PIK3R4_Hsap FEYDKSLGSTRFFKVARAKH-REGLVVVKVFAIQDPTLPLTSYKQELEELKIR--LNSAQ
PIK3R4_Mmus FEYDKSLGSTRFFKVARAKH-REGLVVVKVFAIQDPTLPLTSYKQELEELKIR--LHSAQ
CG9746_Dmel IAFSSNMGSTRFFKVAKAKT-DEGQIVVKVFVKHDPTLPLEDHKERLEGIKKTLSLANAV
ZK930.1_Cele CDAVENLGSTRFMKVARGRT-HEGVFVYKVFVRQDL-ASLDPFPQRIIDIRKA--LMKSP
VPS15_Scer VHYVSQLNSSRFLKTCKALD-PNGEIVIKVFIKPKDQYSLRPFLQRIRAQSFK--LGQLP
Vps15_Ddis IVFKKSLGNARFLKTVKAYHSEEGYVVVKIYKKRNTKESLEKYKIMLKEIKDNFNITPSF
15015_Tthe ------------------------------------------------------------
VPS15_Spur ------------------------------------------------------------
CC1G_08691_Ccin IIYEKSLGSSRFLKTVKCKH-RNGYLVIKIFVKPDPGLTLRNYHKRLKNDKESL--VDIA
AqueK216_Aque ------------------------------------------------------------
VPS15-1_Smoe ------------------------------------------------------------
VPS15-2_Smoe ------------------------------------------------------------
GK073_Glam YHAENP-------------QT-KQDFILKVFVKLED-IDLSIFKFMLSHYREKINR-CCP
PIK3R4_Hsap NCLPFQKASEKASEKAAMLFRQYVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQAHK-
PIK3R4_Mmus NCLPFQKAAEKASEKAAMLFRQYVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQAHK-
CG9746_Dmel NCLPFQRVEL--IDKAAYIMREYVKHSLYDRVSTRPFLTVLEKKWITFQILCALNQCHK-
ZK930.1_Cele NCCPIKKVLV--KQKYAVMVRAFQKHTLFDRLSTRPFVVEAEKMWYIFLLFKALSQCET-
VPS15_Scer HVLNYSKLIE--TNRAGYMIRQHLKNNLYDRLSLRPYLQDIELKFIAFQLLNTLKDIHN-
Vps15_Ddis NIMPYQHFIE--TDRSGYLIRQYFHNNLYDRLSTRPFLSMIEKKFIAFQLLKALEQSSF-
15015_Tthe ----------------------------------KPSLSSFEKNWILFQTLIAIYCVHKL
VPS15_Spur ------------------------------------------------------------
CC1G_08691_Ccin NVYNYQVFVE--TERAGYIIRQWVASNLYDRISTRPFLTMVEKRWISFQLLNALRDARN-
AqueK216_Aque NVLPYQNFWD--SDKAAFLVRQHVQYNLYDRISTRPYLNNIEKKWIVFQLLKALEGCHE-
VPS15-1_Smoe -------WHE--TDKAAYLLRQYFFSNLHERLSTRPFLSTIQKKWLAFQLLHAVKQSHD-
VPS15-2_Smoe -------WHE--TDKAAYLLRQYFFSNLHERLSTRPFLSTIQKKWLAFQLLHAVKQSHD-
GK073_Glam HVLPYMGEYE--SKTHGFLIRPMLYQSLPEFILQNPWLTRGHKVLYSIQMILAVKEMHE-
PIK3R4_Hsap SGVRHGDIKTENVMVTSWNWVLLTDFASF-KPTYLPEDNPA-DFNYFFDTSRRRTCYIAP
PIK3R4_Mmus SGVRHGDIKTENVMVTSWNWVLLTDFASF-KPTYLPEDNPA-DFNYFFDTSRRRTCYIAP
CG9746_Dmel QKICHGDIKLENILITSWNWILLSDFASF-KPTYLPEDNPA-DYTYFFDTSRRRTCYIAP
ZK930.1_Cele AGVCHGDLKSQNVLISSTNWLQITDFAPF-KPCFLTHDNPS-SFTFFFDTSRRQSCYIAP
VPS15_Scer LNIVHGDIKTENILVTSWNWCILTDFAAFIKPVYLPEDNPG-EFLFYFDTSKRRTCYLAP
Vps15_Ddis KGVFHGDIKSENVLVTTSNWVYLSDFACY-KPTFIPEDNPA-DFSFYFDTSGRRTCYIAP
15015_Tthe ENIFHGAIRSSNILLTTSNHAFLTDFANY-KPLYIDEANQIRDLRFFYKTH-ENNSTLAP
VPS15_Spur -------------------------------------------------------CYIAP
CC1G_08691_Ccin RKVSHGDIKSENILVTSWNWVYLTDFASY-KPTYLPLDDPS-DFSFYFDTSGRRTCYLAP
AqueK216_Aque KKVYHGDLKTENVLLTGWGWVFLTDFASF-KPTLLPADNPA-DYTFFFDTSRRRNCYVAP
VPS15-1_Smoe RGVCHGDIKCENVLVTSWNWIYLTDFASF-KPTYIPDDNPA-DFSFFFDTGGRRRCYLAP
VPS15-2_Smoe RGVCHGDIKCENVLVTSWNWIYLTDFASF-KPTYIPDDNPA-DFSFFFDTGGRRRCYLAP
GK073_Glam AGLVHGDIKLSNFLVTHTHSLMLTDFAPF-KPYQVSMSNPV-ALSYYFTD------TIAP
:**
PIK3R4_Hsap ERFVDGGMFATELEYMRDP---------------------------------------ST
PIK3R4_Mmus ERFVDGGMFATELEYMRDP---------------------------------------ST
CG9746_Dmel ERFVKTLASDDDGGN-GNMS-------------------------------V----IHTD
ZK930.1_Cele ERFISATEYDEKLR----------------------------------------------
VPS15_Scer ERFNSKLYQD--------------------------------------------------
Vps15_Ddis ERFYETNRGAP-------------------------------------------------
15015_Tthe EKFKNNVEQQLIAL----------------------------------------------
VPS15_Spur ERFVEGSSSRPVDSATSETVEGLQVRQDVKGGELTPAMDIFSVGFVEGSSSRPVDNATSE
CC1G_08691_Ccin ERFYTQANNPDISA-K-K----------------------------------------SR
AqueK216_Aque ERFVHASSYSQSSS----------------------------------------------
VPS15-1_Smoe ERFYDPKTES--------------------------------------------------
VPS15-2_Smoe ERFYDPKTES--------------------------------------------------
GK073_Glam ERIVQADEELD-------------------------------------------------
*::
PIK3R4_Hsap PLV-DLNSNQRTRGELKRAMDIFSAGCVIAELFTEGV-PLFDLSQLLAYRNGHFF-----
PIK3R4_Mmus PLV-DLNSNQRARGELKRAMDIFSAGCVIAELFTEGV-PLFDLSQLLAYRNGHFF-----
CG9746_Dmel SII-R-LAPSYAGNTLLPAMDIFSAGCALLELWTEGT-APFELSQLLAYRRGERDL----
ZK930.1_Cele -----DGQDEWLFGSLTPKMDMFSAGCIVFELLCDR--PPFTYSSLCEYRSM--------
VPS15_Scer --------GKSNNGRLTKEMDIFSLGCVIAEIFAEGR-PIFNLSQLFKYKSNSYDV---N
Vps15_Ddis -----------SNNELTPKMDIFSLGCVIAELFLDGF-PIFDFSQLLSYRKGEYS-----
15015_Tthe -----D-QIAPKLLKDLQSMDIFSLGCVISDLYFEGDQPLFTYEQVQKFKAKQYT-----
VPS15_Spur TVEGLQVRQDVKGGELTPAMDIFSVGCVIAELFTEGN-APFDLSQLLAYCSGAYS-----
CC1G_08691_Ccin IAA-MEDTPGKRDGKVTEAMDCFSAGCVIAELFLEGA-PLFTLSQLFKYREGELN-----
AqueK216_Aque ----ASDS-FQRNKPLTYEMDIFSLGCVTAELFLDGQ-LI--------------------
VPS15-1_Smoe --------PVSPGGALKPSMDMFSLGCVIAELFLEGQ-ALFDLSQLLGYRKRLYD-----
VPS15-2_Smoe --------PVSPGGPLTPSMDMFSLGCVIAELFLEGQ-ALFDLSQLLGYRKRLYD-----
GK073_Glam -----------TLLLPTMEADVFSLGSALLELWTSI-K-PFDLPTLFEYRDAKTGNIINY
* ** *. :: .
PIK3R4_Hsap PEQVL-NKIEDHSIRELVTQMIHRE-PDK-RLEAEDYL------------------K
PIK3R4_Mmus PEQVL-NKIEDRSIRDLVTQMINRE-PEK-RLEAEDYL------------------K
CG9746_Dmel VEKHL-AGIENERLRNLLASMIDIH-SMN-RKSAEDYLD----------------QE
ZK930.1_Cele ---------NDADAGNMLLRLIQDV-PAPYRPLLRLLLNRD-------------PSF
VPS15_Scer REFLM-EEMNSTDLRNLVLDMIQLD-PSK-RLSCDELLNKYR-----------GIFF
Vps15_Ddis PEPIIRQRIQDPNIQTLILHMIQKD-PDQ-RYTPEKYISKWNTV-FPQYFSFAHQFI
15015_Tthe PESII-KKIQCQKTQQLVHKIIMEENEEN-RIGIEEVLK----------------YF
VPS15_Spur PDAVL-EQIEDEHIKDLCKHMLQKD-PSK-RMSAEQYLVKGRGTAF-------PEFF
CC1G_08691_Ccin VDTQL-ASIEDEGIRNLIKEMIHLD-PTA-RPTFDSLLHTS-------------RGT
AqueK216_Aque --------------------------------------------------------F
VPS15-1_Smoe PLPSL-EKISDTGIKNMILQMIHVV-PES-RLSCDDYLET---------------WA
VPS15-2_Smoe PLPSL-EKISDTGIKNMILQMIHIV-PES-RLSCDDYLET---------------WA
GK073_Glam VLSLL-DHITHEELRGLVHAMINPI-PSQ-RIDLST--------------------L