PDK1_Hsap FKFGKILGEGSFSTVVLARELAT----SREYAIKILEKRHIIKENKVPYVTRERDVMSRL
Pk61C_Dmel FIFGRYIGEGSYSIVYLAVDIHS----RREYAIKVCEKRLILRERKQDYIKREREVMHQM
PDK1_Mmus FKFGKILGEGSFSTVVLARELAT----SREYAIKILEKRHIIKENKVPYVTRERDVMSRL
pdk-1_Cele ILKNIPLA----KTVFRCREVAT----DAMFAVKVLQKSYLNRHQKMDAIIREKNILTYL
PKH2_Scer FKFGSVIGDGAYSTVMLATSIDT----KKRYAAKVLNKEYLIRQKKVKYVSIEKTALQKL
PKH1_Scer FKFGEQLGDGSYSSVVLATARDS----GKKYAVKVLSKEYLIRQKKVKYVTVEKLALQKL
W04B5.5_Cele YSVEKEVGEGSFSTVYLARRKEPKNDENPEVALKICLKRLILKNKMVPYIHREKEALALI
YDR466W_Scer FIFKEELGHGSYSTVFKALDKKS---PNKIYAIKVCSKKHIIKEAKVKYVTIEKNTMNLL
Pdk1A_Ddis FIIGKVLGEGSYGAVVLGTEKET----QQQYAIKILEKKQIIKENKIKYVQIEKEIFCKS
Pdk1B_Ddis FDFIRTIGKGAYGKVKLVIEKET----QLIFASKILNKKLIIKEKKAKYVNTEKTILDSL
8643_Tthe FSNNKNLGRGSFGEVILAKNKSN----NEFCAIKILEKSYLAREKKQYQVFIEKEVLTHI
PDK1_Spur FRFGTILGEGSYSEVVLATEIAT----GNQYAIKVLEKRHIIREKKEKYVLREKEVLSRL
CC1G_15192_Ccin FDVGEEIAWGSLATIVEGVHKKS----GKLFAIKMLNKMQLSKKKMVRSAMLEKDALIAL
AqueK012_Aque FNFDRIIGEGSYSTVSS------------CALVKILDKRHIIKEKKVQYVSREKDVLARI
PDK1-2_Smoe FAYGRLLGMGSYSKVVRAKKKDS----GAEFALKIMDKKHITKENKVAYVKMERLILDHL
PDK1-1_Smoe -------------QVVRAKKKDS----GAEFALKIMDKKHITKENKVAYVKMERLILDHL
GK002_Glam FDVIDFLGEGSYGKVYRAIDAET----GLEVGLKVINRKALENDKLLYTLDREVVALRTA
: *: : : .. * :
PDK1_Hsap D-----HPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKI--GSFDETCTRFYTAEIV
Pk61C_Dmel T----NVPGFVNLSCTFQDQRSLYFVMTYARKGDMLPYINRV--GSFDVACTRHYAAELL
PDK1_Mmus D-----HPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKI--GSFDETCTRFYTAEIV
pdk-1_Cele SQECGGHPFVTQLYTHFHDQARIYFVIGLVENGDLGESLCHF--GSFDMLTSKFFASEIL
PKH2_Scer N----NSPSVVRLFSTFQDESSLYFLLEYAPNGDFLSLMKKY--GSLDETCARYYAAQII
PKH1_Scer N----GTKGIFKLFFTFQDEASLYFLLEYAPHGDFLGLIKKY--GSLNETCARYYASQII
W04B5.5_Cele SREENAHPGIVTLYATFQDSESLYFVLEYAKYGDLCTLMQKQPDSKFNVADSRYYAANLL
YDR466W_Scer AQ--KHHAGIIKLYYTFHDEENLYFVLDFAPGGELLSLLHKM--GTFNDIWTRHFTAQLI
Pdk1A_Ddis N-----HPNIVKLFFTFRSEQCLYYVLELCSQGDLLHQIKKV--GSFDYRSCQYYVAEII
Pdk1B_Ddis D-----NPNIVKLFYTFQDENNLYFILEYCPNGDLLGALKKA--GCFSIDVVRFYAAEIL
8643_Tthe R-----FDGIIQLLGSFKDNQFLYFVLEYCEGGEFSSYLQHNF-KFLNQDTIKFYAAEIV
PDK1_Spur D-----HPFFVRLYFTFQDNYKLYFGLSLAKRGELLPYIKKL--GSFDESSSRFYTSEII
CC1G_15192_Ccin SS--HPHPGIVRLHYCFQDAANLYFVLDLAPNGDLKSLTLKT--GSLSLECARYYTAQMI
AqueK012_Aque D-----HPFFVKLYFTFQDKDNLYFGLSFAEQGELLDYLRKV--GAFDENATRFYTSEIV
PDK1-2_Smoe D-----HPGVVRLFFTFQDTHNLYMGLECCHGGELFDQIRRK--GRLSLEEARFYAAEIV
PDK1-1_Smoe D-----HPGVVRLFFTFQDTHNLYMGLECCHGGELFDQIRRK--GRLSLEEARFYAAEIV
GK002_Glam QN--KNLTNIIRLYSKTDKNDFTTLILEYASLGDLSSLIKCY--RVLPEDWTRFLIAEII
. * . : *:: : :. ::::
PDK1_Hsap SALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESK---------------
Pk61C_Dmel LACEHMHRRNVVHRDLKPENILLDEDMHTLIADFGSAKVMTAHN----------------
PDK1_Mmus SALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESK---------------
pdk-1_Cele TGLQFLHDNKIVHRDMKPDNVLIQKDGHILITDFGSAqafE-------------------
PKH2_Scer DAIDYLHSNGIIHRDIKPENILLDGEMKIKLTDFGTAKLLNPTNNSV-------------
PKH1_Scer DAVDSLHNIGIIHRDIKPENILLDKNMKVKLTDFGTAKILPEEPSNTAD-----------
W04B5.5_Cele SALEHIHKLGIIHRDVKADNLLVKSDGRIMLTDFGSSKFLSDYQKIQEN-----------
YDR466W_Scer DALEFIHSHGIIHRDLKPENVLLDRDGRLMITDFGAAATIDPSLSGDSAKF---------
Pdk1A_Ddis SGLEHLHSLGIVHRDLKPENILMSSDLHVKITDFGTGKILPPPQSSQQQQQQQQQQQQLP
Pdk1B_Ddis IALEYLHGKGIAHRDLKPENILLGKNQHLKLSDFGSAKQLSIGSH---------------
8643_Tthe YILENLHKNGIIHRDLKPENLMLTKDNHLKIIDFGTCGFDRRIPEDLFQKI---------
PDK1_Spur LALEYLHSMGIIHRDLKPENILLNEKMHIQITDFGTAKIIGADDKK--------------
CC1G_15192_Ccin DAINLMHEAGVAHRDIKPENCLLDKSMRIKIADFGSAYVTSTPL----------------
AqueK012_Aque IALEYLHGKGIIHRDLKPENILLNKDMHIQITDFGTAKIFESDE----------------
PDK1-2_Smoe DVLEYIHGQGLIHRDLKPENLLLTADGHIKVADFGSAKVTTPLQNG--------------
PDK1-1_Smoe DVLEYIHGQGLIHRDLKPENLLLTADGHIKVADFGSAKVKYLSFSCSFLVS---------
GK002_Glam LGLEGLHSIGYCHRDIKPSNILLTRGGHVRIADFGTSKQLPLDEVSMAIGTK--------
: :* ***:*..* :: : : ***:
PDK1_Hsap ------------------------------------------------------------
Pk61C_Dmel ------------------------------------------------------------
PDK1_Mmus ------------------------------------------------------------
pdk-1_Cele ------------------------------------------------------------
PKH2_Scer ------------------------------------------------------------
PKH1_Scer ------------------------------------------------------------
W04B5.5_Cele ------------------------------------------------------------
YDR466W_Scer --------------------N---------------------------------------
Pdk1A_Ddis TNSSGNLSSLLNNVNNLSVST---------------------DLTQQQQNRTSSVDSAST
Pdk1B_Ddis ------------------------------------------------------------
8643_Tthe --------------NNIKKKF---------------------PQ---------------E
PDK1_Spur ------------------------------------------------------------
CC1G_15192_Ccin ------------------------------------------------------------
AqueK012_Aque ------------------------------------------------------------
PDK1-2_Smoe ------------------------------------------------------------
PDK1-1_Smoe --------------------F---------------------------------------
GK002_Glam -------------------SFPPSAYMSTSSAAASNDSQGTLQ-----------------
PDK1_Hsap ------------------------------------------------------------
Pk61C_Dmel ------------------------------------------------------------
PDK1_Mmus ------------------------------------------------------------
pdk-1_Cele ------------------------------------------------------------
PKH2_Scer ----------------------------------------------------------SK
PKH1_Scer ----------------------------------------------------------GK
W04B5.5_Cele ----------------------------------------------------------PV
YDR466W_Scer ----------------------------------------------------------SD
Pdk1A_Ddis TDSMISPNLQPTTTTTNNNNNNNNNNNNNNNNTAAGSNTNTNTNTNINTNINANINNIKT
Pdk1B_Ddis ------------------------------------------------------------
8643_Tthe TD--------------------------------------------------------PM
PDK1_Spur ------------------------------------------------------------
CC1G_15192_Ccin ------------------------------------------------------------
AqueK012_Aque ------------------------------------------------------------
PDK1-2_Smoe -----------------------------------------------------------L
PDK1-1_Smoe ----------------------------------------------------------SV
GK002_Glam -K--------------------------------------------------------KL
PDK1_Hsap ------QARANSFVGTAQYVSPELLTEKSAC-KSSDLWALGCIIYQLVAGLPPFRAG---
Pk61C_Dmel ------RHRKASFVGTAQYVSPEVLQNGPIT-PAADLWALGCIVYQMIAGLPPFRGS---
PDK1_Mmus ------QARANSFVGTAQYVSPELLTEKSAC-KSSDLWALGCIIYQLVAGLPPFRAG---
pdk-1_Cele ----ENTARRTTFVGTALYVSPEMLADGDVG-PQTDIWGLGCILFQCLAGQPPFRAV---
PKH2_Scer -PEYDLSTRSKSFVGTAEYVSPELLNDSFTD-YRCDIWAFGCILFQMIAGKPPFKAT---
PKH1_Scer -PYFDLYAKSKSFVGTAEYVSPELLNDNYTD-SRCDIWAFGCILYQMLAGKPPFKAA---
W04B5.5_Cele -EEEQPTGRRSSFVGTAFFVTPELLTGSEMS-PSSDLWAFSVTLYLFLTGIYPFNDM---
YDR466W_Scer SNGSKDNQNCASFVGTAEYVSPELLLYNQCG-YGSDIWALGCMIYQFVQGQPPFRGE---
Pdk1A_Ddis -TEIPKLTRNNSFVGTAEYVSPELISNKETS-TDSDLWALGCIIYQMASGRVPFRGK---
Pdk1B_Ddis ----HKGSRSGSFCGTAEYVCPELLTEKSAG-VEADIWSYGCLLYQLVSGKLPFKGF---
8643_Tthe -DDEDSRTRSSTFVGTAEYVSPELLEGEICT-SSADLWALGCIIYRMFVGNTPFVDVND-
PDK1_Spur ----EGQPRAKSFVGTAQYVSPELLTEKSAT-KSSDLWALGCIVYQLQAGLPPFRAS---
CC1G_15192_Ccin -----STPKTNTFVGTAAFLSPEVLLRQEANPRGPDLWAVGACLFFYLFGTYPFSAM---
AqueK012_Aque ------DEKASSFVGTAEYVSPELLQSKVAY-KSSDLWALGCIIYQFLAGRPPFHAAYVN
PDK1-2_Smoe -SDAQADDKSCTFVGTAEYVSPEVLNGHPVT-IGADLWALGCIIYQMLEGRPPFKGG---
PDK1-1_Smoe -HFRFTDDKSCTFVGTAEYVSPEVLNGHPVT-IGADLWALGCIIYQMLEGRPPFKGG---
GK002_Glam -QNM-DQQPRCSIYGTVCYNAPESNRHGLLYMSPQDVWGLGCILYECLTGMPAFMGD---
:: **. : ** *:*. . :: * .*
PDK1_Hsap ------------NEYLIFQKIIKLEYDFP---------EKFF-PKARDLVEKLLVLDATK
Pk61C_Dmel ------------NDYVIFKEILDCAVDFP---------QGFD-KDAEDLVRKLLRVDPRD
PDK1_Mmus ------------NEYLIFQKIIKLEYHFP---------EKFF-PKARDLVEKLLVLDATK
pdk-1_Cele ------------NQYHLLKRIQELDFSFP---------EGFP-EEASEIIAKILVRDPST
PKH2_Scer ------------NEYLTFQKVMKVQYAFT---------PGFP-LIIRDLVKKILVKNLDR
PKH1_Scer ------------NEYLTFQKVMKIQYAFT---------AGFP-QIVKDLVKKLLVRDPND
W04B5.5_Cele ------------SEYLVFRRIQDILYTFS---------EDFPDENAKNLIERLLVKEQKS
YDR466W_Scer ------------NELKTFEKIVALDYPWGPNNRINNSTSPIN-PLVINLVQKILVIEVNE
Pdk1A_Ddis ------------TEFLTFQKVSNRELVYP---------INMN-PVIKDLVEKLLVIKPTD
Pdk1B_Ddis ------------NEYQTFLLITKREFSYP---------DNFD-KCCMNLIDQLLDLDPYK
8643_Tthe ---------ATNNEFKVFNKVKACQYYIP---------DSVP-PEAADLIKNLLKRNPFE
PDK1_Spur ------------NEYMIFQKIIKLEYDFP---------DGFS-QTARDLVSKLLVIDPSK
CC1G_15192_Ccin ------------TDYLIMERIKKLDYKIP---------EGCD-PDAADLIKRLLVHHPQE
AqueK012_Aque YTCSPPLFIMCRNEYLCFQKIIKHEYSIP---------DGFP-DNAKDLVENLLVSDPTK
PDK1-2_Smoe ------------SEYLTFQKVLAKDLVIP---------SHFP-SAAKELINKLLNLEPDK
PDK1-1_Smoe ------------SEYLTFQKVLAKDLVIP---------SHFP-SAAKELINKLLNLEPDK
GK002_Glam ------------VELAIMQAIEKQKVIVP---------KTVS-PDAADLIKRLLTKDPTK
: : : ::: .:* .
PDK1_Hsap RLGCEE--MEGYGPLKAHPFF
Pk61C_Dmel RLGAQDE-FGYYESIRAHPFF
PDK1_Mmus RLGCEE--MEGYGPLKAHPFF
pdk-1_Cele RITS--------QELMAHKFF
PKH2_Scer RLTI--------SQIKEHHFF
PKH1_Scer RLTI--------KQIKAHLFF
W04B5.5_Cele RLTS--------QEIKEHKFF
YDR466W_Scer RISL--------EQIKRHPYF
Pdk1A_Ddis RLGSSST-PGGFDNLKAHPFF
Pdk1B_Ddis RPTI--------SEIKNHEFF
8643_Tthe RIGGGEPGVNDINTLKKHPFF
PDK1_Spur RLGCDE--CGGYPALKAHPFL
CC1G_15192_Ccin RLGVPP--NSSIDELRQHPFF
AqueK012_Aque RLGCDK--MGGYPPLKAHYFF
PDK1-2_Smoe RPGAGP---AGYTALKSHAFF
PDK1-1_Smoe RPGAGP---AGYAALKSHAFF
GK002_Glam RFNG------GWRAIKKHPFF
* : * ::