RET_Hsap MAKAT-------SGAAGLRLLLLLLLP---------------------------------
Ret_Dmel MESTT-------IV--FVTL-LTIITQ---------------------------------
RET_Mmus MAKAT-------SGAAGLGLKLILLLP---------------------------------
RET_Spur MLLHCYEIIKSLSTNNWYNLKEITFPTSFCEQNLVCVRHGLIKKSRRLQINNCRRKSSDK
AqueK399_Aque MSETL-------C-----------------------------------------------
AqueK400_Aque MFVTV-------D-----------------------------------------------
AqueK401_Aque ------------------------------------------------------------
AqueK402_Aque SPT---------------------------------------------------------
RET_Hsap -LLG-KVALGLYFSRDAYWEKLYVDQAAGT-----PLLYVHALRDAPEEVP-SFRLGQHL
Ret_Dmel -RKH-CAAVDVYFPTTSVKFNLPINEESESIFSKIPLAQFQVLRMED----------NRL
RET_Mmus -LLG-EAPLGLYFSRDAYWERLYVDQPAGT-----PLLYVHALRDAPGEVP-SFRLGQHL
RET_Spur KALGTVKGFQVYFPANQYMYSVPADFPLNRTIARVLALTRHAVNDARADISYSIRHDHHR
AqueK399_Aque ------------------------------------------------------------
AqueK400_Aque ------------------------------------------------------------
AqueK401_Aque ------------------------------------------------------------
AqueK402_Aque ------------------------------------------------------------
RET_Hsap YGTYRTRLHENNWICIQEDTGLLYLNRSLD--------------------HSSWEKLSVR
Ret_Dmel ASDYLYSLEQNPLLRINSSSGEIYMRTDYRSPNSSATFLVTA----FPRDQPDHELLNVS
RET_Mmus YGVYRTRLHENDWIRINETTGLLYLNQSLD--------------------HSSWEQLSIR
RET_Spur TAREDGGANLEKYFSINSTTGSLMLITNITGNDIRLPVRATAHLCGKVSEGSTWIRLKVR
AqueK399_Aque ------------------------------------------------------------
AqueK400_Aque ------------------------------------------------------------
AqueK401_Aque ------------------------------------------------------------
AqueK402_Aque ------------------------------------------------------------
RET_Hsap NRGFPLLTVYLKVFLSPTSLREGE--CQWPGCARVYFSFFNTSFPACSSLKPRELCFPET
Ret_Dmel HLS---LEVTPQPLEEYCSELEHI--CFWSS---------------------AQYTIAES
RET_Mmus NGGFPLLTIFLQVFLGSTAQREGE--CHWPGCTRVYFSFINDTFPNCSSFKAQDLCIPET
RET_Spur H-------------------REPSCMCRISS-----------------VMRIHESEFPTQ
AqueK399_Aque ------------------------------------------------------------
AqueK400_Aque ------------------------------------------------------------
AqueK401_Aque ------------------------------------------------------------
AqueK402_Aque ------------------------------------------------------------
RET_Hsap RPSFRIRENRPPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALD
Ret_Dmel HGPYRRKDFFEPVLIGALNSRAAKYLCPHVSLEYSLNAGSS-HFV--LKQNRLYTRQTLD
RET_Mmus AVSFRVRENRPPGTFYHFHMLPVQFLCPNISVKYSLLGGDSLPFRCDPDCLEVSTRWALD
RET_Spur SLAFLYQPTGNPGSEVA---------------------GST-TFEISSASHRYGALCALA
AqueK399_Aque ---------------------------PDIW-----------------------------
AqueK400_Aque ---------------------------N--------------------------------
AqueK401_Aque ------------------------------------------------------------
AqueK402_Aque ------------------------------------------------------------
RET_Hsap REQREK-------YELVAVCTVHAGA-REEVVMVPFPVTVYDEDDSAPTFPAGVDTASAV
Ret_Dmel HDELNGLNAKAGQLQARITCTVKLSSRDQRKFSRILDIKLLDRNDNGPKLQESSSKFDFY
RET_Mmus RELREK-------YVLEALCIVAGPGANKETVTLSFPVTVYDEDDSAPTFSGGVGTASAV
RET_Spur RRCNNS-------YC---SCPLH----------------------RAECFCSAIESTIA-
AqueK399_Aque ----------------------------------SFVVKFLDSNQVTPGYRYDEGIKLP-
AqueK400_Aque ------------------------------------------------------------
AqueK401_Aque ------------------------------------------------------------
AqueK402_Aque ------------------------------------------------------------
RET_Hsap VE---FKRKEDTVVATLRVFDADVVPASGELVRRYT---STLLPGDTWAQQ---------
Ret_Dmel LEQPYFQADEEA-GKKVIYVDKDTLEANAHLVYAVHNDSHGLFRPDCHAYE-----ADHT
RET_Mmus VE---FKRKEGTVVATLQVFDADVVPASGELVRRYT---NTLLSGDSWAQQ---------
RET_Spur -------------CIRLSALDYASLYTTGDLVLNQT---IAHHQYRSWVRHAEVSIIGGE
AqueK399_Aque ------------------------------------------------------------
AqueK400_Aque ------------------------------------------------------------
AqueK401_Aque ------------------------------------------------------------
AqueK402_Aque ------------------------------------------------------------
RET_Hsap ----TFRVEHWPNETSVQANGSFVRATVHDYRLV---LNRNLSISENRTMQLAVLVN---
Ret_Dmel GRPHTIVSCQLRFSR-----NGVFRETPYCVSL----EARDLTIV-SRVDA---------
RET_Mmus ----TFRVEHSPIETLVQVNNNSVRATMHNYKLI---LNRSLSISESRVLQLAVLVN---
RET_Spur VARETFGIRKGIVDG-----P-----EEHDKTLIEIYLLRTIPRDLSGPVEFVVRIDGHG
AqueK399_Aque ------------------VCNN--------------------------------------
AqueK400_Aque ------------------------------------------------------------
AqueK401_Aque ------------------------------------------------------------
AqueK402_Aque ------------------------------------------------------------
RET_Hsap ---DSDFQGPGA-GVLLLHFNVSVLPVS-LHLPSTYSLSVSRRARRFAQIGKVCVENCQA
Ret_Dmel -------MSATA-N-VCYHINLSKLHESEQELPQALP--LRARQHRIF--------ESEE
RET_Mmus ---DSDFQGPGAGGILVLHFNVSVLPVT-LNLPRAYSFPVNKRARRYAQIGKVCVENCQE
RET_Spur CGRHSNETARGG-RTLDIALNVTIWPVV-NYESTVYS-----------------------
AqueK399_Aque ------------TAKLIDYLNL--------------------------------------
AqueK400_Aque ------------------------------------------------------------
AqueK401_Aque ------------------------------------------------------------
AqueK402_Aque ------------------------------------------------------------
RET_Hsap FSGINVQYKLHSSGANC------------------------------------STLGVVT
Ret_Dmel FNGDSAGRSLSPPTVDYDKDVSVYRSAASNFRVVQPDSFLDLMRLRSIRFDIVEDKLGAF
RET_Mmus FSGVSIQYKLQPSSINC------------------------------------TALGVVT
RET_Spur -------------------------NITAGSRIVDLSSALST-SKRPLRFVNEEYWHSMF
AqueK399_Aque -------------TSDC------------------------------------CSDGGIK
AqueK400_Aque ------------------------------------------------------------
AqueK401_Aque ------------------------------------------------------------
AqueK402_Aque ------------------------------------------------------------
RET_Hsap SAEDTSGILFVNDTKALRRP--KCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAG
Ret_Dmel GITSTSGIVFVKNPQVLEEA-PE-TIYFLNVTWIDQQRLSHVRVINVHLVHGR--PENTS
RET_Mmus SPEDTSGTLFVNDTEALRRP--ECTKLQYTVVATDRQTRRQTQASLVVTVEGTSITEEVG
RET_Spur ELQETMGIVYVTNRTALRLIAPRNVTLYVECGSLGDVLNAGIIINLTITIE---------
AqueK399_Aque VPQPTKTTTKVINTSTTPVP--HSTTIQTT--------------------RSTPLIPAIG
AqueK400_Aque ------------------------------------------------------------
AqueK401_Aque ------------------------------------------------------------
AqueK402_Aque ------------------------------------------------------------
RET_Hsap C-------PLSCAVSKRRLECEECGGLGSPTGRCEWRQGD-GKGITRNFSTCSPSTKTCP
Ret_Dmel CELKVKSRSQTCAQIKYQSQCVRYCGLATGGGSCQWRGSN-SAMFGTRYGSCVPESRYCP
RET_Mmus C-------PKSCAVNKRRPECEECGGLGSPTGRCEWRQGD-GKGITRNFSTCSPSTRTCP
RET_Spur ------KTGDSCSRHRNRADCLTHCGMGSMHGHCSWRGGGMQRAMSTLYATCTPDVKTCP
AqueK399_Aque T----------------------------PS-----------------------------
AqueK400_Aque ------------------------------------------------------------
AqueK401_Aque ------------------------------------------------------------
AqueK402_Aque ------------------------------------------------------------
RET_Hsap DGHCDVVETQDIN-ICPQDCLRG-SIVGGHEPGE-PRGIKAGYGTCNCFPEEEKCFCEPE
Ret_Dmel DHVCDPLEELNPM-ACPQDCTPAGRIVGPHSSNENKRGIYSASGTCIC-EDNGKCSCAPL
RET_Mmus DGHCDAVESRDAN-ICPQDCLRA-DIVGGHERGE-RQGIKAGYGICNCFPDEKKCFCEPE
RET_Spur DNRCDLVEMENRNDICPQDCTTIT-T-------------------------TKEPVPLQE
AqueK399_Aque ------------------------------------------------------------
AqueK400_Aque ------------------------------------------------------------
AqueK401_Aque ------------------------------------------------------------
AqueK402_Aque ------------------------------------------------------------
RET_Hsap DIQ--------------------------------DP-----------LCDELCRT-VIA
Ret_Dmel DEEPKMKKPRKRKNETEAEPLLGVRRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVIT
RET_Mmus DSQ--------------------------------GP-----------LCDALCRT-IIT
RET_Spur DPG--------------------------------DE-----------LCGPECYL-GVC
AqueK399_Aque -AS--------------------------------NQ-----------LTSALIPG-MIS
AqueK400_Aque ------------------------------------------------------------
AqueK401_Aque ------------------------------------------------------------
AqueK402_Aque ------------------------------------------------------------
RET_Hsap AAVLFSF-IVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLD
Ret_Dmel CPLLFVLLLLCLLIAQR-KMLQRRLGKQSMTT-----------------SSKQALP---E
RET_Mmus AA-LFSL-IISILLSIFCVCHHHKHGHKPPIASAEMTFCRPAQGFPISYSSSGTRRPSLD
RET_Spur AGVFLTA-LITIILAVR-KRRARRHQRRAYTSSI---FKPPI-DAPNTTRASMVLA---E
AqueK399_Aque ILLMLLV-VLAIVLSVACCVKKA--RNRKQLMNKEFSIKTNCSLLLKS------------
AqueK400_Aque ------------------------------------------------------------
AqueK401_Aque ------------------------------------------------------------
AqueK402_Aque ------------------------------------------------------------
RET_Hsap SMENQ-VSVDAFK----I-LEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGY
Ret_Dmel SGG-GDFALMPLQSGFRFESGDAKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGI
RET_Mmus STENQ-VPVDSFK----I-PEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGRAGY
RET_Spur YAD-EMTSGRSFGFKGRFE-QDSKWEFPLDKLLFEDELGEGHFGRVVRAQALSIRGHTGY
AqueK399_Aque NKENIYFSDKTFEISSDYTNQLSKYIISGSSINVQETAGQGEFGIVYRGVMT--RENQMP
AqueK400_Aque -------------FSSHLEQLLVKYSIPASQINLQEAVGQGEFGIVYRALLA--TGKDVP
AqueK401_Aque ------------------------------------------------------------
AqueK402_Aque ----------------------------------------------------------VK
RET_Hsap TTVAVKMLKEN-ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPL--LLIVEYAKY
Ret_Dmel TTVAVKMLKKG-SNSVEYMALLSEFQLLQEVSHPNVIKLLGACTSSEAP--LLIIEYARY
RET_Mmus TTVAVKMLKEN-ASQSELRDLLSEFNLLKQVNHPHVIKLYGACSQDGPL--LLIVEYAKY
RET_Spur TTVAVKMLKRDTATSAELHDLLTELELLKLLNHTNVIRLLGACIPKDPFETCVIVEYCKY
AqueK399_Aque QPVAVKTLKGF-YSKSDVD-----------------------------------------
AqueK400_Aque QVVAVKT-----------------------------------------------------
AqueK401_Aque -----MALE---------------------------------------------------
AqueK402_Aque LPLKWMALE---------------------------------------------------
RET_Hsap GSLRGFLRESRKVGPGYLGSGGSRNSSSLD-------HPDERALTMGDLISFAWQISQGM
Ret_Dmel GSLRSYLRLSRKIECAGVDFA---------------DG--VEPVNVKMVLTFAWQICKGM
RET_Mmus GSLRGFLRDSRKIGPAYVSGGGSRNSSSLD-------HPDERVLTMGDLISFAWQISRGM
RET_Spur GCLREFLRLNRKKA-LYTEYSISNESSSIPGLSRGKDVIKRFDIGFKEIASFAWQICKGM
AqueK399_Aque ------------------------------------------------------------
AqueK400_Aque ------------------------------------------------------------
AqueK401_Aque ------------------------------------------------------------
AqueK402_Aque ------------------------------------------------------------
RET_Hsap QYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIES
Ret_Dmel AYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPES
RET_Mmus QYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKKSKGRIPVKWMAIES
RET_Spur HYISSLKVVHRDLAARNVLVAEGLLLKISDFGLTRDVYERGLYERQSKSLLPVKWMAVEA
AqueK399_Aque -----------------------------------------------------------S
AqueK400_Aque ------------------------------------------------------------
AqueK401_Aque -----------------------------------------------------------S
AqueK402_Aque -----------------------------------------------------------S
RET_Hsap LFDH---IYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDN--CS
Ret_Dmel LADH---VYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPEN--CS
RET_Mmus LFDH---IYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDN--CS
RET_Spur LYDN---VFTVKSDVWSFGILLWEIVTMGAIPYPGVTAERLCQLLRDGYRMDRPEE--CS
AqueK399_Aque LLDECIIMMSFDNLNWSYGVMCWEVFSLGRVPYPGLDPVGVVELLDTGGRLYTPNNEACS
AqueK400_Aque --------LKEKSDIWSYGVLCWEVFNGGKTPFPGLDPAGVIELLDTGGRLNCPHNDACS
AqueK401_Aque LHYG---IFSENSDVWSYGVLCWEVFSAGKIPYSGMDPTGLVELLDGGQRLSCPDNKACS
AqueK402_Aque IHDG---LFSEKSDVWSYGVLCWEVFSLSRVPYPGLDPVGVVELLDTGGRLHTPNNEACS
. .. **:*:: **:.. . *:.*: . : .** * *: *.: **
RET_Hsap EEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDG-----
Ret_Dmel EAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGNNAKYIDLETNAVSNPLYCGDDSALIT
RET_Mmus EEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKSRDYLDLAASTPSDSLLYDDG-----
RET_Spur EELF----------------------------VPQSEYLDLSDINGD-------L-----
AqueK399_Aque KEIYSLMTSCWSESPDDRPVFSDLVSSINALIEPLAGYLDFADINSC---V---------
AqueK400_Aque DKIYELMLSCWLECPNDRPLFSEL------------------------------------
AqueK401_Aque EDIYSLMQQCWAESPDDRPLFSDLVASVNALIVPLASYLIVSNDSTF-Q-L---------
AqueK402_Aque KEIYSLMMSCWSESPDDRPVFSDLVSSINALIEPLAGYLDFTDINSC---V---------
. ::
RET_Hsap ------------------------------LSEEETPLVDCNNAPLPRALPSTWIENKLY
Ret_Dmel TELGEPESLQHLWSPPKIAYDIHDQATSYDQSEEEMPVTS--TAPPGYD-----------
RET_Mmus ------------------------------LSEEETPLVDCNNAPLPRSLPSTWIENKLY
RET_Spur --------------------------S---SDEENEEVVECHKEQ--CC-----------
AqueK399_Aque ------------------------------------------------------------
AqueK400_Aque ------------------------------------------------------------
AqueK401_Aque ------------------------------------------------------------
AqueK402_Aque ------------------------------------------------------------
RET_Hsap GMSDPNWPGESPVPLTRADGTNTG-FPRYPNDSV-------------YANWMLSPSA---
Ret_Dmel ------------LPRPLLDATANGQVLRYENDLRFPLNIRKSSCTPSYSNMTSEPPATTS
RET_Mmus GMSDPNWPGESPVPLTRADGTSTG-FPRYANDSV-------------YANWMVSPSA---
RET_Spur ------------LLRKNRDGEKSC-DPRGISHTA-------------SF-----------
AqueK399_Aque ------------------------------------------------------------
AqueK400_Aque ------------------------------------------------------------
AqueK401_Aque ------------------------------------------------------------
AqueK402_Aque ------------------------------------------------------------
RET_Hsap --------------------AKLMD-----------------------------------
Ret_Dmel LPHYSVPVKRGRSYLDMTNKSLIPDNLDSREFEKHLSKTISFRFSSLLNLSETKEVSPGW
RET_Mmus --------------------AKLMD-----------------------------------
RET_Spur -----------------------------------------------------------W
AqueK399_Aque -----------------------EN-----------------------------------
AqueK400_Aque ------------------------------------------------------------
AqueK401_Aque ----------------------NHD-----------------------------------
AqueK402_Aque -----------------------EN-----------------------------------
RET_Hsap --TFDS
Ret_Dmel QAEDAV
RET_Mmus --TFDS
RET_Spur YIVSVL
AqueK399_Aque --DIKA
AqueK400_Aque ----NT
AqueK401_Aque --HIYY
AqueK402_Aque --DIKV