgK223_Mmus ESKDAVHS--TEGS-GRRGG-DCSPTCREQGPRTRPTEEEK--QGLSFPRECCGQG-STA
SgK269_Mmus EN-SGVSY--GQGS---VQS-TISSDCT--SPGSSFTEESRSETASSLSQKVCNGGISPG
Spk390_Spur ----------GNGA----------------------------------------------
AqueK185_Aque ----------------------------------------------------RDISLSPL
SgK223_Hsap HPSCLGPK-KLSLTSEAAISSDGLSCGSGSGSGASSPFVPHLESDYCSLMKE--------
SgK269_Hsap NPGDSKDMKEIEPNYESP-SSNNQDKDS-SQASKSSIKVPETHKAVLALRLEEKDGKIAV
SgK223_Mmus NPPRLGPK-KPSLNSEAASSSDGLSCGS-SRSGASSPFAPHLENDYCSLVKE--------
SgK269_Mmus NPGNSKDIAETESNFESP-PGNNEEKDE-SLTSKSSVKVPETHKAVLALRLQEKDGKIAV
Spk390_Spur ------------------------------------------------------------
AqueK185_Aque P------------------PARSQTVDS-KQV----------------------------
SgK223_Hsap ----PAPEKQQDPGCPGVTPSRCLGLTGEPQPPAH--PRE--------------------
SgK269_Hsap QTEKEESKASTDVAGQAVTINL-VPTEEQAKPYRVVNLEQPLCKPYTVVDVSAAM----A
SgK223_Mmus ----PASGKQQDLSGHFLTSGKCVGQAAELQPASL--LRD--------------------
SgK269_Mmus HTEKPESKASTDIAGQAVTISL-VPVEEQTKPYRVVNLEQPLCKPYTVVDVSAAM----A
Spk390_Spur ------------------------------------------------------------
AqueK185_Aque ----------------------------------------GVVKPYAVVDLHETLKQIQS
SgK223_Hsap ------------------------------------------------------------
SgK269_Hsap SEHLEGPVNSPKTKSSSSTPNSPVTSSSLTPGQISAHFQKSSAIRYQEVWTSSTSPRQKI
SgK223_Mmus ------------------------------------------------------------
SgK269_Mmus SEHLG----RPKIKGSSSTPNSPVTSPALTPGQINAHLKKSSAIRYQEVWTSSTSPRQKI
Spk390_Spur -----------------------------------------KQLVFDDIHLSS-------
AqueK185_Aque QDHFL----RPRVGSCG-------------------------------------------
SgK223_Hsap ----------------------AT------------------------------------
SgK269_Hsap PKVELITSGTGPNVPPRKNCHKSAPTSPTATNISSKTIPVKSPNLSEIKFNSYNNAGMPP
SgK223_Mmus ----------------------PV------------------------------------
SgK269_Mmus PKIELSTGGPGPNVPPRKNCHKSAPTSPTATNISSKTIPVKSPNLSEIKFNSYNNAGMPP
Spk390_Spur -------------SPPLKSALRSTQSEPLRTDAEGKVVPKRPVR----------------
AqueK185_Aque ------------------------------------------------------------
SgK223_Hsap -----QPEPIYAESTKRKKAAPVPSKSQAKIEHAAAAQGQGQVCTGNAWAQKAASGWGRD
SgK269_Hsap FPIIIHDEPTYARSSKNAIKVPIVINPNAYDNLAIYKSFLGT------------------
SgK223_Mmus -----QPEPIYAESAKRKKAAPGPPRPEPKKEQVPAGHSQGQVWTGDTWIQKTPPSWSQD
SgK269_Mmus FPIIIHDEPSYARSSKNAIKVPIVINPNAYDNLAIYKSFLGT------------------
Spk390_Spur ------------------------------------------------------------
AqueK185_Aque -------TVFLYDATKRRIEAPLALQR---------------------------------
SgK223_Hsap --SPDPTPQVSATITVMAAHPEEDHRT---------------------------------
SgK269_Hsap ----SGELSVKEKTTSVISHTYEEIETESKVPDNTTSKTTDCLQTKGFSNSTEHKRGSVA
SgK223_Mmus REGANPAPQVATTITVIAAHPEEDHRT---------------------------------
SgK269_Mmus ----SGELSVKEKTTSVISHTYEEIETESKVSDSTPSKLTDCPQAKGFSNSTERKRGSVA
Spk390_Spur ------------------------------------------------------------
AqueK185_Aque ------------------------------------------------------------
SgK223_Hsap -------------------IYLSSPDSAVGVQWPRGPVSQNSEVGEEETSAG-QGLSSRE
SgK269_Hsap QKVQEFNNCLNRGQSSPQRSYSSSHSSPAKIQRATQEPVAKIEGTQESQMVG--SSSTRE
SgK223_Mmus -------------------IYLSSPDSAVGVQWPRGPSNQDLQAGEEEPLVA-QGLTSRE
SgK269_Mmus QKVQEFNNCLNRGQSSPQRSYSSTHSSPAKIQRPTQEPAGKTEGAQGSQVPGSSSNSTRE
Spk390_Spur ---------------------IIAPED-----------------------------AAID
AqueK185_Aque ------------------------------------------------------------
SgK223_Hsap SHAHSASES---------------------KPKERPAIPPK--LSKSSPVGSPVSPSAGG
SgK269_Hsap KASTVLSQIVASIQPPQSPPETPQSGPKACSVEELYAIPPDADVAKSTPKSTPVRPK---
SgK223_Mmus SHPHNVTEN---------------------TAKEKPAIPPK--LSKSSPGGSPVSPA---
SgK269_Mmus KASAVLCQIVASIQPPQTPPEAPQSSPKACSVEELYAVPPDADTTKSIPKNPPVRPK---
Spk390_Spur THSHSTVLR---------------------SDYTNLALVPQV--HLDD------------
AqueK185_Aque --------R---------------------ERKERKSIVPK--RKAP---------P---
:: *.
SgK223_Hsap PPVSPLADLSDGSSGGSSIGP-------QPPSQGPADPAPSCRTNGVAI-SDPSRCPQPA
SgK269_Hsap ---SLFTSQPSGEAEAPQTTDSPTTKVQKDPSIKPVTPSPSKLVTSPQS-EPPAPFPPPR
SgK223_Mmus ---PPLTDHSDGNTGGSSVGP-------QLLSRVPANLTSSCHTNGVATAGDSAKCPPPA
SgK269_Mmus ---SLFTSQSSGEGEAHQTTESPTAKIQKDPSTKPVTSPPSKLVTSAQS-EPPPPFPPPR
Spk390_Spur -------------------------TIH--------------------------------
AqueK185_Aque ---PPVTRSPGHAYGGRAKK--------------------NTLTTGNRM-SRSSSVPTPL
SgK223_Hsap ASSAS---------------------------------------EQRRPRF-QAGTWSRQ
SgK269_Hsap STSSPYHAGNLLQRHFTNWTKPTSPTRSTEAESVLHSEGSRRAADAKPKRWISFKSFFRR
SgK223_Mmus TSSSVL--------------------------------------DQRRPRY-QTGAWSRQ
SgK269_Mmus STSSPYHASNLLQRHFTNWTKPTSPTRSTEAESILHSEGSRRAADAKPKRWISFKSFFRR
Spk390_Spur ------------------------------------------------------------
AqueK185_Aque ITDA--------------------------------------------------------
SgK223_Hsap CRIEEEEEVEQEL---------------------LSHSWGRETKNGPTDHSNSTTWHRLH
SgK269_Hsap RKTDEEDDKEKEREKGKLVGLDGTVIHMLPPPPVQRHHWFTEAKGESSEKPAIVFMYRCD
SgK223_Mmus CRIEEEEEVGQEL----------------------SQSWGRELENGTADHSNSSTWHRLH
SgK269_Mmus RKTDEEEEKEKEREKGKLVGLDGTVIHMLPPPPVQRHHWFTEAKGEASEKPAIVFMYRCD
Spk390_Spur ------------------------------------------------------------
AqueK185_Aque -----EEEV-----------------------------------------HNSSV-----
SgK223_Hsap PTDGS-SGQNSKVG------TGMSKSASFAFEFPKDRSGIETFSPPPPPPKSRHLLKMNK
SgK269_Hsap PAQGQLSVDQSKARTDQAAVMEKGRAENALLQ---DSEKKRSHSSPSQIPKK--------
SgK223_Mmus PIDGT-SGQNSKTN------SGMSKSASFAFEFPKDRGRLEAFSPPPPPPKSRHLLKMNK
SgK269_Mmus PDQGHLSVDQSKAG------AEKGRAEEVLLR---NSEEKKSSYLPSQIPDK--------
Spk390_Spur ------------------------------------------------------------
AqueK185_Aque ------------------------------FIPLNDVSKSKEKSPPCKPPRTQS------
SgK223_Hsap SSSDLEKVSQGSAE--------------------SLSPSFRGVHVSFTTGSTDSL-ASDS
SgK269_Hsap ---ILSHMTHEVTEDFSPRDPRTVVGKQDGRGCTSVTTALSLPELEREDGKEDISDPMDP
SgK223_Mmus SSSDLEKVSQSSAE--------------------SLSPSFRGAHVSFTTGSTDSL-ASDS
SgK269_Mmus ---ACSRVTHEVAGELSPRDPRTPAGKQDG---TSVTPTLPPPDLEREEEKDDTLDPTDV
Spk390_Spur --KDAETQVNDSPQRV--------------------------------------------
AqueK185_Aque -----------------------------------------------TYMS---------
SgK223_Hsap RTCSDGGPSSELAHSPTNSGKKLFAPVP-----FPSGS----------TEDVSPSG-PQQ
SgK269_Hsap NPCSATY---------SNLGQSRAAMIPPKQPRQPKGAVDDAIAFGGKTDQEAPNASQPT
SgK223_Mmus RPCSDGGPSYEPTHSPTISGKKLFAPVP-----FPSGS----------TEDVSPGGGPAQ
SgK269_Mmus SPCSATY---------SNLGQSRAAMIPPKHPRHPKGAVDDAIAFGEKTDQEGLNASQPT
Spk390_Spur ------------------------------------------------------------
AqueK185_Aque ---------------------------------------FDEVAIGAKTA----------
SgK223_Hsap PPPLPQKKIVSRAASSPDGFFWTQGSPKPGTASPKLNLSHSETNV--HDESHFSYSLSPG
SgK269_Hsap PPPLPKKMII-RANTEPISKDLQK---------------SMESSLCVMANPTYDIDPNWD
SgK223_Mmus PPPLPQKKIVSRAASSPDGFFWTQGSPKPRTASPKLNLSHSETNVCAHDEPPFNCSLNSG
SgK269_Mmus PPPLPKKMI--RANTEPISKDLQK---------------AMESSLCVMANPTYDIDPNWD
Spk390_Spur ------------------------------------------------------------
AqueK185_Aque ------------------------------------------------------------
SgK223_Hsap NRHHP----------VFSSSDPLEKAFKGSGHWLPAAGLAGNRGGCGSPGLQCKGAPS--
SgK269_Hsap ASSAGSSISYELKGLDIESYDSLERPLRKERP---VPSAANSISSLTTLSIKDRFSNSME
SgK223_Mmus NRSHH----------VFSSSEPLGKAFKGNAPWAPALGLANSKGGCGSPSLQCRAATS--
SgK269_Mmus ASSAGSSISYELKGLDVESYESLERPLHKERP---VPSAANSISSLATLSVKDRFSNSME
Spk390_Spur -----------------------------------EPSLADARCS---------------
AqueK185_Aque ----------------CSDYEPLHRFSQQNSP---SGTMRSS-------------ITA--
.
SgK223_Hsap ASSSQLSVSSQASTGSTQLQLHGLLSNISSKEGTYAKLGGLYTQSLARLV----------
SgK269_Hsap SLSSRRGPSCRQGRGIQKPQRQALYRGLENREEVVGKIRSLHTDALKKLA----------
SgK223_Mmus TSSSQLSVSSQASSSSTQLQLHSLLSSISSKEGTYAKLGGLYTQSLARLV----------
SgK269_Mmus SLSSRRGLSYRQTRSIQKPQRQALYRGLDNREEVVGKLRSLHTDALKRLA----------
Spk390_Spur -------LNPLNSSSLDQSSQRNL----------LNDVSAVHRQALTQLSRTTPRTPLDW
AqueK185_Aque TISSDVAIASLSLLHQFQELFDDT----------LGNIASRHFEELTSTD----------
: .: . : : *
SgK223_Hsap AKCEDLFMGGQKKELHFNENNWSLFKLTCNKPCCDSGDAIYY-CATCSEDPGSTYAVKIC
SgK269_Hsap VKCEDLFMAGQKDQLRFGVDSWSDFRLTSDKPCCEAGDAVYY-TASYAKDPLNNYAVKIC
SgK223_Mmus TKCEDLFMGGQKKELRFNENYWSLFKLTCNKPCCDSGDAIYY-CATCSEDPGSIYAVKIC
SgK269_Mmus VKCEDLFMAGQKDQLRFGVDSWSDFRLTSDKPCCEAGDAVYY-TASYAKDPLSNYAVKIC
Spk390_Spur TECEDSVWKEQ----------------ATSEPKCRSAGAAFF-GVTHPTNPSSPTGLLVC
AqueK185_Aque Q--------------HLQDMNWSDITDSVDL---KNKHQLYFHMQPISLEPLD-------
: . :: . . :* .
SgK223_Hsap KAPEPKTVSYC-----SPSVPVHFNIQQDCGHFVASVPSSMLS--SPDAP-K--------
SgK269_Hsap KSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPNRLLPWEDPDDPEKDEDDMEET
SgK223_Mmus KTPEPKSASYC-----SPSVPVHFNIQQDCGHFVASVPSSMLA--SPDTSSK--------
SgK269_Mmus KSKAKESQQYYHSLAVRQSLPVHFNIQQDCGHFLAEVPSRLLPWEDPDAPEKAEDGTEDS
Spk390_Spur CDPNKATQVL-QMAEMTKSMATHPNLISV-SH----------------A-TK--------
AqueK185_Aque ------RDRHRTELSIAKTLTPHLNLSLPRGTL-QQAPVDY-------------------
::. * *: .
SgK223_Hsap -----------DPVPALPTHPPAQ-------------EQDCVVVITREVPHQTASDFVRD
SgK269_Hsap EEDAKGETDGKNPKPCSEAASSQKENQ----GVMSKKQRSHVVVITREVPCLTVADFVRD
SgK223_Mmus -----------DTAPAVSPQPPAQ-------------EQDCVVVITREVPHQTASDFVRD
SgK269_Mmus EEEGKAETLGGNPEPCSETEPSQKENQ----RVTNRKQRSHVVVITREVPHLTVADFVRD
Spk390_Spur -----------DTIT---IDPSLLEQRKTRSSPLTGGSIETALVFTDDLPTGNVAEYVSQ
AqueK185_Aque ----------------IEFLPDAKE---------------YVVRDTSCLPDKVPLEKILP
. .: * :* : :
SgK223_Hsap SAASHQAEPEAYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCT-LQAG-PGP
SgK269_Hsap SLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCDLRLENLLLVHYQ-PGGTAQGF
SgK223_Mmus SMASHRAEPEVYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLAHCN-PQSS-PGP
SgK269_Mmus SLAHHGNSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCDLRLENLLLVQHQ-PGGAAQGP
Spk390_Spur NTEKHEHLPEVYERDVALMLLQLCQGLCELQSRSMCLESLKLDHLLLTESGLPGGG----
AqueK185_Aque -LWNKSLSEEEYMQAVLLILVQVLRGLNYLYNNGIVHRDIGIESLLAWTYR-SSADH---
: : * : * ::*:*: ** * : .: :: ** .
SgK223_Hsap APAPA-PAPAAAAPPCSSAAPPAGGTLSPAAGPASPEGPREKQLPRLIISNFLKAKQKPG
SgK269_Hsap G--PAEPSPTSSYP------------------------------TRLIVSNFSQAKQKSH
SgK223_Mmus SATPTVPTTTSRCP---SAA--------PAATTACQGGPGEKQLPRLIISNFLKAKQKPG
SgK269_Mmus S--PADPCPTLACP------------------------------TRLIVSNFSQAKQKSH
Spk390_Spur --------------------------------------------HRLVINHLMGAEV---
AqueK185_Aque ---------------C-----------------------------IIKLKNFTYALHRPG
: :.:: *
SgK223_Hsap GTPNLQ----------QKKSQARL------APEIVSASQYRKFDEFQTGILIYELLHQPN
SgK269_Hsap L-VDPE----------ILRDQSRL------APEIITATQYKKCDEFQTGILIYEMLHLPN
SgK223_Mmus GTTNLQ----------QKKSQARL------APEIVSASQYRKFDEFQTGILIYELLHQPN
SgK269_Mmus L-VDPQ----------ILRDQSRL------APEIITATQYKKCDEFQTGILIYEMLHLPN
Spk390_Spur ------------------VSPART------DQKEVASKLEQKCHEFDVGILIFEFLHQPN
AqueK185_Aque PISATTFVFAYDELSWLGGVESHLPPEIVDTPSNVNTLDYSHTDSFAVGCLIHELMTGTS
:: . : : : ..* .* **.*:: ..
SgK223_Hsap PFEVRAQLRERDYRQEDLPPLPALSLYSPGLQQLAHLLLEADPIKRIRIGEAKRVLQCLL
SgK269_Hsap PFDENPELKEREYTRADLPRIPFRSPYSRGLQQLASCLLNPNPSERILISDAKGILQCLL
SgK223_Mmus PFEVRAQLRERDYRREDLPPLPTLSLYSPGLQQLAHLLLEADPIKRIRIGEAKRVLQCLL
SgK269_Mmus PFDENPELKEKEYTRTDLPRIPLRSPYSWGLQQLASCLLNPNPSERILISDAKGILQCLL
Spk390_Spur PFSTRTSLIISDYTADDLPGIPVKSSLSADLRTIAAKLLAKNPQDRLTCNQAVSLLQCLL
AqueK185_Aque PFDKDPQLVYKTYTHDDLPSISNEIKVSVYLETLTYLLLSRDPLKRLGLGDALLLTQSML
**. ..* * *** :. * *. :: ** :* .*: .:* : *.:*
SgK223_Hsap WGPRRELVQQPGTSEE--ALCGTLHNWIDMKRALMMMKFAEK------AVDRRRGVELED
SgK269_Hsap WGPREDLFQTFTACPSLVQRNTLLQNWLDIKRTLLMIKFAEK------SLDREGGISLED
SgK223_Mmus WGPRRELVEQPCTSEE--VLCNTLHNWIDMKRALMMMKFAEK------AVDRRRGVELED
SgK269_Mmus WGPREDLFQIFTTSATLAQKNALLQNWLDIKRTLLMIKFAEK------SLDREGGISLED
Spk390_Spur WGPPSTVYTDNANTAE--ALNQELERWLVAEQAKMVTKVALYSLLGRASSDNKSGLTLSD
AqueK185_Aque WLPHSWLECSLPK--------TDIENHLLFLKGKTIAQIA--------QQDAQDLLALET
* * : :.. : : : :.* * . : *.
SgK223_Hsap WLCCQYLASAEPGALLQSLKLLQL---------------L
SgK269_Hsap WLCAQYLAFATTDSLSCIVKILQH---------------R
SgK223_Mmus WLCCQYLASAEPGALLQSLKLLQL---------------L
SgK269_Mmus WLCAQYLAFATTDSLSYIVKILQY---------------R
Spk390_Spur QLQCQYLSDSTVDTCKEAMRMLHGKNESETVNVIDSDLDL
AqueK185_Aque VLKADFLATCDSSRLVRALAVMNNK-----MNEQRSSKSQ
* .::*: . . : :::