ROS_Hsap MKNIYCLIPK--------------------------------------------------
sev_Dmel MTTTHINQQAPGTSSSSSNSQNASPSKIVVRQQSSSFDLRQQLARLGRQLASGQDGHGGI
ROS_Mmus MKNICWLTLK--------------------------------------------------
ROS_Spur MASIISDT----------------------------------------------------
rol-3_Cele MLSLHLRSLA--------------------------------------------------
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap -------LVNFATLGC-LWISVVQCTVLNS----CLKSCV-TNLGQQLDLGTP-------
sev_Dmel STILIINLLLLILLSI-CCDVCRSHNYTVHQSPEPVSKDQMRLLRPKLDSDVVEKVAIWH
ROS_Mmus -------LVKFVVLGCIIWISVAQSTVLSS----CLTSCV-TNLGRQLDSGTR-------
ROS_Spur ----------------------------GQ----CDAPC-------------R-------
rol-3_Cele -----ILFLLFFLL----HDVVKSATVFSSSLKTCQSQCEERNLAYPLDSGEVHWTGLAE
AqueK407_Aque ----------------------------------CCCCCF-V--G---------------
ROS_Hsap HN--------------------------------------------------LSEPCIQG
sev_Dmel KHAAAAPPSIVEGIAISSRPQSTMAHHPDDRDRDRDPSEEQHGVDERMVLERVTRDCVQR
ROS_Mmus YN--------------------------------------------------LSEACIHG
ROS_Spur -----------------------------------------------------NSSCSTG
rol-3_Cele YNY-------------S----------------------------------SRISSCRHG
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap CHF---W--N----------S---VDQKNCALKCNDTYATVC-ERESCEVGCSSAEGAY-
sev_Dmel CIVEEDLFLDEFGIQCEKADNGEKCYKTRCTKGCAQWYRALK-ELESCQEACLSLQF---
ROS_Mmus CQF---W--N----------S---VDQETCALKCNDTYATIC-ERESCEVGCSNAEGSY-
ROS_Spur CSS---W--D----------N---STLSQCHAVCNETYTSEPFRVQYCQSGCLFAENEY-
rol-3_Cele CED---V--D----------E----RESKCDVKCSEEGI----VSNACKQGCRAVLVSFL
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap ------------EEEVLENA------------------------DLPTAPFASSIGSHNM
sev_Dmel ---------YPYDMPCIGACEMAQRDYWHLQRLAISHLVERTQPQLERAPRADG-QSTPL
ROS_Mmus ------------EEEVLEST------------------------ELPTAPFASSIGSHGV
ROS_Spur ------------AKAVIDEI------------------------GQPSSPQPSNMGTTSL
rol-3_Cele AQAQALLIQVHVNMEVLETSMK---LKWEFPETLAEELKEIANADI--------------
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap TLRWKS---A-NFSGVKYIIQWKYAQLLG-SWTYT-----------------------KT
sev_Dmel TIRWAMHFPEHYLASRPFNIQYQFVDHHGE-ELDLEQEDQDASGETGSSAWFNLADYDCD
ROS_Mmus TLRWNP---A-NISGVKYIIQWKYAQLPG-SWTFT-----------------------ET
ROS_Spur TLSWTA---A-SHQDVRYLVQWRYVEGGGEAWNYYGS--------------------GEP
rol-3_Cele --FWF----SQ-TKPLNGILGWRWTSLPQN-SFR-------------------------N
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap VSRPSYVVKPLHPFT---EYIFRVVWIFTAQ--LQLYSPPSPSYRTHPHGVPETAPLIRN
sev_Dmel EYYVCEILEALIPYT---QYRFRFELPFGENRDEVLYSPATPAYQTPPEGAPISAPVIEH
ROS_Mmus VSKLSYTVEPLHPFT---EYIFRVVWIFTAQ--LHLYSPPSPSYRTHPYGVPETAPLILN
ROS_Spur ISETTLDITDLIPYA---LYQFRVVWVITPR--HTLTSPATSNVQTQPSGVPSTAPIITS
rol-3_Cele SSLSS---EVHVPFEHGEHVEVRLAL--SYRN-QVLVS-RTTTYHLPLSKSGTTLEVIGQ
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap IESSSPDTVEVSWDPPQFPGGPILGYNLRLISKN------QK-LDAGTQ----RTSFQFY
sev_Dmel LMGLDDSHLAVHWHPGRFTNGPIEGYRLRLSSSE------GNA-TSEQLVPAGRGSYIFS
ROS_Mmus MESWSPDTVEVSWAPPHFPGGPILGYNLRLISKN------QK-LDSGTQ----RTSFQFY
ROS_Spur IVSSSPTTISLTWDPPPFPNGPIIGYTIAVQNFFNETGIVLD-VDGSTT----EATVVDS
rol-3_Cele L-QLSDDRVAVCYR----TNQPTPKFKLTIMTLN------DNTINTEES----IARCHLF
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap STLP-NTIYRFSIAAVNEVGEGPEAESSITTSS----SAVQQ-----EEQWLFLSRKTS-
sev_Dmel QLQ-AGTNYTLALSMINKQGEGPVAKGFVQTHS-A---RNEKPAKDLTESVLLVGRRAVM
ROS_Mmus STLP-NTTYRFSIAAVNEVGEGPEAESTVTTPS----PSVQE-----EEQWLFLSRKTS-
ROS_Spur SLRA-LTLYAVSVRARNMEGGGISDMVNVTTGAEPENVAVDY-----WENFIFISDSDG-
rol-3_Cele SNLPRDNCCKASISAIDEHGATTA-FVEIKLDF-Y-VNQVEIELVSVASSRLIFSNGTH-
AqueK407_Aque -------------------------------------------------------RK---
ROS_Hsap -----------LRKRSLK--HLVDEAHCLRLD-AIYHNITGISVDVHQQI-VYFSEGTLI
sev_Dmel WQSLEPAGENSMIYQSQE--ELADIAWS----KREQ-QLWLLNVHGELRS-LKFESGQMV
ROS_Mmus -----------LRKRSLK--YLVDEAHCLWSD-AIHHNITGISVYAQQQV-VYFSEGTVI
ROS_Spur ----------RIHRRTID------------------------------------------
rol-3_Cele -----------LLESEIDQYALGDSATVIPFPLPTDDTITAIAGISDTTIAIGSSKGSLW
AqueK407_Aque ------------------------ETHAFRPD----------------------------
ROS_Hsap WAKKAANMSD------VSDLRIFYRGSGLISSISIDWLYQRMYFIM-DELVCVCDLENC-
sev_Dmel SPA----------QQLKLDLGNISSGRWVPRRLSFDWLHHRLYFAM-ESP-----ERN--
ROS_Mmus WMKGAANMSD------VSDLRIFYQGSGLVSSISIDWLYQRMYFIM-DKLVYVCELKNC-
ROS_Spur ----PANLTL------ATSEVLYTNQSTAPTKLDVDWLNEQLYFVQ-GTEILRCDLNVS-
rol-3_Cele TYQMSANQTDEDQPSSVIQLKTVGEMDTKINQIEIDHIQRTLYAVQHDKGIIRCKLRTME
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap -----SNIEEITPPSI-----------SAP-QKIVADSYNGYVFYLLRD-GIYRADLPVP
sev_Dmel ----QSSFQIISTDLLGESTQKVGESFDLPVEQLEVDALNGWIFWRNEE-SLWRQDLHGR
ROS_Mmus -----SNLEEITPFSL-----------IAP-QKVVVDSYNGYLFYLLRD-GIYRVNLPLP
ROS_Spur ------GCSVAVANLG-----------SVP-VEMKVDPFSGYLFWSERDVGIRRTSLTSS
rol-3_Cele AEESPNCVLIVNNDAL-----------NAP-KEITLDSVNGHVYTLNADNKVYRTEMVAF
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap SGRCAEAVRIVESC----------------------------------------------
sev_Dmel MIHRL--LRIRQ------------------------------------------------
ROS_Mmus SGRDTKAVRIVESG----------------------------------------------
ROS_Spur TVEASSADIIINLLGQSSFTVLSETFQILYSNSTGNSMYSASLDGGNQKAMHVAEDTSNH
rol-3_Cele NATGI--ETVAS------------------------------------------------
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap ------------------------------------------------------------
sev_Dmel ------------------------------------------------------------
ROS_Mmus ------------------------------------------------------------
ROS_Spur QFINVTSIVYFNSSLTWTFARETGGVVACAFDPSYNHRDNEQIFFEGNPGQFSQGDLFLC
rol-3_Cele ------------------------------------------------------------
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap ------------------------------------------------------------
sev_Dmel ------------------------------------------------------------
ROS_Mmus ------------------------------------------------------------
ROS_Spur VDGYHGLDVFYPTYQPIPIPAFPPTDLQVLFTEDEIGQPSSPQPSNIGTTSLTLSWTAAS
rol-3_Cele ------------------------------------------------------------
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap ------------------------------------------------------------
sev_Dmel ------------------------------------------------------------
ROS_Mmus ------------------------------------------------------------
ROS_Spur HQDVRYLVQWRYVEGGGEAWNYFGSGEPISETTLDITDLIPYTLYQFRVVWVITPRHTLT
rol-3_Cele ------------------------------------------------------------
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap ------------------------------------------------------------
sev_Dmel ------------------------------------------------------------
ROS_Mmus ------------------------------------------------------------
ROS_Spur SQATSSVQTLPFGVPSTAPTITSIVSSSPTTISLTWDPPPFPNGPIIGYTIAVQNFFNEA
rol-3_Cele ------------------------------------------------------------
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap ------------------------------------------------------------
sev_Dmel ------------------------------------------------------------
ROS_Mmus ------------------------------------------------------------
ROS_Spur RIVLGVGGSTTEATVVDSSLRASTLYAVSVRARNMEGEGISDTVNITTGAEPQNLGVVPY
rol-3_Cele ------------------------------------------------------------
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap ------------------------------------------------------------
sev_Dmel ------------------------------------------------------------
ROS_Mmus ------------------------------------------------------------
ROS_Spur LVIGVTSLSFTNLSEMSSVSLVEYGKRIIDSDPLLNDIHTVDNENSTISDVAVDYWENFI
rol-3_Cele ------------------------------------------------------------
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap ------------------------------------------------------------
sev_Dmel ------------------------------------------------------------
ROS_Mmus ------------------------------------------------------------
ROS_Spur FISDSDGRIHRRTIDPANLTLAPSEVLYTDQSTAPTKLDVDWLNEQLYFVQGTEKLSPQL
rol-3_Cele ------------------------------------------------------------
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap ------------------------------------------------------------
sev_Dmel ------------------------------------------------------------
ROS_Mmus ------------------------------------------------------------
ROS_Spur ALAAVCGTFSMKNEESIHYSGEILRCDLNVSGCSVAVANLGSVPVEMKVDPFSGYLFWSE
rol-3_Cele ------------------------------------------------------------
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap ---------------------------TLKDFAIKPQAKRIIYFNDTAQVFMSTFLDGSA
sev_Dmel ----------------------------PGWFLVQPQHFIIHLMLPQEGKFLEISYDGGF
ROS_Mmus ---------------------------TLKDFAVKPQSKRIIYFNDTMQLFMSTFLDGSA
ROS_Spur QDVGIRRTSLTSSTVEASSVDIIINLSGQSSFTVLSETFQILYSNSTGNSMHSASLDGSN
rol-3_Cele ----------------------------LQYLQ-DMSPSNGIFFDVSKFLLYSALQNGSM
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap SHL--------ILPRIPFA----------DVKSFACENNDFLVTDG-KVIFQQDALSFNE
sev_Dmel KHP---------LPLPPPSNGAGNGPASSHWQSFALLGRSLLLPDSGQLILVEQQGQAAS
ROS_Mmus FHR--------VLPWVPLV----------TVKSFACENNDFLITDG-KAIFQQDSLSFNE
ROS_Spur QKA--------M-HVAEDT----------SNHQFINVTSIVYFNSSLTWTFARETGSVAS
rol-3_Cele MTLNPVTDHVHIFKDVGYA----------DIQHFRIKN-DLIYWMK-KKCGETDADE--N
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap FIVGCDLSHIEE----------------------FGFGNLVIFGSSSQ---------LHP
sev_Dmel PSASWPLKNLPD-----------------------CWAVILLVPESQP---------LTS
ROS_Mmus FIVGCDLSHIEE----------------------FGFGNLVIFGSSVQ---------SYP
ROS_Spur CFLGDPNYNYRDTERIFFEGNPGQFTQGDLFLCVDGYHGLDVFYPTYQ---------PIP
rol-3_Cele CIFAENLQRSEE-----------------------DIPNKFTYSSSLMSFGVLEEILLKP
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap LPG-RPQELSVLFGSHQALVQWKPPALAIGANVILISDIIELFELGPSAWQNWTYEVKVS
sev_Dmel AGG-KPHSLKALLGAQAAKISWKEPERNP--------------YQSADAARSWSYELEVL
ROS_Mmus LPG-HPQEVSVLFGSREALIQWTPPALAIG--------------ASPSAWQNWTYEVKVY
ROS_Spur IPAFPPTDLQVLFTE------------------------------GEEAWEEWLYEILLT
rol-3_Cele RIT-AVSTIAMLTSDKTARVSWDESNTLP-------------FQAQGSSWRNFTYFLKVT
AqueK407_Aque ------------------------------------------------------YE----
*
ROS_Hsap TQDPPEVTHIFLNISGTMLNVPELQSAMKYKVSVRASSPKR-PGPWSEPSVGTTLVPA-S
sev_Dmel DVASQS-AFSIRNIRGPIFGLQRLQPDNLYQLRVRAINVDGEPGEWTEPLAARTWP-L-G
ROS_Mmus SQDILEITQVFSNISGTMLNVPELQSSTKYTVSVRASSPKG-PGPWSAPSVGTTLVPA-T
ROS_Spur NLQIGN-TVTLTGLQEDSALVDNLNGSTEYSVQVRAYSIGG-LGPLSETFSGSTLIEV-D
rol-3_Cele APDITDFSPIEIYTSNTEMKI-DVTPGNIYNAQVQVCSDDFCSIPTS--TSNTALPDLGD
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap EPPFIMAVKE-DGLWSKPLNSFGPG-EFLSSDIGNV-SDMDWYNNSLYYSDTKGDVFV--
sev_Dmel PHRLRWASRQ-GSVIHT--NELGEGLEVQQEQLERLPGPMTMVNESVGYYV-TGDGLLHC
ROS_Mmus EPPFIMAVKE-DGLWSKPLCSFGPG-EFLSSDVGNV-SDMDWYNNSLYYSDTKGNVYV--
ROS_Spur VEPYLILANA-TDVWRSQLDGNAES-RLLSP-QATI-KDIEWYQGYYIWSSTMGDLY---
rol-3_Cele VVPFVFTKRQADDIISV--DILGNIIPAD-------------------------------
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap ----WLLNGTDISENYH-L-PSI-AGAGALAFEWLGHFLYWAGKTY-VIQRQ------SV
sev_Dmel INLVHSQWGCPISEPLQ--------HVGSVTYDWRGGRVYWTDLARNCVVRM------DP
ROS_Mmus ----RPLNGMDISENYH-I-PSI-VGAGALAFEWLGHFLYWAGKTY-VIQRQ------SV
ROS_Spur ----RSAEGDVIEEQLTFVPPGVRSSVDAIAVDWLSEFIYWADRDQNQIIRGRLSNQSSV
rol-3_Cele -------DSVKIVEKLQ---------YPHV-LDNTTKTVYLAG--DHSVSRS------I-
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap LTGHTDIVTHVKLLVNDMVVDSVGGYLYWTTLYSVESTRLNGESS--LVLQTQPWFSGKK
sev_Dmel WSGSRELLPV--FEANFLALDPRQGHLYYATSSQLSRHGSTPDEA--VTYYRVNGLEG-S
ROS_Mmus LTGHTDIVTHVKLLVNDMAVDSVGGYLYWTTLYSVESTRLNGESS--LVLQAQPWLSGKK
ROS_Spur VTSPTSINA-FANDVQDIAIDSVQAYIYWTSSSSVEGSRLNGESP--LVFYEIGDLSLDV
rol-3_Cele --------------------------ILIASSYKITSYRLPTTFDFEYFSCEEPLEACSE
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap VIALTLDLSDGLLYWLVQDSQ-C----IHLYTAVLRGQSTGDTTITEFAAWSTSEISQNA
sev_Dmel IASFVLDTQQDQLFWLVKGSG-A----LRLYRAPLTAGGDSLQMIQQIKGVFQAVPDSLQ
ROS_Mmus VIALTLDLSDGLLYWLVQDNQ-C----IHLYTAVLRGWSGGDATITEFAAWSTSEISQNA
ROS_Spur VAGLTLDLGGGYVYWFVVSRQ-GVTEELKLFRARLAGISPDPMSTTEEIGEVLSETTSLA
rol-3_Cele VMGISSDDTTGMVHFLTQARNGT----ITLWESDPENR-----TPRDIASVPSIVPFRRF
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap LMYYSGRLFWING--FRIITTQEIGQKTSVSVLEPARFNQFTIIQT-SLKPLPGNFSFTP
sev_Dmel LLRPLGALLWLERSGRRARLVRLAAPLDVMELPTPDQASPASALQLLDPQPLPPRD---E
ROS_Mmus LMYYSGRLFWING--FRIITAQEIGQRTSVSVSEPAKFNQFTIIQT-SLKPLPGNFSSTP
ROS_Spur LHFYSSKLFWINSQ-SRVEVSDDRGQRQALL--PATDVQALTIVQE-TLKPLPEGYSERP
rol-3_Cele LILHDKMILVT-KNN------HIVQTDKKLK-----VVNVATELERV-DHILPLRY---A
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap KVIPDSV-QESSFRI-EGNASSFQILWNGPPAVDWGVVFYSVEFSAHS------KFLASE
sev_Dmel GVIPMTV-LPDSVRLDDGHWDDFHVRWQPSTSGGNHSVSYRLLLEFGQ------RLQT-L
ROS_Mmus KVIPDPV-QESSFRI-EGHTSSFQILWNEPPAVDWGIVFYSVEFSTHS------KFLIIE
ROS_Spur TVVAEEI-SPSSIQV-TGTWDDFNITWQASTEVNYGIVFYTIAVTAPE------QTYT-E
rol-3_Cele T-ISHKIEFSDEIKFIDGSKTNLQ--WTLSPPLEAGTVLFKVSIFREKMGGQDPPIIT-I
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap QH----SLPVFTVEGLEPYA-LFNLSVTPYTYWGKGPKTSLSLRAPETVPSAPENPRIFI
sev_Dmel DL----STPFARLTQLPQAQLQLKISITPRTAWRSGDTTRVQLTTPPVAPSQPRRLRVFV
ROS_Mmus QQ----SLPIFTVEGLEPYT-LFNLSVTPYTYWGKGQKTSLSFRAPESVPSAPENPRIFI
ROS_Spur TV----QSASYNIKNLTPFQ-SLDITISPYTYWATTPETAAQMMSPMSVPSVPLNPRAFA
rol-3_Cele QSETNFTIPSEVLEAWSSAQ-RFDVSVQAMTPWATAVLNRTGLTAPVKPPTSPTQLRIFA
AqueK407_Aque ------------LRGLRALN-SRT------------------------------------
:
ROS_Hsap LPSGKC-CNKNEVVVEFRWNKPKHENGVLTKFEIFYNISNQSITNKTCEDWIAVNVTPSV
sev_Dmel ERLATA-LQEANVSAVLRWDAPEQGQEAPMQA-LEYHISCWVGSELHEE----LRLNQSA
ROS_Mmus LSSGRY-TKKNEVVVEFRWNKPKHENGVLTKFEIFYHISKQSGTNRSTEDWMSASVIPPV
ROS_Spur IDSTDIMTGTTMYSAEFRWSEPAEINGVFEGYNVSW------GTDV--EQLTVFNVSVDV
rol-3_Cele TQQ-KT-VDGPRALISFFWGPPSEWNGTPYQ--YIVNCTKDDGKL--------ITIDSSE
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap MSFQL-----EG------------MSPR-----------------CFIAFQVRAFTS---
sev_Dmel LEARV-----EH------------LQPD-----------------QTYHFQVEARVAATG
ROS_Mmus MSFQL-----EA------------VSPE-----------------YTVAFQVRVFTS---
ROS_Spur DVFSF-----AN------------LTAN-----------------TTYFFQVEGFTS---
rol-3_Cele LKPLVKLFAIDSTNSLISINDLAHEEPRRETRQVAQPVKLEYQAMAFIGEDLYAVR---K
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap KGPGPYADVVKSTTSEINPFPHLITLLGNKIV-FLDMDQNQVVWTF-S--AERVISAVCY
sev_Dmel AAAGAASHAL-HVAPEVQAVPRVLYANAEFIG-ELDLDTRNRRRLVHT--ASPVEHLVGI
ROS_Mmus KGPGPFSDIVMSKTSEIKPCPYLISLLGNKIV-FLDMDQNQVLWTF-S--LEGDVSTVGY
ROS_Spur VGSGPATDPVSITTGVSPPPPTIVVSKGNAGVTLTDPDTKEEIPLL-G---GIAISVVAF
rol-3_Cele EGESAQPVLV-------------------------QIDTNHIDNTVHKVSIGGDVTRIDA
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap TADNEMG---YYAEGDSLFLLHLHNRSSS------ELFQDSLVFDITVITIDWISRHLYF
sev_Dmel EGEQRLL---WVNEH-VELLTHVPGSAPA------KLAR--MRAEVLALAVDWIQRIVYW
ROS_Mmus TTDDEMG---YFAQGDTLFLLNLRNHSSS------KLFQDALVSDIRVIAVDWIARHLYF
ROS_Spur VASEDKV---FFVE----------------------------------------------
rol-3_Cele MTSDWVGNRLIFVAGTNVYQLSLEPFLSTSLLNPHKLIQLTSATDAKQLAYDPFMNTAYL
AqueK407_Aque ----------------------------Q------SLTNPH-------------------
ROS_Hsap ALKESQ--NGMQVFDVDL---EHKVKYPREVKIHNRNSTIISFSVYPLLSRLYWTEVSNF
sev_Dmel AELDATAPQAAIIYRLDLCNFEGKILQGERVWSTPRGRLLKDLVALPQAQSLIWLEYEQG
ROS_Mmus ALKASQ--NGTQIFNVDL---EHKVKSPREVKTCKAHTTIISFSIYPLLSRLYWTEVSDL
ROS_Spur ------------------------------------------------------------
rol-3_Cele L---TK--NGS-LFALDM---NKNTEANLAL----TVSCLASQTVTWMMTEFAWNRASS-
AqueK407_Aque ----------------------------------------------------YWS-----
ROS_Hsap GYQMFYYSIISHTLHRILQPTATNQQNKRNQCSCNVTEFELSGAMAIDTSNLE----KPL
sev_Dmel S------------------PRN----------------GSLRGRNLTDGSELEWATVQPL
ROS_Mmus GHQMFYCNISNHTSQHVLQPKASNQ-HGRSQCSCNVTESELSGAMTVDTSDPD----RPW
ROS_Spur ------------------------------------------------------------
rol-3_Cele ----------------------------------------------------------PK
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap IYFA------KAQEIWAMDL-EGCQCWRVITVPAMLAG---KTLVSLTVDGDLIYWIITA
sev_Dmel IRLHAGSLEPGSETLNLVDN-QGKLCVYDVARQLCTAS---ALRAQLNLLGEDSIAGQLA
ROS_Mmus IYFT------KRQEIWAMDL-EGCQCWKVIMVPT-IPG---KRIISLTVDGEFIYWIMKT
ROS_Spur -----------------------------------------------------------T
rol-3_Cele IYAL------TWNGLIYVDLTEDSQCNEVRIDWTKFGDKGLKDISSFAIADKLFAFV-T-
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap KDSTQIYQAKKGN--------GAIVSQVKALRSRHILAYSSV-MQPFPDKAFLSLASDT-
sev_Dmel QDSGYLYAVKNWSIRAYGRRRQQLEYTVELEPEEVRLLQAHN-YQAYPPKNCLLLPSSGG
ROS_Mmus KDDAQIYQAKKGS--------GAILSQVKASRSKHILAYSSA-LQPFPDKAYLSLASDM-
ROS_Spur SGDLEIYRSKL-D--------GSDREEVE--------GFTSVGSGPATDPVSITTGVSP-
rol-3_Cele SSEMLIY----------GKDTV-TPITIANPPLKQILAVSQS-SQPYPERSCFELPSSKG
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap VEPTILN-ATNTSLTIRLPLAKTNLTWY-GITSPTPTYLVYYAEVNDRKNSSDLKYR---
sev_Dmel SLLKATD-CEEQRCLLHLPMITASEDC--PLPIPGVRYQLNLTLAK-EPGSEEHDHGMEP
ROS_Mmus VEATILY-ATNTSLTLKLPPVKTNLTWH-GITHPTSTYLIYYMEAN-RANSSDRRHK---
ROS_Spur PPPTIVVSKGNAGVTLTDPDTKEETPLLGGIAISVVAFVA--------------------
rol-3_Cele IVFSIVN-EGKTGSFLEVTKSSSSSSCQ-EVSMPQTQYEIYFTRK----NTDKVKH----
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap ----ILEFQDSIALIED-LQPFSTYMIQIAVKNYYSDPLE---HLPPGKEIWGKTKNGVP
sev_Dmel LGQWLLGAGESLNLT-D-LLPFTRYRVSGILSSFYQKKLALPTLVLAPLE--LLTASATP
ROS_Mmus ----MLESQENVARIEG-LQPFSMYMIQIAVKNYYSEPLE---HLPLGKEIQGQTKSGVP
ROS_Spur ------------------------------------------------------------
rol-3_Cele ----VRSFSDRIHVENGILDKETDYDVTVTWLNRYS-PAS---GVSASKS--FRTGFGYP
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap EAVQLINTTVRSDTSLIISWRESHKPNGPKESVRYQLAISHLAL-IPE--TPLRQSEFPN
sev_Dmel SPPRNFSVRVLSPRELEVSWLPPEQLRS--ESVYYTLHWQQELDGENV--QDRREWEAHE
ROS_Mmus GAVCHINATVLSDTSLHVFWTESHKPNGPKESVRYQLVMSYLAP-IPE--TPLRQGEFPS
ROS_Spur -------------SEDKVFFV------------------------------------ETS
rol-3_Cele SAPRDPHAIPVTPDTVYLYWNLPETLNAPISEIKYKISQQAAGISVPTSIAVIALSETVS
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap GRLTL-----L-------VTRLSGGNIYVLKVLACHSEEMWCTESHPVTVEMF-------
sev_Dmel RRLETAGT-HR-------LTGIKPGSGYSLWVQA-HATPTKSNSSERLHVRSFAELPELQ
ROS_Mmus AKLSL-----L-------ITKLSGGQLYVMKVLACHPEEMWCTESHPVSVNMF-------
ROS_Spur GDLEI-----Y-------RSKLDGSDREE-------------------------------
rol-3_Cele SNISSDTTSCLINPCRVKIANLRPSNEYKFWVTA----------THISHLDAATILKDDD
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap --------NTPEKPYSLVPEN---TSLQFNWKAPLNVN-LIRFWVELQKWKY-NEFYHVK
sev_Dmel LLELGP------------------YSLSLTWAGTP-DP-LGSLQLECRSS---AE--QLR
ROS_Mmus --------DTPEKPSALVPEN---TSLQLDWKARSNVN-LTGFWFELQKWKY-NEFYHVK
ROS_Spur ------------------------------------------------------------
rol-3_Cele AVSSEAVARTLDVPGTLRPDNVTGSSLLLRWNGLEPEHRPSSIAVQYRESGGANNEWQFP
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap TS--CS-QGPAYVCNITNLQPYTSYNVRVVVVYKTGE-----------NSTSLPESFKTK
sev_Dmel RNVA----GNHTKMVVEPLQPRTRYQCRLLLGYAATPGA--------PLYHGTAEVYETL
ROS_Mmus AS--CS-QGPVYVCNITDLQPYTSYNIRVVVVYTTGE-----------NSSSIPESFKTK
ROS_Spur ------------LLELGNQQPYQAGFV---------------------------------
rol-3_Cele MNVSFEPDVTTELVPITNLLSATSYDYRFVATYTGTYTIDGKVLAFKEDYLQLPQQARTK
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap AGVPNKPGIPKLLEGSKN--SIQWEK-AEDNGCRITYYILEIRKSTSNN--LQNQN-LR-
sev_Dmel GDAPSQPGKPQLEHIAEEVFRVTWTA-ARGNGAPIALYNLEALQARSD---IRRRRRRRR
ROS_Mmus AGVPSKPGIPKLLEGSKN--SIQWEK-AEDNGSRLMYYTLEVRKGISND--SQNQS-SR-
ROS_Spur ---------------------IDWV-----------------------------------
rol-3_Cele AGVPTAPQFVEAKQDEEG-WIVTWKEPMSDGGSPITSYAVETRINKTAEWEIAERGLDG-
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap ----------------------WKMTFNGSCSSVCTWKSKNLKGIFQFRVVAAN-NLGFG
sev_Dmel RNSGGSLEQLPWAEEPVVVEDQWLD-FCNTTELSCIVKSLHSSRLLLFRVRARSLEHGWG
ROS_Mmus ----------------------WKVVFNGSCSSICTWRSKNLKGTFQFRAVAAN-EIGLG
ROS_Spur -------------------------------SQILYWSDNS--AIYSF------------
rol-3_Cele ----------------------WKTWWRPGKSDTTSSTSTSSTEVSEFRIRAAN-IEGFG
AqueK407_Aque --------------------------------------RDN-------------------
ROS_Hsap EYSGISENIILVGDDFWIPET--SFILTIIVGIFLVV-TIPLTFVWHRRLK--NQK----
sev_Dmel PYSEESERVA---EPFVSPEKRGSLVLAIIAPAAIVS-SCVLALVLVRKVQ--KRRLRAK
ROS_Mmus EYSEISEDITLVEDGVWITET--SFILTIIVGIFLVA-TVPLTFVWHRSLK--SHK----
ROS_Spur -----------------------------------DT-TLPVSMAIMEEVYEAPEG----
rol-3_Cele AYAYTEDKKEE-KEEEPSSVLPYLLLLSI---IFLLAAMILVACF---------------
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap -SAK-------EGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPR
sev_Dmel KLLQQSRPSIWSNLSTLQT-QQQLMAVRNR-----------AFSTTLSDADIALLPQINW
ROS_Mmus -ASK-------EGLSVLNDNDKELAELRGLAAGVGLANACYAVHTVPTQEEIENLPAFPR
ROS_Spur -NTV-------EGISV--NPHGK-MAIRQ-------ENSNY---------------AVTS
rol-3_Cele ----------------------------------------------------WYLPVVNY
AqueK407_Aque --------------------------------------------FKCTEEDLESLNKFPR
.
ROS_Hsap EKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMS
sev_Dmel SQLKLLRFLGSGAFGEVYEGQLKT--EDSEEPQRVAIKSLRKGASE--FAELLQEAQLMS
ROS_Mmus EKLSLRLLLGSGAFGEVYEGTAIDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMS
ROS_Spur EKLSLEHMSEHGSYKML-------------NVLILQLMTLRKGATDEDKQEFLKEATVMG
rol-3_Cele STVTFNDYIDTCAYGIVHSGTAEEVPMSWEKDVRVAIKKLKPNHSFQEKMMFMKEAILLN
AqueK407_Aque NKLRLENFIDRGEFGEVYQGTALDILGQGTGPTPVAVKTLRKGSTEDEQRKFLSEAALMS
. : : : : : : .*: . : ::.** ::.
ROS_Hsap KFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGP----LLTLVDLVD
sev_Dmel NFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLA
ROS_Mmus KFNHPNILKQLGVCLLGEPQYIILELMEGGDLLSYLRKARGTTFHGP----SLTLLDLVE
ROS_Spur KFKHPNIVLLMGVCLDNDPQYIIQELMEGGDLLCYIRAARMPAPTNS----KITLMDQIE
rol-3_Cele NLDHPNIVKELGVCITPGQELILLEYMEGGNLLKFLQKSTPNEYQSS----ELSPRDLLS
AqueK407_Aque NFNHINIVKVLGVCLNNDPIYIIMELMPGGDLLKFLREARRD-HGPP----LLTQSELVQ
::.* **: :*:*: :: * * .*:** ::: : . :: : :
ROS_Hsap LCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYT--SPRIVKIGDFGLARDIYKNDYYR
sev_Dmel MCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYR
ROS_Mmus LCVDISKGCVYLEQMHFIHRDLAARNCLVSVKDYT--SPRVVKIGDFGLAREIYKNDYYR
ROS_Spur IILDTVKGCEHLEELHFVHRDLAARNCLVSTKSYEA-HERVVKIGDFGLARDIYKNDYYR
rol-3_Cele ISVDIARGMNYLERLPHVHKNLSARKCLLAGR------PGVTKL-EMGMSKELSNGQVNR
AqueK407_Aque VALDVAQGCRYLEQQHFIHRDIAARNCLVSSKG----ADRVIKIGDFGLAKDLYSSDYYQ
: :* .* :** .:*::::.*:**:: *: ::*::::: ..: :
ROS_Hsap KRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQT
sev_Dmel KEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKE
ROS_Mmus KRGEGLLPVRWMAPENLMDGIFTSQSDVWSFGILVWEILTLGHQPYPAHSNLDVLNYVQA
ROS_Spur KEGEGLLPVRWMAPEGLMDGYFSVQSDVWAFGILMWEVMSRGQQPYPARSNVEVLRFVEA
rol-3_Cele SDLENMEIVRWMAPEVLKDFQFSSKSDVWAYGVLLYEVFSFGEVPYGDKDNRRIMTDVRN
AqueK407_Aque VEGQRKLPVRWMAPEALTQGKFSIESDVWSFGILLWEIMTFGNQPYPGRTNQEVLQFVTG
: ****:** * : *: :****::*:* :*::: *. ** : * :: *
ROS_Hsap GGRLEPPRNCPD-DLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSI-YKSRDEAN
sev_Dmel GGRLQQPPMCTE-KLYSLLLLCWRTDPWERPSFRRCYNTLHAISTDLRRTQM--AS----
ROS_Mmus GGRLEPPRNCPD-DLWNLMSQCWAQEPDQRPTFHNIQNQLQLFRNVFLNNV-SHCGEAAP
ROS_Spur GGRLSQPDQCPD-EIYMMMRRCWERSTEDRPSFKMLKEMIQDYRRKS-----------VG
rol-3_Cele GSVLPIPSYCPSKRIYKVIKQCLTSDSTKRANFATILKIFETFRDDQKCQDD--KP-IQF
AqueK407_Aque DGRLDKPEDCSS-RLYKLMQCCWKKYASERPKFAQIVDVISSYWDHLNNKRDSYCSDD--
.. * * *.. :: :: * . .*..* . :
ROS_Hsap NSGVINESFEGEDGDVICLNSDDIMP----VALMET----------K-NRE-------GL
sev_Dmel ----------ATAD-TVV------------------------------------------
ROS_Mmus TGGVINKGFEGEDDEMVTLNSDDTMP----VALMET----------K-NQE-------GL
ROS_Spur PNGADNFAFEGDG-KVDYSRLKDIPP--EMEDYLLPIDSKGDIIKDKPNIELPPDIDYDL
rol-3_Cele NDGTDNTNFSASQD-STSSREPP-SPSHRMRDFIDT----------R-DLE-------PP
AqueK407_Aque --------------------DDEEL-----EDILQR----------RPSRP-------SR
ROS_Hsap NYMVLA-------------------------------TECGQGEEKSEGPLGSQESESCG
sev_Dmel --------------------------------------SCSRPEFKVRFDG---------
ROS_Mmus NYMVLA-------------------------------TKCSQGEGSYEGPLGPKELGSCD
ROS_Spur AEKDLASASFKEEQKKEKRKGSKK--G-SLRGRLPGGASAADPTPRLEAAL---------
rol-3_Cele SPSHLNQSFGGFEHPYEGERPATMWNGSGARNSAKNSIGRSMKKEKLRNPI---------
AqueK407_Aque TSSVRSGFVNL----------------------ARQGSMRIRNSFRRRGSL---------
.
ROS_Hsap LRKEEKEPHA----DK-----DFC------------------------------------
sev_Dmel QPLEEHREHNERPEDE-----NL-------------------------------------
ROS_Mmus LKKDKKQPQA----DK-----DFC------------------------------------
ROS_Spur HDLENNRERGRDIDDQ-----RYLKY---------------------PVGSVSKATGAGV
rol-3_Cele HSMDDLVARNQRPLSIHSEDTESTDYGASSSMYSPGSSNRISSQVDPPIGRLSSAPGIGI
AqueK407_Aque HRKEEHDS----------------------------------------------------
:.
ROS_Hsap ------------------------------QEKQV-------------------------
sev_Dmel --------------TL---REVPLKDKQL-------------------------------
ROS_Mmus ------------------------------QEPQV-------------------------
ROS_Spur ANATDGAVGGATGPAVD----------DGSAEGAVGYSAGATMNGDAPNRTDLSNYAQAG
rol-3_Cele VNDAFE----SSNPSLNLSRSWAGLSREVNQNPAGAGSS-----GTLPQ-----------
AqueK407_Aque ------------------------------------------------------------
ROS_Hsap ---------------------AYCPSGK--------PEGLNYACLTHSGYG-DGSD
sev_Dmel ----------------------------------------------YANEG-VSRL
ROS_Mmus ---------------------AYGSPGL--------SEGLNYACLAHSEHG-DVSE
ROS_Spur KRHPNPFRANSMEELDGYDNLSFASSGAKASGGAKPSGGISVTGD-ITATD-YANV
rol-3_Cele -------HTNSAGHLRL-PGVQVGAGGGRVYRNASGGGG-------PSNRGRISQV
AqueK407_Aque -------------------------------------HGQNHAGL-NSE---EDLV
: