PKD3_Hsap       IFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQE--SQLRNEVAILQNLHHP
PKD2_Hsap       IFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQE--SQLRNEVAILQSLRHP
PKD1_Hsap       IFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQE--SQLRNEVAILQNLHHP
CG7125_Dmel     IFPDEVLGSGQFGVVYGGVHKKTQREVAIKVIDKLRFPTKQE--AQLKNEVAILQNISHC
PKD3_Mmus       IFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQE--SQLRNEVAILQNLHHP
PKD2_Mmus       IFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQE--SQLRNEVAILQSLRHP
PKD1_Mmus       IFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQE--SQLRNEVAILQNLHHP
T25E12.4_Cele   IFAEEVLGSGQFGTVYGGIHRRNGQHVAVKLIDKLKFPPNKE--DLLRAEVQILEKVDHP
W09C5.5_Cele    VLSDKTLGSGQFGTVYSAIQRHSGKEVAVKVISKERFSKKGSGAESMRAEVAILQQTCHP
PKD_Spur        IFPDEILGSGQFGIVYGGVHRTSGRQVAIKVIDKFRFPTKQE--TQLKNEVAILHKVRHP
AqueK080_Aque   IFPEEILGSGQFGTVFGGQNRTTGKSVAIKVIDKLRFPHKQD--TALRQEVTILQFLDHP
                ::.:: ******* *:.. :: . : **:*:*.* :*. : .    :: ** **.   *

PKD3_Hsap       GIVNLECMFETPERVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFK
PKD2_Hsap       GIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFK
PKD1_Hsap       GVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFK
CG7125_Dmel     GVVNLERMFETPERIFVVMEKLKGDMLEMILSHARGRLSERVTKFLITQILIALKYLHSQ
PKD3_Mmus       GIVNLECMFETPERVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFK
PKD2_Mmus       GIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFK
PKD1_Mmus       GVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFK
T25E12.4_Cele   GVVHFMQMLETTDRIFVVMEKLKGDMLEMILSSEKGRLSERTTQFLVAQILEALRYLHHL
W09C5.5_Cele    GIVCLEFMCETKDKIFVVMEKMNGDMLEMILSQELGRLNSRATKFLLVQILCALKYLHDQ
PKD_Spur        GVVNLEQMFETPERVFVVMEKLKGDMLEMILSSVHGRLFERVTRFLISQILIALKYLHSK
AqueK080_Aque   GIIYLEQMFETPEKIYIAMEKMNGDMLEMILSSPNSRLSERVTKFLVYQILAALQYLHKK
                *:: :  * ** :::::.***::*********   .** .: *:*:: *** **: **

PKD3_Hsap       NIVHCDLKPENVLLAS-AEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKG
PKD2_Hsap       NIVHCDLKPENVLLAS-ADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQG
PKD1_Hsap       NIVHCDLKPENVLLAS-ADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKG
CG7125_Dmel     NIVHCDLKPENVLLSS-DAEFPQVKLCDFGYARIIGEKSFRRSVVGTPAYLAPEVLRNKG
PKD3_Mmus       NIVHCDLKPENVLLAS-AEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKG
PKD2_Mmus       NIVHCDLKPENVLLAS-ADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQG
PKD1_Mmus       NIVHCDLKPENVLLAS-ADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKG
T25E12.4_Cele   NIVHCDLKPENILLNS-NSDFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKG
W09C5.5_Cele    GIAHCDLKPENVLLSDMGSNFPQTKICDFGYARFIPESQFRKTVVGTPAYLPPEVLQRKG
PKD_Spur        SIVHCDLKPENVLLSS-DGDFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKG
AqueK080_Aque   DIVHCDLKPENVLLTS-ESGMPQVKLCDFGFARIIGEKSFRKSIVGTPAYLAPEVLKNEG
                .*.********:** .    :**.*:****:**:* *..**:::*******.****  :*

PKD3_Hsap       YNRSLDMWSVGVIIYVSLSGTFPFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNL
PKD2_Hsap       YNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGAIDLINNL
PKD1_Hsap       YNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNL
CG7125_Dmel     YNRSLDMWSVGVIIYVSLSGTFPFNEEEDINDQIQNAAFMYPPNPWKEISSNAIDLINNL
PKD3_Mmus       YNRSLDMWSVGVIVYVSLSGTFPFNEDEDINDQIQNAAFMYPPNPWREISSEAIDLINNL
PKD2_Mmus       YNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISSGAIDLINNL
PKD1_Mmus       YNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNL
T25E12.4_Cele   FNRSLDMWSVGVIVYVSLSGTFPFNEDEDINDQIQNAEFMYPPTPWKEISENAIEFINGL
W09C5.5_Cele    YNKSLDMWSVGVIIYVTLSGTFPFNEGEEISEQIQNASFMFPTEPWSEVEPLAVDLIQKL
PKD_Spur        YNRSLDMWSVGVIVYVSLSGTFPFNEDEEITDQIHNAAFMFPPNPWNEISEGAIDLIRNL
AqueK080_Aque   YNRSLDLWSVGVIIYVSLSGTFPFNEDEEISDQIHNAAFMYPPDPWAAITQEAIDLVSKL
                :*:***:******:**:********* *:* :**:** **:*. **  :   *::::  *

PKD3_Hsap       LQVKMRKRYSVDKSLSHPWL
PKD2_Hsap       LQVKMRKRYSVDKSLSHPWL
PKD1_Hsap       LQVKMRKRYSVDKTLSHPWL
CG7125_Dmel     LQVKQRKRYTVDKSLLHYWL
PKD3_Mmus       LQVKMRKRYSVDKSLSHPWL
PKD2_Mmus       LQVKMRKRYSVDKSLSHPWL
PKD1_Mmus       LQVKMRKRYSVDKTLSHPWL
T25E12.4_Cele   LQVKMSKRYTVTKAQSQIWM
W09C5.5_Cele    LKVEIEARMSIEQCLDHGWL
PKD_Spur        LQVKIRKRYTADKSLAHPWL
AqueK080_Aque   LQINRRSRFKTTQALNHIWL
                *:::   * .  :   : *: